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INT1

Victor ID 4640
Gene Name INT1
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3637595
NCBI Protein GI 68470378
Locus Tag CaO19.11733
Genbank Accession AACQ01000021
Protein Accession XP_720693
Taxonomy ID 237561
Chromosome No 5
Gene Starting Position 74546
Gene Ending Position 79525
Gene Strand (Orientation) +
Protein pI 5.93
Protein Weight 179793.75
Protein Length 1659
DNA Sequence 
>gi|68470561:74546-79525 Candida albicans SC5314 chromosome 5 Ctg19-20202, whole genome shotgun sequence
AATGAACTCAACTCCAAGTAAATTATTACCGATAGATAAACATTCTCATTTACAATTACAGCCTCAATCG
TCCTCGGCATCAATATTTAATTCCCCAACAAAACCATTGAATTTCCCCAGAACAAATTCCAAGCCGAGTT
TAGATCCAAATTCAAGCTCTGATACCTACACTAGCGAACAAGATCAAGAGAAAGGGAAAGAAGAGAAAAA
GGACACAGCCTTTCAAACATCTTTTGATAGAAATTTTGATCTTGATAATTCAATCGATATACAACAAACA
ATTCAACATCAGCAACAACAGCCACAACAACAACAACAACTCCCACAAACCGACAATAATTTAATTGATG
AATTTTCTTTTCAAACACCGATGACTTCGACTTTAGACCTAACCAAACAAAATCCAACTGTGGACAAGAT
AAATGAAAATCATGCACCAACTTATATAAATACCTCCCCCAACAAATCAATAATGAAAAAGGCAACTCCT
AAAGCGTCACCTAAAAAAGTTGCATTTACTGCAACTAATCCCGAAATTCATCATTATCCAGATAATAGAG
TCGAGGAAGAAGATCAAAGTCAACAAAAAGAAGATTCTGTTGAGCCACCCTCAATACAACATCAATGGAA
AGACCCTTCTCAATTCAATTATTCTGATGAAGATACAAATGCTTCAGTTCCACCAACACCACCACTTCAT
ACGACGAAACCTACTTTTGCGCAATTATTGAACAAAAACAACGAAGTCAATCTGGAACCAGAGGCATTGA
CAGATATGAAATTAAAGCACGAAAATTTCAGCAATTTATCATTAGATGAAAAAGTCAATTTATATCTTAG
TCCCACTAATAATAACAATAGTAAGAATGTGTCAGATATGGATCTGCATTTACAAAACTTGCAAGACGCT
TCGAAAAACAAAACTAATGAAAATATTCACAATTTGTCATTTGCTTTAAAAGCACCAAAGAATGATATTG
AAAACCCATTAAACTCATTGACTAACGCAGATATTCTGTTAAGATCATCTGGATCATCACAATCGTCATT
ACAATCTTTGAGGGATGACAATCGTGTCTTAGAATCAACGCCTGGGTCACCTAAGAAGGTTAATCCTGGA
TTGTCTTTAAATGACGGTATAAAGGGGTTCTCTGATGAGGTTGTTGAATCATTACTTCCTCGTGACTTAT
CTCGAGACAAATTAGAGACTACAAAAGAAAATGATGCACCAGAACACAACAATGAGAATTTTATTGATGC
TAAATCGACTAATACCAATAAGGGACAACTCTTAGTATCATCTGATGATCATTTGGACTCTTTTGATAGA
TCCTATAACCACACTGAACAATCAATTTTAAATCTTTTGAATAGTGCATCACAATCACAAATTTCGTTAA
