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NMB1966

Victor ID 3025
Gene Name NMB1966
Sequence Strain (Species/Organism) Neisseria meningitidis MC58
NCBI Gene ID 904178
NCBI Protein GI 15677796
Locus Tag NMB1966
Protein Accession NP_274960.1
Other Database IDs UniProtKB-ID: Q9JXN0_NEIMB
UniRef100: UniRef100_Q9JXN0
UniRef90: UniRef90_C1HV46
UniRef50: UniRef50_Q9JXN0
UniParc: UPI00000C482B
EMBL: AE002098
EMBL-CDS: AAF42295.1
RefSeq_NT: NC_003112.2
HSSP: Q97UY8
EnsemblGenome: EBNEIG00000010586.
EnsemblGenome_TRS: EBNEIT00000010586
EnsemblGenome_PRO: EBNEIP00000010206
GenomeReviews: AE002098_GR
KEGG: nme:NMB1966
TIGR: NMB1966
HOGENOM: HBG758042
OMA: DSPWVRQ
ProtClustDB: CLSK878312
BioCyc: NMEN122586:NMB_1966-MONOMER
Taxonomy ID 122586
Gene Starting Position 2056826
Gene Ending Position 2057626
Gene Strand (Orientation) -
Protein Name ABC transporter, ATP-binding protein
DNA Sequence 
>gi|77358697:2056826-2057626 Neisseria meningitidis MC58, complete genome
TTTATCCCAACAGGTCCTGCTGCAACGACGTTTGCGCCGGATAACGGTATGCTACGGGGCCGTCTGCCAG
CCCGCCGACAAACTGGCGCACCCAAGGCGAATCCAGTTCGCGCATTTCCTGCGGCGAGCCGGAGAACATA
ATTTCGCCGTGCGCCAAGAAAATCACCTGATCGACGATTTCCAAAGATTTTTCAATGTCGTGCGTTACCA
TAATACTGGTCGAACGCAAAGCCTTGTTGACGCGGCTGATCAAGTGGGCAATCACGCCCAAGGAAATCGG
ATCGAGGCCGGTAAACGGCTCGTCGTACAACATAATTTCAGGGTCGAGCGCAATCGTGCGGGCAAGCGCG
ACGCGGCGCGACATCCCGCCGGACAACTCGGACGGCATCAGGTTTTCCACACCGCGCAGACCGACCGCGT
TCAATTTCAACAAAACCAAATCCCGAATCACCGCTTCCGGCAGGCGCGTCAGTTCGCGCATCGGAAAAGC
GATATTGTCGAATACCGACAAATCAGTAAACAGCGCGCCGTGTTGGAACAATACGCCCATACGGCGGCGG
TGTTCATACAACTCGTCAGCCGAAAAGCCCGCCAAATCCCGTCCTTCAATCAAAACCTGCCCGGACTGCG
GACGAATCTGTCCTGTAATCAGTCGCATCAGCGTGGTTTTGCCGCTGCCCGAACCGCCCATTACGGCAGC
AAAATTGCCTTGCGGAATGCTGAAATTGATGTTCTTCAGAATCGGGCGGTCGCCATACGCGAAGGCGACG
TCTTTCATTTCGATAAAGGGGGATGGGCTCA
Protein Sequence 
>gi|15677796|ref|NP_274960.1| ABC transporter ATP-binding protein [Neisseria meningitidis MC58] MSPSPFIEMKDVAFAYGDRPILKNINFSIPQGNFAAVMGGSGSGKTTLMRLITGQIRPQSGQVLIEGRDLAGFSADELYEHRRRMGVLFQHGALFTDLSVFDNIAFPMRELTRLPEAVIRDLVLLKLNAVGLRGVENLMPSELSGGMSRRVALARTIALDPEIMLYDEPFTGLDPISLGVIAHLISRVNKALRSTSIMVTHDIEKSLEIVDQVIFLAHGEIMFSGSPQEMRELDSPWVRQFVGGLADGPVAYRYPAQTSLQQDLLG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: NMB1966 mutant was less adhesive and invasive for human bronchial epithelial cells, had reduced survival in human blood and was attenuated in a systemic mouse model of infection (Li et al., 2009).
COG COG1127Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Li et al., 2009: Li MS, Chow NY, Sinha S, Halliwell D, Finney M, Gorringe AR, Watson MW, Kroll JS, Langford PR, Webb SA. A Neisseria meningitidis NMB1966 mutant is impaired for invasion of respiratory epithelial cells, survival in human blood and for virulence in vivo. Medical microbiology and immunology. 2009; 198(1); 57-67. [PubMed: 19050914].