| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
aroE from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5794959
|
|
161870711
|
NMCC_1783 |
|
YP_001599884.1 |
shikimate dehydrogenase |
Virulence factor |
MUTATION: aroE mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rfaK from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5794989
|
|
161870550
|
NMCC_1616 |
|
YP_001599722.1 |
alpha 1,2 N-acetylglucosamine transferase |
Virulence factor |
MUTATION: rfaK mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
metF from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795024
|
|
161869855
|
NMCC_0886 |
|
YP_001599024.1 |
5,10-methylenetetrahydrofolate reductase |
Virulence factor |
MUTATION: metF mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rnc from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795078
|
|
161869625
|
NMCC_0642 |
|
YP_001598793.1 |
ribonuclease III |
Virulence factor |
MUTATION: rnc mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
fhs from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795151
|
|
161869376
|
NMCC_0383 |
|
YP_001598543.1 |
formate--tetrahydrofolate ligase |
Virulence factor |
MUTATION: fhs mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
pilX from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795172
|
|
161869822
|
NMCC_0851 |
|
YP_001598991.1 |
type IV pilus assembly protein PilX |
Virulence factor |
MUTATION: pilX mutant has reduced adherence to human epithelial cells [Ref6755:Hélaine et al., 2005]. |
15612917
|
|
|
gdhA from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795290
|
|
161870555
|
NMCC_1621 |
|
YP_001599727.1 |
glutamate dehydrogenase |
Virulence factor |
MUTATION: gdhA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rfaF from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795358
|
|
161870387
|
NMCC_1433 |
|
YP_001599559.1 |
ADP-heptose:LPS heptosyltransferase II |
Virulence factor |
MUTATION: rfaF mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
fba from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795400
|
|
161869346
|
NMCC_0352 |
|
YP_001598513.1 |
fructose-1,6-bisphosphate aldolase |
Virulence factor |
MUTATION: fba mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ptsI from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795401
|
|
161869148
|
NMCC_0142 |
|
YP_001598314.1 |
phosphoenolpyruvate-protein phosphotransferase |
Virulence factor |
MUTATION: ptsI mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
grxC from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795405
|
|
161869428
|
NMCC_0436 |
|
YP_001598595.1 |
glutaredoxin 3 |
Virulence factor |
MUTATION: grxC mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rsmB from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795455
|
|
161870942
|
NMCC_2036 |
|
YP_001600122.1 |
16S RNA methyltransferase |
Virulence factor |
MUTATION: rsmB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
pbp3 |
Neisseria meningitidis 053442 |
5795502
|
|
161869423
|
NMCC_0431 |
|
YP_001598590.1 |
Penicillin-binding protein 3 |
Virulence factor |
MUTATION: pbp3 mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ilvI from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795606
|
|
161870432
|
NMCC_1480 |
|
YP_001599604.1 |
acetolactate synthase isozyme III large subunit |
Virulence factor |
MUTATION: ilvI mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroB from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795648
|
|
161869406
|
NMCC_0414 |
|
YP_001598573.1 |
3-dehydroquinate synthase |
Virulence factor |
MUTATION: aroB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
lipB from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795650
|
|
161869101
|
NMCC_0091 |
|
YP_001598267.1 |
capsule polysaccharide modification protein |
Virulence factor |
MUTATION: lipB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
pnp from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795721
|
|
161869702
|
NMCC_0722 |
|
YP_001598869.1 |
polyribonucleotide nucleotidyltransferase |
Virulence factor |
MUTATION: pnp mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
pilQ from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795870
|
|
161869408
|
NMCC_0416 |
|
YP_001598575.1 |
type IV pilus assembly protein PilQ |
Virulence factor |
MUTATION: pilQ mutant were unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
aroC from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795881
|
|
161870528
|
NMCC_1593 |
|
YP_001599700.1 |
chorismate synthase |
Virulence factor |
MUTATION: aroC mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
purL from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5795982
|
|
161869205
|
NMCC_0209 |
|
YP_001598371.1 |
phophoribosylformylglycinamidine synthase |
Virulence factor |
MUTATION: purL mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ilvD from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796004
|
|
161870035
|
NMCC_1068 |
|
YP_001599204.1 |
dihydroxy-acid dehydratase |
Virulence factor |
MUTATION: ilvD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
tonB from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796129
