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SPF1

Victor ID 5141
Gene Name SPF1
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3646573
NCBI Protein GI 68488657
Locus Tag CaO19.30
Genbank Accession AACQ01000181
Protein Accession XP_711837
Taxonomy ID 237561
Chromosome No 2
Gene Starting Position 24678
Gene Ending Position 28349
Gene Strand (Orientation) -
Protein Name potential ER membrane P-type ATPase
Protein pI 5.69
Protein Weight 128426.92
Protein Length 1223
DNA Sequence 
>gi|68488670:24678-28349 Candida albicans SC5314 chromosome 2 Ctg19-10014, whole genome shotgun sequence
TCTATGCATCAACTTCATCTTCTTCTCTTAATGCAATATCAGCAGCTTTAGAATTCATAAAGAAATATTT
CAAAACGTATTCAATTGCAAAAGTAACCACCAAATCTAATATTATGCATCCAGTTAATTTAGTCTTGAAA
TCAATTGTCATTGGAACAAATTGCATAACTTCATTCAATTCAGGAATAAATTCCGTTGAACAAGAAAATG
TTAACCCAGCAACACCCAATAATCCATAATACATACCCTTGTTGGAAGTAATACTTTCTCTGAATGGTAA
TCCAATATAGTTAACGGCAAATGTAGAAACTTGTTGTGCTAATTGTAATAAGAACATACCAGTATTCAAC
AAAGATGGACTAAATTCTTTTTCTAAATCAACTTTTGGCTCTCTTGGTTCAAGAATATAAATTTCCCTGG
TAATATAAATCAAAGTAATAATATGAACGGCAAATTGTCCTAAAATGGATCCCATGATATAAATATTGAA
AATACCATCTTGAGGTCTTTCCTTAGATAATTTCTCTAATGGTCTACCACGTGAAATAGATAAGAAACAC
ACAGATAATAAAATACCAGAAATAGTGGCTTGTCCATCACCAAATTTCATACCAGCTAAATACAACACAG
AAAGGGAATAAGAAGAAATCAAACAATTCAATGCCAAAATCTTGTACATTTGAATTGTTGACACTAAGGC
AACACGACCTTGACGAATGATATGAGTAACAGTATTAACATTGGCCAATTTAGAAGTAAATGGAGCTGCC
ACAGAAGCATCACCCAATTTCAAAACTGGTGCTTCATCTTCAGCTTCAGCATCATTCATGGCTCCAAGAA
TTGTATCAGCAAAATTACTGTTAGTATTAAACCCACCATTAGCAGCATTCTTTTCTGGAACTTTAACAGG
TTCTTTCATGGCTTCAACAACTGCTTTTCTCATATCATCAGTAATAGTAACACCTTTCTTTTCCATGGCT
TCCAAATATTTAGGATTCAAAGGTCCTGGAGGATATAAATGAGCAATGATGGCAGGAACTGGTGGTGCTG
GTTTTCCCCAATTATTGAAAATTTGAGATTGTTTTTCATAAACTTTTAATGTAGCTTCAATCTTTCTATT
TTCAGCAATCTTATTCATACCTTCTTCAGTACCATTCAAAAGAGCAACCCCAATATTGGCTTGTTTCAAT
GCGCCAACATCATTAGTACCATCACCACACATCAATGTATTATAACCTGCATCTTTCAATGAAGTAATAA
TAAATTCCTTTTGTGTTGGTGAAACTCTAGCGTAAACCCAAGTGTGTTTTAACAATTCCAAAATTTGTTC
ATGATCACTCAAATAATTCAAAGCGTATCCAGTGATACAAATATCATATTTGCTAAACAATTCAAGATTA
