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CST20

Victor ID 4627
Gene Name CST20
Sequence Strain (Species/Organism) Candida albicans SC5314
NCBI Gene ID 3637661
NCBI Protein GI 68470348
Locus Tag CaO19.11717
Genbank Accession AACQ01000021
Protein Accession XP_720678
Taxonomy ID 237561
Chromosome No 5
Gene Starting Position 44500
Gene Ending Position 48186
Gene Strand (Orientation) -
Protein pI 7.06
Protein Weight 128005.5
Protein Length 1228
DNA Sequence 
>gi|68470561:44500-48186 Candida albicans SC5314 chromosome 5 Ctg19-20202, whole genome shotgun sequence
ATTAATCAGATTCACTCATTTTTTTCAATCGAGCAATTTTCACTAATGGACTTAACGACGATACATCATC
ACATTCAGTAATAAAATTATCATGTAATAATTCATCAGCATCAGCTCTTTTATTAAAGTCAACTTGTAAA
CACCATGCCAAAAATTTTCTAATATCATAACTTAAAGATTCGGGATCTTTTAATTTTGGTGTACCATTAG
TTGCAATAAGATATAATGCCCTCAATGGAGTTTCATTCAAATATGGTGGTTCACCTTCTAACATTTCTAT
AATCATAATACCCAATGACCAAACATCAACTTTTGGACCATATTCTTTACGTGAAACAATTTCTGGTGCC
ATCCAATATGGTGTACCCACCATAGTGATACGTTTCAGATTGATTTCATTGATTTGAGCACAAAACCCAA
AATCAGTGATCTTGATGTTACCGTCCATATTTAATAAAATATTATCGGATTTAATATCACGATGGATAAC
CCCTTTAGAATGTAAAAACTTAAGACCTTTCAAAGTTTCGCGACATACAACTCCAATTTGACCTTCAGTC
ATAACACTATGAGTTACTATATCGGTAAGGGATCCACCTTCCATATATTCCATAATCACCCATAAATCAC
CTTTTAAAAGATATGAATCAATAAAATTGACAATATTAGGATGCAGACTACCTTTCATAACCAAAATTTC
ATTAATAATTAATTCTTTTTTAGGTTGTTGTTCTAAATTCATTTGTTTTATGGCAACAATATTGGATTTA
TCACGAACATCATGAGCAAGGAAAACTCCACCAGAGGCACCTTGACCAATTTTAACTAAATCAACATATA
ATTCATTTGGATCTCCAGGATTACAAATTGTCTTTAATTTGGCAATAATTTGTAAGTTTTTACGTTTCTT
TTCTTCTCGTTTCTTTTGGGCTATCAAAGCTGCTTGTTTGGCATCACGGCCACCACCAGATCCAGAAGGC
GGTTTTTTATTTGGTACAGGTACTGGTGGAGCAATATTACTACCACCGCTAGCCGTGTCAGCATTATTTT
GCCCAGTCTCCTGTTGTCTATTTTGTCTTTCATTCTTCTCTCGTAGTCTTTGTATTTCTTCAAGTTCTCT
AGCCTTCTTCTCACGTAATTTCTGTTGTGCTTCCTGATATTTAGTTTGTTGAATTTCATAAATATTAGTT
GGGGCAGTAACATCAGCTAATGCTTGCAGAGGAGCAGTACGTTGTTGAGGTATCTCAGAAGTCTGTTCCG
ATAATAAATTGGCTGGTGGCGCAGGAGGCACAGGTGGTGCAGGTGATGCCAGTGGAGGCGGCGGAGGTGC
TCTATGAGCCTTGAACTCATTTATTCTTTGTCTTGGTAAAGCATTATTCTCACCGCCAAACGCGGCACTT
GCTGGAATAGGAGCAGTTGTCGATCCATTTGTTGCTGGTCTCAATTGACTTGACAAAGATGCCGAATGCG
