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DUR1,2

Victor ID 5146
Gene Name DUR1,2
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3644729
NCBI Protein GI 68484977
Locus Tag CaO19.8402
Genbank Accession AACQ01000123
Protein Accession XP_713627
Taxonomy ID 237561
Chromosome No 1
Gene Starting Position 60028
Gene Ending Position 65469
Gene Strand (Orientation) -
Protein pI 5.94
Protein Weight 185537.03
Protein Length 1813
Protein Note likely multifunctional enzyme similar to S. cerevisiae DUR1,2 (YBR208C) urea carboxylase and allophanate hydrolase; allele of CaO19.780(Navarathna et al., 2012)
DNA Sequence 
>gi|68484984:60028-65469 Candida albicans SC5314 chromosome 1 Ctg19-20073, whole genome shotgun sequence
ATTATTCTAAAACAACCACTAAATCACCGGCCTCCACCATATCCCCATTCTTGTGGTAAATTTTAAGCAC
CTTACCATCTCTTGGTGCATTAACAACCATTTCTGTTTTCATTGCTTCAACAACAATCAATGGCTGATGA
GCAGTAACTTTATCTCCAACTTCAACTACTGATTTCCAGAATCTACCAGAATATTCAGAATACACCAATT
CAGCATTATCATCAAATTTTTCGTCATCTTGAACTTTAGTTCCCAGTTTTTCCAATTCACTGTTTGAGAT
TTGAATCAATCTATTGAATTCTTCTAATTTCTCACCTCCTTGGTTTTGTTGGAATTCCTCAATTGATTTA
GAGTTTTCTTGAATCCATTCCAAATATTTACCATGATCGAAAACTGATTCAACAATATCAACTTTGAATT
TACCAGCATTCATTTGTTCAGAAAATGCATCAACTTCTTCTTCAGTAACAGGATAAAATTCAATTTGATC
GAATGGACTCAATAACCATGGTTTAGTGTTTGGTGAGTGTTCACCTAAACTCAATTTATCCCAAATTGGA
ACTGTCCTTCCAACTAATTGATAACCACCTGGTGATTCCATGGTATAAATACACATATAATTACCACCAA
TACCAACAGTACCATTTGGAGTAAAAGTTCTTGATGGATTATATTTGGTACCCAATAATCTATGTCTTGG
GTCTAATGGAACGGCGCATGGTGCCCCAAGGAAGACGTCCCCTAAACCTAAAACCAAAAATCTGGCAGTA
TACAACATATCTTTAACATCTGTTCTTGTGATTCCATTAATGTTAGCAATAAAATCAACATTGTTTGGTA
ACCATGGTGCCTCACTTCTAATGGTTTCTTGGTATCTTTTGACTGCATCCAATGTTTTCTTGTCTTCAAA
AGCCATTGGTAATTTAATAATTCTCGAACTCACTTTCCATTTGTTAACAAATATGATTTCCTTTTCATAA
GAAACTAAAGTATCCAAGGCTTCCTTTTGGGTGATTTCATCAGTATATTCAACCAACACTGATCTAACAC
CAGCAGATAATTCAAAAATACCTTTAGGTTTATATTCTTTGACCATTGCATCTAATTTGTGGATTCTGTA
AGCCAAATTCAAATCAAGAAGATTGTCTCCGTATTCAACAAGAATATATCTATCACCAGCTTGACGATAG
GTTACTTTTGGAGCATTTGAAGAAACTTTGAATTGATGCAAGATTGGGTTTTCTGGAGCTGATAATGAAA
CGGTTTCTAAAGATGGCAAATCACCAGATAAGTTTTCAATTGCAGCATTTTGTTGTTTTTTCAAATTTTT
AGCAGATTCATAACTTATTGGGACAAATTGAATTGATTCACCTGGTTTGACTTGACCAACTTTCCATAAT
