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HSP104

Victor ID 5145
Gene Name HSP104
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3642228
NCBI Protein GI 68479564
Locus Tag CaO19.13747
Genbank Accession HC749752
Protein Accession XP_716146
Taxonomy ID 237561
Chromosome No R
Gene Starting Position 30917
Gene Ending Position 33616
Gene Strand (Orientation) -
Protein pI 5.22
Protein Weight 94530.91
Protein Length 899
DNA Sequence 
>gi|68479687:30917-33616 Candida albicans SC5314 chromosome R Ctg19-20247, whole genome shotgun sequence
TTTAGTCAAGTCCAGGTGAGGTGAATCTGGCTTCGTCATCATCTTCATCCTCTGAGTCTTGCCAGTTATC
AACATCATTCATTTCCACATCTTCTGGTTCATGGTTAGGTAAAATCTCCAAACCTTTTTCGCCAAGAACA
ACTCTAGCAGTTTCTTTATCTTGGATTTGCCCTTTCAACAACATTACAGCCAACCTGTTCAAAATCTCGT
TTTGGATCAAGCGGTTCAATGGTCTTGCACCCAAGTCAGGTGACCATCCATTCTTGCACAAGTACTCCAT
GGCATCATCATCTAGCTTCAATTGTATAGCCTTACCATTAGCAGTGAATCTGTTTTCAATTTCGGACAAC
CTGATCTTGACAATCTTGGAAATGGCTTTTCTCGACAATCTGTTAAACACAACAATACTGGAAATACGGT
TGATAAATTCAGGTCTGAAATGTGCTCTCACAGCATCCATTACATGTTCCTTTGTGTTGGCATCAATCTT
GCTTCCCTTGGCGGCATTGATGTAGTTTGCACCCAAATTAGACGTCATTATGAAAATGGCATTCGAGCAG
TTAACAAGCTTACCTTGAGAAGAGGTAACTCTGCCGTCATCCAAAATCTGTAACAACACAGTCAACACTT
CAGGAGCAGCTTTTTCAACTTCATCCAACAAGACCACAGAGTATGGCCGTCTGATTAATGGCTCAGTCAA
GATACCACCTTCTTCATATCCAACATAACCTGGAGCAGCACCCAACAATTTTGAAGCAGACCATTTGTCT
CCCAATTCAGAGCAGTCAATTCTAATAATTGCCTTTTCGTCTGCAAAGAGAAAACCAGCAAGCTTCTTAG
CCAATTCAGTCTTACCCGAACCAGAAAGACCCAAAAACAAAAAGGATGGTGGTTGGTTAGGATTAGCCAA
ACCCGATCTTCTTAATCTGATGGCATTGGAGACTGCCTTCACAGCTTCCGATTGTCCAACAACTTCTTTC
GACAATTCTGCTTCCATATTGATCAATTTATTGTTTTCTGCTTGCGACAATTTCGTGACAGGGATACCAG
TCAATCTAGCAGCGGTTTCACATATTTGTTCTGGTCCAACTGCATTCTTCAACAAGCTGTCCAAATTAGA
AGCTTCCTCTTCAGCAACTTTGACTTCTAACTCTTCAATTTGCTTCTGGATATCTGGGATAGCAAAGTAT
CTCAAGTCAGCAGCAGTAGCAGTATCGTATCTTCTTTCAGCATCTTGAGCTTTGATCTCAAGTTCATCCA
ATTTTCTTTTGGCAGCAGTCAATTGTTCATGACTAGCACGTTCTTGTCTGTATCTCTCGTTCAATGGTCC
AATTTTTTCTTCCAATTCTGCTTTCTTCTTTTTGGCCAAATTCAAACGTTCCTTGGAAGCAGAGTCTGCA
TCTTTGTCTCTTTCTAATGCATTGATTTCGACATCTACCAAATGCAATTGTCTTTCCAAAGTGTCCAACT
CTTCTGGCTTAGAGTCTCTAGCCACAGCAACAGCAGCAGCACTCTCATCAACAAGATCAACAGCTGAATC
AGGTAATGCTCTGTATGTCAAGTATCTTGAAGCCAACTGAGCAGCAGTGACCAATGCACTATCCAATATA
CGGACCCCATGGTGAATTTCATATTTAGGCTGGATACCTCTTAAAATGGCAACAGTTTCTTGCACGGTGG
CGGCAGGAACATCGATTTTTTGGAATCTTCTTTCAAATGCACCATCTTTGGAAATGAACTTTCTGTATTC
AGCAAAGGTAGTAGCACCAATACAATGTAATGCACCTCTGGCCAACATTGGCTTCAACAAATTAGCAGCA