|
|
161870577
|
NMCC_1643 |
|
YP_001599749.1 |
TonB protein |
Virulence factor |
MUTATION: tonB mutant is unable to replicate within human epithelial cells [Ref6757:Larson et al., 2002]. |
11854233
|
|
|
ampD from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796140
|
|
161869605
|
NMCC_0621 |
|
YP_001598772.1 |
anhydro-N-acetylmuramyl-tripeptide amidase |
Virulence factor |
MUTATION: ampD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rfaE from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796145
|
|
161869766
|
NMCC_0786 |
|
YP_001598933.1 |
ADP-heptose synthetase |
Virulence factor |
MUTATION: rfaE mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
pilF from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796169
|
|
161870741
|
NMCC_1814 |
|
YP_001599914.1 |
type IV pilus assembly protein |
Virulence factor |
MUTATION: pilF mutant were unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
metG from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796183
|
|
161869048
|
NMCC_0031 |
|
YP_001598214.1 |
methionyl-tRNA synthetase |
Virulence factor |
MUTATION: metG mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ptsH from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796187
|
|
161869147
|
NMCC_0141 |
|
YP_001598313.1 |
sugar transport PTS system phosphocarrier protein HPR |
Virulence factor |
MUTATION: ptsH mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
dprA from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796233
|
|
161870938
|
NMCC_2032 |
|
YP_001600118.1 |
DNA processing chain A |
Virulence factor |
MUTATION: dprA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ntrY |
Neisseria meningitidis 053442 |
5796235
|
|
161870940
|
NMCC_2034 |
|
YP_001600120.1 |
nitrogen regulation protein NtrY, putative |
Virulence factor |
MUTATION: ntrY mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroD from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796331
|
|
161870315
|
NMCC_1357 |
|
YP_001599485.1 |
3-dehydroquinate dehydratase |
Virulence factor |
MUTATION: aroD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
lgtA from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796357
|
|
161869284
|
NMCC_0289 |
|
YP_001598451.1 |
lacto-N-neotetraose biosynthesis glycosyl tranferase |
Virulence factor |
MUTATION: lgtA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
dedA from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796649
|
|
161870537
|
NMCC_1602 |
|
YP_001599709.1 |
putative DedA protein |
Virulence factor |
MUTATATION: dedA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
exbD from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796685
|
|
161870575
|
NMCC_1641 |
|
YP_001599747.1 |
biopolymer transport protein |
Virulence factor |
MUTATION: exbD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
exbB from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796686
|
|
161870576
|
NMCC_1642 |
|
YP_001599748.1 |
biopolymer transport protein |
Virulence factor |
MUTATION: exbB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
dedA from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796698
|
|
161869935
|
NMCC_0967 |
|
YP_001599104.1 |
putative DedA protein |
Virulence factor |
MUTATION: dedA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
opcA from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796699
|
|
161869936
|
NMCC_0968 |
|
YP_001599105.1 |
outer membrane protein precursor |
Virulence factor |
Bacteria expressing low or undetectable levels of Opc protein failed to adhere to or invade eukaryotic cells [Ref6758:Virji et al., 1992]. |
1435257
|
|
|
hmbR from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796721
|
|
0
|
NMCC_1579 |
|
- |
hemoglobin receptor |
Virulence factor |
MUTATION: hmbR mutant was attenuated in an infant rat model [Ref6759:Stojiljkovic et al., 1995]. |
7783623
|
|
|
siaD |
Neisseria meningitidis 053442 |
5796762
|
|
161869086
|
NMCC_0075 |
|
YP_001598252.1 |
alpha-2,8 polysialyltransferase |
Virulence factor |
MUTATION: siaD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
nadA from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796858
|
|
161870678
|
NMCC_1750 |
|
YP_001599851.1 |
quinolinate synthetase A |
Virulence factor |
MUTATION: NadA mutation decreases epithelial adhesion of capsulate N. meningitidis and invasion by acapsulate N. meningitidis [Ref6760:Carbonnelle et al., 2009]. |
19481311
|
|
|
galU from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796882
|
|
161869571
|
NMCC_0586 |
|
YP_001598738.1 |
UTP--glucose-1-phosphate uridylyltransferase |
Virulence factor |
MUTATION: galU mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
hrpA from Neisseria meningitidis 053442 |
Neisseria meningitidis 053442 |
5796971
|
|
161869191
|
NMCC_0194 |
|
YP_001598357.1 |
ATP-dependent RNA helicase HrpA |
Virulence factor |
MUTATION: hrpA mutants are deficient in the ability to live/grow in HeLa cells [Ref6761:Talà et al., 2008]. |
18680551
|
|
|
aroB from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4674848
|
|
121634271
|
NMC0406 |
|
YP_974516.1 |
3-dehydroquinate synthase |
Virulence factor |