ATGCATTAGAAAAACAAAAGCAAATACAGGAACAAGAACAAACACAAGCAGCAGAGCCTGAAGAAGAAAC
TTCGTTTAGTGATAATATCAAAGTTAAACAAGAGCCAAAGAGCAATTTGGAGTTTGTCAAGGTTACCATC
AAGAAAGAACCAGTTCTGGCCACGGAAATAAAAGCTCCAAAAAGAGAATTTTCAAGTCGAATATTAAGAA
TAAAAAATGAAGATGAAATTGCCGAACCAGCTGATATTCATCCTAAAAAAGAAAATGAAGCAAACAGTCA
TGTCGAAGATACTGATGCATTGTTGAAGAAAGCACTTAATGATGATGAGGAATCTGACACGACCCAAAAC
TCAACGAAAATGTCAATTCGTTTTCATATTGATAGTGATTGGAAATTGGAAGACAGCAATGATGGCGATA
GAGAAGACAATGATGATATTTCTCGTTTTGAGAAATCAGACATTTTGAACGACGTATCACAGACTTCTGA
TATTATTGGTGACAAATATGGAAACTCATCAAGTGAAATAACCACCAAAACATTAGCACCCCCAAGATCA
GACAACAATGACAAGGAGAATTCTAAATCTTTTGAAGATCCAGCTAATAATGAATCATCGCAACAACAAT
TGGAGGTACCGCATACAAAAGAAGATGATAGCATTTTAGCCAACTCGTCCAATATTGCTCCACCTGAAGA
ATTGACTTTGCCCGTAGTGGAAGCAAATGATTATTCATCTTTTAATGACGTGACCAAGACTTTTGATGCA
TACTCAAGCTTTGAAGAGTCATTATCTAGAGAGCACGAAACTGATTCGAAACCAATTAATTTCATATCAA
TTTGGCATAAACAAGAAAAGCAGAAGAAACATCAAATTCATAAAGTTCCAACTAAACAGATCATTGCTAG
TTATCAACAATACAAAAACGAACAAGAATCTCGTGTTACTAGTGATAAAGTGAAAATCCCAAATGCCATA
CAATCCAAGAAATTCAAAGAGGTAAATGTCATGTCAAGAAGAGTTGTTAGTCCAGACATGGATGATTTGA
ATGTATCTCAATTTTTACCAGAATTATCTGAAGACTCTGGATTTAAGGATTTGAATTTTGCCAACTACTC
CAATAACACCAACAGACCAAGAAGTTTTACTCCATTGAGCACTAAAAATGTCTTGTCGAATATTGATAAC
GATCCTAATGTTGTTGAACCTCCTGAACCGAAATCATATGCTGAAATTAGAAATGCTAGACGGTTATCAG
CTAATAAGGCAGCGCCAAATCAGGCACCACCATTGCCACCACAACGACAACCATCTTCGACTCGTTCCAA
TTCAAATAAACGAGTGTCCAGATTTAGAGTTCCCACATTTGAAATTAGAAGAACTTCTTCAGCATTAGCA
CCTTGTGACATGTATAATGATATTTTTGATGATTTTGGTGCGGGTTCTAAACCAACTATAAAGGCAGAAG
GAATGAAAACATTGCCAAGTATGGATAAAGATGATGTCAAGAGGATTTTGAATGCAAAGAAAGGTGTGAC
TCAAGATGAATATATAAATGCCAAACTTGTTGATCAAAAACCTAAAAAGAATTCAATTGTCACCGATCCC
GAAGACCGATATGAAGAATTACAACAAACTGCCTCTATACACAATGCCACCATTGATTCAAGTATTTATG
GCCGACCAGACTCCATTTCTACCGACATGTTGCCTTATCTTAGTGATGAATTGAAAAAACCACCTACGGC
TTTATTATCTGCTGATCGTTTGTTTATGGAACAAGAAGTACATCCGTTAAGATCAAACTCTGTTTTGGTT
CACCCAGGGGCAGGAGCAGCAACTAATTCTTCAATGTTACCAGAGCCAGATTTTGAATTAATCAATTCAC