TCTGATTTACCATCACCCATCAACATGTGGATTTCATCAATGAACAAGATGATAAACTCTTTGGATTTTT
CAATTTCATTCAAAACACCTTTCAATCTTTCCTCAAACTCACCCTTGTATTTTGCACCTGCAGTCAATGC
ACCCAAATCAAGAGCAAATAATCTTGAGCCAGCCAAAACATTTGGAACGTCCCCATCAACTATTCTTTGT
GCAACACCTTCAACAATAGAAGTCTTACCAACACCAGCATCACCAATCAACACCGAGTTCGATTTGCTTC
TTCTTGCCAAAACTCTGATGACTCTTCGAATTTCTTCCTCTCTACCAATTACAGGATCAATCTTACCTTC
CCTAGCCTTTTCGGTAAAATCTTCACAATACTTGTTCAAAAATTCATAAGATGAAGACGAATCAGCTTGT
CTGGAGTCAATCCTTTGGGACCCTCTCAATTCAATAGCTTGTGTCTTTATTGTGTCAACACTCATACCAG
CTTCTTTGAAAATATCTTTAATTGATTGGTCCTCCAAGAGCGCCAACAAAATATGGTCCTGAGCAACATA
TGAGTCCTTTTGTTGTTGTTTGATTTTGTTGGCCTTCGTTAACACCTGGCCTGCTTGATAGCTTGGTCGT
ATTTCATCTGGAGGGGGGTTCTGAGATGGTATTTTAACCAAATGTCTGTTCACGATTCTTTCGAAATCGC
CCCATTCGTATCTTGCTCTCTTGACCAACGTTTTCAAATACTGTGTTGAGCCTTCAGTATCATCTGATGG
GATAAATGCAGCAAGAAAATGAAGGGGTAACAATTGCGAATTGGCCTGTTGTTTTGCCAATTCAGTAGCA
TTATTGATAATCTTGATAGCGTTATCTGTAAAATCTTCCA
Protein Sequence 
>gi|68479564|ref|XP_716146.1| hypothetical protein CaO19.13747 [Candida albicans SC5314]
MEDFTDNAIKIINNATELAKQQANSQLLPLHFLAAFIPSDDTEGSTQYLKTLVKRARYEWGDFERIVNRH
LVKIPSQNPPPDEIRPSYQAGQVLTKANKIKQQQKDSYVAQDHILLALLEDQSIKDIFKEAGMSVDTIKT
QAIELRGSQRIDSRQADSSSSYEFLNKYCEDFTEKAREGKIDPVIGREEEIRRVIRVLARRSKSNSVLIG
DAGVGKTSIVEGVAQRIVDGDVPNVLAGSRLFALDLGALTAGAKYKGEFEERLKGVLNEIEKSKEFIILF
IDEIHMLMGDGKSDAANLLKPMLARGALHCIGATTFAEYRKFISKDGAFERRFQKIDVPAATVQETVAIL
RGIQPKYEIHHGVRILDSALVTAAQLASRYLTYRALPDSAVDLVDESAAAVAVARDSKPEELDTLERQLH
LVDVEINALERDKDADSASKERLNLAKKKKAELEEKIGPLNERYRQERASHEQLTAAKRKLDELEIKAQD
AERRYDTATAADLRYFAIPDIQKQIEELEVKVAEEEASNLDSLLKNAVGPEQICETAARLTGIPVTKLSQ
AENNKLINMEAELSKEVVGQSEAVKAVSNAIRLRRSGLANPNQPPSFLFLGLSGSGKTELAKKLAGFLFA
DEKAIIRIDCSELGDKWSASKLLGAAPGYVGYEEGGILTEPLIRRPYSVVLLDEVEKAAPEVLTVLLQIL
DDGRVTSSQGKLVNCSNAIFIMTSNLGANYINAAKGSKIDANTKEHVMDAVRAHFRPEFINRISSIVVFN
RLSRKAISKIVKIRLSEIENRFTANGKAIQLKLDDDAMEYLCKNGWSPDLGARPLNRLIQNEILNRLAVM
LLKGQIQDKETARVVLGEKGLEILPNHEPEDVEMNDVDNWQDSEDEDDDEARFTSPGLD
Molecule Role Virulence factor
Molecule Role Annotation the hsp104Ãâ mutation Decreased the virulence of Candida albicans in the Caenorhabditis elegans infection model. Worms infected with the homozygous mutant showed a clearly increase in survival relative to animals infected with the wild-type Candida albicans strains. The results show a temperature-independent role for Hsp104 in support of Candida albicans virulence, in addition to its key role in governing thermotolerance.(Fiori et al., 2012)
References