MUTATION: aroB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
fba from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4674894
|
|
121634217
|
NMC0350 |
|
YP_974462.1 |
fructose-1,6-bisphosphate aldolase |
Virulence factor |
MUTATION: fba mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rfaF from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4675030
|
|
121635198
|
NMC1456 |
|
YP_975443.1 |
ADP-heptose:LPS heptosyltransferase II |
Virulence factor |
MUTATION: rfaF mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
metG from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4675118
|
|
121633907
|
NMC0007 |
|
YP_974152.1 |
methionyl-tRNA synthetase |
Virulence factor |
MUTATION: metG mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroC from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4675192
|
|
121635321
|
NMC1598 |
|
YP_975566.1 |
chorismate synthase |
Virulence factor |
MUTATION: aroC mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
gdhA from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4675196
|
|
121635346
|
NMC1625 |
|
YP_975591.1 |
glutamate dehydrogenase |
Virulence factor |
MUTATION: gdhA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
metF from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4675430
|
|
121634746
|
NMC0921 |
|
YP_974991.1 |
5,10-methylenetetrahydrofolate reductase |
Virulence factor |
MUTATION: metF mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ampD from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4675580
|
|
121634464
|
NMC0617 |
|
YP_974709.1 |
N-acetyl-anhydromuranmyl-L-alanine amidase |
Virulence factor |
MUTATION: ampD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rnc from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4675618
|
|
121634484
|
NMC0637 |
|
YP_974729.1 |
ribonuclease III |
Virulence factor |
MUTATION: rnc mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
pilQ from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4675619
|
|
121634273
|
NMC0408 |
|
YP_974518.1 |
pilus secretin |
Virulence factor |
MUTATION: pilQ mutant were unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
aroD from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4675764
|
|
121635135
|
NMC1383 |
|
YP_975380.1 |
3-dehydroquinate dehydratase |
Virulence factor |
MUTATION: aroD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
exbB from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4675875
|
|
121635363
|
NMC1649 |
|
YP_975608.1 |
biopolymer transport protein |
Virulence factor |
MUTATION: exbB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
tonB from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4675898
|
|
121635364
|
NMC1650 |
|
YP_975609.1 |
TonB protein |
Virulence factor |
MUTATION: tonB mutant is unable to replicate within human epithelial cells [Ref6757:Larson et al., 2002]. |
11854233
|
|
|
ilvD from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4675932
|
|
121634888
|
NMC1090 |
|
YP_975133.1 |
dihydroxy-acid dehydratase |
Virulence factor |
MUTATION: ilvD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
lgtA from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4675978
|
|
121635586
|
NMC1902 |
|
YP_975831.1 |
lacto-N-neotetraose biosynthesis glycosyl tranferase |
Virulence factor |
MUTATION: lgtA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ptsH from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4676011
|
|
121635703
|
NMC2025 |
|
YP_975948.1 |
sugar transport PTS system phosphocarrier protein HPR |
Virulence factor |
MUTATION: ptsH mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
pilF from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4676178
|
|
121635535
|
NMC1844 |
|
YP_975780.1 |
type IV pilus assembly protein |
Virulence factor |
MUTATION: pilF mutant were unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
dedA from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4676301
|
|
121634825
|
NMC1016 |
|
YP_975070.1 |
DedA protein ortholog |
Virulence factor |
MUTATION: dedA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
nadA from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4676346
|
|
121635470
|
NMC1772 |
|
YP_975715.1 |
quinolinate synthetase |
Virulence factor |
MUTATION: NadA mutation decreases epithelial adhesion of capsulate N. meningitidis and invasion by acapsulate N. meningitidis [Ref6760:Carbonnelle et al., 2009]. |
19481311
|
|
|
rfaK from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4676380
|
|
121635341
|
NMC1619 |
|
YP_975586.1 |
alpha 1,2 N-acetylglucosamine transferase |
Virulence factor |
MUTATION: rfaK mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
lipB from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4676394
|
|
121633961
|
NMC0067 |
|
YP_974206.1 |
capsule polysaccharide modification protein |
Virulence factor |
MUTATION: lipB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ilvI from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4676427
|
|
121635234
|
NMC1497 |
|
YP_975479.1 |
acetolactate synthase isozyme III large subunit |
Virulence factor |
MUTATION: ilvI mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ptsI from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4676530
