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SAP5

Victor ID 4679
Gene Name SAP5
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3639268
NCBI Protein GI 68473645
Locus Tag CaO19.5585
Genbank Accession AACQ01000034
Protein Accession XP_719147
Taxonomy ID 237561
Chromosome No 6
Gene Starting Position 131423
Gene Ending Position 132679
Gene Strand (Orientation) +
Protein pI 6.14
Protein Weight 42274.95
Protein Length 418
DNA Sequence 
>gi|68473734:131423-132679 Candida albicans SC5314 chromosome 6 Ctg19-10230, whole genome shotgun sequence
AATGTTCTTGAAAAATATCTTGAGTGTTCTTGCTTTTGCTTTATTAATTGATGCTGCTCCAGTTAAAAGA
TCTCCAGGGTTTGTTACCTTAGACTTTAATGTCAAGAGATCTCTTGTTGATCCAGATGATCCAACTGTTG
AAGCTAAAAGATCTCCTTTATTTTTAGAGTTTACTCCCTCAGAATTTCCCGTCGATGAGACTGGTAGAGA
TGGTGATGTGGACAAAAGAGGACCTGTTGCAGTTACTTTGCACAATGAAGCTATTACTTATACTGCTGAT
ATTACTGTTGGTTCAGATAACCAAAAACTTAATGTTATTGTTGACACTGGGTCTTCTGACTTGTGGATTC
CAGATTCAAACGTTATTTGTATTCCAAAATGGCGTGGTGACAAAGGAGACTTCTGTAAGAGTGCTGGTTC
TTATTCCCCAGCATCTTCCCGCACTTCCCAAAATTTGAATACCCGTTTTGACATTAAATATGGTGACGGT
TCTTACGCTAAAGGTAAGTTGTATAAAGATACCGTTGGTATTGGTGGTGTTTCTGTTAGAGATCAATTAT
TTGCTAACGTTTGGTCTACTAGTGCTCGTAAGGGTATTTTAGGTATTGGTTTTCAAAGCGGCGAAGCTAC
CGAGTTTGATTACGACAATCTTCCTATTAGTTTGAGAAATCAAGGTATTATTGGTAAAGCTGCTTATTCC
CTCTACCTTAACTCTGCTGAAGCTTCTACTGGGCAAATTATTTTTGGTGGTATTGACAAGGCCAAGTACA
GTGGCTCTTTAGTTGATTTACCAATCACTTCCGAAAAAAAATTAACTGTCGGTTTAAGATCTGTCAATGT
TAGGGGACGAAATGTTGATGCTAACACTAATGTCCTTTTAGATTCTGGTACTACTATCAGTTATTTCACT
AGAAGTATTGTTCGTAACATTCTCTATGCCATAGGTGCTCAAATGAAGTTTGACTCTGCTGGTAATAAAG
TTTATGTTGCTGATTGTAAAACTTCAGGTACCATTGATTTCCAATTTGGTAATAACCTCAAGATCTCCGT
TCCTGTTTCCGAATTCCTTTTCCAAACATATTACACTAGTGGTAAACCTTTCCCAAAATGTGAAGTTCGT
ATTCGTGAAAGTGAAGATAATATTCTTGGTGACAACTTTTTAAGATCAGCTTATGTTGTCTACAATTTGG
ACGATAAGAAAATCTCCATGGCTCCAGTTAAATACACTTCCGAGTCTGACATTGTTGCTATTAATTA
Protein Sequence 
>gi|68473645|ref|XP_719147.1| secretory aspartyl proteinase SAP5p [Candida albicans SC5314]
MFLKNILSVLAFALLIDAAPVKRSPGFVTLDFNVKRSLVDPDDPTVEAKRSPLFLEFTPSEFPVDETGRD
GDVDKRGPVAVTLHNEAITYTADITVGSDNQKLNVIVDTGSSDLWIPDSNVICIPKWRGDKGDFCKSAGS
YSPASSRTSQNLNTRFDIKYGDGSYAKGKLYKDTVGIGGVSVRDQLFANVWSTSARKGILGIGFQSGEAT
EFDYDNLPISLRNQGIIGKAAYSLYLNSAEASTGQIIFGGIDKAKYSGSLVDLPITSEKKLTVGLRSVNV
RGRNVDANTNVLLDSGTTISYFTRSIVRNILYAIGAQMKFDSAGNKVYVADCKTSGTIDFQFGNNLKISV
PVSEFLFQTYYTSGKPFPKCEVRIRESEDNILGDNFLRSAYVVYNLDDKKISMAPVKYTSESDIVAIN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a sap4/sap5/sap6 null mutant is attenuated in guinea pigs and mice (Hube et al., 1997).
References
Hube et al., 1997: Hube B, Sanglard D, Odds FC, Hess D, Monod M, Schäfer W, Brown AJ, Gow NA. Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infection and immunity. 1997; 65(9); 3529-3538. [PubMed: 9284116].