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PGA13

Victor ID 5142
Gene Name PGA13
Sequence Strain (Species/Organism) Candida albicans _SC5314
Chromosome No 22
Gene Strand (Orientation) ?
Protein Length 456
Protein Note putative glycosylphosphatidylinositol protein(Gelis et al., 2012)
Protein Annotation localized in the cell wall and is involved in wall integrity and viability of wall-regenerating protoplasts(Gelis et al., 2012)
DNA Sequence 
>CR_08510W_A|PGA13 COORDS:Ca22chrRA_C_albicans_SC5314:1838836-1840206W (1371 nucleotides)
ATGAGATCTCCATCACTCGCTGTTGCTGCTACCACTGTTTTGGGTTTGTTTTCCTCCAGT
GCCTTAGCTTACTATGGTAATACTACCACCGTTGCTTTAACTACTACAGAATTCGTCACT
ACTTGTCCTTACCCAACCACTTTCACTGTGAGCACATGTACCAATGATGTATGTCAACCA
ACAGTGGTTACAGTCACTGAAGAAACAACAATCACTATTCCTGGTACTGTAGTCTGTCCT
GTTGTCCTGACACCTTCAGGTAGTGCTAGTGCTAGTGCCAGTGCCGGTGCCAGCTCCGAA
GAAGAAGGAAGCGTTGTCACCACTCAAGTCACCGTCACTGATTTCACCACCTACTGTCCT
TACCCAACCACATTAACCATCACCAAATGTGAAAACAACGAATGTCACCCAACCACAATT
CCTGTGGAAACAGCCACTACCGTTACTGTCACTGGTGAAGTGATTTGTCCAACCACTACA
TCTACTTCTCCAAAAGAATCTTCTTCTGAAGCTGCTTCTTCTGAAGTGATCACTACTCAA
GTTACAGTTACAGATTACACTACATACTGTCCATTACCAACTACCATTGTTGTTTCTACT
TGTGATGAAGAAAAATGCCATCCAACCACTATTGAGGTATCTACCCCAACTACAGTTGTT
GTTCCAGGTACTGTTGTTTGTCCAACTACTTCTGTTGCCACCCCATCACAATCAGAAGTA
GCCACCAAGCCAACCACTATTAATTCGGTTGTCACTACTGGTGTCACTACAACTGACTAC
ACAACATACTGTCCATCACCAACCACCATTGTTGTTTCTACTTGTGATGAAGAAAAATGC
CATCCAACCACTATTGAGGTATCTACCCCAACTACTGTCGTTGTCCCAGGTACTGTTGTT
CACCCAAGTACTTCTGCTACCATTATCACCACCACTGCTGAACAACCACCAGCATCTCCA
GAGGTTTCCACTATTGAATCTGTGGTTACTACTCCTGCTACATTGACTGGCTACACCACT
TATTGTCCAGAACCAACTACTATTGTGTTGACCACTTGTTCTGACGATCAATGTAAACCT
CATACAGTTTCTGCCACTGGTGGTGAAACCGTCAGCATTCCTGCCACCATTGTGGTGCCA
AGCAGCCATACTACTCAAGTGGAAATCACTGTCTCCTCAGCCTCAGTGCCAGCTTCAGAA
AAGCCAACCACTCCAGTAACTGTTGCTGCAGTTTCCAGTTCTCCAGCTGTATCCACTGAA
ACTCCATCATTGGTGACACCTGCTATTTCCATTGCTGGCGCTGCTGCTGTCAATGTTGTT
CCAACCACAGCATTCGGGCTCTTTGCCATTATTCTTGCATCAATCTTTTAA
Protein Sequence 
>CR_08510W_A|PGA13 COORDS:Ca22chrRA_C_albicans_SC5314:1838836-1840206W, translated using codon table 12 (456 amino acids)
MRSPSLAVAATTVLGLFSSSALAYYGNTTTVALTTTEFVTTCPYPTTFTVSTCTNDVCQP
TVVTVTEETTITIPGTVVCPVVSTPSGSASASASAGASSEEEGSVVTTQVTVTDFTTYCP
YPTTLTITKCENNECHPTTIPVETATTVTVTGEVICPTTTSTSPKESSSEAASSEVITTQ
VTVTDYTTYCPLPTTIVVSTCDEEKCHPTTIEVSTPTTVVVPGTVVCPTTSVATPSQSEV
ATKPTTINSVVTTGVTTTDYTTYCPSPTTIVVSTCDEEKCHPTTIEVSTPTTVVVPGTVV
HPSTSATIITTTAEQPPASPEVSTIESVVTTPATLTGYTTYCPEPTTIVLTTCSDDQCKP
HTVSATGGETVSIPATIVVPSSHTTQVEITVSSASVPASEKPTTPVTVAAVSSSPAVSTE
TPSLVTPAISIAGAAAVNVVPTTAFGLFAIILASIF*
Molecule Role Virulence factor
Molecule Role Annotation PGA13 encoding a GPI protein in Candida albicans, which is highly up-regulated during cell wall regeneration in protoplasts. Compared to the parental strain, the homozygous pga13Ãâ mutant processed shorter and irregular hyphae. All pga13Ãâ mutants (homo-, heterozygous and reintegrant) showed a sharply attenuated virulence in a mouse model. Above all, these results indicated that Pga13 is a determinant of C. albicans pathogenicity.(Gelis et al., 2012)
Additional Molecule Role Virulence factor
References