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PMT1

Victor ID 4664
Gene Name PMT1
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3641393
NCBI Protein GI 68477979
Locus Tag CaO19.5171
Genbank Accession AACQ01000060
Protein Accession XP_716993
Taxonomy ID 237561
Chromosome No 7
Gene Starting Position 92266
Gene Ending Position 94899
Gene Strand (Orientation) +
Protein pI 6.95
Protein Weight 93783.36
Protein Length 877
DNA Sequence 
>gi|68478018:92266-94899 Candida albicans SC5314 chromosome 7 Ctg19-10219, whole genome shotgun sequence
TATGGCAAAGAAACCGGTCACACCCGCTTCTAAAGTTGCTGCAAAACAGGCTGCTGTTAGAAGCAGACAC
CAAGAAGATGTATTCACACTTGATCCATTGATAGATCCAATATTTCAAAAGGGAGAATTGCGTTCGTATT
TGGTAACCGAACCTTCTCCTAGTGTTCTTAAAAAAAGACTGATTCACACCAAAGAATACTGGATGCTTTC
AAGTTTATTATTAATTGCTTTCTACGTTAGAATGTATAATTTATCCAATCCAAACTCAGTAGTTTTCGAT
GAAGTCCATTTTGGTGGGTTTGCCAGAAAATATATTTTGGGTACTTTTTTCATGGATGTACACCCTCCAT
TGGCTAAAATGCTTTTTGGAGCTGTTGGAGCCATTGGTGGATTCAAAGGTGATTTTGAATTTAAATCAAT
TGGTGATAAATTTCCTGATTCTACACCTTATATATTTATGAGACAATTCCCAGCATTGTTGGGTGTTGGA
ACTGTTATCTTGTGCTATTTGACTTTGAGACAATCAGGTGTTAGACCAATTATTGCTTATATAACTACCT
TTTTATTGATTATTGAAAACTCCAATGTCACTATTTCAAGATATATTTTGTTAGATTCCCCCTTGATTTT
CTTTATTGCTGCTGCTATTTATGCTTGGAAGAAATTTGAAATTCAAATTCCATTCACCTTTGGCTGGTAT
AGAAGTTTATTGGCAACTGGTATTGCTCTTGGTTTAGCATTGAGTTCCAAATGGGTTGGTTTGTTTACCG
TTGCCTGGGTTGGTTTCTTATGTATCTACCAATTGTGGTTCCTTATTGGTGATTTATCAGTAAGTACCAA
AAAAATTTGGGGCCATTTTTTCGCAAGAGGAATTATCTTGTTGGGTGTACCAATTGCCTTATATCTTGGA
TTTTTTGCCATTCATTTCCAATTATTAAATAAAGAAGGTGATGGAGGTGCCTTTATGAGTAGTGCCTTTA
GAGCCGGATTGCAAGGTAATAAAATTCCAAGAGATATTACCGAACAAGTTGGATTAGGATCAGTTGTTAC
TATTCGTCACGTTGATACTCAAGGTGGATATTTGCATTCACATGAACATTTCTATCAAACAGGTTCCAAA
CAACAACAAATTACCTTATATCCTCATTTGGACTCTAACAACAAGTGGTTAATTGAACCTTACAACGGCA
CCATCCATAATGAAACTTTTGTTCCTTTAATTAACGGTATGAAGATTAGATTGAAGCATATTAATACTGG
TAGAAGATTGCATTCACATGATGAAAAACCTCCAGTTAGTGAACGTGACTGGCAAAAGGAATGTTCATGT
TATGGATACGATGGATTTGCTGGTGATGCAAATGATGATTGGGTTGTTGAAATTGTCAATTATAGATCAC
AAAAGGGTGAAGCTCAAACATTTGTTAAAGCCATCAATACTATTTTCAGATTGAGACATGCCATGACCGG
TCATTATTTGTTTTCCAGTGAAGTGAAATTACCAGAATGGGGGTTTGGTCAACAAGAAGTCACTAGTGCT
TCACAAGGTAAACGTGCATTAACACATTGGTATATTGAAACCAATGAAAACAGTATATTGCCTCCTTCAG
AAGCCAAAATTATCAATTATCCTAAATTATCCCTTTGGCAAAAAGTTGTTGAATCACACAAGAGAATGTG
GAAGATTAATCAAGGATTAACTTCACATCATCATTGGCAATCTAGTCCATCTGAATGGCCATTATTGTTG