|
|
121635702
|
NMC2024 |
|
YP_975947.1 |
phosphoenolpyruvate-protein phosphotransferase |
Virulence factor |
MUTATION: ptsI mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroE |
Neisseria meningitidis FAM18 from Neisseria meningitidis FAM18 |
4676581
|
|
121635506
|
NMC1810 |
|
YP_975751.1 |
shikimate dehydrogenase |
Virulence factor |
MUTATION: aroE mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
purL from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4676582
|
|
121635654
|
NMC1972 |
|
YP_975899.1 |
phosphoribosylformylglycinamidine synthase |
Virulence factor |
MUTATION: purL mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
mltB from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4676597
|
|
121634994
|
NMC1212 |
|
YP_975239.1 |
murein hydrolase |
Virulence factor |
MUTATION: mltB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
exbD from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4676643
|
|
121635362
|
NMC1648 |
|
YP_975607.1 |
biopolymer transport protein |
Virulence factor |
MUTATION: exbD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroG from Neisseria meningitidis FAM18 |
Neisseria meningitidis FAM18 |
4676702
|
|
121635563
|
NMC1874 |
|
YP_975808.1 |
phospho-2-dehydro-3-heoxyheptonate aldolase |
Virulence factor |
MUTATION: aroG mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
lipB from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
906200
|
|
15793213
|
NMA0185 |
|
NP_283035.1 |
capsule polysaccharide modification protein |
Virulence factor |
MUTATION: lipB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
metG from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
906284
|
|
15793293
|
NMA0275 |
|
NP_283115.1 |
methionyl-tRNA synthetase |
Virulence factor |
MUTATION: metG mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ptsH from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
906394
|
|
15793399
|
NMA0391 |
|
NP_283221.1 |
sugar transport PTS system phosphocarrier protein HPR |
Virulence factor |
MUTATION: ptsH mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ptsI from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
906395
|
|
15793400
|
NMA0392 |
|
NP_283222.1 |
phosphoenolpyruvate-protein phosphotransferase |
Virulence factor |
MUTATION: ptsI mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
purL from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
906445
|
|
15793449
|
NMA0445 |
|
NP_283271.1 |
phosphoribosylformylglycinamidine synthase |
Virulence factor |
MUTATION: purL mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
lgtA from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
906518
|
|
15793522
|
NMA0524 |
|
NP_283344.1 |
lacto-N-neotetraose biosynthesis glycosyl tranferase |
Virulence factor |
MUTATION: lgtA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
fba from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
906580
|
|
15793578
|
NMA0587 |
|
NP_283400.1 |
fructose-1,6-bisphosphate aldolase |
Virulence factor |
MUTATION: fba mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
fhs from Neisseria meningitidis Z2491 |
N eisseria meningitidis Z2491 |
906612
|
|
15793607
|
NMA0617 |
|
NP_283429.1 |
formate--tetrahydrofolate ligase |
Virulence factor |
MUTATION: fhs mutant is attenuated in rats [Ref6754:Sun et al., 2000] |
11062540
|
|
|
aroB from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
906642
|
|
15793633
|
NMA0647 |
|
NP_283455.1 |
3-dehydroquinate synthase |
Virulence factor |
MUTATION: aroB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
pilQ from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
906644
|
|
15793635
|
NMA0650 |
|
NP_283457.1 |
pilus secretin |
Virulence factor |
MUTATION: pilQ mutant were unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
NMA0798 |
Neisseria meningitidis Z2491 |
906788
|
|
15793772
|
NMA0798 |
|
NP_283594.1 |
two-component system regulator |
Virulence factor |
MUTATION: NMA0798 (phoP) mutant is avirulent in mice [Ref6762:Newcombe et al., 2004]. |
14688113
|
|
|
galU from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
906836
|
|
15793818
|
NMA0848 |
|
NP_283640.1 |
UTP--glucose-1-phosphate uridylyltransferase |
Virulence factor |
MUTATION: galU mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ampD from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
906854
|
|
15793836
|
NMA0867 |
|
NP_283658.1 |
N-acetyl-anhydromuranmyl-L-alanine amidase |
Virulence factor |
MUTATION: ampD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rnc from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
906875
|
|
15793857
|
NMA0888 |
|
NP_283679.1 |
ribonuclease III |
Virulence factor |
MUTATION: rnc mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rfaE from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907010
|
|
15793990
|
NMA1034 |
|
NP_283812.1 |
DP-heptose synthetase |
Virulence factor |
MUTATION: rfaE mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
metF from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907108
|
|
15794085
|
NMA1139 |
|
NP_283907.1 |
5,10-methylenetetrahydrofolate reductase |
Virulence factor |
