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RBT1

Victor ID 4669
Gene Name RBT1
Sequence Strain (Species/Organism) Candida albicans
NCBI Nucleotide GI 9963981
NCBI Protein GI 9963982
Protein Accession AAG09787.1
Taxonomy ID 5476
Gene Strand (Orientation) ?
Protein Name repressed by TUP1 protein 1
Protein Note cell wall protein; GPI modified; predicted secretion signal sequence and GPI addition sequence indicate cell wall localization, as does a long repetitive S/T/P-rich region at the C-terminus that is presumably O-glycosylated; both ends of the protein are similar to Candida albicans cell wall protein HWP1; deletion of the gene confers no morphological phenotypes, but appears to decrease virulence in mouse and rabbit infections; Rbt1p
DNA Sequence 
>gi|9963981|gb|AF254142.1| Candida albicans repressed by TUP1 protein 1 (RBT1) gene, complete cds
TATCTTTGTCATTATAAGGCGTGTTTTGGTTTTGGTTTTGGGGTTTTGTTTTTTCGTTTTTAATGCAAGA
ATCTTAGCTTTGTTTTGCATGATTTTCGGGTTTAATGCATAGTGCGATATTTGATAACCCTGGCACAGCA
TCTTTGTTTCCACTAATGTTCATTGCATTTTTAAAATTTTTCAGTACCCTACGCCAATTAAACCAAATAC
CCTCCAATGCTTTGTCTCGCAATAATTAAACATTTTCAAGAATGTTCTCTTTTTTAGATTTTTCAATTCT
TTGTTTTTTAATCACAAATATGAAAACATTTTCGACAGATTCGTTTTAGTATTTTTATAATTCTACACAA
AGTTAAATTTTTCACACTGTTTTAAGTTCGACTTTGGAATGTTAATGCTTCTATTTTTTCAATTCGGATC
TTGAAAGACAATTACCCGTTGATTTCAACAATTAATCAATGGTTATAATATGATCAAATTACTTTCCCAA
AAACTATAAATAAAGGTAAGATTTACCGGATTTTGAACTTGTAATTTTCTTATTTTTCTATCCCATCAAC
AAGATCAAACAAAATACAAATCTCGTATTATTCATTCGCTTTAATTTTTATCAACTATGAGATTTGCAAC
TGCCCAACTCGCTGCCCTCGCTTACTACATTTTATCCACTGAGGCTACTTTCCCATTATTGGGTGACATC
TTTAATTGTATTCCACACAACACTCCTCCTGTCTGTACTGACTTGGGTCTTTACCACGATAGCTCCATTT
CCCTTAGTGGTTCCAAGAACAAGAGAGAAGCTGAAATTGTCAATGAAGATGGTACAATTGAAAAGAGAAC
TTTTGGAAGCGCTGGTGTAAATGCCGGTTTCAATGCCGCATTTGTCGTGTCTAATGCCAAAAAATTATCT
GACGGTTCTTATGGTATTGATTGTAACTTCAAGAGTGATTCTTCTGTCCAATTGAACCTGGCCTTTGGTA
AAAAAGTTAAACAATTGAGTATCACCGGTACTGGTTATTCTGATATTTCATTATTAGGAAATGTTGCTAA
TCCATTTGAATGGTCAGCTTCCTTGAAAGTCAAAGCAGAAATTGTTAAAGGAAAATGTTGTCTTCCATCA
GGTTTCAGAATCGTTACAGATTTCGAAAGCAACTGTCCTGAATTTGATGCCATCAAACAATTTTTTGGCA
GTTCTCAAATAATTTACAAAGTCAATGCCGTTTCTAACGCAATTGGTACTTTTGATGCTTCTGCATTATT
CAATGCTCAAGTCAAAGCCTTCCCTGCCAAGAGAGAATTAGATGAATTTGAAGAATTAAGTAACGATGGT