TCAGATTCAGCAACAACTGCTTCACAAACAAACCCACCTAAGGATGGACCATCGCATGTTAAAATGACTG
GTTCGTCACCAGTGAAATTGATAGCACCCATGGAATAAACATAATCATGAGTGTTTGATGGATGTAACCC
ACCTTCGCCACCATCCTTTCTAGCCCATTTAGGTTTTGGTCCAATCAATCTAACACCAAATCTGTTGGAA
TTATAATGCACTTTCCAAGTGGAAGAGAAAAATTCCTCAACCGATTCAGCTTTAAAAAAATCTGGAGATC
CATGTGGACCACAGGTAACACCAATCTTCCAAACTTTGTTGTCATAATTTGGAATTAATGATGCTGGAAC
AGGAGTTGGTTGGGAAATGGGGCCTGGTAAAGTACAACTTGTAACATCAGGTTGTCCCAAAAATAAAACA
TCACCCAATTTCAAGACTCTACCATTGTAACCACCCAAATTACCTAATGCAAAAGTTGATCTTGAACCCA
AATATTCAACAACATCAACACCGCCTCTAATGGCCAAGTAAGCTCTGCAACCAGTAGACAATTTACCAAT
ATCCAATTTATCTCCACTTTTGATGTTAATTGGTTCCCATTGATTAACTTCAACTTGGTTAACTTCAACT
TTAGTCTTACCACCAGTAACAGCAACAACACAATCTTGATGGAACAAAAGTTTTGGTCCATTCAATGTGA
TTTCAATACCAGGAGATGCTGCATCGTTACCAACAATTTGATTAGCAACTCTGAATGAATATTGATCCAT
ACAACCTGATGGTGGAACCCCAATGTGCCAGTAGCCCCTTCTACCGGGGTAGTCTTGTACTGTAGTGTAA
GCACCTGGTTGTAAAATTTCAATGGCATGTGGCTTGTAGTCATAAGAGTCCAAAACTTTGGTGGCTACAG
CTGCTTCCTCAAACATTTTCGAATTAGCAATCGATCTCAAATAGTCAACATTGGTGATACATCCATAAAC
AACAGTTTCATTCAATGCTTGACGTAACTTCTTTAAGGCATCATCTCTATCCTTACCATGAACAATGATT
TTAGCTAAGGTGGGGTCATATTCAGCAGAAACAATAGTACCTTTTTCAACCCAACTATCGATTCTAGCCC
ATTCAGGGAATTTTACTTCTGTCAATTGACCTGGTGATGGCATGAAACCTTTAACTGGATTCTCGGCATA
TAATCTAGCTTCCATTGATGCTCCTTTGACTTCAATTTTTTGGTTGAAATCAGGTGGGGTGTCTGCAGCT
ATCAAAAGCATCCATTCAACTAAATCTAATCCAGTGACCATTTCTGTAATTGGATGTTCAACTTGTAATC
TGGCATTTACTTCTAAAAAGTAGAATTCATCTCTCTTGGGATCGTAAATATATTCCACTGTACCGGCACA
TTTATATTTCATAGATGAACCAAGTGATTCAGCTGCTTTTCTCATTTTATTTCTGGTTTCTTCTGGTAAA
TTGGGTGCAGGTGTCTCTTCAATGATCTTTTGGTTTCTACGTTGTAAAGAACAATCTCTTTCACCAACAG
CAATGGCATTACCGTAACCATCACCTAACATTTGGATTTCAACGTGTCTGGCATTTTCAACAAATCTTTC
CAAAAATACCCCTGAGTCTCCGAAATAGGATTTTCCTTGATGTTGAACGGTTTCAAAAACTCTTTCAATA
TCTTTTTCAGAATCTACTTTTTGTAAACCAATACCACCACCACCTGCAGTAGATTTGACCATAATTGGAT
ATTCCAATTTGGCAGCAATCGCTCTGGCTTCTTTGGCATCTTTCACCAAACCTGAACCAGGAACCAACGG
CACTCCAGCTTTTTCGGCAATTTCTCTAGCTGAATGTTTTAATCCCAATTTTCTAATGGCATCACCAGAT
GGACCAACAAACACAATTCCTTCTTTACCACAACGATCGGAGAAATCCGCATTTTCGGATAAGAACCCAT
AACCTGGGATGATAGCTTCTGCACCAGACTCCTTGGCTGCTTTGATAACTTTTTCAATGTTGATATAAGT
TTCAGCAGCTGTTGTACCATGCAATGGAATTGCAACATCTGCCATTAATGAGTGTTGAGCATACTTATCT
