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NAG5

Victor ID 4638
Gene Name NAG5
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3646114
NCBI Protein GI 68487751
Locus Tag CaO19.9701
Genbank Accession AACQ01000162
Protein Accession XP_712286
Taxonomy ID 237561
Chromosome No 6
Gene Starting Position 43546
Gene Ending Position 45027
Gene Strand (Orientation) +
Protein pI 5.04
Protein Weight 51052.19
Protein Length 493
DNA Sequence 
>gi|68487764:43546-45027 Candida albicans SC5314 chromosome 6 Ctg19-20140, whole genome shotgun sequence
TATGACTGAGACTAGCATTAGTGGGTTGCGTGGCCCCAAGTCCATGTATTTTATGGAGATTGTTGATGTG
TCGTCGCAAGAATCCAGTGTGTTGTCGAGTATTGTTGAATCGTTTACGTCTGCGGTATCTGCATCGAACT
TGGGGGTATACTCTGATGAAGTGCTTTGTGATATCAAACTGTCGTTGAAAGAGAATTCCCCAATTACTAT
GTTACCTAACTATAATGTCTCCCCTACAGGCGACGAGCATGGACAGTATTTGGTTATTGATTTAGGAGGG
TCGACATTGAGAATAGCAGTGGTAGACATTTCCAAGCCACACCCAAATTTGTCGAGAAGTGAGAGGATAA
CTATAGTTGTGGAAAAGAGTTGGATTATTGGCAACGACTTTAAGAGGATTGATGGTGAGTTTTTCAAGTA
TATTGGGTCCAAGATTAACGAGATATTGATGGGACAGAATGTTATTGATGTAAAGTCGGTTATCAATACT
GGTATAACCTGGTCGTTCCCGTTGGAAACAACCGACTACAATAGAGGCAAGATCAAGCATGTTTCCAAAG
GGTATACTGTGGGAGAGGATATTTACGACAAGGATTTAAAGATGGTTTTGGAAGACACGTTGAGACAAGA
GTACGGGTTGACACTTGACGTGCAGTCTATATTGAACGACTCGTTGGCGGTGTATTCTGCTGGGTGCTTT
ATTGATTCGAAGATGAAGTTGGCCATGGTGTTGGGGACAGGGATTAACATGTGCTGTTCCCTAAAAAGGT
CAAGTGATATCCACCCCTCCAAGATGTTGGCTGATGCTACGTTGTTTAATTGTGAGCTCTCGTTGTTTGG
CCAGAATCTATGTAAAGACTTTGCTACGAAATATGATATCATTATAGACAAGAGGTTTGCTGGTTTGCTG
CACCACTTTAAGACGTTTATGGAGCCTGACCCTATTACAAAAACGCTTTTCCAGCCGCACGAGTTGATGA
CTAGTGGGAGGTACTTGCCAGAATTGACGAGGTTGGTGGTGGTAGATTTGATTGAGGCTGGCGAGATTTT
TCAAAATGTTGACCACCAACAGATGTACCAAGAGTATGGTGGGTTTAGTGGGGAGTTGATTTGTTTTGTG
CATGAGAATGACGATTATGATGATATACATGACAAGTTGTGCAAGGCCTACGGCTGGACGACGGTTGGGT
TGAGTGACATTGTCTGCTTGAAAGAAGTTGTATCGTGCATTATCAAGCGGGCGGCGTTTATTGTTGCCAA
TGCGATTATTGCGTTTTTCAAATTGTTGGGCAGTGACGAGTTGGGTGGTGATGTGACGATTGGGTATGTG
GGGTCGGTCTTGAACTACTTTCACAAGTATAGACGGTTGATTGTTGAGTATGTGAATAGCGCAGAGGAGG
CCAAGGGGATAAAGGTTGACTTGAAGTTGATTGAAAATAGCTCGATTATAGGTGCTGCCATAGGTGCTGC
CTATCATAAGTA
Protein Sequence 
>gi|68487751|ref|XP_712286.1| N-acetylglucosamine kinase [Candida albicans SC5314]
MTETSISGLRGPKSMYFMEIVDVSSQESSVLSSIVESFTSAVSASNLGVYSDEVLCDIKSSLKENSPITM
LPNYNVSPTGDEHGQYLVIDLGGSTLRIAVVDISKPHPNLSRSERITIVVEKSWIIGNDFKRIDGEFFKY
IGSKINEILMGQNVIDVKSVINTGITWSFPLETTDYNRGKIKHVSKGYTVGEDIYDKDLKMVLEDTLRQE
YGLTLDVQSILNDSLAVYSAGCFIDSKMKLAMVLGTGINMCCSLKRSSDIHPSKMLADATLFNCELSLFG
QNLCKDFATKYDIIIDKRFAGLSHHFKTFMEPDPITKTLFQPHELMTSGRYLPELTRLVVVDLIEAGEIF
QNVDHQQMYQEYGGFSGELICFVHENDDYDDIHDKLCKAYGWTTVGLSDIVCLKEVVSCIIKRAAFIVAN
AIIAFFKLLGSDELGGDVTIGYVGSVLNYFHKYRRLIVEYVNSAEEAKGIKVDLKLIENSSIIGAAIGAA
YHK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a DAC1/NAG1/HXK1(NAG5) mutant is highly attenuated in a murine systemic candidiasis model and was less adherent to human buccal epithelial cells in vitro (Singh et al., 2001).
References
Singh et al., 2001: Singh P, Ghosh S, Datta A. Attenuation of virulence and changes in morphology in Candida albicans by disruption of the N-acetylglucosamine catabolic pathway. Infection and immunity. 2001; 69(12); 7898-7903. [PubMed: 11705974].