Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

TOP2

Victor ID 5140
Gene Name TOP2
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3642722
NCBI Protein GI 68480866
Locus Tag CaO19.10391
Genbank Accession AACQ01000083
Protein Accession XP_715586
Taxonomy ID 237561
Chromosome No 4
Gene Starting Position 9672
Gene Ending Position 14057
Gene Strand (Orientation) -
Protein Name DNA topoisomerase II similar to S. cerevisiae TOP2
Protein pI 6.31
Protein Weight 157856.64
Protein Length 1461
DNA Sequence 
>gi|68480961:9672-14057 Candida albicans SC5314 chromosome 4 Ctg19-20162, whole genome shotgun sequence
TCTATTCATCTACAATAAAATCATCATCGTCATCTCCATCACTCATAACAATATCGTCTTCTTCATCCTC
ATCCTCGTCATCACTATCTATAATGACCGGTTTTTTCTTAGTATTTCTCTTTGTTGTAGAAGCAGTTTCT
CTAGTTCTTCTCTCTTTTGGTTCTGGTTTATCAAAATTTCCTAATATTTCAAGATCTTCTAATTCGTCTA
AAATAGACTGCTTACCGGAGGATTTCGGTTTTTTAGATTTTTCAGCAGCTGGCGTAGCAGACCTTGATTT
GGTCTCTTTTTTAACTTTAGTGGAAGAAGACAGATTCAAATTAAATATATCCTCGTCATCATCGTCATCA
CTGAAAAGTGTAATTGTTTCAATTTCTTTATTTGATGTTGCTCTACCTGATGGTTTAGTTGTCTTTTTAG
CACTACTACTTGATGAAGAGAAGAATGATAAAATATCATCTTTTTCTTTAGGTTTGGAAGAAGATGATGC
TTGCGGTTCATTTGAAGCCTCTTTCTTAACAACTGGCTTAGCTGAAATACTTTTCTTTTCTTTTGGTTCA
ACTTTGACTTTTTTATTATTTGGCTGGTCTTTGGTAGCAGTAGCCTTGGCTCTTCTCTTTGTCGATTTTT
TCTTCCCGTTAGAAGCCAAAGATTCTCTTTCTTGTTCGTCACGAAGTAAAAACTTGTCAAATTCAGCCAA
AAATTCATCTAAATCTTGGTTCCAAAGATCCTTTGCTGATTTCGACAATAATGCATTCAATTCTGCTTCC
TTTTGATCACGTTGTTGCATTATTCTCATAAAACGTTCATAAGTTAAAGACCAAATTGCCATACCCAACA
AATAATCATAGGATGAATAAATTGTTTCTGGAACATGGGCTGCTTGTTCGGGCTCTCCTTCTTGAATATT
AGCTACAGAGGTATTACCGACGTCTTCGTCACCTTCTTGTTCTTGTGTTTCCTCTTCCTCATCGGCATCG
TCACCAGTCAATAATTCTTCACTGGATTTGATTGGTTTCCCATCTTTACTGAATTTTGTAAAATTATGTT
CTTCTAGCAACGCAACCAATTGTTTCTTTTTCTTGTTAGCAACACTCAATTGTTTCTCAATTATCATCTT
GATAAATCTCGCCTGTTCACTCAACATCAACAATTGATTTTGTAAATTGTCAGTCATATAATCTTTTCTC
TTTTGATAGTATTCTAATCGAACATAATAGAAATCTTTAATTATTTCTAAAACATCATTATATTTTTTGA
TTCTACCCATAGGATCAAAGGCAACCATATTGGCCAAACTCAATGAAGAAACCAACTTGAACCTCTCCAA
AAGACCAATACGCAACGACTTTTGCATTTCCGCATCAGTCAATTTGATAACAAACCTGATAGATGTAGTA
TGGTGCTCTTCCATATCTTTAATCCATGGCTGGGTCTTTTCATTCCCAAACCCACTGAGCAAAAATTCTT
TGACATTGTTAGTCCAAGTTTTGACTGGGATTTCAGTAATTTCAACTGTATTCAGATCAATTTGTTCGAT
TCGTCCAGAAACTTTAAACTTTTGCGGTCCCATTGGTTCAAGGTCACCACCCCATCCTTTATACCATGGT
GTCATCTCCTGCAATTCTTCACCATTCATTAATCTTCTGATATTTGTAACAAGATCTTTTGGATTGTATG
