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VPS4

Victor ID 4695
Gene Name VPS4
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3637703
NCBI Protein GI 68470797
Locus Tag CaO19.4339
Genbank Accession AACQ01000022
Protein Accession XP_720644
Taxonomy ID 237561
Chromosome No 5
Gene Starting Position 214175
Gene Ending Position 215494
Gene Strand (Orientation) +
Protein pI 5.3
Protein Weight 45856.19
Protein Length 439
DNA Sequence 
>gi|68470818:214175-215494 Candida albicans SC5314 chromosome 5 Ctg19-10202, whole genome shotgun sequence
CATGTCGGGGGCGTCTGATTTTTTATCCAAAGGTATAGATCTTGTACAAAAAGCTATTGATGCTGATACG
GCCACTCGGTATGAAGAAGCCTATAAATTGTATTATAATGGATTAGATTATTTAATGTTAGCAATAAAAT
ATGAGAAGAATCCTAAATCCAAAGAATTAGTCAAGAGCAAATTCACTGAATATTTAACTCGAGCAGAACA
ATTAAAAGATCATTTAGAAAAGCAAGCACAAAATAAATCAACGGCAGAAAGTTCTGTAAATGGATCGACC
AAGGCAAAAAAATCTAATGGTGATGGCAATGGAAGTGGAGATGATAATGATGATGCTGACACGAAGAAAT
TACGTGGGGCATTAGCTGGAGCTATTCTTCTGGAAAAACCTAATGTCAAATGGTCAGATATTGCTGGATT
GGACGCTGCTAAGGAAGCATTAAAAGAAGCAGTTATATTACCGGTGAAATTCCCGCAATTATTTGTTGGT
AATAGGAAACCAACTTCAGGTATATTATTATATGGACCACCAGGGACAGGTAAATCTTATTTGGCGAAAG
CAGTAGCCACGGAAGCTAATTCGACATTTTTCAGTGTATCATCATCAGATTTAGTATCTAAATGGATGGG
GGAATCAGAAAGATTAGTGAAACAATTATTTACTATGGCAAGAGAAAACAAACCCTCAATTATATTTATT
GATGAAGTCGATGCACTTTGTGGACCTCGAGGAGAAGGTGAAAGTGAAGCTTCTAGAAGAATAAAAACCG
AATTATTAGTACAAATGAATGGGGTGGGTAATGATTCTCAAGGTGTGTTAGTTTTGGGGGCAACCAATAT
CCCATGGCAATTGGATGCTGCCGTTAGAAGAAGATTTGAACGAAGAATTTATATTGCCTTACCGGATGTC
GAAGCAAGAACAAGAATGTTTGAAATAAATATTGGTGACGTGCCCTGTGAATGTACCCCACATGATTATA
GAACATTAGCAGAAATGACCGATGGATATTCTGGTCACGATGTTGCCGTGGTGGTAAGAGATGCATTAAT
GCAACCAATTCGTAAAATACAACAAGCGACCCATTTCAAACCAGTGATTGATGAGACTGATGGGAAAGAA
AAATTAACACCTTGTTCTCCTGGTGATGAAGGTGCTAGAGAAATGAATTGGATGGATCTTGCCACTGATG
AATTGAAAGAACCTCCATTGACAATCAAAGATTTTATAAAGGCCATTAAAAATAATCGACCAACAGTTAA
TGAAGCAGATATTGCACAACATGTTAAATTCACAGAAGATTTCGGTCAAGAAGGTAATTA
Protein Sequence 
>gi|68470797|ref|XP_720644.1| potential vacuolar sorting ATPase [Candida albicans SC5314]
MSGASDFLSKGIDLVQKAIDADTATRYEEAYKLYYNGLDYLMLAIKYEKNPKSKELVKSKFTEYLTRAEQ
LKDHLEKQAQNKSTAESSVNGSTKAKKSNGDGNGSGDDNDDADTKKLRGALAGAILSEKPNVKWSDIAGL
DAAKEALKEAVILPVKFPQLFVGNRKPTSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMG
ESERLVKQLFTMARENKPSIIFIDEVDALCGPRGEGESEASRRIKTELLVQMNGVGNDSQGVLVLGATNI
PWQLDAAVRRRFERRIYIALPDVEARTRMFEINIGDVPCECTPHDYRTLAEMTDGYSGHDVAVVVRDALM
QPIRKIQQATHFKPVIDETDGKEKLTPCSPGDEGAREMNWMDLATDELKEPPLTIKDFIKAIKNNRPTVN
EADIAQHVKFTEDFGQEGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: vps4 mutant is greatly attenuated for virulence in a mouse model of disseminated candidiasis (Lee et al., 2009).
References
Lee et al., 2009: Lee SA, Jones J, Hardison S, Kot J, Khalique Z, Bernardo SM, Lazzell A, Monteagudo C, Lopez-Ribot J. Candida albicans VPS4 is required for secretion of aspartyl proteases and in vivo virulence. Mycopathologia. 2009; 167(2); 55-63. [PubMed: 18814053].