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ALS3

Victor ID 4588
Gene Name ALS3
Sequence Strain (Species/Organism) Candida albicans
NCBI Nucleotide GI 29373982
NCBI Protein GI 29373983
Protein Accession AAO72959.1
Taxonomy ID 5476
Gene Strand (Orientation) ?
Protein Name agglutinin-like sequence 3
Protein Note cell-surface adhesin
DNA Sequence 
>gi|29373982|gb|AY223552.1| Candida albicans agglutinin-like sequence 3 (ALS3) gene, ALS3-large allele, complete cds
ATGCTACAACAATATACATTGTTACTCATATATTTGTCGGTTGCGACTGCAAAGACAATCACTGGTGTTT
TCAACAGTTTTAATTCATTGACTTGGTCTAATGCTGCTACGTATAATTATAAGGGACCAGGAACCCCAAC
TTGGAATGCTGTTTTGGGTTGGTCTTTAGATGGTACTAGTGCAAGTCCGGGAGATACATTCACATTGAAT
ATGCCATGTGTGTTTAAATTTACTACTTCTCAAACATCTGTTGATTTGACTGCTCATGGTGTTAAATATG
CTACATGTCAATTTCAGGCAGGTGAAGAATTTATGACCTTTTCTACATTAACATGTACTGTGAGCAATAC
TTTGACTCCATCTATTAAGGCTTTGGGTACTGTCACTTTACCACTTGCATTCAATGTAGGTGGAACTGGT
TCTTCTGTTGATTTGGAAGATTCTAAATGTTTTACTGCTGGTACTAACACAGTTACATTTAATGATGGTG
GCAAGAAAATCTCAATTAATGTTGATTTTGAAAGGTCAAATGTCGATCCAAAAGGGTACTTAACTGATTC
CAGAGTTATACCAAGTCTCAACAAAGTGTCAACTCTTTTTGTTGCACCACAATGTGCAAATGGTTACACA
TCTGGTACAATGGGATTCGCTAACACTTATGGTGATGTTCAAATTGACTGTTCAAATATTCATGTTGGTA
TTACAAAAGGATTGAATGATTGGAATTATCCGGTTTCATCTGAATCATTTAGTTACACCAAAACTTGTTC
ATCTAATGGTATCTTTATCACATATAAAAACGTTCCTGCCGGTTATCGTCCATTTGTTGACGCTTATATT
TCTGCTACAGATGTTAATTCGTACACCTTGTCGTATGCTAATGAATATACTTGTGCTGGTGGTTATTGGC
AACGTGCACCTTTCACATTAAGATGGACTGGATACAGAAATAGTGATGCTGGATCTAACGGTATTGTTAT
TGTGGCTACTACCAGAACAGTTACAGACAGTACTACCGCCGTGACCACCTTACCATTCGATCCTAACCGC
GACAAAACTAAGACAATTGAAATTTTGAAACCTATTCCAACAACTACAATCACAACATCATATGTTGGTG
TGACTACTTCCTACCTGACCAAAACTGCACCAATTGGGGAAACTGCTACTGTTATTGTTGATATTCCATA
TCACACTACCACTACTGTTACCAGTAAATGGACAGGAACAATTACTTCCACCACAACACATACTAATCCA
ACTGACTCAATAGACACTGTCATTGTACAAGTTCCACTGCCAAACCCAACTGTTACTACCACTGAATATT
GGTCTCAATCATTTGCTACCACCACCACCATTACTGGACCACCAGGAAACACTGATACTGTTTTAATCAG
AGAGCCACCAAACCATACTGTCACTACAACCGAGTATTGGTCAGAATCTTACACTACTACTAGTACTTTC
ACTGCTCCTCCAGGTGGAACTGATTCAGTTATTATCAAGGAACCTCCAAATCCAACTGTTACAACTACCG
AGTACTGGTCAGAATCTTACACTACCACTACTACTGTCACCGCTCCACCAGGAGGTACTGATACCGTGAT
TATCAGAGAACCACCAAACCATACTGTAACCACAACTGAATACTGGTCACAATCTTACACTACAACCACC
