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PMR1

Victor ID 4663
Gene Name PMR1
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3638043
NCBI Protein GI 68471207
Locus Tag CaO19.7089
Genbank Accession AACQ01000024
Protein Accession XP_720380
Taxonomy ID 237561
Chromosome No 7
Gene Starting Position 192859
Gene Ending Position 195612
Gene Strand (Orientation) +
Protein pI 5.97
Protein Weight 93431.7
Protein Length 917
DNA Sequence 
>gi|68471280:192859-195612 Candida albicans SC5314 chromosome 7 Ctg19-10262, whole genome shotgun sequence
AATGAGTGCTAATCCATATGATATAGAGCATAAGTTACCACCACAACGTGCAAACACCCCATCACTCAAG
TACTCTCAAAAATCAATTGAAGAAACTGCAGCAGACTTACAAACCGACATCAAATTGGGTTTAACCAATA
GTCAGGACGTGTTAAATAGACGATCCATTCATGGAATCAACGAATTAAATGGAGATGAAGAGGAGAGCCT
ATTGTGGAAATTCATTTCATCATTCTACCAAGATCCTTTGATTTTGCTTTTGATTGGTTCTGCTGTGATT
AGTTTTTGGATGGGCAATAAGGATGACGCCATATCGATCACATTAGCCATCACTATAGTTGTAACTGTTG
GATTTGTTCAAGAATATAGATCCGAAAAGTCTTTGGAAGCATTAAATAAGTTAGTCCCTGCAGAGGCTAA
GTTAACAAGAACTGGAAGCACATCCAGTGTGTTGGCCCAGGTTTTAGTTCCAGGTGATTTGGTCCATTTC
TCACAAGGTGACAGAATCCCCGCAGACATTAGATTGACAGAGGCGGTTCATTTAACCATTGATGAAAGTA
ATTTAACTGGTGAAAACAGGCCCGTGAAAAAGACCGTAGACACGGTTAACTCTTCTGATCCAGCAGTTAC
AGAAAGAACTGACATTGCATTCATGGGTACATTGGTCAGAGACGGACATGGTAGTGGTATTGTTGTTGCA
ACAGCAGGTCAAACCGTGTTTGGGTCAGTGTTTGAAATGATGAGCGACATTGAAAAGCCCAAAACCCCAT
TGCAACAAGCAATGGATAAATTGGGGAAGGACTTGTCGATTTTCAGTTTTATTGTTATTGGTATAATTTG
TCTCATTGGGATATTCCAAGGCCGTTCGTGGCTAGACATGTTTCAAATTTCTGTGTCTTTGGCGGTTGCT
GCTATTCCTGAAGGGTTACCTATTATTGTTACCGTTACCTTAGCATTGGGTGTGTTACGTATGGCCAGAC
AAAAGGCAATTGTTAGACGTTTACCAAGTGTTGAAACATTGGGATCTGTCAATGTTATTTGCTCAGACAA
AACCGGTACATTAACCCAAAATCACATGACAGTCACCAAAATATGGACAGCCGACTTCAAAGGAAGCTTC
AACACCCCCTTTTTGGCAGTAGAAAGACTTGATGACAATACTTTGCATCATCAACTTACATCCAATATGC
ACAAAGTTTTAGAGTGTGGTAATATTTGTAACAACGCCAGATATTCTACTGAGAGTGAGAAATACGTTGG
GAACCCAAGTGATATTGCCCTTGTTGAATGCTTGCCCCATTTTGGTTTGGAAGATATGAGAGGACAGAAA
CAAAGACTTTATGAATTACCATTTTCTTCAAATAGAAAATACATGGCAGTTTGTGTGCATACTGGCGACA
TTGAAAAATCCGAAACCATTGCCAAAGGTGCCACCGAGAAAATATTGCAACTTTGTGATCGTTACTATGA
CGAAAATGGATCCGTGAAACCATTGACAGAAGCTATTGAGGAGTCCATTCACGAAAAGTCTCGTTCGTTG
GCAAGAGATGGGTTGAGAGTGTTAGCGTTTGCTAAAAACAATAAGAAATTTGACGAAAAGACAACAGAAC
CCACAGATTTGGTGTTTTGCGGTTTAATTGGTATGAAAGATCCACCAAGACCAAAAGTGGGACAATCGAT
CGCAAGGTTAATGCAAGGTGGTGTGCATGTTATTATGATTACTGGAGACTCCCCTACAACTGCAGTAAAT
ATTGCCAGACAAATCGGTATCCCTGTGGTTGGAGACCATGCTGTATTGACAGGTGACCAAATTGATAGTT