GTTACTCACAGCAAGAGAACTTTGGGTTTGCTTTTGGGTTTGCTTAAGAAAGTTACTGGTGGATGTGATA
CTTTACAACAATTCTGTTGGGACTGTCAATGTGACACCCCATCTCCATCAACTACCACCGTAAGTACTTC
ATCTGCTCCATCTACTTCCCCAGAATCATCTGCTCCATCTACTACTACAGTTACCACTTCATCTTCTCCA
GTTACTTCTCCAGAATCTAGTGTTCCAGAAACTACTACCGTTACTACTTCATCTGTCCCAGAAACTACTC
CAGAATCATCAGCTCCAGAAACCACCACAGTTACTACTTCATCTGTTCCTTCTACTACCCCAGAGTCTTC
TGCTCCAGAAACCACTCCAGAATCATCAGCTCCAGAATCTAGTGTTCCAGAATCATCAGCTCCAGAAACC
ACTCCAGAATCATCAGCTCCAGAATCTAGTGTTCCAGAATCATCAGCTCCAGAAACTGAAACTGAAACCA
CTCCAACTGCTCACTTAACTACTACTACTGCTCAAACTACTACTGTTATAACTGTTACTTCATGCTCTAA
CAATGCTTGTAGCAAAACTGAAGTAACCACAGGTGTTGTTGTTGTCACTTCTGAAGATACTATTTACACT
ACCTTCTGTCCATTAACTGAAACCACCCCAGTTCCTTCAAGTGTTGATTCTACTTCAGTCACTTCTGCTC
CAGAAACCACCCCAGAATCTACTGCCCCAGAATCATCTGCTCCAGAATCTAGTGCCCCAGAATCATCTGC
ACCAGTCACTGAAACACCAACTGGTCCAGTTTCCACTGTTACTGAGCAATCAAAGACCATCGTCACCATC
ACCTCATGCTCCAACAATGCATGCAGTGAATCTAAGGTCACCACTGGTGTTGTTGTTGTTACATCTGAAG
ATACTGTTTACACTACATTCTGTCCATTAACTGAAACTACTCCAGCTACTGAATCAGCCCCAGAATCATC
TGCACCAGCCACTGAATCAGTTCCAGCTACTGAAAGTGCTCCAGTTGCTCCAGAATCATCTGCACCAGGT
ACTGAAACCGCACCAGCTACCGAATCAGCTCCTGCCACTGAAAGTTCTCCAGTTGCTCCAGGTACTGAAT
CTTCCCCAGTTGCCCCAGAATCATCAGCACCAGCTACTGAATCAGCACCAGCCACCGAATCTTCCCCAGT
TGCTCCAGGTACTGAAACCACTCCAGCTACTCCAGGTGCTGAATCAACTCCAGTTGCTCCAGTTGCCCCA
GAATCATCAGCTCCAGCTGTTGAATCTTCTCCAGTTGCTCCAGGTGTCGAAACTACTCCAGTTGCACCAG
TTGCTCCTTCTACCACTGCAAAAACTAGTGCTCTCGTCTCTACGACTGAGGGTACTATTCCAACTACATT
AGAATCTGTTCCTGCCATTCAACCATCTGCTAACTCCTCATACACTATTGCTTCAGTCTCTTCATTCGAA
GGTGCTGGTAACAACATGAGATTAACTTATGGTGCTGCTATTATTGGTCTTGCTGCATTCTTGATCTAAT
TCTAGTTACTGATACTATATCTTTTTCTTTTTCTGTTTGGATTTCTACTAATTACATTTTTCAATTTTCG
GTTTTCAATATTATGACAAAGGTTATTGTATTGAATATTTACTTTGGTACATAAAAAAAAGTTGGTGCTT
TTTTTCTTTTAGAATTGTTTTGTTTAGATTTCGTATTTTCTTCTTATTCTGCTTTTCATTTTCGGTGTAT
AGATTACAACTTACAATAAATACCATTTTTTTTCTATTAAATTTTTCATCACATTGATTAGTTTTCAACT
TGAAAAGAATTCGAATTG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: rbt1 mutant is attenuated in both a rabbit cornea model and a mouse systemic infection model (Braun et al., 2000).
References
Braun et al., 2000: Braun BR, Head WS, Wang MX, Johnson AD. Identification and characterization of TUP1-regulated genes in Candida albicans. Genetics. 2000; 156(1); 31-44. [PubMed: 10978273].