MUTATION: metF mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
gdhA from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907187
|
|
15794847
|
NMA1964 |
|
NP_284669.1 |
glutamate dehydrogenase |
Virulence factor |
MUTATION: gdhA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroG from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907267
|
|
15795051
|
NMA2180 |
|
NP_284873.1 |
phospho-2-dehydro-3-heoxyheptonate aldolase |
Virulence factor |
MUTATION: aroG mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
pilF from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907288
|
|
15795030
|
NMA2159 |
|
NP_284852.1 |
type IV pilus assembly protein |
Virulence factor |
MUTATION: pilF mutant were unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
aroE from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907318
|
|
15795000
|
NMA2129 |
|
NP_284822.1 |
shikimate dehydrogenase |
Virulence factor |
MUTATION: aroE mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
nadA from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907353
|
|
15794965
|
NMA2090 |
|
NP_284787.1 |
quinolinate synthetase |
Virulence factor |
MUTATION: NadA mutation decreases epithelial adhesion of capsulate N. meningitidis and invasion by acapsulate N. meningitidis [Ref6760:Carbonnelle et al., 2009]. |
19481311
|
|
|
tonB |
Neisseria meningitidis |
907455
|
|
15794867
|
NMA1985 |
|
NP_284689.1 |
TonB protein |
Virulence factor |
MUTATION: tonB mutant is unable to replicate within human epithelial cells [Ref6757:Larson et al., 2002]. |
11854233
|
|
|
exbD from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907458
|
|
15794865
|
NMA1983 |
|
NP_284687.1 |
biopolymer transport protein |
Virulence factor |
MUTATION: exbD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
exbB from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907459
|
|
15794866
|
NMA1984 |
|
NP_284688.1 |
biopolymer transport protein |
Virulence factor |
MUTATION: exbB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rfaK from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907476
|
|
15794842
|
NMA1959 |
|
NP_284664.1 |
alpha 1,2 N-acetylglucosamine transferase |
Virulence factor |
MUTATION: rfaK mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroC from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907493
|
|
15794822
|
NMA1939 |
|
NP_284644.1 |
chorismate synthase |
Virulence factor |
MUTATION: aroC mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
dedA from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907554
|
|
15794185
|
NMA1250 |
|
NP_284007.1 |
DedA protein ortholog |
Virulence factor |
MUTATION: dedA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
opcA from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907555
|
|
15794186
|
NMA1251 |
|
NP_284008.1 |
outer membrane protein precursor |
Virulence factor |
Bacteria expressing low or undetectable levels of Opc protein failed to adhere to or invade eukaryotic cells [Ref6758:Virji et al., 1992]. |
1435257
|
|
|
ilvI from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907658
|
|
15794659
|
NMA1766 |
|
NP_284481.1 |
acetolactate synthase isozyme III large subunit |
Virulence factor |
MUTATION: ilvI mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ilvD from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907768
|
|
15794282
|
NMA1361 |
|
NP_284104.1 |
dihydroxy-acid dehydratase |
Virulence factor |
MUTATION: ilvD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
mltB from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
907882
|
|
15794388
|
NMA1488 |
|
NP_284210.1 |
murein hydrolase |
Virulence factor |
MUTATION: mltB mutant is attenuated in rats [Ref6754:Sun et al., 2000].
|
11062540
|
|
|
aroD from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
908048
|
|
15794553
|
NMA1659 |
|
NP_284375.1 |
3-dehydroquinate dehydratase |
Virulence factor |
MUTATION: aroD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rfaF from Neisseria meningitidis Z2491 |
Neisseria meningitidis Z2491 |
908116
|
|
15794620
|
NMA1727 |
|
NP_284442.1 |
ADP-heptose:LPS heptosyltransferase II |
Virulence factor |
MUTATION: rfaF mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
metG from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
902133
|
|
15675970
|
NMB0030 |
|
NP_273096.1 |
methionyl-tRNA synthetase |
Virulence factor |
MUTATION: metG mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
lipB from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
902187
|
|
15676016
|
NMB0083 |
|
NP_273146.1 |
capsule polysaccharide modification protein LipB |
Virulence factor |
MUTATION: lipB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
NMB0103 |
Neisseria meningitidis MC58 |
902207
|
|
15676031
|
NMB0103 |
|
NP_273161.1 |
putative bacteriocin resistance protein |
Virulence factor |
MUTATION: NMB0103 mutant was unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
rsmB from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
902216
|
|
15676040
|
NMB0112 |
|
NP_273170.1 |
16S RNA methyltransferase |
Virulence factor |
MUTATION: rsmB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