TGAGTGAAGAAGCCCTTACCAAAGCTATTCACGATGTTTCGGTGTTTGCGAGAACCACTCCGGAGCACAA
AGTCACTATTGTGAAAGCTTTGCAAAGAAGAGGCGATATCGTTGCTATGACTGGGGATGGTGTGAATGAC
GCACCAGCTTTGAAATTGGCTGACATTGGTATAGCAATGGGTAAAAATGGTACAGATGTTGCTAAAGAAG
CTGCAGATATGGTTTTGACAGATGACGACTTTTCTACAATCCTTAGTGCTATTGAAGAAGGTAAAGGTAT
TTTCAACAACATACAGAATTTCATTACTTTCCAATTGAGTACCAGTATTGCTGCATTGACTTTGGTTGCC
TTATCTACTTTTTTCGGTTTGCCTAACCCCTTGAATGCTATGCAAATCTTGTGGATTAATATCTTGATGG
ATGGTCCTCCAGCCCAGTCTCTTGGTGTCGAGCCAGTTGATCACGAAGTTATGAATAAACCTCCAAGAAA
ACGTAACGATGTGATTCTTACCCAACAGGTTATCAAAAGAGTTTTGCAATCTGCTGCCATTATCATTGTT
GGCACCATGTATGTGTTCATTAAAGAGATGACTGACGGTGTGATTACTGCTAGAGACACGACCATGACCT
TTACGTGTTTTGTGTTGTTTGATATGTTTAATGCCTTGTCGTGCCGTCATTATTCCAAGCTGATTTTCGA
ATTGGGAATGACTAATCAAATGTTTAATTTTGCTGTCCTTGGATCATTGATAGGCCAATTTTGTGCCGTT
TATGTGCCTTTTTTCCAAAGCATTTTCCAAACAGAGGCTCTAAACTTTGGAGATATTTTGCGTTTGGTTA
TTTTGACAAGTACTGTATTTGCTGTGGATGAAATTAGAAAGTGGTTACGTAGAAGGAAAACTGTGTATAC
CAATAACTATAGTTATGGTGTATA
Protein Sequence 
>gi|68471207|ref|XP_720380.1| hypothetical protein CaO19.7089 [Candida albicans SC5314]
MSANPYDIEHKLPPQRANTPSLKYSQKSIEETAADLQTDIKLGLTNSQDVLNRRSIHGINELNGDEEESL
LWKFISSFYQDPLILLLIGSAVISFWMGNKDDAISITLAITIVVTVGFVQEYRSEKSLEALNKLVPAEAK
LTRTGSTSSVLAQVLVPGDLVHFSQGDRIPADIRLTEAVHLTIDESNLTGENRPVKKTVDTVNSSDPAVT
ERTDIAFMGTLVRDGHGSGIVVATAGQTVFGSVFEMMSDIEKPKTPLQQAMDKLGKDLSIFSFIVIGIIC
LIGIFQGRSWLDMFQISVSLAVAAIPEGLPIIVTVTLALGVLRMARQKAIVRRLPSVETLGSVNVICSDK
TGTLTQNHMTVTKIWTADFKGSFNTPFLAVERLDDNTLHHQLTSNMHKVLECGNICNNARYSTESEKYVG
NPSDIALVECLPHFGLEDMRGQKQRLYELPFSSNRKYMAVCVHTGDIEKSETIAKGATEKILQLCDRYYD
ENGSVKPLTEAIEESIHEKSRSLARDGLRVLAFAKNNKKFDEKTTEPTDLVFCGLIGMKDPPRPKVGQSI
ARLMQGGVHVIMITGDSPTTAVNIARQIGIPVVGDHAVLTGDQIDSLSEEALTKAIHDVSVFARTTPEHK
VTIVKALQRRGDIVAMTGDGVNDAPALKLADIGIAMGKNGTDVAKEAADMVLTDDDFSTILSAIEEGKGI
FNNIQNFITFQLSTSIAALTLVALSTFFGLPNPLNAMQILWINILMDGPPAQSLGVEPVDHEVMNKPPRK
RNDVILTQQVIKRVLQSAAIIIVGTMYVFIKEMTDGVITARDTTMTFTCFVLFDMFNALSCRHYSKSIFE
LGMTNQMFNFAVLGSLIGQFCAVYVPFFQSIFQTEALNFGDILRLVILTSTVFAVDEIRKWLRRRKTVYT
NNYSYGV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pmr1 mutant was severely attenuated in virulence in a murine model of systemic infection (Bates et al., 2005).
References
Bates et al., 2005: Bates S, MacCallum DM, Bertram G, Munro CA, Hughes HB, Buurman ET, Brown AJ, Odds FC, Gow NA. Candida albicans Pmr1p, a secretory pathway P-type Ca2+/Mn2+-ATPase, is required for glycosylation and virulence. The Journal of biological chemistry. 2005; 280(24); 23408-23415. [PubMed: 15843378].