ATTTTATCTGATGATTTGAATGGGATAACAACTGATTCAGTAACATTTCTCCATACCAAATTGTCATATT
CACCAATCTCATGATGGTCTTCAGGAGCATCCAAAATCAAAACTTCTTTAGTGGTAATATTAACCTCTTT
GGCAACATGGCAAGCAGTTAATGGATTATCACCAGTAATCATAATAGATCTATGTGATGATTCATTCAAC
ATTTTAATTGTTTCAATGGCATCATCTTTCAATGGACAATGGAAAACAATAAACCCGGCGAAATGTAAAT
CAGATTCAATATCTTCACGTTTAACTTTGTTGACATTGACACTGGATTCTAAATATTTATAAGCAAGTGC
CAAAACACGGGATCCAGATCTAGTGAAAGATTTATAAATCTTTTCATAATTTTCAGGGGCATCAACAATC
ATATTACGAATGGTTTCTGGAGCACCTTTGGCAGCAACAAAATTCTTACCAGAGATGGTATTAATCTGGG
AAATAGTAGAAGATCTCTTAAGGGCAGATGAGAACTGGAAACGACGTAAAATCTTTATTTTTTCTGATTT
GCCTTTACCCTTTTTACTTTCTCTTTCAACAGTATCATGAGTACCAACATTCCAATGAGCTGCTTTTAAT
GTAGCTTGTTCCATTGGGTCACCAACAACTTCACCATCATCTAATCTAACCAATGCATGAGCTGAACCCA
ATACATAAGAAGTGGTTTCTGGTGCATCTTCACAAATATGTAAATGATGAATATCATCGTTTTTGAAACC
AGCTAAACCTTCAAACACCAAATCTTCAGCAGTTAAAGTACCGGTTTTATCAAAACAACAAACATCAATT
CTACCAGCTAAGGGAATTCTGAATGGTTCAGTACAATAGATGTAGAATTTTTGCAATTTAGATAATGATG
AATTCACAGCCATGGTCAATTCCATAGGTAATTCAGGAGGAACAACAGAAGTGATGACAATGATACAATC
CAAGATTAATTTAGATTGAATTCTACCCATTCTTGTACCTTCGACCCAAACATACCAAGAAGCAGCAATG
GCAAATATTAACAAAAACAAAATGAAAAAGAATGCTTCTTTATTACCAACAGAAACACGTTCACTAGAGA
AAATCATCATACGAACTAATGAACCTTGAGATGTTTCAAACCCAGTTTTTGTGACTACGGCAAATGCACC
ATTATCTGGAGCAACAGGGACAATTGGTGATTCAGGTTTAGTAACTTGTAAAGCCATGGTACCACCGTGT
AAAATTGAGTTTTTATCAAATCCTTCTGGTTGTAATTGTTCATCTGCTGGTCTTAATTTAATAGATTCTT
TCAATAATGGAGTAGATTCACCTGATAACATGGCTTCATTGACAATCGCTGATCCATCAACTAGCAATAA
ATCACATGGTAAAGCACTTCCTTCATTAGTTCTTGTAATTGAGATCAAATCTCCAGGCAACAAATCTGTA
GTAGGAATTTTAACCCATTTGCCATCTCTATAAGCATATACATCGTATGGTTTGATACCCATGCTTTGAA
ACTCAGCCATAGTGGTTCTTCTTTGGAAGACAGTAGTCATTTCAAAGGAAACTAACATAAATAAGGAAAA
CAAGGAATAATACCATTGTTCATCCATACACCAAAGGGCAACACAAAAGATTTGGAAAACAAAAAATGGT
GCAACTGCGTGTTCTTTGAATAATTCCATAAATGTAGGAATTGGGATATCAAACCTATTAGATCCATAAT
TTCTAATCATTTTTTCTAAATCTCCTGATAAACCTTTAGTATTTTGATAAACGGCCAATTTTGGTGCTTC
ATCGAAAACAAATTCTGGTGGAGAAAATTTCCCAATTTTAGAATGAAATAAGTATCTTCTCTTTTGATAT
AAGAAACTAACTTGTTTTTCACCATCATGGAAAGTTTCACGATTAATTTCACAGATTTCACCCATACCGG
