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TUP1

Victor ID 4693
Gene Name TUP1
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3639369
NCBI Protein GI 68473930
Locus Tag CaO19.6109
Genbank Accession AACQ01000035
Protein Accession XP_719068
Taxonomy ID 237561
Chromosome No 1
Gene Starting Position 185905
Gene Ending Position 187449
Gene Strand (Orientation) -
Protein pI 5.84
Protein Weight 54447.55
Protein Length 514
DNA Sequence 
>gi|68473943:185905-187449 Candida albicans SC5314 chromosome 1 Ctg19-10237, whole genome shotgun sequence
CTTATTTTTTGGTCCATTTCCAAATTCTGGCTTTACAATCGCCACTACCTGTAGCGAAGATACCTTCGGT
TCCCTTTGAGTTTAGGGATACAGCGACTGAGATGACCGAGTTGCGGTGGCCCTGCAACATCAACAATGGG
TTACCTGAAGCTTGGTCCCAGAAAATGACACCACGGTCCTTTGAGCCCGACAAAATGTACTCGTTGTCGG
GGGTACAGCAGACCGACAAAACAAAGTCCTTGTGGCCAATGTAGGTTACCTCGCAGGTCGACTTTTTGTC
GGACTTGCCTTCCAAGTGCCACAACTTGACGGTTCTGTCTAAGGACCCGGAAGCGATTTGTTCGCCGTTG
TTGGAGAAGGCGACAGAGTAGACTGAATCTTCGTGGCCATTGCCGTTTTCGTTGCCGGAGTCTAAGCGTT
CGACCAAGAACCCGGTAGTTGAGTCCCACACTCTAACGGTTCTATCTAATGAGCCGGCAGCAATGAGTTT
GCCGTCGGGGGAGACGGCCACGGTGGTGACGCCGTCTTCGATCGACAAAGTCAAGGAACACTGGGAGGTT
CTCAAGTCCCAGATTCTGACTGACCTATCGCCGGAGCCTGAAACCAACCTATCGCCATCAGGGAAAAAGT
CTAACGAGTAAATGTCTTGTTCGTGGCCCCTCAAGATTTTGATAATTCTCTTTGTGCTCAAATCCCAGAT
TCTAATCAACTTGTCTTCTGCACCTGTCGCCAAGAGTTTTCCGTCAGGGGAGAAACACACAGATCTGATG
TACAAGTCGCCTGAGGCGGTGGTGTTGTCGTCTTTGTTTTCGTTGGAGGACTCGTCAATCAATTTGGCGA
CCAACTCTCCGGTGGTGACATTGAACACTTGGGTGGTTTTGTTGCAACCGGTGGCGATGAACTTGCCGTC
TCTGGAAAATCTCACGCAGCAAACAACTGACGAGTGGTCTAAGGAGTGGACCATGTCAATATCCAAGTCT
TTGGAGAACGCTGGGTTGTACAACACATAGTATTCGAGGTGCTGTTTCTTGAACTCGGGGTTGGCTTTGG
CAATGTCTAAATCTTGCAAGAATGGTGGGATTTCCTTGACGTGGTTAGCTCTTTGGGTGGGGTTGACAAT
GTATTGTGACTTGTCGATAACCGATAATGATGTGACCGGGGTTGGTGGAGCAGGTGGGGCGGCAGGTGGT
GCCACAATCTGTTGTTGTTGCTGCTGTTGCTGTTGTTGTTGCTGTTGTTGCTGTTGCTGTTGTTGTTGGA
AGCCATTCTTCATTTGCCTGTCTCTAGTGTCCAACTCGTTCTTTAACCTCAATATCTCTTCCTCGTATGC
CTCTTTGATTTTTCTATGGGCCAACTCCAAGTCATACACTGTTTGGCGGATTTGTTGCATTTCGGCAGCT
TGTTGTTGGTACTTTGAGTCATAATCTTCTTGGACCTTTTTGAAACTGCTTGCTTCGTTTGAGGCGTAGT
CGAATTCAGTTTTGATTGCATCCAACAACTCTGTCAAACGTTGTTGGTGCTGGGTGCGTTGGGGATACAT
GGACA
Protein Sequence 
>gi|68473930|ref|XP_719068.1| transcriptional repressor of filamentous growth [Candida albicans SC5314]
MSMYPQRTQHQQRLTELLDAIKTEFDYASNEASSFKKVQEDYDSKYQQQAAEMQQIRQTVYDLELAHRKI
KEAYEEEILRLKNELDTRDRQMKNGFQQQQQQQQQQQQQQQQQQQQIVAPPAAPPAPPTPVTSLSVIDKS
QYIVNPTQRANHVKEIPPFLQDLDIAKANPEFKKQHLEYYVLYNPAFSKDLDIDMVHSLDHSSVVCCVRF
SRDGKFIATGCNKTTQVFNVTTGELVAKLIDESSNENKDDNTTASGDLYIRSVCFSPDGKLLATGAEDKL
IRIWDLSTKRIIKILRGHEQDIYSLDFFPDGDRLVSGSGDRSVRIWDLRTSQCSLTLSIEDGVTTVAVSP
DGKLIAAGSLDRTVRVWDSTTGFLVERLDSGNENGNGHEDSVYSVAFSNNGEQIASGSLDRTVKLWHLEG
KSDKKSTCEVTYIGHKDFVLSVCCTPDNEYILSGSKDRGVIFWDQASGNPLLMLQGHRNSVISVAVSLNS
KGTEGIFATGSGDCKARIWKWTKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tup1 mutant is significantly reduced in the ability to invade and injure endothelial cells (Phan et al., 2000).
References
Phan et al., 2000: Phan QT, Belanger PH, Filler SG. Role of hyphal formation in interactions of Candida albicans with endothelial cells. Infection and immunity. 2000; 68(6); 3485-3490. [PubMed: 10816502].