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PGA29

Victor ID 5143
Gene Name PGA29
Sequence Strain (Species/Organism) Candida albicans
Chromosome No 22
Gene Strand (Orientation) ?
Protein Length 204
Protein Note glycosylphosphatidylinositol-modified protein(de et al., 2010)
DNA Sequence 
>C4_04050C_A|RHD3 COORDS:Ca22chr4A_C_albicans_SC5314:867722-868336C (615 nucleotides)
ATGAAATTCCTTGCTATTTTATCCTTGTCTAGCTCTGCTCTTGCTACCATCTCATCCATT
CAATTATTTGCCAAATCCGACGATTCAAAAGTTGATGGTCTTGGTTTATACTCCAAACAC
GAAGGTGCTGCCATTGATTACTTGTTCCTCGGTAAGAACGGTGCTGACTTGAAATACGAT
GACGAAAAGAAACAAATTTTCCAAGAATTGAAAACTTCTTCAATCACCGTTAGACAACTG
TTCACTTTGGGTGGTGACGTTTACGAATTAGGTGCTACTGACAATTTCATCCCAGTCACT
ATTAACAAAGATGGTACTCTTAGTTTCACTGGTGATGACAAAGTTTACGCTTCCAAGAAT
GTCAACGATCCATACCGTTACTCTGAAAGCGAATACGCTGTTTCTAACAAAAAAACCGAT
GACAGTGCCCCAATCACCATTGTTGCCAAATTTTCTGACGACAAGGCTGCTGAAACCAGT
GGTGTTGCACAAGCTGCTTCAAGCAGTGCTGGCCCAGCTCAAGCCTCTGTTTCCAACTTT
GAAGGTGCTGCTGGCCAAAACAAATTAAGCTATGGTGTTGGTATGGCTGCTGTTGTTGCT
GGATTAGTCATGTAA
Protein Sequence 
>C4_04050C_A|RHD3 COORDS:Ca22chr4A_C_albicans_SC5314:868336-867722C, translated using codon table 12 (204 amino acids)
MKFLAILSLSSSALATISSIQLFAKSDDSKVDGLGLYSKHEGAAIDYLFLGKNGADLKYD
DEKKQIFQELKTSSITVRQSFTLGGDVYELGATDNFIPVTINKDGTLSFTGDDKVYASKN
VNDPYRYSESEYAVSNKKTDDSAPITIVAKFSDDKAAETSGVAQAASSSAGPAQASVSNF
EGAAGQNKLSYGVGMAAVVAGLVM*
Molecule Role Virulence factor
Molecule Role Annotation The pga29 deletion mutant is less virulent, and infection of reconstituted human epithelium with the pga29 mutant results in a diminished induction of proinflammatory cytokines, such as GM-CSF, TNF, IL-6 and IL-8. Deletion of PGA29 leads to reduced tissue invasion of infected reconstituted human epithelium, and is slightly reduced in virulence in a mouse model of haematogenous disseminated candidiasis compared to the WT strain. (de et al., 2010)
References