dprA from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
902220
|
|
15676044
|
NMB0116 |
|
NP_273174.1 |
DNA processing chain A |
Virulence factor |
MUTATION: dprA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
tufA |
Neisseria meningitidis MC58 |
902247
|
|
15676067
|
NMB0139 |
|
NP_273197.1 |
elongation factor Tu |
Virulence factor |
MUTATION: tufA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
lpxA |
Neisseria meningitidis MC58 |
902285
|
|
15676105
|
NMB0178 |
|
NP_273236.1 |
UDP-N-acetylglucosamine acyltransferase |
Virulence factor |
MUTATION: lpxA mutant is attenuated in mice [Ref6763:Zarantonelli et al., 2006]. |
16988225
|
|
|
aroG from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
902423
|
|
15676225
|
NMB0307 |
|
NP_273357.1 |
phospho-2-dehydro-3-heoxyheptonate aldolase |
Virulence factor |
MUTATION: aroG mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
NMB0313 |
Neisseria meningitidis MC58 |
902429
|
|
15676230
|
NMB0313 |
|
NP_273362.1 |
hypothetical protein |
Virulence factor |
MUTATION: NMB0313 mutant was unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
pilF from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
902445
|
|
15676245
|
NMB0329 |
|
NP_273378.1 |
type IV pilus assembly protein |
Virulence factor |
MUTATION: pilF mutant were unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
aroE from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
902474
|
|
15676273
|
NMB0358 |
|
NP_273407.1 |
shikimate 5-dehydrogenase |
Virulence factor |
MUTATION: aroE mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
nadA from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
902509
|
|
15676308
|
NMB0394 |
|
NP_273443.1 |
quinolinate synthetase |
Virulence factor |
MUTATION: NadA mutation decreases epithelial adhesion of capsulate N. meningitidis and invasion by acapsulate N. meningitidis [Ref6760:Carbonnelle et al., 2009]. |
19481311
|
|
|
NMB0541 |
Neisseria meningitidis MC58 |
902656
|
|
15676447
|
NMB0541 |
|
NP_273586.1 |
hypothetical protein |
Virulence factor |
MUTATION: NMB0541 mutant was unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
galU from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
902749
|
|
15676538
|
NMB0638 |
|
NP_273681.1 |
UTP--glucose-1-phosphate uridylyltransferase |
Virulence factor |
MUTATION: galU mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ampD from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
902779
|
|
15676566
|
NMB0668 |
|
NP_273710.1 |
N-acetyl-anhydromuranmyl-L-alanine amidase |
Virulence factor |
MUTATION: ampD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rnc from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
902798
|
|
15676584
|
NMB0686 |
|
NP_273728.1 |
ribonuclease III |
Virulence factor |
MUTATION: rnc mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
hfq |
Neisseria meningitidis MC58 |
902863
|
|
15676646
|
NMB0748 |
|
NP_273790.1 |
host factor-I |
Virulence factor |
MUTATION: hfq mutant is attenuated in rats [Ref6764:Fantappiè et al., 2009]. |
19223479
|
|
|
pgm |
Neisseria meningitidis MC58 |
902905
|
|
15676688
|
NMB0790 |
|
NP_273832.1 |
phosphoglucomutase |
Virulence factor |
MUTATION: pgm mutant is attenuated in mice [Ref6765:Plant et al., 2006]. |
16428785
|
|
|
rfaD |
Neisseria meningitidis MC58 |
902942
|
|
15676725
|
NMB0828 |
|
NP_273870.1 |
ADP-L-glycero-D-mannoheptose-6-epimerase |
Virulence factor |
MUTATION: rfaD mutant is attenuated in mice [Ref6763:Zarantonelli et al., 2006]. |
16988225
|
|
|
metF from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903063
|
|
15676836
|
NMB0943 |
|
NP_273981.1 |
5,10-methylenetetrahydrofolate reductase |
Virulence factor |
MUTATION: metF mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
metH |
Neisseria meningitidis MC58 |
903064
|
|
15676837
|
NMB0944 |
|
NP_273982.1 |
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase |
Virulence factor |
MUTATION: metF mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
pilQ from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903122
|
|
15678016
|
NMB1812 |
|
NP_274809.1 |
pilQ protein |
Virulence factor |
MUTATION: pilQ mutant were unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
NMB1012 |
Neisseria meningitidis MC58 |
903150
|
|
15676901
|
NMB1012 |
|
NP_274047.1 |
hypothetical protein |
Virulence factor |
MUTATION: NMB1012 mutant was unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
dedA from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903189
|
|
15676938
|
NMB1052 |
|
NP_274086.1 |
dedA protein |
Virulence factor |
MUTATION: dedA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
opc |
Neisseria meningitidis MC58 |
903235
|
|
15676939
|
NMB1053 |
|
NP_274087.1 |
class 5 outer membrane protein |
Virulence factor |
Bacteria expressing low or undetectable levels of Opc protein failed to adhere to or invade eukaryotic cells [Ref6758:Virji et al., 1992]. |
1435257
|
|
|
fhs from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903260
|
|
15677675
|
NMB1839 |
|
NP_274836.1 |
formate--tetrahydrofolate ligase |
Virulence factor |
MUTATION: fhs mutant is attenuated in rats [Ref6754:Sun et al., 2000].
