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PHR1

Victor ID 4659
Gene Name PHR1
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Nucleotide GI 857671
NCBI Protein GI 857672
Protein Accession AAA68196.1
Taxonomy ID 5476
Gene Strand (Orientation) ?
Protein Name pH responsive protein
Protein Note shows 56% identity to GPI-anchored gp115 from S. cerevisiae
DNA Sequence 
>gi|857671|gb|M90812.1|YSAPHR1A Candida albicans pH responsive protein (PHR1) gene, complete cds
GAATTCATCGACGCCTCATTCATACTAATATAATAGGTGTTGCAACATCAAAATCATTTCATCGCTAATA
CAAACATCCGAGATTAATCTTGTCCATTGGCAATATAATTAACACCACTGCCAATACATATAAATCAAAT
CAGCATTAACTAATAGTATTTATTAATTACTTAGAAAAGCCGGGCTGCGTTTTTTTGTTTCATTCATAGA
TTTACTTATTTCCATTTAACATACCAAACTACAGGTTGAAGCCAAAAAAAAATGTATTCATTAATCAAAT
CATTGGCCACATTTGCCACACTCTTTTCATTAACTTTAGCCAAGTTTGAATCGTCCACCCCACCAGTTGA
AGTTGTTGGTAACAAATTTTATTTTTCCAATAATGGGTCTCAGTTTTTAATCAGGGGTATCGCCTATCAG
CAAGATGCCGCGGGCTCAGTTTCCTCCGGTTACGACGCCGATCCTAATAGAAAATACAATGATCCTTTAG
CCGATCGTGACGCTTGTAAACGTGACGTCAAGTATTTCAAAGAATCAAACACCAATACTTTGAGAGTTTA
TGCTATTGACCCAGATAAGGATCATGAAGAGTGTATGAAAATTTTCAGTGACGCTGGTATTTACATTGTT
GCTGATTTATCAGAACCAACTGTATCGATTAACAGAAACAACCCAGAATGGAACTTGGATTTATACAAAC
GTTATACAAAAGTCATTGATAAGATGCAAGAATATTCTAATGTTTTGGGATTTTTTGCTGGTAACGAAGT
AACTAATAATCGTTCAAATACCGATGCTTCTGCATTTGTTAAGGCTGCCATTAGAGATATGAAGAAATAC
ATCAAGGAGTCTGATTATAGACAAATTCCTGTTGGTTATTCATCCAATGATGACGAAGAAATTAGAGTCG
CCATTGCCGATTATTTCTCTTGTGGTTCATTAGATGATCGTGCTGATTTCTTTGGTATCAATATGTATGA
ATGGTGTGGCAAATCAACTTTCGAAACCTCAGGTTACAAGGACAGAACTGAAGAAATCAAGAACTTGACT
ATCCCAGCCTTCTTCTCCGAATATGGATGTAATGCTAACCGTCCACGTTTGTTCCAAGAAATTGGTACCT
TGTATTCCGATAAGATGACTGATGTTTGGTCCGGAGGTATTGTTTATATGTATTTTGAAGAGGCTAACAA
ATACGGTTTGGTTCTGGTTGATGGTAATTCGGTCAAGACATTATCTGACTACAACAATTACAAATCAGAA
ATGAACAAAATAAGCCCATCCCTTGCCCATACTTCAACATTATCCAGTTCTGACGCCAGCAAGACTTTGC
AATGTCCAGGAACTGCTGCTAGCACTTGGAAAGCTGCAACTAATTTGCCACCAACTCCAGATGAAAGTTA
CTGTGATTGTATTTCCAAGTCATTAGAATGTGTTGTTGCTGACGATGTTGATAAAGAAGACTATGGTGAC
TTGTTTGGTCAAGTTTGTGGTTATATCGATTGCTCGGCTATTTCTGCCGATGGTAGCAAAGGTGAATATG
GTGTTGCTTCCTTCTGTTCTGATAAAGATCGTTTGTCATATGTGTTGAACCAGTATTACCTTGACCAAGA
CAAGAAATCCAGTGCTTGTGATTTCAAAGGCAGTGCTTCAATCAATAGCAAGGCTAGTGCTAGTGGCAGC
TGCAAAGCTGTTAGTGGAGTAGCTACTGGTAAGGCATCTTCCTCTGGTGGAAGCTCCAAATCTGGATCTT
CCTCTGCATCTGCTTCTGGATCATCAAGCAGCAGCACCAGCTCTGGGTCCAGCTCAAGCTCTGGAGTTAA
AGCAACTCAACAAATGTCTATGGTCAAATTGGTTTCAATTATTACTATTGTTACTGCATTTGTTGGTGGT
ATGTCCGTTGTTTTTTAAATCAATGAAGACTAACCGATATGAAGGGTTCTGTTGTATAGGACGAATATAT
ATAGTTTAATAAGAGTTCATTATTTAAAAGTTCCAATTTGAAATCAACTTGGTACACATATCTATT
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: phr1 mutant is attenuated in mice (Ghannoum et al., 1995).
References
Ghannoum et al., 1995: Ghannoum MA, Spellberg B, Saporito-Irwin SM, Fonzi WA. Reduced virulence of Candida albicans PHR1 mutants. Infection and immunity. 1995; 63(11); 4528-4530. [PubMed: 7591097].