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SAP6

Victor ID 4680
Gene Name SAP6
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3639229
NCBI Protein GI 68473561
Locus Tag CaO19.5542
Genbank Accession AACQ01000034
Protein Accession XP_719105
Taxonomy ID 237561
Chromosome No 6
Gene Starting Position 54399
Gene Ending Position 55655
Gene Strand (Orientation) -
Protein pI 8.24
Protein Weight 42356.11
Protein Length 418
DNA Sequence 
>gi|68473734:54399-55655 Candida albicans SC5314 chromosome 6 Ctg19-10230, whole genome shotgun sequence
TCTAATTAATAGCAACAATGTTAGACTCGGAAGTGTATTTAACTTGAGCCATGGAGATTTTCTTATCGTC
CAAATCGTAAACAATGTAAGCTGATCTCATGAAGTTGTCACCAAGAATATTATCTTCACTTTCACGAACA
CGAATTTCACATTTTGGATAAGGTTTACCATTAGTGTAATACAATTGGTAAAGGAATTCCGAAGCAGGAA
CGGAGATCTTGAGGTTTTTATCGAATTGGAAATCAACGGTACCTGAAGTTTTACAATCAGCAACATAAGC
TTTATTACCAGCAGAATCAAAATGCACTTGACCACCTAAGGCATAGATAATGCTACGAGCAATACTTGGA
GTGAAATAACTGATAGTAGTACCAGAATCTAAGAGGACACCAGCGTTGACATTAACATTTCGTCCCATAA
CATTGACAGATCTTAAACCGACACTTAATGTTCTGTCAGAAGTAATTGGTAATTCAACTAAAGAGCCACT
GTACTTGGCCTTGTCAATACCACCAAAAATAATTTGCCCAGAAGAAGCTTCAGGAGAGTTAAGGAAGAGG
GAATAAGCATTTTTAGCAATAATGCCTTGTTTTTTCAAACTAATAGGAAGATTGTCGTAAGGAGTTCTGG
TAGCTTCGTTGGCTTGGAAACCAATACCTAAAATACCTTTATGAGCACTAGTAGACCAAACGTTAGCAAA
TAATTGATTTTTAACAGAAGCACCACCAATACCAACGGTATCTTGATACAAGTTACCTTTTGCGTAAGAA
CCATCAGCATATTTAATTTCAAAACGGGTATTCAAATTTTTGGAAGTGCTAGAAGCAGCTGGAGAATAAG
AACCGTTATTCTTACAGAAGTCACCTCTGTCACCACGCCATTTTGGAATACAAATGGCTTTTGAGTCTGG
AATCCACAAATCAGAAGACCCAGTGTCAACAATAACGCTAAGCTTTTGGTTATTGGAACCAACAGTAATA
TCAGCAGAATAAGTAATAATTTCATTGTCCAATTTAACTGCAACAGGTCCTCTTTTGTCCACACCATCAT
TTCTACCAGTATCATCGACGGGAATTTTTGTGGGATCAAGATCTAAAAATAAAGGTGATCTTTTAGATTC
GACAGTTGGATCATCTGGATCAACAAGGGATCTTTTGACATTAAAGTCTAAGGTAACAAACCCTGGAGAT
CTTTTAACTGGAGCAGCATCAATTAATAAAGCGAAAGCAAGAACACTCAAGATATTTTTCAACAACA
Protein Sequence 
>gi|68473561|ref|XP_719105.1| secretory aspartyl proteinase SAP6p [Candida albicans SC5314]
MLLKNILSVLAFALLIDAAPVKRSPGFVTLDFNVKRSLVDPDDPTVESKRSPLFLDLDPTKIPVDDTGRN
DGVDKRGPVAVKLDNEIITYSADITVGSNNQKLSVIVDTGSSDLWIPDSKAICIPKWRGDRGDFCKNNGS
YSPAASSTSKNLNTRFEIKYADGSYAKGNLYQDTVGIGGASVKNQLFANVWSTSAHKGILGIGFQANEAT
RTPYDNLPISLKKQGIIAKNAYSLFLNSPEASSGQIIFGGIDKAKYSGSLVELPITSDRTLSVGLRSVNV
MGRNVNVNAGVLLDSGTTISYFTPSIARSIIYALGGQVHFDSAGNKAYVADCKTSGTVDFQFDKNLKISV
PASEFLYQLYYTNGKPYPKCEIRVRESEDNILGDNFMRSAYIVYDLDDKKISMAQVKYTSESNIVAIN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a sap4/sap5/sap6 null mutant is attenuated in guinea pigs and mice (Hube et al., 1997).
References
Hube et al., 1997: Hube B, Sanglard D, Odds FC, Hess D, Monod M, Schäfer W, Brown AJ, Gow NA. Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infection and immunity. 1997; 65(9); 3529-3538. [PubMed: 9284116].