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HSF (CTA8)

Victor ID 5149
Gene Name HSF (CTA8)
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3634947
NCBI Protein GI 68464767
Locus Tag CaO19.4775
Genbank Accession AACQ01000001
Protein Accession XP_723461
Taxonomy ID 237561
Chromosome No 1
Gene Starting Position 124667
Gene Ending Position 126952
Gene Strand (Orientation) +
Protein pI 5.79
Protein Weight 83359.33
Protein Length 761
Protein Note similar to S. cerevisiae Heat Shock Factor HSF1 (YGL073W) RNA Pol II transcriptional activator; allele of CaO19.12238 (Nicholls et al., 2011)
DNA Sequence 
>gi|68465034:124667-126952 Candida albicans SC5314 chromosome 1 Ctg19-10215, whole genome shotgun sequence
TATGATTATGAATATGACTACTGATTATAGAGATCCATTACTCGATTTGTTTGGTACAGAGTCTAACTCT
GGCAATGAAACATCATCTCCCAGTGACATTCCAGTTATCAACAGAAGTGGCACATTTAATCAACAACAAT
TTAGCCCCTTGTTAACCCAACAACTGTTATACAATACACCTAACTCTGGATCTACTCCGAATATTTTTGA
CCCAAACTATACCCAGATGCAGGAGGAACAAACATCTCCATCTCTGAACAAACTTCAACCAGAAGATCCC
CCAAGAAAGAAAAGGAACACTAGAAGTCAGACAAAGATACACCAACAACTGGAAGGAGATGAATACAACT
CAAATGATTACAAAGATCTGATAGATTTAGACAAACCACCAGTTGTTGAACCAAGTCCTCCGTTTTTTGT
TGAAAGTGACACTACCCCTGAATTTGTGATTCCAACACCTACCCTGGAACAACAACAGCAACAACATCAC
GAGTTAATCGCACAAGACTACCAACGTTCCAATAATTCAAATCAATTTGGAAACTTGACCCATTATGAAC
CAAATCTTCCTCCATTACCTCCTTTATCAGAGAGTATACTTCCACAGACAAACACTTTCCATCCATTAGT
GTTGCCACATGACCCAAGACACGCTATTACTGCTGGCCCAGCTAATAACAGTCAACAACAACAACAACGA
CAACAGCAAGACTCACTGATACCATCAGATGGTATTTCTTCCAAGATACAACAACTTCATGCACCTTCAT
TGTCAAACAATCAATCAGCATCTCAACGTAAAAAGAAAGAAAGTTCCGGGCCCAAAACACGTCCTGCATT
TGTTATGAAAATCTGGTCGATGGTGAACGATCCTGCCAATCATGAATATATCAGATGGAATGATGACGGG
AAGACTTTCCAAGTGTTTCACCGTGAAGATTTTATGAAGGTTATATTACCCAAATATTTCAAGCATAATA
ATTTTGCTAGTTTTGTGAGACAATTAAATATGTATGGATGGCACAAAGTGCAGGATGTCGCTAATGGTAC
CTTAAATCAAAACTCGGACAAGAATGGACAAGATGAAATATGGCAATTTGAGAATCCAAACTTTATAAAG
GATCGAGAAGATTTATTGGATAAGATTGTGAGAAACAAGAGTAGTTCAAACCAAGATGACGTTTCTGGAG
TTTCATTCAATGGGATAAACAATAGTGCAAATTTGTCGTTGATTTTACAAGAGTTGGAAACAATCAAGAT
GAATCAGTATGTTATATCTGAAGATTTAAGAAGAGTGCGACAAGATAACAAGATGTTATGGCAAGAGAAC
TACCTAAATAGAGAAAGAAATCAAGTACAAGGCCGCACATTGGATAAAATATTAAAGTTTTTATCTGTTG