GGATCTGAATAGACAGCAATAGATTTTACCCCCAATTTTTTCAAAGTTTTGATTATTCTAACGGCAATTT
CTCCTCTATTGGCAACCAAAACTGAATTGAATGGTTTTTTGGAGGCACGCAAATGTTCTTGATACTTTTT
CCAACCGCCAAATTCAGTAATGTCAACAGTACCAGGTTGTTTGTAACCAAATTCTTCACAGATAAAAGAT
TTACACCATTCACCTGATTTTAATTCGACCGATCCAATACCTAATGGTTCAGGAACAAATTTGATAAATT
GTCCAAATTTCTCTTTTGGAATACTATAGGTTTCAACAGCTATATGTTCACCATCGGATTCCACTCTTCT
CAAACCAGGTTTGGCAACGGGTCCTGTCTTCGGCAAGGCATATAATTTATAGTTTTTCGAAGTTGTTGTT
GATTCAATAAATCGAGCATCAACTTTTTCCAATTGCCAATGTAATTCAAATCCTTTAAGATGAGCTCCAA
CAACAGCCAATTTAACAGTTTCTTCGGGGGTAGATTTTGGTAATAAGTACAATTCATCATGGATGGTAGA
CACTTTCTTTTGTGAAACACCACATGTACGTAAATTGTCGAGTTTCAAGTAACGACTGGCTAAGTCTAAT
AATGCATAATCGTTGAACTTGTGTGATAACAATGTGACACCGAAGGGTAATCCATCATTTCTGAATCCTG
CTGGGATAGCTAGTGCAGACATATCTGCCAAGTTGACAAAGTTGGTATAAGTACCTTGACATGAGTTGAC
TTTGATTGGTTCGTTGGTGACTTCTTCGATTGTTGGATTCAATGGGGCTGTTGGTACAATAATAGCATCA
ATGCCTTCTAACAATTTGTTGACTCTCTTCACAATTCCCTGTCTTTTGTATTCATATTGGAAACAAGTGG
CTGCAGAATAATGTTCTCCACCTTTAATAATTTTGGTGACTGTTGGATCCAAATCCTTTTCCGGTGGATT
TGTGGCAAAGAAATCTTTAACAGCAACATAACGTTCAGCAACCCATGGACCTTCATATAAGCATCTAGCT
AATTCTAACAATGGTTCAATATCCAAAGATACCAATTCACACCCGATTTTTTCAAATTTAGCAACTGCTT
CTTGGTATAATTTAGGGTTTTCTTTCTCGCCGTACCATAACAAATTGGTTGGTACTACAACTCTAGGTTT
TTTGCCAAATTTCAATAATGGATTTTTTGGCATTGATCTTGAAAATTCGTCATGTTCATCTTCTTCTGCC
ATAATATTAAACGTAAGCTGTGCATCTTGCAAATTCAATGCAAATATCGAAACACAATCAAGTGACTTAC
ATGCTGGAACAACACCTGAACATGAAAAGACACCTTTTGTTGGTTTCAATCCAATAAGATTATTCAATGC
TGCGGGGACTCTTCCTGATCCAGCAGTATCGGTACCTAATGCAATTGGAACAATACCTCTAGCAACCACC
GAGGCAGATCCGGCTGAAGATCCACCACTGACGTACTTTGGATTGAATGTATTTGGAGTTATTCCGTAGG
GAGACCTTGTACCGACTAAACCTGTTGCAAATTGATCTAAATTGGTTTTCCCAATAACTATGGCACCGGC
ATCTCTTAACAATCTAACTGTAGTGGCATCTTTTGACGGAGAGTAAGCAAATGAAGGACAAGCTGCTGTA
GTTTCAAATGTTTTAGCATCTATGTTATCTTTAACTGCTATGGGGACCCCGTATAACGGTAAATCTCGTT
TATTCGATTTTGATTGTAAAAATTTCCATTGGTGTTCCAAATTCTCTATGGAAGCTAAGGATATCCAAGC
AGGATCTTCTGGAGCAGCTTTTTGGGATTTTAATAATTGGGATAATAATTCAAAAGATTCATCTGGTGTT
GATTCGTAATGAAACTTTTTCCAATCTTCTACTGACCAACCTAAGTATGACA
Protein Sequence 
>gi|68484977|ref|XP_713627.1| likely multifunctional urea amidolyase [Candida albicans SC5314]
MSYLGWSVEDWKKFHYESTPDESFELLSQLLKSQKAAPEDPAWISLASIENLEHQWKFLQSKSNKRDLPL
