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CaTOP1

Victor ID 4690
Gene Name CaTOP1
Sequence Strain (Species/Organism) Candida albicans
NCBI Protein GI 1762119
Other Database IDs CDD:48065
CDD:128712
CDD:29496
Taxonomy ID 5476
Gene Strand (Orientation) -
Protein Name topoisomerase I
Protein Length 780
Protein Note Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic)...; cd03488
Protein Sequence 
>gi|1762119|gb|AAB39507.1| topoisomerase I [Candida albicans]
MSSSDEEDIALSRLAKKSSSITSASTYEDDEDDDIPLAKKSRKKRVESDYEEDEDEVPLKKRKLSNGRAK
KQVKTETKVKKEPKSANKSKSTSKKDTKVKKEKTTVKKESKATSTKVKEESKTQSDSQASVKSETPEEDQ
GYKWWEVNQEEEGDGYIKWQTLEHNGVMFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDH
AKNPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFEKLREEKKAMSREEKKRIKEEKEKEEE
PYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVVSEQVTLNLGKDAKIPEPPAGHQWGEIRH
DNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFETARKLRDHVDSIRKDYTKMLKSEKMQDRQMA
TAMYLIDVFALRAGGEKGEDEADTVGCCSLRYEHVTLKPPNKVIFDFLGKDSIRFYQEVEVDKQVFKNLR
IFKKSPKQPGDDLFDRINPSLVNRQLQNYMKGLTAKVFRTYNASKTMQDQIDIIENEGTVAEKVAKFNAA
NRTVAILCNHQRTVSKTHGDSVQRINDKLKKFMWQKIRLKKMILQLEPKLKKKDSKYFEEIDDLLKEDIE
HIHHTIIKRQREQAKKKLERDNEKLKLEGKPLLTESDIKDKLDKIDELEKEYQKELKTGKPIVTKNATVE
KLKQQIETLENKILNVSIQLKDKEDNSEVSLGTSKMNYIDPRLIVMFSKKFDVPIEKLFTKTLREKFIWA
IESADENWRF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a single gene knockout TOP1 mutant is attenuated in mice (Jiang et al., 1997).
References
Jiang et al., 1997: Jiang W, Gerhold D, Kmiec EB, Hauser M, Becker JM, Koltin Y. The topoisomerase I gene from Candida albicans. Microbiology (Reading, England). 1997; 143 ( Pt 2); 377-386. [PubMed: 9043115].