AAGGAATATTTGTAGACCAACCGGTACCAATACCTTCAGCACCATTTACCAAAATCATAGGCAAAACTGG
CAAGTACCATTCAGGCTCAACAGTTTGCTCATCATCTTGAACATAAGTGTACAAGGGATCATCCAATGGA
TTGAATATTTTACGAGTAATCTCACTCAATTCTGTGAAAATATATCTCGCAGCAGAGAAATCTTTACCAC
CAGCAGCACGCGAACCAAAAGAACCATTTGGTTTTAATACGTTAATGTTGTTTGATCCAACGAAATTTTG
GGCAAGACCAATTATAGTTTGCACTAATGACTGTTCACCATGATGATATCCCGTGTTTTCACTCACATAC
CCTGCTAATTGTGCAACTTTAATTTCACTTCTCAATTTTTTCTTGAAACAACCATACAAGACTTTTCTTT
GACCTGGTTTGAACCCATCTAAAACCGACGGAATCGATCTTACATTATCAGACATTGAAAACAAAATCAA
CTCTTTGTTGATAAAATCACTTATTGGAATTTCAGTAATCTCAGGATCAAGATGGGTACCTGGTAAAAAC
CCTTGTAACCATTCCTTTCTTTCATCAGCTTTCTTTTTCAGAAATGCTAAATCAATGTAATCTTTATCTT
CACCTTGCAATGCATGAAATCTCTTTAAATGACGATCCAAGGCAGTAAAATATTCACGTGCTTCCATAGG
AGTAGAAGTACCCAAACCTTTGTAATACTTCTGAGTCCAACGACATTGTTTCCCTTCAGTATCTCTCCAA
TGCTCAAATTCCGGCATTGTGTAGAATGGTATAACACGTTTACCACCAGCACCTCTTGCTTTAACAGTGA
CTTTGACAATAGGGGTAATAAACTCAAGTAAGAATCCGGGAATGTCTAACAATCCAGGGAAAGATGTTTC
TAAAAAGTTAATAATTAACCCCTTGATATGCGACCCATCCTGATCTTGATCTGTCATGATCATAATATGA
CCATATCTCAATGATTTGATATTTTCAGCTGTGTAAACTTTTTTATGTTGCAACCCAATAATTTGTTTCA
ATGAGTTGATTTCTGCATTTTTGGAAATTTGATCTGCCGAAGCTTCACGAACATTCAATAATTTACCACG
TAACGGGAAACATCCATAATAATCTCTCCCAACAACGGAAAGCCCAGCAACAGCTAAATTCATAGCAGAA
AGCCCTTCTGTTAAGATCAAAGTACAATTGTGTCCATCTTTTGTACCAGCTTTGTTTGCATCAACCAAAT
TAACTTGACCCTTAATACGCAGTTTTCTACTACCATCGGCTTTTTGAAGTGCCTTGTCTTCGTTGGCGTT
GGCAATAGCTCTGATTTTATCTACTATACTGGTTTTCAAAATACGGTTGATTAAGTTATCATTAGCAACA
AACTTATCTTTACCACCAAATTGAGACACTTTTGTTGTTAATTGTTCTTTAGTCTGGGAAGTGAAAGCAG
GGTTTTCAATAAGACAGTTGATAAATAAAAACATATTATCCCTCACTTCTTGAGGCTTAATCATAAGTTT
CTTCTTACCTTTTTCCTTCTTGGATAAGGTCTCTACTAACTTATTGATTATTTGATCGGAAACGTATTTG
ACATGTGTACCTCCAGATGTTGTGGCAATGGAGTTGACAAAACTGACTTGATTAAATGAACCATCACTAA
CAGCAAATGCAACTTCCCATCTATCATTAAACACTTCATGTACAATGGTGGTGAAATTTTTAATGGTTCC
ATCTTGTGGTTCAGGTTCAGGTGACCTTTCTTTGATAGCTTTGACATACATTTCCACGTAACCTTTAAAA
CTGGAGATGTTCAACCTCTTATCATTTAAATAAATGTTACAGTTTTTCACAGTACCACATAAATCATAAA
CTCTTCTTCTTAAAACAGATAAAAGATCATTATCCAAACAGTCCATATCGAATTTACTCAAGTCGGGTCT
GAAAGTAATCTTGGTATATTCCTTTTTGGGTCTTAAAGTGGTGATTTTTGGTTTTGACACATTTGACATA
TTATTTGTCCAAGATTGTTTATACAATTTCCCCATATTCAAATCAGCAGTTTCCACTTCAAATTGGGTAG
AGAAAATATTACACAACTTAGCACCAAACCCATTTCTACCACCAGTAACTTTTTTCTGGTCGTCATCATA
GTTGGAAGAAGTTAACAAGTTACCAAAAATCAATTCAGGAATGTACATATTTTCTTTGGTGTGCATTTCA
ATTGGTATACCTTTCCCATCATTCATTACTTCTATTATGTTGTTTTCAGCATCGATTTTGACTCTGATAT
