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Kex2

Victor ID 4644
Gene Name Kex2
Sequence Strain (Species/Organism) Candida albicans WO-1
NCBI Nucleotide GI 2511731
NCBI Protein GI 2511732
Protein Accession AAB80929.1
Taxonomy ID 5476
Gene Strand (Orientation) ?
Protein Name proteinase
Protein Note convertase; probably in trans Golgi network
DNA Sequence 
>gi|2511731|gb|AF022372.1| Candida albicans proteinase (Kex2) gene, complete cds
TCTAGAGTAGTGATATCAAATGTTTGGGAATTGTGCACTACCAAGATTAACTGCAACTATACTCAACTAG
CACTACTGAAAAATGCAAATTAAACCTATAATACATAATTCTTAACCTTACAATTAACATATACATATAT
CTATCATATCATTTAATAAATATTATCTAGTTTACGGTAGTAGTGGTATAAGAAATAGATAGAAGAATAA
CTTAAACAAAGAAAAATGTAACTCTTCCCCCAATTTTTTTTTTTTTGTACTCCAATACACTACCAATTTT
GTGGCATATTTGTTTCTACTTCTTATTTGTGGTGGTGAAAATATTTATAAACTACAAACCCTGTAAGTTC
ACATATGCATATACTCTATGGAATGTTAATAGCATTTGGTACTACAGAATGCTATTTTTACACGAATAAT
TTGCGTTTATAAATATCGTCTATTAAATTAGTTGAAAGAGGAAAGAAGAGGCGGAATCAAAAAGAAAGAA
AGAAATTGACATTAATTTCAAGCCAACGTCAAAAACAATCAACGAGAAAGAAAAAACTTCAATTTTGATC
AACCAGGAATTTTTTTTTTTTTTTCAACCCTTTGACGTGTTCACTAGAAGTTGTTATTGTTGTTTGTTGA
TATATATATATATATTTATTCTTTTTCAAATCACTAATATATTAGATTCTTATCTGTCATAGAAGATAGA
AGTTACAACCAACCCACACATACTATGTTGCCAATAAAATTACTAATATTTATATTGGGATATTTATTAT
CACCAACTTTACAACAATATCAACAAATTCCTCCTCGAGATTATGAAAATAAAAATTATTTTTTAGTTGA
ATTAAATACTACTAATTCTCAAAAACCTTTAATTGATTTCATATCCCATTATAGGGGTCATTATAATTTT
GAACATCAATTATCATCATTAGATAATCATTATGTTTTCAGTATTGATAAATCTCATCCTCATAATTCGT
TTTTAGGTAATCATAATTCAAATGAATATAATTTAATGAAACGACAATTAGGTCATGAACAAGATTATGA
TGAATTGATTTCTCATGTTGAATCTATTCATTTATTACCCATGAAAAAACTTTCTAAAAGAATACCTGTC
CCTATTGAAATGGAAGATGTGGTGTTTGATAATCGTGATGATACTGGTTCTGATAATCATGAGGCAACAG
ATGAAGCTCATCAAAAATTGATAGAAATTGCTAAGAAATTAGATATTCATGATCCAGAATTCACTACTCA
ATGGCATTTAATCAATTTAAAATATCCTGGTCATGATGTTAATGTCACTGGTCTTTGGTTAGAAGATATT
TTAGGTCAAGGTATAGTCACAGCATTAGTTGATGACGGAGTTGATGCAGAAAGTGATGATATTAAACAAA
ATTTTAACTCTGAAGGGTCATGGGATTTTAATAATAAAGGCAAATCTCCTTTACCTCGACTTTTCGATGA
TTATCATGGTACTAGATGTGCTGGAGAAATAGCTGCTGTGAAAAATGATGTTTGTGGTATTGGTGTAGCA
TGGAAATCGCAAGTTAGTGGGATTAGAATATTATCTGGCCCTATTACTTCATCTGATGAAGCTGAAGCTA
TGGTATATGGATTAGATACTAATGATATTTATTCATGTTCTTGGGGCCCTACTGATAATGGTAAAGTCTT
ATCAGAACCAGACGTAATAGTGAAAAAAGCCATGATTAAAGGAATTCAAGAAGGTCGTGATAAAAAGGGA
GCAATCTATGTTTTCGCTTCTGGAAATGGTGGTAGATTTGGTGATTCTTGTAATTTCGATGGTTATACTA
ATTCTATTTATTCAATTACTGTTGGTGCCATTGATTATAAAGGATTACATCCACAATATTCTGAAGCTTG
