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TPK2

Victor ID 4691
Gene Name TPK2
Sequence Strain (Species/Organism) Candida albicans strain 1161
NCBI Nucleotide GI 7578501
NCBI Protein GI 7578502
Protein Accession AAF64072.1
Taxonomy ID 5476
Gene Strand (Orientation) ?
Protein Name protein kinase A
Protein Note fosmid clone obtained from B. B. Magee
DNA Sequence 
>gi|7578501|gb|AF134300.1| Candida albicans protein kinase A (TPK2) gene, complete cds
CACCAAATTGAGGTCAATTAAAGAACAACTTGTATAGTTCTACCACACTATTTTGAAGAGTCAGGTACAG
TTCGTAGTTTCTCAACATAATATATCAACCTATCAATACTCGGATTGCAGGTCAATTTAGTTTACAACCA
CCAATTGCCAAAGTATTGGATTCTACTTTTTCCGACTTGTAAGTGAACACAAAGAAGATTAGACAAACAA
TCACCCAATCACACCTACTACTCACCCAATTTCCATTCCACCTTTTTTTTTCGAAAAAAATAACCTTCCC
CCTTTTTGATGGTGAATCTTTTAAAGAAACTTCACATCACCAAGCTGCATCAACTGAATCATTCCAATTC
GGACAGTAATTCCTTAAACTCAAACACATCAATGGACAATCATCAACAACAACAGCAGCTTCAGCAATAT
CAGCAACAATTTCAACAACCGCAGCAACAACTTTATCCAGGCGAACAAATAGTTCACCCTGCTGCAGCCC
AAACTGGACAAAATACTACAAATGTAACAGCAGTGTCGAGCTCCAACATTACCCAATCTGCTACCTCATC
ACTCCATTCACAGCAATTGCAGCATGTAGATGTTTCCAAATCGGCTGCTGAAGAAGCCATCAGAAGATCG
TTGTTGCCTGAACGTTCTACTGTTTCAAAGGGGAAATACTCTTTGACTGATTTCTCAATTATGAGAACTT
TGGGAACAGGTTCCTTTGGTAGAGTACATTTAGTGAGATCAGTTCACAATGGTAGATATTATGCTATCAA
AGTTTTGAAGAAGCATCAAGTTGTGAAAATGAAGCAAGTTGAACACACAAATGATGAAAGAAGAATGTTG
AAGTTGGTTGAACATCCATTTTTGATTAGAATGTGGGGGACTTTCCAAGATTCCAAAAATTTATTTATGG
TTATGGACTATATTGAAGGGGGAGAGTTATTTTCATTGTTAAGAAAGTCTCAGAGATTTCCCAATCCAGT
AGCCAAGTTTTATGCAGCAGANGTTACCTTGGCTTTGGAGTATTTGCACAGTCATGATATTATCTATCGT
GATTTGAAACCAGAAAATATATTATTGGATAGAAATGGTCATATAAAGATTACAGATTTTGGATTTGCCA
AAGAAGTTAGTACCGTTACATGGACGTTATGTGGTACCCCCGATTATATTGCCCCAGAAGTCATAACAAC
CAAACCCTATAACAAGTCGGTGGACTGGTGGTCGTTGGGGGTATTGATTTTTGAAATGTTGGCAGGTTAC
ACTCCATTTTATGATTCGACTCCAATGAAAACTTATGAAAAAATTTTGGCAGGCAAAATACATTACCCAA
GTTTTTTTCAACCTGATGTGATTGATTTGTTGACTAAATTAATAACTGCTGATTTGACAAGAAGATTGGG
TAATTTGATCAACGGACCAGCAGATATCAGAAATCATCCCTGGTTTCTGGAAGTGGTATGGGAGAAATTG
TTGGCAAAGGATATTGAAACTCCTTATGAACCACCAATCACAGCTGGGGTTGGTGATTCGTCATTGTTTG
ACCATTATCCAGAAGAACAATTAGACTACGGAAGCCAAGGAGAAGATCCTTATGCTCTGTATTTCCTTGA
CTTTTGAATTGAGAGGAGATGAACTTTCATAAATGAATAAATGACTAAATAATAACGATAGTAACTGTAA
GAAAAATAGGTGGTCAAAGATGAAACTCGTATCGGTTTAAGAATAAAGTCTACATTTAATTATAATTAAT
GCACATTAATATTTTCGTTTTGTTATTATACGAATGACTTAACATGTTGACTCTTCCTTGTCTGCTTTGT
TTTTCGGTATTTTTTTTTTATTTCTTTGCCTTTATGTATCTATATTAAATGTACAAAATATATTACATGA
TATTCCAAATATCTTGCTTTCTTAAAAGTCTTTGAAAACTCAAACTAGCTATGGCCCTGTTGTATTCAAT
AAAAATTACAATGCATGATAGTAAACACACTAACAATACCCTTGACATGAGTCAAAATCAATATTTTCAA
CACCCAGAATATCTTACGCCTGGAAAACATGTTTACAATTCAAACAAACAAAAAACAAAATCATACTGGT
ATCTTTTCTTCGTTGTTGACTTTGGAAAAACACACATTCATGATGTCCACAATCCGGACATTCTTTATCT
GATCGAGGTAAAGTAGGATCATTTCCAATATCTTCAACAACACCTGCAG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tpk2/tpk2 mutant has reduced capacity to invade and damage oral epithelial cells and is also attenuated in mice (Park et al., 2005).
References
Park et al., 2005: Park H, Myers CL, Sheppard DC, Phan QT, Sanchez AA, E Edwards J, Filler SG. Role of the fungal Ras-protein kinase A pathway in governing epithelial cell interactions during oropharyngeal candidiasis. Cellular microbiology. 2005; 7(4); 499-510. [PubMed: 15760450].