CTACTAGAAATGTGCTGAACAACAGTGATAATGTCGCCATCAGTGGTAATGCTAGTACTATTAGTTTCAA
CCAATTGGATATGAATTTTGATGACCAAGCTACAATTGGTCAAAAAATCCAAGAGCAACCTGCTTCAAAA
TCCGCCAATACTGTTCGTGGTGATGATGATGGATTGGCCAGTGCACCTGAAACACCAAGAACTCCTACCA
AAAAGGAGTCCATATCAAGCAAGCCTGCCAAGCTTTCTTCTGCCTCCCCTAGAAAATCACCAATTAAGAT
TGGTTCACCAGTTCGAGTTATTAAGAAAAATGGATCAATTGCTGGCATTGAACCAATACCAAAAGCCACT
CACAAACCGAAGAAATCATTCCAAGGAAACGAGATTTCAAACCATAAAGTACGAGATGGTGGAATTTCAC
CAAGCTCCGGATCAGAGCATCAACAGCATAATCCTAGTATGGTTTCTGTTCCTTCACAGTATACTGATGC
TACTTCAACGGTTCCAGATGAAAACAAAGATGTTCAACACAAGCCTCGTGAAAAGCAAAAGCATCACCAT
CGCTATCATCATCATCATGATAAACAAAAAACTGATATTCCGGGTGTTGTTGATGATGAAATTCCTGATG
TAGGATTGCAAGAACGAGGAAAATTATTCTTTAGAGTTTTAGGAATTAAGAATATCAATTTACCCGATAT
TAATACTCACAAGGGAAGATTCACTTTAACGTTGGATAATGGAGTGCATTGTGTTACTACACCAGAATAC
AACATGGACGACCATAATGTTGCCATAGGTAAAGAATTTGAGTTGACAGTTGCTGATTCATTAGAGTTTA
TTTTAACTTTGAAGGCATCATATGAAAAACCTCGTGGTACATTAGTAGAAGTGACTGAAAAGAAAGTTGT
CAAATCAAGAAATAGATTGAGTCGATTATTTGGATCGAAAGATATTATCACCACGACAAAGTTTGTGCCC
ACTGAAGTCAAAGATACCTGGGCTAATAAGTTTGCTCCTGATGGTTCATTTGCTAGATGTTACATTGATT
TGCAACAATTTGAAGACCAAATCACCGGTAAAGCATTACAGTTTGATCTCAATTGTTTTAATGAATGGGA
AACCATGAGTAATGGCAATCAACCAATGAAAAGAGGCAAACCTTATAAGATTGCTCAATTGGAAGTTAAA
ATGTTGTATGTTCCACGATCAGATCCAAGAGAAATACTACCAACCAGTATTAGATCTGCATATGAAAGCA
TCAATGAATTAAACAATGAACAGAATAATTACTTTGAAGGTTATTTACATCAAGAAGGAGGTGATTGTCC
AATTTTTAAGAAACGTTTTTTCAAATTAATGGGTACTTCTTTATTGGCTCATAGTGAAATATCTCATAAA
ACTAGAGCCAAAATTAATTTATCAAAAGTTGTTGATTTGATTTATGTTGATAAAGAAAACATTGATCGTT
CCAATCATCGAAATTTCAGTGATGTGTTATTGTTGGATCATGCATTCAAAATCAAATTTGCTAATGGTGA
GTTGATTGATTTTTGTGCTCCTAATAAACACGAAATGAAAATATGGATTCAAAATTTACAAGAAATTATC
TATAGAAATCGGTTCAGACGTCAACCATGGGTAAATTTGATGCTTCAACAACAACAACAACAACAAAGCT
CCCAACAGTA
Protein Sequence 
>gi|68470378|ref|XP_720693.1| integrin-like protein [Candida albicans SC5314]
MNSTPSKLLPIDKHSHLQLQPQSSSASIFNSPTKPLNFPRTNSKPSLDPNSSSDTYTSEQDQEKGKEEKK
DTAFQTSFDRNFDLDNSIDIQQTIQHQQQQPQQQQQLPQTDNNLIDEFSFQTPMTSTLDLTKQNPTVDKI