TTCTGCTGTTATGGTGGTTACTTATTCTTCTGGATCAGGTGAACATATTCATACCACTGATATCAAGAAA
AAATGTTCGGCAACTCATGGTGGTACTTCTGCTGCTGCACCTTTAGCTAGTGGGATTTATTCATTAATAT
TATCAGCTAATCCTAATTTAACTTGGAGAGACGTTCAATATATTTCTGTATTAAGTGCTACTCCTATAAA
TGAAGAAGATGGTAATTATCAAACTACAGCTTTGAACAGAAAATATTCTCATAAATACGGTTATGGTAAA
ACTGATGCTTATAAAATGGTTCATTTCGCTAAAACTTGGGTAAATGTTAAACCTCAAGCTTGGTATTATA
GTGATATCATTGAAGTTAATCAAACTATTACTACTACCCCAGAACAGAAAGCTCCAAGTAAGCGTGATTC
TCCTCAGAAAATCATTCATTCATCAGTTAATGTTAGTGAGAAAGATTTAAAAATTATGAATGTTGAAAGA
GTTGAACATATTACTGTTAAAGTAAATATTGATTCTACTTATAGAGGTAGAGTTGGTATGAGAATTATTT
CTCCCACGGGGGTTATTAGTGATTTAGCAACTTTCCGAGTTAATGATGCTTCAACTAGAGGATTTCAAAA
TTGGACATTTATGTCAGTAGCTCATTGGGGTGAAACTGGTATTGGAGAATGGAAAGTTGAAGTTTTTGTT
GATGATTCAAAAGGTGATCAAGTTGAAATTAATTTCAAAGATTGGCAATTTAGAATATTTGGTGAATCTA
TTGATGGTGATAAGGCAGAAGTTTATGATATAACTAAAGATTATGCTGCTATAAGAAGAGAATTATTAGA
AAAAGAAAAACAAAATAGTAAATCAACCACTACAACCAGCAGTACTACTACTGCTACTACCACAAGTGGC
GGAGAAGGTGATCAAAAAACTACTACACTGGCAGAAAATAAAGAATCTACAACAAAAGTGGACAATCTGG
CAAGCATTACCACTAGTCAAACTGCATCTTTGACATCATCAAATGAACAACATCAACCAACTGAATCAAA
TTCTGATTCTGATTCTGATACCGATGATGAAAATAAACAAGAAGGTGAAGAAGACAATGACAATGACAAT
GACAATGGCAACAAAAAGGCCAATTCTGATAATACAGGATTTTACCTTATGTCAATTGCTGTTGTTGGAT
TCATTGCTGTATTATTAGTTATGAAATTCCATAAAACTCCAGGAAGTGGTCGTCGTCGTAGAAGAAGAGA
TGGTTATGAATTTGATATTATTCCTGGTGAAGATTATAGTGATTCTGACGATGATGAAGATGATTCCGAC
ACTAGGCGTGCTGATGACGATTCATTTGATTTAGGTCATAGAAATGACCAAAGAGTAGTATCGGCATCAC
AACAACAAAGACAATACGATAGACAACAAGATGAAGCTAGAGATCGATTATTTGATGATTTTAATGCTGA
AAGTTTACCTGATTATGAAAATGATATGTTTAAGATTGGCGATGAAGAAGAGGAAGAAGAGGAAGAAGAG
GAGGGACAACAATCAGCAAAAGCACCATCAAATTCAGAAGGAAATTCAGGAACTTCGACTAAAAAATAAG
GATAACGAGGCTGACGAGGATCATAAAGATGTTGTTGGTACACAGTAGATACAATACAATAATTATTATT
ATTAGACCTACACACCAAGAAATGATACATACCCTAAAGGCATTGTTTTATTAAATAGAATTGAAATATA
TATATATATATATATAAAAGATTTTCCGATC
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: kex2/kex2 mutants are highly attenuated in a mouse systemic infection model and persist within cultured macrophages for at least 24 h without causing damage (Newport et al., 2003).
References
Newport et al., 2003: Newport G, Kuo A, Flattery A, Gill C, Blake JJ, Kurtz MB, Abruzzo GK, Agabian N. Inactivation of Kex2p diminishes the virulence of Candida albicans. The Journal of biological chemistry. 2003; 278(3); 1713-1720. [PubMed: 12419804].