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purL from Neisseria meningitidis 053442

Victor ID 2897
Gene Name purL from Neisseria meningitidis 053442
Sequence Strain (Species/Organism) Neisseria meningitidis 053442
NCBI Gene ID 5795982
NCBI Protein GI 161869205
Locus Tag NMCC_0209
Protein Accession YP_001598371.1
Other Database IDs UniProtKB-ID: A9M0M4_NEIM0
UniRef100: UniRef100_A9M0M4
UniRef90: UniRef90_Q5F7J4
UniRef50: UniRef50_Q47XX7
UniParc: UPI000161052C
EMBL: CP000381
EMBL-CDS: ABX72418.1
RefSeq_NT: NC_010120.1
EnsemblGenome: EBNEIG00000012324.
EnsemblGenome_TRS: EBNEIT00000012324
EnsemblGenome_PRO: EBNEIP00000011866
GenomeReviews: CP000381_GR
KEGG: nmn:NMCC_0209
HOGENOM: HBG335309
OMA: ERGIAYY
ProtClustDB: PRK05297
BioCyc: NMEN374833:NMCC_0209-MONOMER
Taxonomy ID 374833
Gene Starting Position 213436
Gene Ending Position 217422
Gene Strand (Orientation) -
Protein Name phophoribosylformylglycinamidine synthase
DNA Sequence 
>gi|161869018:213436-217422 Neisseria meningitidis 053442, complete genome
GTTAGCCCAAGGCTTTACGTGCGCCGGCAAAGAGGCGGTACCAGCCGGACAGTTCCGTCCAGCCTTCCGG
TTTCCAGCTCATTTGCGCGGCGCGGTACACGCGTTCGGGGTGGGGCATCATGATGGTCACGCGGCCGTCG
GCGTTGGTAATGCCGGCGATGCCTTGCGGCGAGCCGTTGGGGTTGAGCGGATAGGTTTGGGTAACCTGGT
TTTGACCGTCCACATATTGCAGCGCGATGCCCAAATCGGCGGAAATATTGCCGCCGTGAAGCGCGAAGTC
GGCGCGGCCTTCGCCGTGGCTGACCACGACAGGCAGGCTGGAGCCTTGCATTTCGTTCAGAATCAGCGAC
GCTGATTTCGGAACGTGAACCATGCTCAGGCGTGCTTCAAACTGTTCGCTCAGGTTGCGTTTGAATTTAG
GCCATGCCTCTGCACCCGGGATAATCTCGGCGAGGTTGCTGACCATCTGGCAGCCGTTGCACACGCCCAA
TGTCAGCGTGTCCGGATCGGCAAAGAAGGCGGCAAATTGGTCGCGCAAGGCAGGGTGGAACAGGATGGAT
TTCGCCCAGCCTTCGCCCGCGCCGAGTACGTCGCCGTAGCTGAAGCCGCCGCACGCCGCCAGCATTTTGA
AGTCGGCAAGGCGGAAGCGGCCTGCCATCAGGTCGGACATATGCACGTCGTAGGCATCGAAACCGGCGCG
AGTGAACGCGGCGGCCATTTCGATTTGCCCGTTTACGCCCTGTTCGCGCAGGATGGCGATTTTGGGTTTC
GCGCCGCTGTTGATAAACGGCGCGGCGATGTCTTCGTTCACGTCGAACTTCACGTCGGCAAACAATGCGC
TGCGTTCGTTGTCGCCAATCAGGGCAAACTCGCTGTCGGCGCAGGCAGGGTTGTCGCGCAGGCGTTGGAT
TTGATGGCTGGTTTCTTGCCAGGTTTGTTGCAGTTTGATTAGGTTGTCAGAAATAAGGTGCGTTTGCCCG
TCGCGGATGATTAACGTGTTCTCATCAGTTAACGTACCGATTTCAAAGACATTATGATGCAGCTGTTGTT
GATAGAATAAATTGATAATATCGGCAACATCTTGTTTTCTAACTTGGATAACAGCACCCAACTCTTCATT
AAATAATGTGCGGGCAATGGTTTCTTGCCATTCAGCCAACGCTTTTACCTCTTCAGTCCGCAATGATTGA
GACAGAGCGGTATGGTTGGTAATAAATGTTTGTGCAAGCAATAAATTTAAATCTATATCCAAGCCGCACC