TCTTCATACTGGGATCTCTGATTTTGTTATCAGCAGCATTAACTAGAATTTCATCAAAGATTTTATACAA
CCCAGGAACAATAGTGACTTCTTTGAACACCATAGATTCAGTTTCTGCGTCAAAACACCACATTTCTGTT
TTGGTTTTCTCAACAGATCCGATATAAGTATCGGGTCTTTTTAAAATATGCTCTAATTGGGAAAGCTTTT
GATATGTCTCTGAAGCATTGGTAGGCTTAGGGGTCGATGAACGCGATGAACTGACAGTGCTATTGGTTGC
ATCACCAAGAGGTTGTTTCAGTTTTGAAGACGCGTTTTTCTTGGTGGATTTTTTAGAAGTTGGAACAAAA
TCATCTTCTGACCCATCAGTAAAATAATCAGATTCTGATTCAGACA
Protein Sequence 
>gi|68480866|ref|XP_715586.1| DNA topoisomerase II [Candida albicans SC5314]
MSESESDYFTDGSEDDFVPTSKKSTKKNASSKSKQPLGDATNSTVSSSRSSTPKPTNASETYQKLSQLEH
ILKRPDTYIGSVEKTKTEMWCFDAETESMVFKEVTIVPGLYKIFDEILVNAADNKIRDPSMKNIRVKIDA
ENNIIEVMNDGKGIPIEMHTKENMYIPELIFGNLLTSSNYDDDQKKVTGGRNGFGAKLCNIFSTQFEVET
ADLNMGKLYKQSWTNNMSNVSKPKITTLRPKKEYTKITFRPDLSKFDMDCLDNDLLSVLRRRVYDLCGTV
KNCNIYLNDKRLNISSFKGYVEMYVKAIKERSPEPEPQDGTIKNFTTIVHEVFNDRWEVAFAVSDGSFNQ
VSFVNSIATTSGGTHVKYVSDQIINKLVETLSKKEKGKKKLMIKPQEVRDNMFLFINCLIENPAFTSQTK
EQLTTKVSQFGGKDKFVANDNLINRILKTSIVDKIRAIANANEDKALQKADGSRKSRIKGQVNLVDANKA
GTKDGHNCTLILTEGLSAMNLAVAGLSVVGRDYYGCFPLRGKLLNVREASADQISKNAEINSLKQIIGLQ
HKKVYTAENIKSLRYGHIMIMTDQDQDGSHIKGLIINFLETSFPGLLDIPGFLLEFITPIVKVTVKARGA
GGKRVIPFYTMPEFEHWRDTEGKQCRWTQKYYKGLGTSTPMEAREYFTALDRHLKRFHALQGEDKDYIDL
AFSKKKADERKEWLQGFLPGTHLDPEITEIPISDFINKELILFSMSDNVRSIPSVLDGFKPGQRKVLYGC
FKKKLRSEIKVAQLAGYVSENTGYHHGEQSLVQTIIGLAQNFVGSNNINVLKPNGSFGSRAAGGKDFSAA
RYIFTELSEITRKIFNPLDDPLYTYVQDDEQTVEPEWYLPVLPMILVNGAEGIGTGWSTNIPSYNPKDLV
TNIRRLMNGEELQEMTPWYKGWGGDLEPMGPQKFKVSGRIEQIDSNTVEITEIPVKTWTNNVKEFLLSGF
GNEKTQPWIKDMEEHHTTSIRFVIKLTDAEMQKSLRIGLLERFKLVSSLSLANMVAFDPMGRIKKYNDVL
EIIKDFYYVRLEYYQKRKDYMTDNLQNQLLMLSEQARFIKMIIEKQLSVANKKKKQLVALLEEHNFTKFS
KDGKPIKSSEELLTGDDADEEEETQEQEGDEDVGNTSVANIQEGEPEQAAHVPETIYSSYDYLLGMAIWS
LTYERFMRIMQQRDQKEAELNALLSKSAKDLWNQDLDEFLAEFDKFLLRDEQERESLASNGKKKSTKRRA
KATATKDQPNNKKVKVEPKEKKSISAKPVVKKEASNEPQASSSSKPKEKDDILSFFSSSSSSAKKTTKPS
GRATSNKEIETITLFSDDDDDEDIFNLNSSSSTKVKKETKSRSATPAAEKSKKPKSSGKQSILDELEDLE
ILGNFDKPEPKERRTRETASTTKRNTKKKPVIIDSDDEDEDEEDDIVMSDGDDDDDFIVDE
Molecule Role Virulence factor
Molecule Role Annotation the TOP2 gene played an important role in pathogenicity of C.albicans. The absence of TOP2 gene increased hypha formation, proteinases and phospholipase secretory activities, and so increased pathogenicity of C. albicans. (Zheng and Yu, 2012)
References