ACTGTTATTGCCCCACCAGGTGGCACTGATTCGGTTATCATTAGAGAACCTCCAAATCCAACTGTCACAA
CCACTGAGTACTGGTCTCAATCTTACGCAACTACCACTACCATTACCGCTCCTCCAGGTGAAACCGATAC
TGTCCTTATTAGGGAACCACCAAATCACACTGTCACTACTACTGAATACTGGTCTCAATCTTACGCAACT
ACCACTACCATTACCGCTCCTCCAGGTGAAACCGATACTGTCCTTATTAGGGAACCACCAAATCACACTG
TCACCACTACTGAATACTGGTCACAATCTTACACTACAACCACCACTGTTATTGCCCCACCAGGTGAAAC
TGATTCAGTTATCATCAAGGAACCACCAAACCCAACTGTCACTACAACTGAATATTGGTCTCAATCTTAC
GCAACTACCACTACCATTACCGCTCCTCCAGGTGAGACCGATACTGTCCTTATTAGAGAACCACCAAACC
ATACTGTAACCACAACTGAGTATTGGTCTCAATCCTATGCAACTACTACTACAATCACTGCTCCTCCAGG
TGAAACCGATACCGTTCTTATTAGGGAACCACCAAATCACACAGTTACTACTACTGAATACTGGTCACAA
TCATTTGCTACAACCACAACTGTAACTGCACCACCAGGTGGTACTGACACTGTTATCATTAGAGAACCAC
CAAATCACACTGTCACTACTACTGAATACTGGTCACAATCATTTGCTACAACCACAACTGTAACTGCACC
ACCAGGTGGTACTGACACTGTTTTAATCAGAGAGCCACCAAACCCAACTGTTACCACCACCGAATACTGG
TCTCAACCTTACACAACCACCACTACAGTTATTGCACCACCAGGTGGAACTGATACTGTGATTATTTATG
ACACCATGTCAAGTTCAGAAATTTCTTCATTTTCTCGTCCTCATTACACCAACCATACAACTTTGTGGTC
TACAACTTGGGTTATTGAAACAAAAACAATTACAGAAACTAGCTGTGAAGGTGATAAAGGTTGTTCTTGG
GTTTCTGTTTCTACTCGTATTGTCACAATTCCTAATAATATCGAAACTCCTATGGTTACTAATACTGTTG
ATTCTACAACCACAGAATCCACTTCACAATCCCCATCTGGTATTTTTTCAGAGTCAGGAGTATCTGTTGA
AACAGAATCTTCTACTGTTACTACTGCTCAAACAAATCCAAGTGTTCCAACAACTGAAAGTGAGGTTGTA
TTTACTACTAAAGGAAACAACGGAAATGGTCCTTATGAATCACCATCTACTAATGTGAAATCAAGTATGG
ATGAAAATTCTGAATTTACTACTTCCACAGCTGCTTCCACTTCTACTGATATTGAAAATGAAACCATAGC
AACAACCGGTTCCGTGGAAGCTTCATCGCCTATCATTTCTTCTAGTGCTGATGAAACTACTACTGTTACT
ACTACTGCTGAATCAACCAGTGTCATTGAACAACCAACAAATAATAATGGTGGTGGTAATGCTCCATCTG
CAACTTCAACTTCATCTCCATCTACAACTACAACTGCTAATAGTGACTCTGTTATTACTAGTACAACATC
AACCAACCAATCTCAATCGCAATCCAATTCTGATACCCAACAAACTACATTGAGTCAACAAATGACTTCA
TCTTTAGTTAGTTTACATATGCTTACTACATTTGACGGATCTGGTTCTGTTATTCAACATTCTACTTGGT
TATGTGGTTTGATCACATTATTATCCTTATTTATTTAA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: als3/als3 mutant was defective in adhesion to both human umbilical vein endothelial cells (HUVEC) and buccal epithelial cells (BEC) (Kelly et al., 2004).
References
Kelly et al., 2004: Kelly MT, MacCallum DM, Clancy SD, Odds FC, Brown AJ, Butler G. The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulence. Molecular microbiology. 2004; 53(3); 969-983. [PubMed: 15255906].