Victors

ALS1
Victor ID	4587
Gene Name	ALS1
Sequence Strain (Species/Organism)	Candida albicans
NCBI Protein GI	7687905
Other Database IDs	CDD:152202
Taxonomy ID	5476
Gene Strand (Orientation)	?
Protein Name	agglutinin-like protein
Protein Length	1260
Protein Note	Cell-wall agglutinin N-terminal ligand-sugar binding; pfam11766
Protein Sequence	>gi\|7687905\|gb\|AAC41649.2\| agglutinin-like protein [Candida albicans] MLQQFTLLFLYLSIASAKTITGVFDSFNSLTWSNAANYAFKGPGYPTWNAVLGWSLDGTSANPGDTFTLN MPCVFKYTTSQTSVDLTADGVKYATCQFYSGEEFTTFSTLTCTVNDALKSSIKAFGTVTLPIAFNVGGTG SSTDLEDSKCFTAGTNTVTFNDGDKDISIDVEFEKSTVDPSAYLYASRVMPSLNKVTTLFVAPQCENGYT SGTMGFSSSNGDVAIDCSNIHIGITKGLNDWNYPVSSESFSYTKTCTSNGIQIKYQNVPAGYRPFIDAYI SATDVNQYTLAYTNDYTCAGSRSQSKPFTLRWTGYKNSDAGSNGIVIVATTRTVTDSTTAVTTLPFNPSV DKTKTIEILQPIPTTTITTSYVGVTTSYSTKTAPIGETATVIVDVPYHTTTTVTSEWTGTITTTTTRTNP TDSIDTVVVQVPSPNPTVSTTEYWSQSFATTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSFATTTTV TAPPGGTDSVIIREPPNPTVTTTEYWSQSFATTTTVTAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTT TVTAPPGGTDSVIIREPPNHTVTTTEYWSQSYATTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSFAT TTTVTGPPSGTDTVIIREPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSY ATTTTVTAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTVTAPPGGTDTVIIREPPNPTVTTTEYWSQ SFATTTTVTAPPGGTDTVIIYESMSSSKISTSSNDITSIIPSFSRPHYVNSTTSDLSTFESSSMNTPTSI SSDGMLLSSTTLVTESETTTESICSDGKECSRLSSSSGIVTNPDSNESSIVTSTVPTASTMSDSLSSTDG ISATSSDNVSKSGVSVTTETSVTTIQTTPNPLSSSVTSLTQLSSIPSVSESESKVTFTSNGDNQSGTHDS QSTSTEIEIVTTSSTKVLPPVVSSNTDLTSEPTNTREQPTTLSTTSNSITEDITTSQPTGDNGDNTSSTN PVPTVATSTLASASEEDNKSGSHESASTSLKPSMGENSGLTTSTEIEATTTSPTEAPSPAVSSGTDVTTE PTDTREQPTTLSTTSKTNSESVATTQATNENGGKSPSTDLTSSLTTGTSASTSANSELVTSGSVTGGAVA SASNDQSHSTSVTNSNSIVSNTPQTTLSQQVTSSSPSTNTFIASTYDGSGSIIQHSTWLYGLITLLSLFI
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: als1p mutant is attenuated in mice (Fu et al., 2002). MUTATION: als1p mutant has attenuated destruction of epithelial destruction in buccal reconstituted human epithelium (RHE) model of oral canididiasis (Zhao et al., 2004).
References	*Fu et al., 2002:* Fu Y, Ibrahim AS, Sheppard DC, Chen YC, French SW, Cutler JE, Filler SG, Edwards JE Jr. Candida albicans Als1p: an adhesin that is a downstream effector of the EFG1 filamentation pathway. Molecular microbiology. 2002; 44(1); 61-72. [PubMed: 11967069]. *Zhao et al., 2004:* Zhao X, Oh SH, Cheng G, Green CB, Nuessen JA, Yeater K, Leng RP, Brown AJ, Hoyer LL. ALS3 and ALS8 represent a single locus that encodes a Candida albicans adhesin; functional comparisons between Als3p and Als1p. Microbiology (Reading, England). 2004; 150(Pt 7); 2415-2428. [PubMed: 15256583].


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ALS1