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UPC2

Victor ID 5134
Gene Name UPC2
NCBI Protein GI 556911682
Other Database IDs CDD:238023
CDD:256752
Taxonomy ID 5476
Gene Strand (Orientation) +
Protein Name transcription factor Upc2
Protein Length 712
Protein Note GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations; cd00067
Protein Sequence 
>gi|556911682|gb|AGZ84121.1| transcription factor Upc2 [Candida albicans]
MMMTVKQESPNSTLNTSEFSSDENLKTNNSEPPKKVSKSSTGKRKYHQKSRNGCSTCKKRRVKCDEQRPV
CGNCTKLKLDCGYLHEPLENILNTKKDIANNEPPSKKRKRKVSTVSAASDSESTTQQATPSLTPSPNHSQ
DIKTQPVIPPTNPLSALSSGLLSAGNLNNLNVAHLVNNLSGLGDLSNLASLGNLASLSNLASLAQLPIDL
SNLGSLLDSPAASNIAASFLGSAAATTVPPTTNSEFKESNQRKSQTQMPPQPTVPITSMGAATTTSSHQQ
ANMPSRSKPQPETLQSSIPATTSGSPGMSYPGCPSNSDPFGRSSDKSLPNISPNMSIPANPLSDPLTQGM
RSNLNMLDLKLMFHYTSVVANTITGAGISDTNIWNCDIPKLAFEHPFLMHSILAFSATHLSRTEKGLDQC
VTCHRGDALRLLREAVLNINADNTDALVASALILIMDSLANASFPSSTSPKSLPASAWIFHVKGAATILT
AVWPLTEASRFYKFISVDLGDLGDIINQGVNMNKSKGIDRENSAYYTDLECHDADIADLFPVLLDSPYLI
TLAYLNKLHKERYKSDFILRIFAFPALLDKQFMGLLMSGDVKAMRIMRSYYKLLRSFTTEMKDKVWFLEG
VSQVLPVNVEEYAGGAGGMHMMMDFLGGGPAIVDDNEIDAEITKFDPSGTLTNKLIDTDNLPSVLTSNLD
LMQGDNGFMNMK
Molecule Role Virulence factor
Molecule Role Annotation Deletion of the transcription factors UPC2 (involved in the control of ERG11) of Candida albicans results in the significant attenuation of virulence in mice, and had a negative impact on fitness, results in the epidemiology of antifungal resistance.(Lohberger et al., 2014)
References