YGVPIAVKDNIDAKTFETTAACPSFAYSPSKDATTVRLLRDAGAIVIGKTNLDQFATGLVGTRSPYGITP
NTFNPKYVSGGSSAGSASVVARGIVPIALGTDTAGSGRVPAALNNLIGLKPTKGVFSCSGVVPACKSLDC
VSIFALNLQDAQLTFNIMAEEDEHDEFSRSMPKNPLLKFGKKPRVVVPTNLLWYGEKENPKLYQEAVAKF
EKIGCELVSLDIEPLLELARCLYEGPWVAERYVAVKDFFATNPPEKDLDPTVTKIIKGGEHYSAATCFQY
EYKRQGIVKRVNKLLEGIDAIIVPTAPLNPTIEEVTNEPIKVNSCQGTYTNFVNLADMSALAIPAGFRND
GLPFGVTLLSHKFNDYALLDLASRYLKLDNLRTCGVSQKKVSTIHDELYLLPKSTPEETVKLAVVGAHLK
GFELHWQLEKVDARFIESTTTSKNYKLYALPKTGPVAKPGLRRVESDGEHIAVETYSIPKEKFGQFIKFV
PEPLGIGSVELKSGEWCKSFICEEFGYKQPGTVDITEFGGWKKYQEHLRASKKPFNSVLVANRGEIAVRI
IKTLKKLGVKSIAVYSDPDKYAQHSLMADVAIPLHGTTAAETYINIEKVIKAAKESGAEAIIPGYGFLSE
NADFSDRCGKEGIVFVGPSGDAIRKLGLKHSAREIAEKAGVPLVPGSGLVKDAKEARAIAAKLEYPIMVK
STAGGGGIGLQKVDSEKDIERVFETVQHQGKSYFGDSGVFLERFVENARHVEIQMLGDGYGNAIAVGERD
CSLQRRNQKIIEETPAPNLPEETRNKMRKAAESLGSSMKYKCAGTVEYIYDPKRDEFYFLEVNARLQVEH
PITEMVTGLDLVEWMLLIAADTPPDFNQKIEVKGASMEARLYAENPVKGFMPSPGQLTEVKFPEWARIDS
WVEKGTIVSAEYDPTLAKIIVHGKDRDDALKKLRQALNETVVYGCITNVDYLRSIANSKMFEEAAVATKV
LDSYDYKPHAIEILQPGAYTTVQDYPGRRGYWHIGVPPSGCMDQYSFRVANQIVGNDAASPGIEITLNGP
KLLFHQDCVVAVTGGKTKVEVNQVEVNQWEPINIKSGDKLDIGKLSTGCRAYLAIRGGVDVVEYLGSRST
FALGNLGGYNGRVLKLGDVLFLGQPDVTSCTLPGPISQPTPVPASLIPNYDNKVWKIGVTCGPHGSPDFF
KAESVEEFFSSTWKVHYNSNRFGVRLIGPKPKWARKDGGEGGLHPSNTHDYVYSMGAINFTGDEPVILTC
DGPSLGGFVCEAVVAESELWKVGQVKPGESIQFVPISYESAKNLKKQQNAAIENLSGDLPSLETVSLSAP
ENPILHQFKVSSNAPKVTYRQAGDRYILVEYGDNLLDLNLAYRIHKLDAMVKEYKPKGIFELSAGVRSVL
VEYTDEITQKEALDTLVSYEKEIIFVNKWKVSSRIIKLPMAFEDKKTLDAVKRYQETIRSEAPWLPNNVD
FIANINGITRTDVKDMLYTARFLVLGLGDVFLGAPCAVPLDPRHRLLGTKYNPSRTFTPNGTVGIGGNYM
CIYTMESPGGYQLVGRTVPIWDKLSLGEHSPNTKPWLLSPFDQIEFYPVTEEEVDAFSEQMNAGKFKVDI
VESVFDHGKYLEWIQENSKSIEEFQQNQGGEKLEEFNRLIQISNSELEKSGTKVQDDEKFDDNAELVYSE
YSGRFWKSVVEVGDKVTAHQPLIVVEAMKTEMVVNAPRDGKVLKIYHKNGDMVEAGDLVVVLE
Molecule Role Virulence factor
Molecule Role Annotation A dur1,2Ãâ/dur1,2Ãâ mutant significantly decreased in virulence in a mouse model than the wild-type strain, showing significantly higher survival rate, better renal function, and decreased and less sustained fungal colonization in kidney and brain.(Navarathna et al., 2012)
References