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TPS1

Victor ID 4692
Gene Name TPS1
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3646212
NCBI Protein GI 68487926
Locus Tag CaO19.13961
Genbank Accession AACQ01000186
Protein Accession XP_712180
Taxonomy ID 237561
Chromosome No 1
Gene Starting Position 37106
Gene Ending Position 38542
Gene Strand (Orientation) -
Protein pI 6.15
Protein Weight 50488.66
Protein Length 478
DNA Sequence 
>gi|68487953:37106-38542 Candida albicans SC5314 chromosome 1 Ctg19-20251, whole genome shotgun sequence
TCTAGTCCCTCAAACTCTTTTGTGGGTTACATTTGTACAATTCTTTAACAAAACTTTCACCCCAAAATCC
TGAAGTGTATTTCGAAATGTAGGTGAACAATTTCTTGAAATTAAATTCCCTCTTTTCTTCTGGTAATGTT
AAACTTTCTTTGATTGCTTCACTTAAATCTTCAGTGTTCCATGGGTTAACAATCAAGGCACCATTAAGTG
ATTGTGCTGCACCAGCAAATTCAGATAAGATCAAGACACCCTTGCGATCTTGTTGACAAGCAATATACTC
GTAACTAACCAAATTCATACCATCTCGAGTAGAACTAACCAAACAAACATCACTGATATTGTATAAACTG
ATCAATTCATCAAAGGGGATGGATTTGTGCAAGTAATGTATAGGGACAAATTCAACAGTACCAAATTCAC
CATTGATCCTTCCAACCAATTCACTCACTGTACTTCTTAAACTTTGATATTCTTCAACATCACCTCTGGA
TGGAACAGCAACTTGGACCAAAACTACTTTGCCAATCCATTCGGGATTTTCATTCAAAAAGACTTCAAAT
GCATGTAATTTTTGCGGAACACCTTTGATATAGTCTAATCTATCAACACCAACAATAACCTTAACGTCTT
TGAATTTAGATTTCAATTGTTTAATACGTTCCACAACACTATCTTTTTTCAAACCGTCAATAAAGTTATC
AACATCAATCCCAATGGGGAAAGCCCCGATGCTGATCGAACGTCCCTGGTACTTTATACCATTAGGTAAA
GTACTGACGTTTGGCACAATTCTTGAAACCGAACTGATGAAATGACGGGCGTAATCATAGGTATGGAATC
CAATTAAATCACAACTCAACACACCTTCAAGAATTTCTTTACGAACGGGCAAAATACGATAAATTTCTGA
TGATGGGAATGGTGTGTGCAAGAAGAATCCAATTTTAATGTTTTTCTTCTTGTTACCAATTTCTTGTCTT
AACATTTCTGGCAAAAGCATTAAATGATAATCATGAACCCAAATCATATCATCATCATTGACTTGTTTGA
CTATTTCCAATGCAAATTTCTTATTGGCTTCAATATATGCTGCCCATGCATTTTCGTCAAAGTTCATTTC
CCCAGGATGATAATGGAAAAGTGGCCATAAAATACTATTTGAAAACCCATTATAATGTAAATCAGCAATC
GTATCACTTAAAAATATGGCTGTACAATTGAATTTGGATTTCAATTCGTCATTTACTTTAGTTTGCTCAT
CTTCTGGAATTTCCAATCCAGGCCATCCATACCATTGAAACTCGGTTGTTTTTTTCAAACCTTGTAATGC
TGTAACGAGTCCACCGGAGGACATGGAATAATCGTATGAACCATTATCCAATCTTTTGATTGTAACAGGT
ATTCTATTTGAAACTACCAAGACTTTTCCTTGAACCA
Protein Sequence 
>gi|68487926|ref|XP_712180.1| hypothetical protein CaO19.13961 [Candida albicans SC5314]
MVQGKVLVVSNRIPVTIKRLDNGSYDYSMSSGGLVTALQGLKKTTEFQWYGWPGLEIPEDEQTKVNDELK
SKFNCTAIFLSDTIADLHYNGFSNSILWPLFHYHPGEMNFDENAWAAYIEANKKFALEIVKQVNDDDMIW
VHDYHLMLLPEMLRQEIGNKKKNIKIGFFLHTPFPSSEIYRILPVRKEILEGVLSCDLIGFHTYDYARHF
ISSVSRIVPNVSTLPNGIKYQGRSISIGAFPIGIDVDNFIDGLKKDSVVERIKQLKSKFKDVKVIVGVDR
LDYIKGVPQKLHAFEVFLNENPEWIGKVVLVQVAVPSRGDVEEYQSLRSTVSELVGRINGEFGTVEFVPI
HYLHKSIPFDELISLYNISDVCLVSSTRDGMNLVSYEYIACQQDRKGVLILSEFAGAAQSLNGALIVNPW
NTEDLSEAIKESLTLPEEKREFNFKKLFTYISKYTSGFWGESFVKELYKCNPQKSLRD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Mice inoculated with 10(6) CFU of the tps1/tps1 mutant did not show visible symptoms of infection 16 days after inoculation, while those similarly inoculated with wild-type cells were dead 12 days after inoculation (Zaragoza et al., 1998).
References
Zaragoza et al., 1998: Zaragoza O, Blazquez MA, Gancedo C. Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity. Journal of bacteriology. 1998; 180(15); 3809-3815. [PubMed: 9683476].