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SAP1

Victor ID 4675
Gene Name SAP1
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3640256
NCBI Protein GI 68475693
Locus Tag CaO19.5714
Genbank Accession AACQ01000046
Protein Accession XP_718053
Taxonomy ID 237561
Chromosome No 6
Gene Starting Position 22845
Gene Ending Position 24020
Gene Strand (Orientation) -
Protein pI 4.99
Protein Weight 38922.31
Protein Length 391
DNA Sequence 
>gi|68475808:22845-24020 Candida albicans SC5314 chromosome 6 Ctg19-10233, whole genome shotgun sequence
TCTAGGTAAGAGCAGCAATGTTTGAAGCAGAAGTGTATTTAACTTGAGCTAAAGAAATTTTATCATCATC
CAAATCATAAACAAGGTAAGCTGATCTCAAAAAGTTATCACCAAGAATATTAGCATCACTAATACCTAAA
AGAAGTTGACATTTTGGATAAGGTTGACCGTTAGCGTAGCTCAACGGAGCAGTAAACTCAGAAGCTGGAA
CAGAAATCTTGGCGTTGTTGTCAAAATTGAAATCAACAGTTCCAGAAGTTTGACAATCAGTAACATAGAA
AGTATGACCTTGACCATCCAGTTTCAATTCAGCTTGGAAGGCATCAATAATATCTTGAGCAACATCTTGT
TGAAGATAAGTAATTGTGGTACCAGAATCTAAAAGAACATCGATATTACCATTGATATTTTTGCCAACAG
CTTTGAGAGAATTCAAAGTGATTCTTAATTCTCTATCAGAAGTGACAGGAACAGCAATCAATGAACCACT
GTATTTAGCTTTGTCAACCCCACCAAAAATGATTTGTCCAGTGGCAGCATTGGGAGAGTTGAGATAAAGT
GAATAAGCATTCTTGGCAATAACTCCTTGGTTCTTCAAAGTAACTGGAACATTATCATAATCACCAGCAG
CCTCATTGGTTTTATAACCAATACCTAAAATCCCTTGAGGAATAGAAGTCTTGGTGATATCGGCAAAGAC
TTGCTTTGTGATTGAAGCACCACCAAAACCAACAGTATCTTTATACAAAGTGCCTTGAGAGGAACTACCA
TCACCATAACCAATATAGAATGGGGTACCCAAATTTTGAGAAGTGGTAGAAGATTTTGGAGTGTAAATAC
CTTTCCCTTTACAGAAATCTGCTGATTGACCAGGACGAGGTTTATCACAAGTAACAGAAGCATCAGGAAC
CCATAAATCAGAAGATCCAGTATCAACAATAACATTAAACTTTTGTTTATTGGAACCAATAGTGATGTCA
GCAGCATAACTAACGTGTTCATTATTTAAAGTAACTGGGAGGGCTTGTCTTTTAACTTTACCTTCTTGAC
CAGTAGCATTAACAGGAGTTTTAATGACATCAAAGTCTAAAGTGACAAAACCTGGGGATCTTTTAGCTGG
AGAAGCATCAACTAATAAAGCAATAGCAAGAGCAATGAAAATATTCTTTAAAAACA
Protein Sequence 
>gi|68475693|ref|XP_718053.1| secretory aspartyl proteinase SAP1p [Candida albicans SC5314]
MFLKNIFIALAIALLVDASPAKRSPGFVTLDFDVIKTPVNATGQEGKVKRQALPVTLNNEHVSYAADITI
GSNKQKFNVIVDTGSSDLWVPDASVTCDKPRPGQSADFCKGKGIYTPKSSTTSQNLGTPFYIGYGDGSSS
QGTLYKDTVGFGGASITKQVFADITKTSIPQGILGIGYKTNEAAGDYDNVPVTLKNQGVIAKNAYSLYLN
SPNAATGQIIFGGVDKAKYSGSLIAVPVTSDRELRITLNSLKAVGKNINGNIDVLLDSGTTITYLQQDVA
QDIIDAFQAELKSDGQGHTFYVTDCQTSGTVDFNFDNNAKISVPASEFTAPLSYANGQPYPKCQLLLGIS
DANILGDNFLRSAYLVYDLDDDKISLAQVKYTSASNIAALT
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sap1 mutant is attenuated in mice and guinea pigs (Hube et al., 1997).
References
Hube et al., 1997: Hube B, Sanglard D, Odds FC, Hess D, Monod M, Schäfer W, Brown AJ, Gow NA. Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infection and immunity. 1997; 65(9); 3529-3538. [PubMed: 9284116].