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ADE2

Victor ID 4585
Gene Name ADE2
Sequence Strain (Species/Organism) Candida albicans ATCC 32354
NCBI Nucleotide GI 1658378
NCBI Protein GI 1658379
Protein Accession AAC49755.1
Taxonomy ID 5476
Gene Strand (Orientation) ?
Protein Name phosphoribosylaminoimidazole carboxylase
DNA Sequence 
>gi|1658378|gb|U69606.1|CAU69606 Candida albicans phosphoribosylaminoimidazole carboxylase (ADE2) gene, complete cds
CGAACCATATCTACTTTTCAACATTAAAACTCTTGGGTCACGTGATGGTATTTAATTTTAGGCTTAGAGT
GAAAAATCAATCCATCGCAGCAATAAAAAGACCCCAAACATTTTGACTCGGTACAATCTTGTCAATGAGA
TGGAAAGAAAAAATAAAAGTAACACCCCCCACCAAAAAGAATCAACTTATACATTACTAATCTATTCATC
TTATTCTCATCACACACGCATATACAAGCACTACACATAATGGATAGCAAAACTGTTGGTATTTTAGGAG
GTGGCCAATTAGGTCGTATGATTGTTGAAGCAGCACATAGATTGAATATCAAGACCGTAATTTTGGACGC
AGCCAAATCACCAGCTAAACAGATCAATGCTCTAGACGATCACGTTGATGGATCGTTCACAAACTATGAT
TCGATTGTGAAATTAGCTGAAAAGGCAGACGTATTAACTGTTGAAATCGAACATGTTGATGTTGATGCTT
TAATCAAAGTTCAAGAGAAATTCCCTAAAGTTGAAATATATCCATTACCTGAAACCATAAGATTGATTCA
AGATAAATATTTACAGAAAAATCATTTAATCAAACACGATGTTGCAGTTACAGAATCTGTTGCAGTTGAA
ACCAACACAGTCGATGACTTGTTACACATTGGGGAAAAGTTTGGATACCCTTATATGTTAAAATCGAGAA
CTTTGGCGTATGATGGTAGAGGTAACTTTGTTGTCAAAGACAAGTCATACTGTGAGAAAGCTTTAGAATT
TTTAAAAGACCGTCCATTATATGCTGAAAAATGGTGTCCTTTCACCAAAGAATTGGCTGTGATGGTTGTC
AGATCATTAGAAGGGGAAGTCTTTGCTTACCCAACTGTTGAAACTATTCATGAAAACAATATTTGGCATT
TAGTGTATGCTCCTGCCAGGATCCCAGATACTTTGGGCCAAAAGGCATCTATATTAGCCAAAAATGCAGT
TAAGTCATTCCCCGGGTGTGGTATTTTCGGTGTTGAAATGTTCTTGTTGGAAAACAACGAATTATTGATC
AATGAAATTGCACCAAGACCTCACAACTCTGGTCATTATACCATTGATGCATGTGTCACTTCACAATTTG
AAGCTCATGTTCGTGCTGTCACAGGATTACCTATGCCAAAGGGGTTCACTGAATTCTCCACTTCCATCAC
CAATGCTATTATGTTGAATGTCTTGGGTGATAAGGCAACCCCAAATAAAGAACTGGAGATTTGTCGCCGT
GCTTTGGAAACTCCACATGCGTCAGTGTATCTTTATGGTAAAGCTACTAGACCAGAGCGAAAGATGGGTC
ATATCAATGTTGTCACATCTTCCATGCAAGATGCCGAGAGTAGATTAAGTTATATATTGGGTGATACCAC
TGAAATTCCTAAATCTTTAGCTACCGACAAGGAATCTCCATTGGTGGGAATAATAATGGGTTCCGATTCG
GATCTACCAGTTATGGCAGTTGGTGCTCGTATTTTGAAACAATTCGGTGTGCCATTTGAACTCACAATCG
TAAGTGCACACAGAACTCCTCATAGAATGTCTGAGTATGCTATTGAAGCACCAAAGCGTGGCTTGAAATG
TATCATTGCTGGTGCAGGTGGTGCTGCTCATTTGCCAGGTATGGTGGCGGCCATGACCCCATTGCCTGTC
ATTGGTGTTCCAGTTAAGGGATCTACATTAGATGGGGTTGATTCGTTACACTCTATAGTACAGATGCCAA
GAGGTATTCCTGTTGCAACTGTTGCTATTAACAATAGTACTAATGCTGCATTGTTGGCAATCAGAATATT
AGGCGCCTATGACTCAAAATGGTTGACTGAGATGAACCAATATATGTTGAACATGGAAACTGAAGTATTA
GGTAAAGCAGAAACTTTAGAAGAAATTGGATATGAAGACTATTTAACTGATAAATTGAAAAAATAGAAAA
AAATATAGATATCAATAGCATATTAAACAAGTAAACGTTATGGTGCAATAAAATTATAATTAATATATAA
AAAGAAATACATCGAACTGAACTAATATATGAGACATTAGAAAATGTGGTGCTTTTCCCTTCTTAGTTGA
TAATACTTTCGGTGAATCACAGAAAGAAATACCAATCCACCACATCTCTAACAGATCT
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ade2 mutant is avirulent in immunosuppressed mice (Donovan et al., 2001).
References
Donovan et al., 2001: Donovan M, Schumuke JJ, Fonzi WA, Bonar SL, Gheesling-Mullis K, Jacob GS, Davisson VJ, Dotson SB. Virulence of a phosphoribosylaminoimidazole carboxylase-deficient Candida albicans strain in an immunosuppressed murine model of systemic candidiasis. Infection and immunity. 2001; 69(4); 2542-2548. [PubMed: 11254618].