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DAC1

Victor ID 4628
Gene Name DAC1
Sequence Strain (Species/Organism) Candida albicans SC 5314
NCBI Nucleotide GI 6137104
NCBI Protein GI 6137106
Protein Accession AAF04335.1
Taxonomy ID 5476
Gene Strand (Orientation) ?
Protein Name N-acetyl-glucosamine-6-phosphate deacetylase
Protein Note SalI fragment
DNA Sequence 
>gi|6137104|gb|AF079804.1| Candida albicans N-acetyl-glucosamine-6-phosphate deacetylase (DAC1) and glucosamine-6-phosphate deaminase (NAG1) genes, complete cds; and hexokinase (HXK1) pseudogene, complete sequence
GTCGACTCCTACCAACACTATGCTGCATCTGCATTAGCCGCTAAAACGTTTGTCAGATCCATCTGGGGTG
CGTGTGTACCCCTCTTCACTATCCAGATGTACCACAGATTAGGCGACGAATGGGCAACCTCCCTTATGGC
ATTCATCTCCTTAGCATGCTGTGCCATCCCATATTTGTTCTACATTTTCGGTGCAAGAATTAGAACCTTT
TCCAAATACGCATACGCTCCAAACATGGATTAAATACACATCTATAAAACAGCAGTTAATTTATCAGTAG
CTCTATCTAAAGGTATATCTGACGATGAACTTCAGTCCAACTTGTAGACTTTCCGAACAAACCCACTCTT
GTCTAAAACAACAAAATCAGCTAAACACCCAACATTCAAAAACCCACGCTCGTGGTCAACGCCAATTGAC
TTGGCAGCATTATTAGTAACAGTCATCACCGCTTGGGGCAAGTGATTTGCGACCACTTGACTAGGTTACG
CACACATTGCGGCAACGTAGTGCAGCTCCAGCTAACGTGTGGTGTTCTCCAAATACAACCGATCACCAGT
CTTTACAATAACCTGCGAGTCCCATTTGTAGTGGCCATCAGGCAAACCTATCAAGTGCATAGCATCAGTC
ACCAAAACACACTTGCTGGGGTTCGACCTATATGCAAGGTTGACCATCGACGGGTCAACATGTACACCAT
CACAGATTAATCCGAAATATGGGGTATCAACAATAGGCGAATTAATCAAACCCACAACACCAGCATTACG
GTGATGTGGCTGTGGCATGGCATTGTACCAAGTGTGTGATCATCGTAGCACCTTTCTCAACAGCTTTCAC
GGCTGTGTCATAATCCGACATCGTATGGCCAATGGAAAACACACAGTTCTTGGATTTAACAACAGGTATC
AAGTCTAAAACACCAGCAATTTCAGGAGCAGCAGTGACAATACACACATTATCAAACAAGTCCCCGTAAA
CTTCTAACAATTTTGATTCACCCTCTTTGGCATCAACAAACGTTTCGACTGGGTGGCACCCTTTCTTTTG
CACATTGATAAATGGCGCCTCACTGAGCTCCAGCGAATCTGTCTGACTTGCCAAAACACTCCTCTTGTAC
ATTGGCAACACTTTGGCATACACTTCTGGGAAGCTTGATGTGACAGTAGGACACGTAGCAGTAACCCCAG
TACTCAAATACTTGGCCATAGCATCTCTATAGAACCGCTTAAACTCAGCAACATCCTCTGCGGTAGACTC
CTCGCCAAGATTGGAAAAGTTCAACCCATAAATACCGTTATTCTGAATATCAATAAACCCAGGTGCTAAT
ATTTGCTGCTTCAAATCTATAACCTCACTAACCAACTCAGGGTTTGCTGGCGGATGACAAATTCTTTTGG
TGGCGTTGTTGACGTACAAGTCAGTAAACTCATACAACTCACCGTTGTCGATCAAATGACAGTTTGTGAA
TCTAGTAAATGACATGCTTAGGGAGAAAGAACAACATAGCAAGTGATGTGGGCAGCCATGGCAATATATA
TATAGGCATTCGGTTGTTCTGGGAGCAAAAAAATGTATCTAGGTTACAAATGTAACACGTTTTTGAGAAA
GAAAAAAAAATGCAACACCCGAAAAAAAAAAATGTAACATCCAGATACCACCACCACCATAAAAGGCCCA
TCATCTGCCAACAATCCAAATGAATACCCCAATTTCTCATCAACCATGAGACAAGCTATATTTTCCAACC
CTAACGATGCTGCTGAGTATTTGGCAAACTATATCATTGCCAAAATCAACTCCACCCCCAGAACATTTGT
TCTTGGCCTTCCAACCGGGTCATCCCCTGAAGGCATTTATGCCAAATTGATCGAAGCCAACAAGCAAGGC