|
11062540
|
|
|
NMB1829 |
Neisseria meningitidis MC58 |
903271
|
|
15677665
|
NMB1829 |
|
NP_274826.1 |
TonB-dependent receptor |
Virulence factor |
MUTATION: NMB1829 mutant was unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
aroB from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903286
|
|
15677650
|
NMB1814 |
|
NP_274811.1 |
3-dehydroquinate synthase |
Virulence factor |
MUTATION: aroB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
grxC from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903309
|
|
15677630
|
NMB1790 |
|
NP_274789.1 |
glutaredoxin 3 |
Virulence factor |
MUTATION: grxC mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
tonB from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903369
|
|
15677576
|
NMB1730 |
|
NP_274733.1 |
TonB protein |
Virulence factor |
MUTATION: tonB mutant is unable to replicate within human epithelial cells [Ref6757:Larson et al., 2002]. |
11854233
|
|
|
exbB from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903370
|
|
15677575
|
NMB1729 |
|
NP_274732.1 |
biopolymer transport protein ExbB |
Virulence factor |
MUTATION: exbB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
exbD from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903371
|
|
15677574
|
NMB1728 |
|
NP_274731.1 |
biopolymer transport protein ExbD |
Virulence factor |
MUTATION: exbD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
NMB1726 |
N eisseria meningitidis MC58 |
903375
|
|
15677572
|
NMB1726 |
|
NP_274729.1 |
hypothetical protein |
Virulence factor |
MUTATION: NMB1726 mutant was unable to colonize human nasopharyngeal tissue in an organ culture model [Ref6756:Exley et al., 2009]. |
18936183
|
|
|
gdhA from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903392
|
|
15677557
|
NMB1710 |
|
NP_274713.1 |
glutamate dehydrogenase |
Virulence factor |
MUTATION: gdhA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rfaK from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903397
|
|
15677553
|
NMB1705 |
|
NP_274709.1 |
alpha-1,2-N-acetylglucosamine transferase |
Virulence factor |
MUTATION: rfaK mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroC from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903428
|
|
15677528
|
NMB1680 |
|
NP_274684.1 |
chorismate synthase |
Virulence factor |
MUTATION: aroC mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
hmbR from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903442
|
|
15677517
|
NMB1668 |
|
NP_274673.1 |
hemoglobin receptor |
Virulence factor |
MUTATION: hmbR mutant was attenuated in an infant rat model [Ref6759:Stojiljkovic et al., 1995]. |
7783623
|
|
|
mpl-1 |
Neisseria meningitidis MC58 |
903566
|
|
15677021
|
NMB1145 |
|
NP_274173.1 |
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase |
Virulence factor |
MUTATION: mpl-1 mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroD from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
903866
|
|
15677303
|
NMB1446 |
|
NP_274458.1 |
3-dehydroquinate dehydratase |
Virulence factor |
MUTATION: aroD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
NMB1638 |
Neisseria meningitidis MC58 |
903951
|
|
15677487
|
NMB1638 |
|
NP_274643.1 |
YhbX/YhjW/YijP/YjdB family protein |
Virulence factor |
MUTATION: MNB1638 (lptA) mutant had an approximately 10-fold decrease in N. meningitidis adhesion to four kinds of human endothelial and epithelial cell lines at an multiplicity of infection of 5,000 [Ref6766:Takahashi et al., 2008]. |
18824535
|
|
|
rfaF from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
904029
|
|
15677379
|
NMB1527 |
|
NP_274534.1 |
ADP-heptose--LPS heptosyltransferase II |
Virulence factor |
MUTATION: rfaF mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ptsH from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
904045
|
|
15677867
|
NMB2045 |
|
NP_275035.1 |
phosphocarrier protein HPr |
Virulence factor |
MUTATION: ptsH mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ptsI from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
904047
|
|
15677866
|
NMB2044 |
|
NP_275034.1 |
phosphoenolpyruvate-protein phosphotransferase |
Virulence factor |
MUTATION: ptsI mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
dgkA |
Neisseria meningitidis MC58 |
904121
|
|
15677409
|
NMB1558 |
|
NP_274565.1 |
diacylglycerol kinase |
Virulence factor |
MUTATION: dgkA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
purL from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
904131
|
|
15677824
|
NMB1996 |
|
NP_274988.1 |
phosphoribosylformylglycinamidine synthase |
Virulence factor |
MUTATION: purL mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
NMB1966 |
Neisseria meningitidis MC58 |
904178
|
|
15677796
|
NMB1966 |
|
NP_274960.1 |
ABC transporter, ATP-binding protein |
Virulence factor |
MUTATION: NMB1966 mutant was less adhesive and invasive for human bronchial epithelial cells, had reduced survival in human blood and was attenuated in a systemic mouse model of infection [Ref6767:Li et al., 2009]. |
19050914
|
|
|
ilvI from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
904184
|
|
15677427
|
NMB1577 |
|
NP_274583.1 |
acetolactate synthase III, large subunit |
Virulence factor |
MUTATION: ilvI mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
lgtA from Neisseria meningitidis MC58 |
Neisseria meningitidis MC58 |
904226
|
|
15677759
|
NMB1929 |
|
NP_274923.1 |
lacto-N-neotetraose biosynthesis glycosyl transferase LgtA |
Virulence factor |
MUTATION: lgtA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ptsH from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8221101
|
|
254804145
|
NMO_0123 |
|
YP_003082366.1 |
phosphocarrier protein HPr |
Virulence factor |
MUTATION: ptsH mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
hrpA from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8221120
|
|
254804179
|
NMO_0159 |
|
YP_003082400.1 |
