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irs4

Victor ID 4642
Gene Name irs4
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3645650
NCBI Protein GI 68486800
Locus Tag CaO19.6953
Genbank Accession AACQ01000148
Protein Accession XP_712754
Taxonomy ID 237561
Chromosome No 3
Gene Starting Position 52420
Gene Ending Position 54336
Gene Strand (Orientation) -
Protein pI 9.64
Protein Weight 68666.02
Protein Length 638
DNA Sequence 
>gi|68486811:52420-54336 Candida albicans SC5314 chromosome 3 Ctg19-10259, whole genome shotgun sequence
TTTATTTTTTCTTTTTAACAGTGACATTAACACCAATTCCACCTAAACTATCCCAAACGACATTATCGAC
TTTTTTTGGCAATTTTCTTCCATATAAACACTGATCCACCAACCACATGCCCACTAAAAATTCATTCTTA
TTCAATGTACCATCTCGTCGAAAATCAATCAAGTTCCATATTTTCTCTAATGTATCACTAGGCAACCTAC
TACGTTTCCATATTCTCTTTACCACAGGCCCACAAATTAATTGGTTAATTTCGACCGAATCCAAATTGTG
TAAGCTGTTGTTACCATTATAATTACTGTCTTCAACAGCAGCCGCAGATAACAATGCAGCTGTTCTCGAG
TGCTCCATTTTAGCTTCCTCTTTGGGATCCTTCTGCGTCTCATAATTAACCCCGTGTAATTTGATCACCA
CTTGACTCATATAATTTCCCTTGTTACTAGCCCAAATCCCCTCGTACCTCTTTTTCTCCTGATCAGTTAA
ATAATTAAGATCATTATGATTCTTCCATGGCTTCAACTCATTAAACCTTGATTTTTTGTCCTTTTTAGTA
TTTGCTTTTCTCATCGTGCTTCTGAAATGCACTTGCTGTTGTGGTTGTCCAAGTAATGGCGTTGTTGATC
TCAGTGGAAGATTGCTGGTAGACTCTTCAGTGTCACTGGTGTTACTCAGATCCATATCACGATAGTAAAT
CCCATTAATTGGTTTTACTTTCTGATGTTTTTTCCGAAACTTTGAACTGTGTTGATGATAATGATTTGCG
TCTGGAAATTGTGGGAAAAGCCTGGTTGTTTCTCCAACTTCCACCTCAGATACCAAATTCTCGTACAGAT
CGGGGTCTGTAAAAGAGTAGACTTCATCAGGGTTTAGAGAATACGATCCACTTGAAATAGTATCTCGCGA
TTTGTCATTTAACTGCATTTGAAAGTCTTCTCCAGGCGGCGGTTTCCTCCGAAGACGACTAGAAACTGTC
ACCTTATTATTTGTACTTTTCAATTCACCATTATCTAATGGTTCATGGTCCTCCTCCCTTTCTCTGTCAT
CAATTTCGTCCTCATCACTATCATGATTTGTGACGTCAATGCTTATTCCGTGTGGTAGATGTCGATCATT
AATGCTTGAGCTAAAAGAAGCAAAAGAATCTGTGGACACCGTGTCGACATCATAGTGATGACTTAAGTTA
CTTACGTCGCTAGTACTTTTATTGAAATCCAAGTTAGGAGATAACGATAAACTAGCGACACTGTTGGAAG
CGATTCTCCGGGTATTCTCAAGTCTGTCTCTCATCTCAGCCAACATTGTTTGCCCCATTTTATCACTGGT
TGTTAACATGGGCGATGTTTTTGTTCTTGAATGCAATGAATGCCGCAAATTCTTTAACATTTCTTGTGGC
GAGTAATCCACAGAAAGCCGTTTAGCCTGTGCATTATTGGGTATTGCTTTTAACTCTATTGATTGTCTTA
CATTCCTAATCATATCTTGAGGTGTTTGAGGAGATTTTGCAATTTCATTTTTAGATGGGATTGTATGTGG
CAGAAGTGTAAAATAATCAGGGTCTGAATCCAAAGCCGACGCTGGAGCTGAAGGTTGAGTCGGGCTTATT
GACGGCAGTGCAATTTGCAAAGCTGGCTGAAGAGAGGCCATGGCAGGAGCTGTATTTAGTCTTTTGAGCT
GTGAAAATTTATTACTCTTTTTTCTTGACGGATGGGCAGGAAGTGGGGTCCGTAGCGCTTGAGGCTGTTG
TTGCTGTTGTTGATGTTGTTTGGTTTGATTTGAGGTACTTCCAATTACACCAAGATGATTCGTGTTATTG
TCTGTTCCATTTAATTTTGTCGTAGATTCTTTCTTCTTCTTTCCAATGCCATTAAATGCAGCCAATGCAG
CTGCATTTGCAGCACTGTTTCCAGACA
Protein Sequence 
>gi|68486800|ref|XP_712754.1| hypothetical protein CaO19.6953 [Candida albicans SC5314]
MSGNSAANAAALAAFNGIGKKKKESTTKLNGTDNNTNHLGVIGSTSNQTKQHQQQQQQPQALRTPLPAHP
SRKKSNKFSQLKRLNTAPAMASLQPALQIASPSISPTQPSAPASALDSDPDYFTLSPHTIPSKNEIAKSP
QTPQDMIRNVRQSIELKAIPNNAQAKRLSVDYSPQEMLKNLRHSLHSRTKTSPMLTTSDKMGQTMLAEMR
DRLENTRRIASNSVASLSLSPNLDFNKSTSDVSNLSHHYDVDTVSTDSFASFSSSINDRHLPHGISIDVT
NHDSDEDEIDDREREEDHEPLDNGELKSTNNKVTVSSRLRRKPPPGEDFQMQLNDKSRDTISSGSYSLNP
DEVYSFTDPDSYENLVSEVEVGETTRLFPQFPDANHYHQHSSKFRKKHQKVKPINGIYYRDMDSSNTSDT
EESTSNLPSRSTTPLLGQPQQQVHFRSTMRKANTKKDKKSRFNELKPWKNHNDLNYLTDQEKKRYEGIWA
SNKGNYMSQVVIKLHGVNYETQKDPKEEAKMEHSRTAALLSAAAVEDSNYNGNNSLHNLDSVEINQLICG
PVVKRIWKRSRLPSDTLEKIWNLIDFRRDGTLNKNEFLVGMWLVDQCLYGRKLPKKVDNVVWDSLGGIGV
NVTVKKKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: an irs4 null mutant strain was associated with attenuated mortality, diminished tissue burdens, less extensive infections, impaired C. albicans hyphal formation and decreased kidney damage in mice (Badrane et al., 2005).
References
Badrane et al., 2005: Badrane H, Cheng S, Nguyen MH, Jia HY, Zhang Z, Weisner N, Clancy CJ. Candida albicans IRS4 contributes to hyphal formation and virulence after the initial stages of disseminated candidiasis. Microbiology (Reading, England). 2005; 151(Pt 9); 2923-2931. [PubMed: 16151204].