GCCCCGCAAACGCCATTTCTACCAAAACGGCAAACAAACCGCCGTCGCTGCGGTCGTGATACGCCAAGAG
TTTGTCTTCGGCGACAAGCTGCTGAATCACGTTGTAAAACGCTTTCAGACGACTTGTATCGTCCAAATCG
GGCGCGTCGCCGCTCATATTGTTGTACACCTGACCAAACGCCGAGCCGCCCATACGCGCTTTGCCGAAGC
CCAAATCGATAAACAGCAATACGCTGTCTTCGACGTTTTTCAGTTCGGGCGTAACGGTTTTGCGTACGTC
TTCCACCGGCGCGAACGCGGAGATAATCAGGCTCAATGGCGAGACGACGGATTTCTTGTCCGCGCCATCC
TGCCAAACGGTTTTCATCGACAGGCTGTCTTTGCCCACGGGGATGCTCAAATCCAATGCCTGACAGGCTT
TGGAAACCGCTTCGACGGTGCGGTAGAGTTTTTCGTCTTCGCCTTCGTTGCCGCACGCCGCCATCCAGTT
GGCAGAAAGTTTGATATTGCCGATGTCGCCGATGTTGACCGCTGCGATGTTGGTGATGGCTTCGCCGATA
CACATTCTGCCCGAAGCAGGCGCGTCAAACAGGGCGACGGCCGGTTTTTCGCCCATAGACATCGCTTCGC
CGCGATAGGTGTTGAAGCCCATCATGGTCACGGCGCAGTCGGCTACGGGGGTTTGGTATTTGCCGACCAT
TTGGTCGCGGTGGGTCATGCCGCCGACGCTGCGGTCGCCGATGGTAATCAGGAAGTTTTTAGCCGCTACG
GCAGGCAGGCGCAGAACGCGGTAGGCGGCTTCGGTAATGTCGATATCGCCGGCATTAAACGGTTTTTTCC
CAAAGGGATTCCCTTCGGTCGCATACGGCGTAACCGTTTTGTCGGTGCGCGTGGTTTTGGGCGGTTTGCC
GAGCAAAACGTTCAACGGCAAATCGACAGGGTTGTTGGAGAACAAATCGTCGCGTACTTTCAAATGGCCG
TCGCCGGTCGCCGTGCCGACTACGGCAAACGGGCAGCGTTCGCGTTCGCAGATGGCGCGGAAGGCATCCA
AATCTTTTTCCAAAATCGACAACACATAACGCTCTTGCGATTCGTTGCACCAGATTTGCAAAGGCGTTAA
ACCGTGTTCTTCCAACGGCACTTCGCGCAACTTGAATACCGCGCCGCGTCCGGCATCGTTGACGAGTTCG
GGGAAGGCGTTGGACAAACCTCCTGCGCCCACGTCGTGGATGGAGATAATCGGGTTTTTGTCGCCGAGCT
GCCAGCAGCGGTCGATGACTTCCTGCGCGCGGCGTTCGATTTCGGGGTTGCCGCGTTGCACGGAGTTGAA
GTCTAAAGAAGCGTCGTTTGTACCGGTATCCATCGAAGAAGCCGCGCCGCCGCCCAAGCCGATAAGCATA
CCCGGGCCGCCCAGTTGGATCAGCAACGCGCCTTCGGGGATTTCGTCTTTATGCGTCTGCTGCGCCTGAA
TGCTGCCCAAGCCGCCCGCAATCATAATCGGTTTGTGGTAGCCGCGAACCTGACCGTCAAATTTTTCTTC
AAAGGTGCGGAAGTAGCCCAAGAGGTTGGGGCGTCCGAATTCGTTGTTGAACGCCGCGCCACCGATGGGG
CCTTCGATCATGATGTCTAAAGGGGAAGCAATATGGTCGGGTTTGCCGTAGGCTTGTTCCCAAGGCTGTT
TGAGGTCGGGGATGTTGAGGTTGGAGACGGTAAAGCCGGTCAAGCCTGCTTTCGGGCGCGAACCTTTGCC
CGTCGCACCTTCGTCGCGGATTTCGCCGCCCGCGCCCGTCGCCGCGCCCGCAAACGGCGCGATGGCGGTC
GGGTGGTTGTGCGTTTCCACTTTCATGATGATATGCGTGTCTTCCTCGTGGAAACGGTAGCCTTGGTTTT
CCGCCGCATCCGGATAGAAACGCTCGATTTTCGCGCCTTCAATCACGGACGAATTGTCTTTATAAGCGAC
GACCGTGCCTTCGGGATGCGCGTTGTGCGTGTCGCGTATCATACCGAAGAGGGATTTCGGCTGTTTTTCG
CCGTTGAGGATGAAGTCGGCGTTGAAGATTTTGTGGCGGCAGTGTTCGCTGTTTGCCTGCGCGAACATCA
TCAGTTCCACATCGGACGGATTACGGTTTAAAGCCTGATAGTTTTCAACCAGATAATCGATTTCGTCGGC
GGAGAGTGCCAAACCCATTTCGGTATTGGCTTTGACTAAAGCCTCTTTACCGCCGCCCAAAACATCGACG