ATP-dependent helicase |
Virulence factor |
MUTATION: hrpA mutant was deficient in the ability to grow/live in HeLa cells [Ref6761:Talà et al., 2008]. |
18680551
|
|
|
purL from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8221129
|
|
254804191
|
NMO_0171 |
|
YP_003082412.1 |
phosphoribosylformylglycinamidine synthase |
Virulence factor |
MUTATION: purL mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
fhs from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8221210
|
|
254804333
|
NMO_0323 |
|
YP_003082554.1 |
formate--tetrahydrofolate ligase |
Virulence factor |
MUTATION: fhs mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroB from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8221238
|
|
254804371
|
NMO_0364 |
|
YP_003082592.1 |
3-dehydroquinate synthase |
Virulence factor |
MUTATION: aroB mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ilvD from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8221600
|
|
254804977
|
NMO_1006 |
|
YP_003083198.1 |
dihydroxy-acid dehydratase |
Virulence factor |
MUTATION: ilvD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
exbD from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8221908
|
|
254805476
|
NMO_1544 |
|
YP_003083697.1 |
biopolymer transport protein ExbD/TolR |
Virulence factor |
MUTATION: exbD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
nadA from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8221962
|
|
254805574
|
NMO_1648 |
|
YP_003083795.1 |
quinolinate synthetase A |
Virulence factor |
MUTATION: NadA mutation decreases epithelial adhesion of capsulate N. meningitidis and invasion by acapsulate N. meningitidis [Ref6760:Carbonnelle et al., 2009]. |
19481311
|
|
|
dedA from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222190
|
|
254804932
|
NMO_0955 |
|
YP_003083153.1 |
DedA protein |
Virulence factor |
MUTATION: dedA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroG from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222370
|
|
254805657
|
NMO_1733 |
|
YP_003083878.1 |
phospho-2-dehydro-3-deoxyheptonate aldolase |
Virulence factor |
MUTATION: aroG mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
metG from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222414
|
|
254805891
|
NMO_1976 |
|
YP_003084112.1 |
Methionyl-tRNA synthetase |
Virulence factor |
MUTATION: metG mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroE from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222416
|
|
254805606
|
NMO_1682 |
|
YP_003083827.1 |
Shikimate 5-dehydrogenase |
Virulence factor |
MUTATION: aroE mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
lgtA from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222431
|
|
254804256
|
NMO_0241 |
|
YP_003082477.1 |
lacto-N-neotetraose biosynthesis glycosyl transferase |
Virulence factor |
MUTATION: lgtA mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
ilvI from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222500
|
|
254805332
|
NMO_1388 |
|
YP_003083553.1 |
acetolactate synthase large subunit |
Virulence factor |
MUTATION: ilvI mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rfaK from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222536
|
|
254805454
|
NMO_1520 |
|
YP_003083675.1 |
alpha 1,2 N-acetylglucosamine transferase |
Virulence factor |
MUTATION: rfaK mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
pilX |
Neisseria meningitidis alpha14 |
8222730
|
|
254804754
|
NMO_0766 |
|
YP_003082975.1 |
type IV pilus assembly protein |
Virulence factor |
MUTATION: pilX mutant had reduced adherence to human epithelial cells [Ref6755:Hélaine et al., 2005]. |
15612917
|
|
|
ptsI from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222774
|
|
254804146
|
NMO_0124 |
|
YP_003082367.1 |
phosphoenolpyruvate-protein phosphotransferase |
Virulence factor |
MUTATION: ptsI mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
pnp from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222779
|
|
254804638
|
NMO_0647 |
|
YP_003082859.1 |
polyribonucleotide nucleotidyltransferase |
Virulence factor |
MUTATION: pnp mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rfaE from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222793
|
|
254804701
|
NMO_0711 |
|
YP_003082922.1 |
ADP-heptose synthase |
Virulence factor |
MUTATION: rfaE mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroD from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222803
|
|
254805227
|
NMO_1279 |
|
YP_003083448.1 |
3-dehydroquinate dehydratase |
Virulence factor |
MUTATION: aroD mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
metF from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222872
|
|
254804826
|
NMO_0840 |
|
YP_003083047.1 |
5,10-methylenetetrahydrofolate reductase |
Virulence factor |
MUTATION: metF mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
rfaF from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222929
|
|
254805293
|
NMO_1348 |
|
YP_003083514.1 |
ADP-heptose--LPS heptosyltransferase II |
Virulence factor |
MUTATION: rfaF mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
aroC from Neisseria meningitidis alpha14 |
Neisseria meningitidis alpha14 |
8222977
|
|
254805436
|
NMO_1499 |
|
YP_003083657.1 |
Chorismate synthase |
Virulence factor |
MUTATION: aroC mutant is attenuated in rats [Ref6754:Sun et al., 2000]. |
11062540
|
|
|
LOS |
Neisseria meningitidis |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: Isolates with an immunotype other than L3,7,9 were less virulent in infant mouse model than N. menigitidis strains with the L2,7,9 LOS immunotype [Ref7277:Mackinnon et al., 1993].
|
7912406
|
|
|
Polysaccharide capsule |
Neisseria meningitidis |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: Non-groupable (acapsular) strains of N. meningitidis are avirulent in an infant mouse model of infection [Ref7277:Mackinnon et al., 1993].
|
7912406
|