ACTTTGATTTAGGAATTGAAGGTAATGATGGTGGTGGAGGAGCAGGTGCAATATGAGTAAACTTATCCCC
ACTTTTTCTAGACCGCATTGACTTTAATGATTTTGACGAAATTGAACGAATTTTGATCTTGCTTGGCGAA
ATATCTTGATGTGATTTAGGGGTTGAAGAACGAATATCGGATTGTGAATCACTCCTTGGTAATGATTGCG
AAGAAGGTGTTTTATGTGACACACTCATGGAAGAAAGCGGTGTTGATGGTGGTTTCGGAGCTGGTCTACT
TGGAATAAATTGACCCTCTTGTACATGGGATGTTGGTGTTCTTGGTGTATACTGAGTAGCATTATCTTCA
TGTGGGTGCTGGTTTTCCAGCTGTTTACTCTCTGTCTTTGTTGGCATTGACTGAGATGGGGTAATCACTT
TTTGCTCAACGTTGTTTTTTTCAATGATCGATGAAGGAGGTGTACGATGGGGACTTGAAGGAGCGCCACC
GCCACCACCACCACTGCCACTGTTACTTCCACCTGGTGTTGCTGGTGGAGTATTTTCATTAGACCAACCA
CTCGAACTGCTTTTATTATTATCAAAATGAAACTTTTTAAATGCAGCGTCATCAGGGTTTTCACTTGTAT
CTTGATAAAACGCCACTATATCCATCACTGCTTGTGGGTGCTGTTGTTGTTCCTTCTTGGTAATACCACT
AGCAGATAATAATCTTTCCCACTCTATTGGCAAACCGGTGTATGAACCATTATCATCAATGCCCACATGG
GCAAGGTGCTTGGCATTGAATGGAGTACTGATCTTAATATTGACTTCCTGTGAGTGGCTATTCAGACCTG
AGTTTGAAGACGACGATGATGACGTTGACTTGTTTTTCCCAAACATTGACGAAAACACACCTCGGACTTT
ACTTCCACTTTTCCGCTTTTTCCCATTTTTAGGAGACAGATTTGAATTTATGCCAACCCCCAACGGTTCT
AGTGAAGATGAACTATTTGTTGAATTGGTATTTATCACTTGTTGATGAAACTTGTTGTGACTCGGGATTA
TAGGAGTAATTGCTGCTGTTTGGTTATGAGCAGTTGAGGTTGAGGTTAATTTTGACGTACCAGATCTTGA
ATTTTTCACCACTGTAGAAGTCGATGTTCCAGAAGTATTTCTTGACGTCGCACTAGTATTTTGTGATAGT
TGACGGGGCAGGTCATCAATATTTTCGTCATCTCGTGTTGGAATTCCTTGTAAAGTATCATTTCTTAAAA
GGTTTGGAGAATTTGTGGCACTACTCAATGTGTCTGTTTCCAGATCCAATTCACTTTTGGTTAATAAATT
GTCAATGTCTATTTCTGGTGGTGGTGGTGCTGCTGCTTGTGCAGGTTTCCCAGGGTCCAATGTAGATTTG
TAACTTGATAAATGAGAACCTCGAGTTGAAGTTGGATTTGATGGTATCTTATGCACAGAAGTTGATGAAG
ATATAACCAGACTCATATCGTGAAATGATGATGTCTTTGAAGTCAGAACCTGTGGCGGTGCACTGCGGGG
TGCAGATAATCTTGCATTTTCATTTTGGTGTTGTAAGGACAATGACAAATCTTCCAAAGACAGTGTATGT
TGTTCTTCCTCTATAACTGCTGGTGAGACATTATTTGTTTCCAATGCATTAAGAGTACCGGGACTTTCAA
GTGTGCCAGGAGAATATGAATCTTTACTGGTACGTTTATTGATTGATTTAGTTAGCTCGGTGTACTGTTT
TTCATTGTCACTATCATCCCCTTGGTGCAAACCTTTCACATTGAATGTCCCTGGCATTCGAGGAGGCATT
CCTTGGGTTTTTTCATCATCGGCTTCACTTGATTCTGGATTGCTCTCGTTGTTGTTGTTGTTGTTGTTAT
TGTTATGTGATTGTTGTGAATCATCAATATCACTAGATCCAGATTCTATAGTCCTATCATTAGTTTCCCC
AGTGTCAACCTCGTCTTGATCAAATTGTTTTATTTTCTCGTGCATTGGAGACCCTAAACTTAATGAAGAA
