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LIG4

Victor ID 4646
Gene Name LIG4
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3642986
NCBI Protein GI 68481400
Locus Tag CaO19.5798
Genbank Accession AACQ01000087
Protein Accession XP_715339
Taxonomy ID 237561
Chromosome No 2
Gene Starting Position 33702
Gene Ending Position 36488
Gene Strand (Orientation) -
Protein pI 7.98
Protein Weight 103331.01
Protein Length 928
DNA Sequence 
>gi|68481487:33702-36488 Candida albicans SC5314 chromosome 2 Ctg19-10234, whole genome shotgun sequence
ATCACCTAAACTTGTAATCGTCAGGATCGGGAATATAATTCATCTTGATTGAAGCTTGAACGAATGCCTC
AGTAACAAAATGTGGAATTCTCGAAGACCCACCATTTTCATCAATAACCATTTCGCGAGAAATTTGGTTT
GACATCTTATCAATTTCACGAAGCATTAGTGGTCTGGAATGGTTATCAGGGATTACTATGTAGCAACATT
CGATAAAATGTTTCGACAAGTCTCCACTGAATCTCTCAATTCTTTCCTTTAAAAATCGAGCACTCAAGTT
ATTCCCACACACGTAAAATGACAAACCTTTGAACAAGTAGATCCAAGGTTTAAGATCACCCCAATCAAAT
CCATTACGAAGGTCTTCAAGTTCACTTTCAGAAAGTTTGGGAACAACAATGTTCAAGGGATGGTGTATGA
TGTATGAGTCTCCATATTGATCAACCATATGGTTAAAATTATCCCAATTTTTACTGGCAAATATAAAATA
TGGTTCTAGTTGAAGAACACATCCTCTTTTAATGCATTCATATATCCAGATTGGTTTCACCAAATCAATT
CCTTTACTTAGATATTGACTGGATACAGGAAGTTCTCGTTCAGTAATCACCATTATTTGGTAGTTTGTTG
CAAGATCAACAGAATTGACAATTTTTCCACCATACTGTTTAACCATTGCTTTCATTTCTTCGATGGTTGT
AACTTCGCCGTCAGCCTCTCTTTTATCACTCATAATCAAAAACTCTATCCCACTAAACAAATCAGATTCA
ACTTTGACTTTTTTCAATTTCAGCTCATTATCTAATGAGTACACAGGTTCACGCTTCTTCCCCAATGCAG
TTTGTGCTTTATTTAAATCATTGATATAATTTGCCTTGATATGCGTGTATTCCTGTAATGTCACACATTC
ATCAATAGATTTGTCTTCTCTTATTTTTCGACAATGATTGTTATGTAAAGTTGACCCCACAGCATACAGG
GTGCCTGCTCGAGTGTCAATTGAACGAGCTCTGATTTCCAAAACTAACGAATCACTCGGATGAATCCAAA
AAGTGGGAATTTTAGTTCCAAATTTGATCAACAGTTCGGGAGGCATTGCCACATCTGTTTTAATCCACTT
TCCATGAGTGAGTCTTTCGATCTTATCAAACTCCTCAATTTCTATACCATTGGCACAGGTGCAAAAACTA
TAATAAACGCCATCAGTTACACTTTTCAATCCGCACATATAGGAGTTTTTTATGGCTGGAGATTTGCCAA
TCACCACAAGATCTAAATTTTCACCAAATTTTTCTAAATACTCTGGTTTGACTTTTATCCAATCTGGGTT
TCTGAACCCATCAATTTCATACTTCAGCTGTACATTCTTCAATACTAAACCCTCACATCGACTACTGACA
ACTTCTCTGATTGCTCTTTCGATATCTTCCAGAGAAGAACCTAGCCGTGTATCTAAAACTTCAAATCTGT
TTGGTATTGGTCTAAGAATTCGGTTCAAGATGTTTTTGCGGAAGAATAACGGATAATTAGTTAAATCTTT
CCCGTTTAAAAACAAAATGTCAAACACAAGGAAAAATGGATATGCTGTCTGTTGTTCATACTGATCGATG
GTTGTAAACTGTCGGACACTTTCTTGAATTGCCAGTGATTTTAAAGTTCCAAATGGAAGGATGACATTAC
GCTCATAATCATAGGCCACCATTTCGCCGTCTAAAATCACAGATTGTATATTTCCGGCAAAAGCATGGGC
CAAAAATTTAGTGAGGGCACCAAACTGGAAACTTTCTCCGTATAAATAAGAGTAATCCTTCAAGCGTCGT