TTTATGGTAATAATGCTAATAAAATATTGAATGGGCACGGATTTGCTGATTTCAGTGATAGTAACAATAT
CATGACTCAATATAGACCATCACCCATGGGATCACCATTACTACTGAGACCACAAACCCAACCACCACCT
TCAAATTCTAGATTTGCAAGAGATAACAATCAGACTGCACAACCTACTTATGAATCACCATTATCAACCA
GCGATACCAATAATAATAACAACAACAGTACCTTTGAATATCAACAAGCTGTCAATCGTCCACGTCTCAT
GTTGACTAACCGAGCACATTCAAGACGTCCAAGTATGTCTAGAACCAAATCTACACCAGAAGGGTCCATA
GAAGAGATAATACGTTCTTATTCTAACGATAAAGCTGCTGAATCTAATGTTAATCGAATGTATGAGCAAT
TAGTTGGTCATCAACCAGGTGCAACTACAAATAACAATAACCATTCTTCCCTGACAGCAATTTCGGCACC
ATCACCACGTCATAGTTTCTTACAAGAATTGAATCTACCAGGCACACCAAGAAACCTTGATGATTTAGAG
AAGCATATTAATAACGAAGGACAATCAATTCAGCAAGTGCAAGACTGGATTGATAAGTTAGCCCAAGAGC
AACATGAAAAACAACAGCAACAACAAGGAAATGAGGATGACGATGATTTTGATGTCAACGAGTTTTTGAA
AGATGCTACTACAACTCCTGGTTCTAATGTGCCAAATGGTGGCCATTATAATAATGGGAATATAAATTTT
GTTGATTCACCAATTGCAATGACTCCAGGCTCAAATGTCAGTTCTAACATAAATGATTCTAATGGTAATG
AGAAGAAACTGAAGAAAAGATCAATCGAAGAAGTTAGCGATCATTA
Protein Sequence 
>gi|68464767|ref|XP_723461.1| potential HSF-type DNA binding transcription factor [Candida albicans SC5314]
MIMNMTTDYRDPLLDLFGTESNSGNETSSPSDIPVINRSGTFNQQQFSPLLTQQSLYNTPNSGSTPNIFD
PNYTQMQEEQTSPSSNKLQPEDPPRKKRNTRSQTKIHQQSEGDEYNSNDYKDSIDLDKPPVVEPSPPFFV
ESDTTPEFVIPTPTSEQQQQQHHELIAQDYQRSNNSNQFGNLTHYEPNLPPLPPLSESILPQTNTFHPLV
LPHDPRHAITAGPANNSQQQQQRQQQDSSIPSDGISSKIQQLHAPSLSNNQSASQRKKKESSGPKTRPAF
VMKIWSMVNDPANHEYIRWNDDGKTFQVFHREDFMKVILPKYFKHNNFASFVRQLNMYGWHKVQDVANGT
LNQNSDKNGQDEIWQFENPNFIKDREDLLDKIVRNKSSSNQDDVSGVSFNGINNSANLSLILQELETIKM
NQYVISEDLRRVRQDNKMLWQENYLNRERNQVQGRTLDKILKFLSVVYGNNANKILNGHGFADFSDSNNI
MTQYRPSPMGSPLLSRPQTQPPPSNSRFARDNNQTAQPTYESPLSTSDTNNNNNNSTFEYQQAVNRPRLM
LTNRAHSRRPSMSRTKSTPEGSIEEIIRSYSNDKAAESNVNRMYEQLVGHQPGATTNNNNHSSSTAISAP
SPRHSFLQELNLPGTPRNLDDLEKHINNEGQSIQQVQDWIDKLAQEQHEKQQQQQGNEDDDDFDVNEFLK
DATTTPGSNVPNGGHYNNGNINFVDSPIAMTPGSNVSSNINDSNGNEKKSKKRSIEEVSDH
Molecule Role Virulence factor
Molecule Role Annotation C. albicans mutant which unable to activate Hsf1 gene display attenuated virulence in mice with systemic candidiasis. The HSF1 mutant displayed significantly reduced fungal burdens and outcome scores compared with the control strains.(Nicholls et al., 2011)
References