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NOT5

Victor ID 4657
Gene Name NOT5
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3640763
NCBI Protein GI 68476703
Locus Tag CaO19.5107
Genbank Accession AACQ01000053
Protein Accession XP_717644
Taxonomy ID 237561
Chromosome No 1
Gene Starting Position 122117
Gene Ending Position 124105
Gene Strand (Orientation) +
Protein pI 4.87
Protein Weight 71975.8
Protein Length 662
DNA Sequence 
>gi|68476732:122117-124105 Candida albicans SC5314 chromosome 1 Ctg19-10218, whole genome shotgun sequence
AATGAGTGCAAGAAAACTACAACAAGAATTTGACAAGCTAAACAAAAAGATTTCTGAAGGGCTTCAAGCA
TTTGATGAGATCAAAGATAAGATTAATGCCACAGAATCAGCTTCACAACGAGAAAAGTTGGAGAACGATT
TGAAGAAAGAGTTGAAGAAATTGCAAAGACTGAGAGACCAGTTGAAACAATGGTTAGGAGATAGTAGCAT
TAAACTAGACAAGAATGTATTGCAGGAGAATCGTACTAAGATTGAACATGCTATGGATCAATTTAAAGAA
TTGGAAAAACTGCTGAAAATAAAACAGTTTTCTAATGAAGGGTTGGAGTTACAAAGCCAACAAAAGCGAT
CACGATTTGGTGATGATGCGAAATATCAAGAAGCTTGCACCTATATAAATGAGGTTATTGAACAATTGAA
TGGTCAAAACGAGGAATTAGAACAAGAGTTAGATTCGTTGAGTGGTCAACTGAAAAGAAAAGGAGGTAGT
TCAATACAGCTGTCTATTGACGATGTGAAATACAAGATAGAACGAAACAATTCTCATATATCCAAGTTGG
AAGAAGTTTTGGAGAATTTGGATAACGACAAATTGGACCCAGCCAGAATCGATGATATTAAAGATGATTT
GGATTATTATGTTGAGAATAATCAAGATGAGGATTATGTCGAATATGATGAATTTTACGATCAGTTAGAA
GTGGATGAAGAAGATGATGTTGAAGTTCAAGGGTCATTGGCACAGATGGCTGCTGAAACCGAAGATGAAA
GGAGGAGAGACGAGGAAAGAAAAAGGGAAGAAAAAGAGAAAGAGAAGCAACAGCAGAATCCACCAAGGAC
GTCTTCTTCCGTGTCCAGCTCCAGTAGTAGTAATCAAAATAATATTGGCAATAATACTCCTCCTGCAACT
CAAATAAAGCCATCAGTAGTGACAGTGGCAGCAATTGGGGACCAAAACAATAACAGTGCGTCATCGGCAT
CTTCAACATCAACGCCTGTGAAGAAGTTGAAACCTACACTTGCTCCAGCACCTGCACCACCACCAATAAC
AAGTGGAACTTCGTATTCAAATGCTATAAAGGCAGCACAGACAGCTAGCACATCATCCACTTCCAATTCT
TCTATTGCTCATACTGCTAATGATAACAACAACACAAACAAAGGCAACCGTTCAGTATCACCTCTTGCTT
CTACCGATAATCATACTCATGCACCAGCAGCAGTGTCCACCCCAGTTAAAGTTTTACCGCCTGGGTTAAA
TCACGATACATCCATGAATTCTACCTTGAGGTCAGAGTCATCATCACCATTAGTTGGTCATGCCAAGGTT
AATAATAACCATGAGTTACAGATTAGCAGATCACAACTGCCAATGGTTTCTAATGAGAATAAGGTATTTA
GTGATACCATTTCTCGAATTGTTAATGTTGCTCACAGCAGACTAAATGACCCATTGCCCTTACAGTCAAT
AACTGGGCTATTAGAGACCTCCTTGTTAAACTGTCCCGATTCGTATGATGCTGAAAAGCCAAGACAGTAT
AACCCAGTTAACGTCCACCCGTCACTGATTGATTATCCACAAGAACCAATGTATGAGTTGAATAGTAGTC
ATTACATGAAAAAGTTTGATAATGATACTTTGTTCTTTTGCTTTTATTATGGCGATGGCATAGATAGCAT
TTCGAAATACAATGCAGCCAAAGAATTGTCGAGACGTGGGTGGGTGTTTAACACTGAATTTAGTCAATGG
TTTTCCAAAGACAGTAAGAATGGAGGCAAGAACCGGTCAATGTCTGTGATACAAAGAGAAGAAGAAAATG
GTAATATTATCGGAGACAACAGCAATGGTAATGAGGAATTACGCGAGAAGATTGATGATAATGGCGGCAT
TCCAAGTAATTACAAGTACTTTGACTATGAAAAGACATGGTTAACACGTCGAAGAGAAAACTATCAATTT
GCTACTGAAAACAGACAGATTTTCCAATG
Protein Sequence 
>gi|68476703|ref|XP_717644.1| potential mRNA deadenylase and CCR4-NOT complex subunit Not5p [Candida albicans SC5314]
MSARKLQQEFDKLNKKISEGLQAFDEIKDKINATESASQREKLENDLKKELKKLQRSRDQLKQWLGDSSI
KLDKNVLQENRTKIEHAMDQFKELEKSSKIKQFSNEGLELQSQQKRSRFGDDAKYQEACTYINEVIEQLN
GQNEELEQELDSLSGQSKRKGGSSIQSSIDDVKYKIERNNSHISKLEEVLENLDNDKLDPARIDDIKDDL
DYYVENNQDEDYVEYDEFYDQLEVDEEDDVEVQGSLAQMAAETEDERRRDEERKREEKEKEKQQQNPPRT
SSSVSSSSSSNQNNIGNNTPPATQIKPSVVTVAAIGDQNNNSASSASSTSTPVKKLKPTLAPAPAPPPIT
SGTSYSNAIKAAQTASTSSTSNSSIAHTANDNNNTNKGNRSVSPLASTDNHTHAPAAVSTPVKVLPPGLN
HDTSMNSTLRSESSSPLVGHAKVNNNHELQISRSQSPMVSNENKVFSDTISRIVNVAHSRLNDPLPLQSI
TGLLETSLLNCPDSYDAEKPRQYNPVNVHPSSIDYPQEPMYELNSSHYMKKFDNDTLFFCFYYGDGIDSI
SKYNAAKELSRRGWVFNTEFSQWFSKDSKNGGKNRSMSVIQREEENGNIIGDNSNGNEELREKIDDNGGI
PSNYKYFDYEKTWLTRRRENYQFATENRQIFQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: NOT5 mutant had reduced adherence to epithelial cells and has attenuated virulence in mice (Cheng et al., 2003).
References
Cheng et al., 2003: Cheng S, Nguyen MH, Zhang Z, Jia H, Handfield M, Clancy CJ. Evaluation of the roles of four Candida albicans genes in virulence by using gene disruption strains that express URA3 from the native locus. Infection and immunity. 2003; 71(10); 6101-6103. [PubMed: 14500538].