AGGGGTATCAATTACTGGAACAAAGAACATAAGCAAGTATATTTGTTGGGTAATGCTGTTACCTGGTGGG
CAGCCACTTTGTCAATTATCACTTTTGGAACCTATGTATTGGTTACTGTTTTCAGATGGCATCTTGGTAC
ACCTTTGTCAACAAATAAACATGTTTTCAATTTCAATGTGCAAACTTTTTCATATGTTTTAGGATGGGCT
TTACATTATCTTCCATTTTTCATTATGGGTAGACAATTGTTTTTACATCATTATTTACCAGCATTATATT
TTGGTATTTTGGCGTTGGGACATTTTTTCGAAATTTTCACTGGTTATTTGACTTCTCGTTCTAAATATTT
CCAACAAGTGGCATTTGTATTAGTTGGATTATTTTCCATTTTAAGTTTGGTATTTTATGTCAATTATTCA
TCTTTAATCTATGGTACTCCCTGGACTAAGGCAAGTTGTGAATTGACCAAACCATTTAGTGGTTGGGATT
ATAATTGTGGCACATTTTTCGATACTTTAGGAGAATATGACATTCAAGAGAAATCATTAGCTTCAGAATC
TGAAATACCAACAGAAACAGTAGTTGTTGAAGCTAAACAAACTCCTAAAGCTGAACCAAAATTGGCTAAA
CAAGATGATCACATTGAATCCCCTGCTGCTGCTGAACCTGTTGAAGAGAAAGAAGTCAAAGAAGAAGTTG
AACAATTGGCACCACCCTTAGCTGTTGATTTTGAAGAAGAAACTCCTAAAGTGGAAGACCCACAAGTTGC
TGATGTAGATGCTTCCAGTAACGATGAAAAATCTGTTGAGGAAAAGCAACAACAAGAACAACAACAAGAA
CAAGAACAGGTTGAAGATGAATCAGTGCATCAAGTTCAACAATA
Protein Sequence 
>gi|68477979|ref|XP_716993.1| hypothetical protein CaO19.5171 [Candida albicans SC5314]
MAKKPVTPASKVAAKQAAVRSRHQEDVFTLDPLIDPIFQKGELRSYLVTEPSPSVLKKRSIHTKEYWMLS
SLLLIAFYVRMYNLSNPNSVVFDEVHFGGFARKYILGTFFMDVHPPLAKMLFGAVGAIGGFKGDFEFKSI
GDKFPDSTPYIFMRQFPALLGVGTVILCYLTLRQSGVRPIIAYITTFLLIIENSNVTISRYILLDSPLIF
FIAAAIYAWKKFEIQIPFTFGWYRSLLATGIALGLALSSKWVGLFTVAWVGFLCIYQLWFLIGDLSVSTK
KIWGHFFARGIILLGVPIALYLGFFAIHFQLLNKEGDGGAFMSSAFRAGLQGNKIPRDITEQVGLGSVVT
IRHVDTQGGYLHSHEHFYQTGSKQQQITLYPHLDSNNKWLIEPYNGTIHNETFVPLINGMKIRLKHINTG
RRLHSHDEKPPVSERDWQKECSCYGYDGFAGDANDDWVVEIVNYRSQKGEAQTFVKAINTIFRLRHAMTG
HYLFSSEVKLPEWGFGQQEVTSASQGKRALTHWYIETNENSILPPSEAKIINYPKLSLWQKVVESHKRMW
KINQGLTSHHHWQSSPSEWPLLLRGINYWNKEHKQVYLLGNAVTWWAATLSIITFGTYVLVTVFRWHLGT
PLSTNKHVFNFNVQTFSYVLGWALHYLPFFIMGRQLFLHHYLPALYFGILALGHFFEIFTGYLTSRSKYF
QQVAFVLVGLFSILSLVFYVNYSSLIYGTPWTKASCELTKPFSGWDYNCGTFFDTLGEYDIQEKSLASES
EIPTETVVVEAKQTPKAEPKLAKQDDHIESPAAAEPVEEKEVKEEVEQLAPPLAVDFEEETPKVEDPQVA
DVDASSNDEKSVEEKQQQEQQQEQEQVEDESVHQVQQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Homozygous pmt1 mutants were avirulent in a mouse model of systemic infection, while heterozygous PMT1/pmt1 strains showed reduced virulence (Timpel et al., 1998).
References
Timpel et al., 1998: Timpel C, Strahl-Bolsinger S, Ziegelbauer K, Ernst JF. Multiple functions of Pmt1p-mediated protein O-mannosylation in the fungal pathogen Candida albicans. The Journal of biological chemistry. 1998; 273(33); 20837-20846. [PubMed: 9694829].