NENHAPTYINTSPNKSIMKKATPKASPKKVAFTATNPEIHHYPDNRVEEEDQSQQKEDSVEPPSIQHQWK
DPSQFNYSDEDTNASVPPTPPLHTTKPTFAQLLNKNNEVNSEPEALTDMKLKHENFSNLSLDEKVNLYLS
PTNNNNSKNVSDMDSHLQNLQDASKNKTNENIHNLSFALKAPKNDIENPLNSLTNADISLRSSGSSQSSL
QSLRDDNRVLESTPGSPKKVNPGLSLNDGIKGFSDEVVESLLPRDLSRDKLETTKENDAPEHNNENFIDA
KSTNTNKGQLLVSSDDHLDSFDRSYNHTEQSILNLLNSASQSQISLNALEKQKQIQEQEQTQAAEPEEET
SFSDNIKVKQEPKSNLEFVKVTIKKEPVSATEIKAPKREFSSRILRIKNEDEIAEPADIHPKKENEANSH
VEDTDALLKKALNDDEESDTTQNSTKMSIRFHIDSDWKLEDSNDGDREDNDDISRFEKSDILNDVSQTSD
IIGDKYGNSSSEITTKTLAPPRSDNNDKENSKSFEDPANNESSQQQLEVPHTKEDDSILANSSNIAPPEE
LTLPVVEANDYSSFNDVTKTFDAYSSFEESLSREHETDSKPINFISIWHKQEKQKKHQIHKVPTKQIIAS
YQQYKNEQESRVTSDKVKIPNAIQSKKFKEVNVMSRRVVSPDMDDLNVSQFLPELSEDSGFKDLNFANYS
NNTNRPRSFTPLSTKNVLSNIDNDPNVVEPPEPKSYAEIRNARRLSANKAAPNQAPPLPPQRQPSSTRSN
SNKRVSRFRVPTFEIRRTSSALAPCDMYNDIFDDFGAGSKPTIKAEGMKTLPSMDKDDVKRILNAKKGVT
QDEYINAKLVDQKPKKNSIVTDPEDRYEELQQTASIHNATIDSSIYGRPDSISTDMLPYLSDELKKPPTA
LLSADRLFMEQEVHPLRSNSVLVHPGAGAATNSSMLPEPDFELINSPTRNVSNNSDNVAISGNASTISFN
QLDMNFDDQATIGQKIQEQPASKSANTVRGDDDGLASAPETPRTPTKKESISSKPAKLSSASPRKSPIKI
GSPVRVIKKNGSIAGIEPIPKATHKPKKSFQGNEISNHKVRDGGISPSSGSEHQQHNPSMVSVPSQYTDA
TSTVPDENKDVQHKPREKQKHHHRYHHHHDKQKTDIPGVVDDEIPDVGLQERGKLFFRVLGIKNINLPDI
NTHKGRFTLTLDNGVHCVTTPEYNMDDHNVAIGKEFELTVADSLEFILTLKASYEKPRGTLVEVTEKKVV
KSRNRLSRLFGSKDIITTTKFVPTEVKDTWANKFAPDGSFARCYIDLQQFEDQITGKALQFDLNCFNEWE
TMSNGNQPMKRGKPYKIAQLEVKMLYVPRSDPREILPTSIRSAYESINELNNEQNNYFEGYLHQEGGDCP
IFKKRFFKLMGTSLLAHSEISHKTRAKINLSKVVDLIYVDKENIDRSNHRNFSDVLLLDHAFKIKFANGE
LIDFCAPNKHEMKIWIQNLQEIIYRNRFRRQPWVNLMLQQQQQQQSSQQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: disruption of INT1 gene in C. albicans suppressed hyphal growth, adhesion to epithelial cells, and virulence in mice (Gale et al., 1998).
References
Gale et al., 1998: Gale CA, Bendel CM, McClellan M, Hauser M, Becker JM, Berman J, Hostetter MK. Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1. Science (New York, N.Y.). 1998; 279(5355); 1355-1358. [PubMed: 9478896].