GTATTAGCTGATGTAGTATTCATGACCTCAGTTGGGGGTGCTAGTGGTGTTGATTCAACTTCAGGTCCAG
GTCCAGGTCCAGAAGCAACCCTCGTTCCAGAGTTTAACTCTGGGTTGTGTAGATGAGAAGACTCATTTGG
ATCTGTTATTGATGTTTGTGTAGGATTGTTCTCTGAAAGTATGCTCA
Protein Sequence 
>gi|68470348|ref|XP_720678.1| likely signal transduction kinase [Candida albicans SC5314]
MSILSENNPTQTSITDPNESSHLHNPELNSGTRVASGPGPGPEVESTPLAPPTEVMNTTSANTSSLSLGS
PMHEKIKQFDQDEVDTGETNDRTIESGSSDIDDSQQSHNNNNNNNNNESNPESSEADDEKTQGMPPRMPG
TFNVKGLHQGDDSDNEKQYTELTKSINKRTSKDSYSPGTLESPGTLNALETNNVSPAVIEEEQHTSSLED
LSLSLQHQNENARLSAPRSAPPQVSTSKTSSFHDMSSVISSSTSVHKIPSNPTSTRGSHLSSYKSTLDPG
KPAQAAAPPPPEIDIDNLLTKSELDSETDTLSSATNSPNLLRNDTLQGIPTRDDENIDDSPRQLSQNTSA
TSRNTSGTSTSTVVKNSRSGTSKLTSTSTAHNQTAAITPIIPSHNKFHQQVINTNSTNSSSSLEPLGVGI
NSNSSPKNGKKRKSGSKVRGVFSSMFGKNKSTSSSSSSNSGSNSHSQEVNIKISTPFNAKHLAHVGIDDN
GSYTGLPIEWERLLSASGITKKEQQQHPQAVMDIVAFYQDTSENPDDAAFKKFHFDNNKSSSSGWSNENT
PPATPGGSNSGSGGGGGGAPSSPHRTPPSSIIEKNNVEQKVITPSQSMPTKTESKQSENQHPHEDNATQY
TPRTPTSHVQEGQFIPSRPAPKPPSTPLSSMSVSHKTPSSQSLPRSDSQSDIRSSTPKSHQDISPSKIKI
RSISSKSLKSMRSRKSGDKFTHIAPAPPPPSLPSIPKSKSHSASLSSQLRPATNGSTTAPIPASAAFGGE
NNALPRQRINEFKAHRAPPPPPSASPAPPVPPAPPANLLSEQTSEIPQQRTAPSQALADVTAPTNIYEIQ
QTKYQEAQQKLREKKARELEEIQRLREKNERQNRQQETGQNNADTASGGSNIAPPVPVPNKKPPSGSGGG
RDAKQAALIAQKKREEKKRKNLQIIAKLKTICNPGDPNELYVDLVKIGQGASGGVFLAHDVRDKSNIVAI
KQMNLEQQPKKELIINEILVMKGSSHPNIVNFIDSYLLKGDLWVIMEYMEGGSLTDIVTHSVMTEGQIGV
VCRETLKGLKFLHSKGVIHRDIKSDNILLNMDGNIKITDFGFCAQINEINSKRITMVGTPYWMAPEIVSR
KEYGPKVDVWSLGIMIIEMLEGEPPYLNETPLRALYLIATNGTPKLKDPESLSYDIRKFLAWCLQVDFNK
RADADELLHDNFITECDDVSSLSPLVKIARLKKMSESD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: CST20 mutant cells were less virulent in a mouse model for systemic candidiasis (Leberer et al., 1996).
References
Leberer et al., 1996: Leberer E, Harcus D, Broadbent ID, Clark KL, Dignard D, Ziegelbauer K, Schmidt A, Gow NA, Brown AJ, Thomas DY. Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proceedings of the National Academy of Sciences of the United States of America. 1996; 93(23); 13217-13222. [PubMed: 8917571].