GTAGAGAAGGTTTCGGATTCGAGATGGTGGAATAATTTGGATGCCGTCTGAAAATCGGGCAATACGGATT
CGGTCATGCGGTCGTGCAGCAACGCCGCCCATTGCTGTTTCTGTTCATCGGTAAGCGCACCTTCCAGCCA
CACCGCCATGCCGCGCTCGATGCGTTCGATGCCTGCCAAACCGCAGTTTTCCGCGATATTGGTCGCCTTG
GAAGCCCACGGCGAAATCGTACCCAAACGGGGCGTGACCAAAAACAAATGCAAGCCCTCGCGCGCTTTTG
GCGTTTGTTCAACGCTTTGCGCCGCCAACAAGGCTTGCAGTTTTTCGACAGTCGCGGCATCCAATGCTTT
CTCGCTGCCGACGAAATACCAAAATTCGCTGCTTAATTTGACTTCGGGCAGACCGAGTGCGGCGGCTTTT
TGCAAGAGTTTTTCGACACGGAAATCGGAAAGGGCGGTAACGCCGCGCAAGGGCAAAACGACAGACA
Protein Sequence 
>gi|161869205|ref|YP_001598371.1| phosphoribosylformylglycinamidine synthase [Neisseria meningitidis 053442] MSVVLPLRGVTALSDFRVEKLLQKAAALGLPEVKLSSEFWYFVGSEKALDAATVEKLQALLAAQSVEQTPKAREGLHLFLVTPRLGTISPWASKATNIAENCGLAGIERIERGMAVWLEGALTDEQKQQWAALLHDRMTESVLPDFQTASKLFHHLESETFSTVDVLGGGKEALVKANTEMGLALSADEIDYLVENYQALNRNPSDVELMMFAQANSEHCRHKIFNADFILNGEKQPKSLFGMIRDTHNAHPEGTVVAYKDNSSVIEGAKIERFYPDAAENQGYRFHEEDTHIIMKVETHNHPTAIAPFAGAATGAGGEIRDEGATGKGSRPKAGLTGFTVSNLNIPDLKQPWEQAYGKPDHIASPLDIMIEGPIGGAAFNNEFGRPNLLGYFRTFEEKFDGQVRGYHKPIMIAGGLGSIQAQQTHKDEIPEGALLIQLGGPGMLIGLGGGAASSMDTGTNDASLDFNSVQRGNPEIERRAQEVIDRCWQLGDKNPIISIHDVGAGGLSNAFPELVNDAGRGAVFKLREVPLEEHGLTPLQIWCNESQERYVLSILEKDLDAFRAICERERCPFAVVGTATGDGHLKVRDDLFSNNPVDLPLNVLLGKPPKTTRTDKTVTPYATEGNPFGKKPFNAGDIDITEAAYRVLRLPAVAAKNFLITIGDRSVGGMTHRDQMVGKYQTPVADCAVTMMGFNTYRGEAMSMGEKPAVALFDAPASGRMCIGEAITNIAAVNIGDIGNIKLSANWMAACGNEGEDEKLYRTVEAVSKACQALDLSIPVGKDSLSMKTVWQDGADKKSVVSPLSLIISAFAPVEDVRKTVTPELKNVEDSVLLFIDLGFGKARMGGSAFGQVYNNMSGDAPDLDDTSRLKAFYNVIQQLVAEDKLLAYHDRSDGGLFAVLVEMAFAGRCGLDIDLNLLLAQTFITNHTALSQSLRTEEVKALAEWQETIARTLFNEELGAVIQVRKQDVADIINLFYQQQLHHNVFEIGTLTDENTLIIRDGQTHLISDNLIKLQQTWQETSHQIQRLRDNPACADSEFALIGDNERSALFADVKFDVNEDIAAPFINSGAKPKIAILREQGVNGQIEMAAAFTRAGFDAYDVHMSDLMAGRFRLADFKMLAACGGFSYGDVLGAGEGWAKSILFHPALRDQFAAFFADPDTLTLGVCNGCQMVSNLAEIIPGAEAWPKFKRNLSEQFEARLSMVHVPKSASLILNEMQGSSLPVVVSHGEGRADFALHGGNISADLGIALQYVDGQNQVTQTYPLNPNGSPQGIAGITNADGRVTIMMPHPERVYRAAQMSWKPEGWTELSGWYRLFAGARKALG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purL mutant is attenuated in rats (Sun et al., 2000).
COG COG0046F, under F: Nucleotide transport and metabolism
References
Sun et al., 2000: Sun YH, Bakshi S, Chalmers R, Tang CM. Functional genomics of Neisseria meningitidis pathogenesis. Nature medicine. 2000; 6(11); 1269-1273. [PubMed: 11062540].