CGTGTTAGTTTCAAAAACGTCGTGACCTTCAACATGGACGAGTATTTGGGATTTGCCCCATCTGACTTGC
AGTCGTACCATTATTTCATGTACGACAAGTTTTTCAACCATATCGATATCCCGCGTGAAAATATCCACAT
CTTGAACGGATTGGCCGCAAACATCGACGAGGAGTGTGCCAACTACGAAAAGAAAATCAAGCAATACGGA
AGAATCGATTTGTTCTTAGGCGGGTTAGGCCCAGAAGGTCATTTGGCATTCAACGAAGCGGGATCATCAA
GAAACTCAAAAACAAGAAAGGTCGAGTTGGTCGAAAGTACCATCAAGGCAAACTGCAGGTTTTTCGGGAA
CGACGAGAGCAAGGTCCCTAAATATGCATTGAGTGTTGGTATTTCCACCATCTTGGACAACTCAGACGAA
ATTGCCATTATCGTGTTGGGCAAAAGTAAACAATTTGCATTGGACAAAACTGTAAACGGGAAACCAAACG
ACCCAAAATACCCATCAAGCTATTTACAAGACCACGCAAATGTCTTGATTGTTTGCGATAACGCTGCCGC
TGGATTAAAGTCAAAGTTGTAGAGATGTATAGAGTCTAGAATATACAGGTAATTTCATGACAAACACTGT
GTGGCAGGTCAAGTTCATTAATCGTAAATAATGTTTACACATCTGATCTATGGCAATATGGACAGAAGTA
AACTATACAGTCAAAACAACTAAACAGCTCAGGCGACAGATAAGAGTTGAAGGGATGTTACTCCAATTAC
ACTAGTGCGATGTACACTTGGGCTTGCTCATTCATCTTATATCATTTTATACATTCTACTTATGATAGGC
AGCACCTATGGCAGCACCTATAATCGAGCTATTTTCAATCAACTTCAAGTCAACCTTTATCCCCTTGGCC
TCCTCTGCGCTATTCACATACTCAACAATCAACCGTCTATACTTGTGAAAGTAGTTCAAGACCGACCCCA
CATACCCAATCGTCACATCACCACCCAACTCGTCACTGCCCAACAATTTGAAAAACGCAATAATCGCATT
GGCAACAATAAACGCCGCCCGCTTGATAATGCACGATACAACTTCTTTCAAGCAGACAATGTCACTCAAC
CCAACCGTCGTCCAGCCGTAGCCTTGCACAACTTGTCATGTATATCATCATAATCGTCATTCTCATGCAC
AAAACAAATCAACTCCCCACTAAACCCACCATACTCTTGGTACATCTGTTGGTGGTCAACATTTTGAAAA
ATCTCGCCAGCCTCAATCAAATCTACCACCACCAACCTCGTCAATTCTGGCAAGTACCTCCCACTAGTCA
TCAACTCGTGCGGCTGGAAAAGCGTTTTTGTAATAGGGTCAGGCTCCATAAACGTCTTAAAGTGGTGCAG
CAAACCAGCAAACCTCTTGTCTATAATGATATCATATTTCGTAGCAAAGTCTTTACATAGATTCTGGCCA
AACAACGAGAGCTCACAATTAAACAACGTAGCATCAGCCAACATCTTGGAGGGGTGGATATCACTTGACC
TTTTTAGGGAACAGCACATGTTAATCCCTGTCCCCAACACCATGGCCAACTTCATCTTCGAATCAATAAA
GCACCCAGCAGAATACACCGCCAACGAGTCGTTCAATATAGACTGCACGTCAAGTGTCAACCCGTACTCT
TGTCTCAACGTGTCTTCCAAAACCATCTTTAAATCCTTGTCGTAAATATCCTCTCCCACAGTATACCCTT
TGGAAACATGGCTTGATGCTTGGCCTCTATTGTAGTCGGTTGTTTCCAACGGGAACGACCAGGTTATACC
AGTATTGATAACCGACTTTACATCAATAACATTCTGTCCCATCAATATCTCGTTAATCTTGGACCCAATA
TACTTGAAAAACTCACCATCAATCCTCTTAAAGTCGTTGCCAATAATCCAACTCTTTCCACAACTATAGT
TATCCTCTCACTTCTCGACAATTGGGTGTGGCTTGGAATGTCTACCACTGCTATCTCATGTCGAC
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a DAC1/NAG1/HXK1 mutant is highly attenuated in a murine systemic candidiasis model and was less adherent to human buccal epithelial cells in vitro (Singh et al., 2001).
References
Singh et al., 2001: Singh P, Ghosh S, Datta A. Attenuation of virulence and changes in morphology in Candida albicans by disruption of the N-acetylglucosamine catabolic pathway. Infection and immunity. 2001; 69(12); 7898-7903. [PubMed: 11705974].