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ERK1

Victor ID 4610
Gene Name ERK1
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3642789
NCBI Protein GI 68481001
Locus Tag CaO19.2886
Genbank Accession AACQ01000083
Protein Accession XP_715542
Taxonomy ID 237561
Chromosome No 4
Gene Starting Position 48743
Gene Ending Position 50014
Gene Strand (Orientation) +
Protein pI 6.51
Protein Weight 47561.76
Protein Length 423
DNA Sequence 
>gi|68481074:48743-50014 Candida albicans SC5314 chromosome 4 Ctg19-10162, whole genome shotgun sequence
AATGATGAATATAGATCAACATCATCAGCTTCAACAGCAACATCAACAACAAATGTTACAACAACAAGCT
CAGGCTCAGGCTCAGGCTCAAGCTCAAGCACAACAACAACAACAACAACAACAACAGGCAGCAGCCGCAG
CCGCAGCAGCTAACGCTGCAGCTACTACTTCTTCTTCTTCCCCTCGTCAAGTTTCATTCAACGTATCTGA
TCATTATCAAATATTAGAAATTGTTGGAGAAGGAGCATATGGAATAGTTTGTTCAGCCATTCATAAACCA
TCACAACAAAAAGTTGCCATTAAAAAAATTGAACCATTTGAAAGAAGTATGTTATGTTTACGTACATTAC
GAGAATTAAAATTATTAAAACATTTTAATCATGAAAATATCATTAGTATATTAGCTATACAACGACCAAT
TAATTATGAATCATTTAATGAAATTTATTTAATTCAAGAATTGATGGAAACTGATTTACATCGAGTCATT
AGAACTCAAAATTTATCTGATGATCATATACAATATTTCATTTATCAAACTTTAAGAGCTTTAAAAGCTA
TGCATTCAGCTAATGTATTGCATCGAGATTTAAAACCACTGAATTTATTATTAAATTCAAATTGTGATTT
AAAAATTTGTGATTTTGGTTTAGCAAGATCAATTGCTTCACAAGAAGATAATTATGGATTCATGACAGAA
TACGTAGCTACAAGATGGTATAGAGCTCCAGAAATCATGTTAACTTTTCAAGAATATACTACTGCTATTG
ATGTTTGGTCAGTTGGTTGTATATTGGCAGAAATGTTGAGTGGTAGACCTTTATTCCCTGGTAGAGATTA
TCATAATCAATTATGGTTAATTATGGAAGTTTTAGGAACACCAAATATGGAAGATTATTATAATATTAAA
TCTAAACGAGCAAGAGAATATATTAGAAGTTTACCCTTTTGTAAAAAAATTCCGTTCAGTGAATTATTTG
CCAATACCAACAACAATACTAGTACTAGTACTAGTAATACTGGCGGTAGGACAAATATTAATCCATTGGC
ATTAGATTTATTAGAAAAATTATTAATTTTTAATCCTGCTAAAAGAATTACTGTTGAAGATGCTTTAAAA
CATCCTTATTTACAATTATATCATGATCCTAATGATGAACCAATTAGTGATAAAATCCCAGAAGATTTTT
TCGATTTTGATAAAATGAAAGATCAATTAACAATTGAAGATTTGAAAAAATTGTTATATGAAGAGATTAT
GAAGCCATTATA
Protein Sequence 
>gi|68481001|ref|XP_715542.1| likely protein kinase [Candida albicans SC5314]
MMNIDQHHQLQQQHQQQMLQQQAQAQAQAQAQAQQQQQQQQQAAAAAAAANAAATTSSSSPRQVSFNVSD
HYQILEIVGEGAYGIVCSAIHKPSQQKVAIKKIEPFERSMLCLRTLRELKLLKHFNHENIISILAIQRPI
NYESFNEIYLIQELMETDLHRVIRTQNLSDDHIQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNSNCDL
KICDFGLARSIASQEDNYGFMTEYVATRWYRAPEIMLTFQEYTTAIDVWSVGCILAEMLSGRPLFPGRDY
HNQLWLIMEVLGTPNMEDYYNIKSKRAREYIRSLPFCKKIPFSELFANTNNNTSTSTSNTGGRTNINPLA
LDLLEKLLIFNPAKRITVEDALKHPYLQLYHDPNDEPISDKIPEDFFDFDKMKDQLTIEDLKKLLYEEIM
KPL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: disruption of the CEK1 gene adversely affects the growth of serum-induced mycelial colonies and attenuates virulence in a mouse model for systemic candidiasis (Csank et al., 1998).
References
Csank et al., 1998: Csank C, Schröppel K, Leberer E, Harcus D, Mohamed O, Meloche S, Thomas DY, Whiteway M. Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis. Infection and immunity. 1998; 66(6); 2713-2721. [PubMed: 9596738].