AATTTGGTGCTGGAGTGATCTTTATATATGAAGCATCAGAAATCTTGTCAACTTTAGTATAATTGAACTT
GGCATTGATATCAATATTCCAATGTGGCATCAACCAAAACAATAAATTCACAGAAACAATAGCAATGGTG
TATACAAAAGTCCATTCTTTACCACCAATGTATTTATCATATTGTTGGAAATAAATTTGTAAAAAGATCG
GATATATAATAGAAAAGGGCCATACATAAGGTCTTAGAAAAACTGCCTTCGGTACCAACAATTCAGCACC
TTGAATTGCCGGATTTGCAACTAAATCAGACA
Protein Sequence 
>gi|68488657|ref|XP_711837.1| potential ER membrane P-type ATPase [Candida albicans SC5314]
MSDLVANPAIQGAELLVPKAVFLRPYVWPFSIIYPIFLQIYFQQYDKYIGGKEWTFVYTIAIVSVNLLFW
LMPHWNIDINAKFNYTKVDKISDASYIKITPAPNSGMGEICEINRETFHDGEKQVSFLYQKRRYLFHSKI
GKFSPPEFVFDEAPKLAVYQNTKGLSGDLEKMIRNYGSNRFDIPIPTFMELFKEHAVAPFFVFQIFCVAL
WCMDEQWYYSLFSLFMLVSFEMTTVFQRRTTMAEFQSMGIKPYDVYAYRDGKWVKIPTTDLLPGDLISIT
RTNEGSALPCDLLLVDGSAIVNEAMLSGESTPLLKESIKLRPADEQLQPEGFDKNSILHGGTMALQVTKP
ESPIVPVAPDNGAFAVVTKTGFETSQGSLVRMMIFSSERVSVGNKEAFFFILFLLIFAIAASWYVWVEGT
RMGRIQSKLILDCIIVITSVVPPELPMELTMAVNSSLSKLQKFYIYCTEPFRIPLAGRIDVCCFDKTGTL
TAEDLVFEGLAGFKNDDIHHLHICEDAPETTSYVLGSAHALVRLDDGEVVGDPMEQATLKAAHWNVGTHD
TVERESKKGKGKSEKIKILRRFQFSSALKRSSTISQINTISGKNFVAAKGAPETIRNMIVDAPENYEKIY
KSFTRSGSRVLALAYKYLESSVNVNKVKREDIESDLHFAGFIVFHCPLKDDAIETIKMLNESSHRSIMIT
GDNPLTACHVAKEVNITTKEVLILDAPEDHHEIGEYDNLVWRNVTESVVIPFKSSDKINLELFSKYDICI
TGYALNYLSDHEQILELLKHTWVYARVSPTQKEFIITSLKDAGYNTLMCGDGTNDVGALKQANIGVALLN
GTEEGMNKIAENRKIEATLKVYEKQSQIFNNWGKPAPPVPAIIAHLYPPGPLNPKYLEAMEKKGVTITDD
MRKAVVEAMKEPVKVPEKNAANGGFNTNSNFADTILGAMNDAEAEDEAPVLKLGDASVAAPFTSKLANVN
TVTHIIRQGRVALVSTIQMYKILALNCLISSYSLSVLYLAGMKFGDGQATISGILLSVCFLSISRGRPLE
KLSKERPQDGIFNIYIMGSILGQFAVHIITLIYITREIYILEPREPKVDLEKEFSPSLLNTGMFLLQLAQ
QVSTFAVNYIGLPFRESITSNKGMYYGLLGVAGLTFSCSTEFIPELNEVMQFVPMTIDFKTKLTGCIILD
LVVTFAIEYVLKYFFMNSKAADIALREEDEVDA
Molecule Role Virulence factor
Molecule Role Annotation Spf1is a putative ER-localized P-type calcium ATPase in C. albicans. Deletion of SPF1 severely attenuated the virulence of Candida albicans in the mouse model. In contrast with the wild-type, SPF1 mutant produced little biomass and is defective for invasion in mouse kidneys. (Yu et al., 2012)
References