GAAAAAAACTTGAAGCTATCACCATCCTTATGAAGAAGCATACGATCACCATCCATTTTCTCTTCGATGT
AAAATTTATTTTCCAATCCTAACTCTTGGAATTTTTTCTCATATGGAGGATCCATTTCATGCTTTCTTTG
TAACTTTTTCACAAGGGTTTTATAACTGGTTGTTAATCTTTCTGACAACTGTGGTTTAAACTTGAAACAA
GGATGTATAGCTAACTGCAGAGGGTCTAGTCTCAAATCGGGATTTGTTGAAAATTGTAATGTCTTTTGTA
AGTCATTGCATATGCTAAACACTCTATATCCATCCGGGTGCCAAGTGTTGAAAAAAAATCTCTCCATGCT
AGTTAAGATCGATTTATTAAGTAGTATATGAATAAGCCATCTTACTTCTGGTATACTTAGATTATCAAAT
AGTGGTTTAAGAATATCTATCTGACCCTGAGACACCTTTTCCAATGCCAATTGATCTAAAGAAGAGTTAA
TTTGCGGTACAGTATATTCCTCGAGTTTATCCACAATTGGCCTCCTTTTGGAAATAATCCTTGATGCTTG
CAATGGCAAATCACGTATCTTTTTCTCATCAATGGAAAACCTTCGTGACCTTTGATACAGTTTGTTCCAA
TCGTGTAATGTGATATAGTCTTCCGATTCCTTGGGGATTTTGTACATTTTAATCAAAAGACGAGCCAATG
CAACTTCTTTGATAAAATATATTCTTCCCGACTTTTCCGGGAATATTAGTTTTGCTGAAGGGTATATATC
ATTGCCAATGTGTGTTCGAAATGTATTTATAAAAGTTTTGATAATGAATGCTTTCTTCTCAGTGACAGTT
CGAAAATCACCAAGACTCTCTTTTCTAACCCCGTCAAGCTTGTCAAACAATTCTTTAGTCAATAAAGTGA
ACGATGGAGTAATATCATTTGGAGAAGGTGGTCGGATGTCGTTTAAAAAATATGTCA
Protein Sequence 
>gi|68481400|ref|XP_715339.1| dsDNA break repair ligase [Candida albicans SC5314]
MTYFLNDIRPPSPNDITPSFTLLTKELFDKLDGVRKESLGDFRTVTEKKAFIIKTFINTFRTHIGNDIYP
SAKLIFPEKSGRIYFIKEVALARLLIKMYKIPKESEDYITLHDWNKSYQRSRRFSIDEKKIRDLPLQASR
IISKRRPIVDKLEEYTVPQINSSLDQLALEKVSQGQIDILKPLFDNLSIPEVRWLIHILLNKSILTSMER
FFFNTWHPDGYRVFSICNDLQKTLQFSTNPDLRLDPSQLAIHPCFKFKPQLSERLTTSYKTLVKKLQRKH
EMDPPYEKKFQELGLENKFYIEEKMDGDRMLLHKDGDSFKFFSRRLKDYSYLYGESFQFGALTKFLAHAF
AGNIQSVILDGEMVAYDYERNVILPFGTLKSSAIQESVRQFTTIDQYEQQTAYPFFLVFDILFLNGKDLT
NYPLFFRKNILNRILRPIPNRFEVLDTRLGSSSEDIERAIREVVSSRCEGLVLKNVQSKYEIDGFRNPDW
IKVKPEYLEKFGENLDLVVIGKSPAIKNSYMCGLKSVTDGVYYSFCTCANGIEIEEFDKIERLTHGKWIK
TDVAMPPESLIKFGTKIPTFWIHPSDSLVLEIRARSIDTRAGTSYAVGSTLHNNHCRKIREDKSIDECVT
LQEYTHIKANYINDLNKAQTALGKKREPVYSLDNESKLKKVKVESDLFSGIEFLIMSDKREADGEVTTIE
EMKAMVKQYGGKIVNSVDLATNYQIMVITERELPVSSQYLSKGIDLVKPIWIYECIKRGCVLQLEPYFIF
ASKNWDNFNHMVDQYGDSYIIHHPLNIVVPKLSESELEDLRNGFDWGDLKPWIYLFKGLSFYVCGNNLSA
RFLKERIERFSGDLSKHFIECCYIVIPDNHSRPLMLREIDKMSNQISREMVIDENGGSSRIPHFVTEAFV
QASIKMNYIPDPDDYKFR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: deletion of one or both copies of LIG4 resulted in attenuation of virulence in a murine model of candidiasis (Andaluz et al., 2001).
References
Andaluz et al., 2001: Andaluz E, Calderone R, Reyes G, Larriba G. Phenotypic analysis and virulence of Candida albicans LIG4 mutants. Infection and immunity. 2001; 69(1); 137-147. [PubMed: 11119499].