Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

mpl-1

Victor ID 3017
Gene Name mpl-1
Sequence Strain (Species/Organism) Neisseria meningitidis MC58
NCBI Gene ID 903566
NCBI Protein GI 15677021
Locus Tag NMB1145
Protein Accession NP_274173.1
Other Database IDs UniProtKB-ID: Q9JRY9_NEIMB
UniRef100: UniRef100_Q9JRY9
UniRef90: UniRef90_B4RLI5
UniRef50: UniRef50_P37773
UniParc: UPI0000030F52
EMBL: AE002098
EMBL-CDS: AAF41532.1
EMBL-CDS: AAF41567.1
RefSeq_NT: NC_003112.2
PDB: 3EAG
EnsemblGenome: EBNEIG00000009667.
EnsemblGenome_TRS: EBNEIT00000009667
EnsemblGenome_PRO: EBNEIP00000009287
EnsemblGenome: EBNEIG00000010238.
EnsemblGenome_TRS: EBNEIT00000010238
EnsemblGenome_PRO: EBNEIP00000009858
GenomeReviews: AE002098_GR
KEGG: nme:NMB1145
KEGG: nme:NMB1183
T
Taxonomy ID 122586
Gene Starting Position 1151328
Gene Ending Position 1152704
Gene Strand (Orientation) +
Protein Name UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase
DNA Sequence 
>gi|77358697:1151328-1152704 Neisseria meningitidis MC58, complete genome
GATGAAACACATCCATATTATCGGTATCGGCGGCACGTTTATGGGCGGGCTTGCCGCCATTGCCAAAGAA
GCGGGGTTTGAAGTCAGCGGTTGCGACGCGAAGATGTATCCGCCGATGAGCACCCAGCTCGAAGCCTTGG
GTATAGACGTGTATGAAGGCTTCGATGCCGCTCAGTTGGACGAATTTAAAGCCGACGTTTACGTTATCGG
CAATGTCGCCAAGCGCGGGATGGATGTGGTTGAAGCGATTTTGAACCTCGGCCTGCCTTATATTTCCGGC
CCGCAATGGCTGTCGGAAAACGTGCTGCACCATCATTGGGTACTCGGTGTGGCGGGGACGCACGGCAAAA
CGACCACCGCCTCCATGCTCGCATGGGTCTTGGAATATGCCGGCCTCGCGCCGGGCTTCCTTATTGGCGG
CGTACCGGAAAATTTCGGCGTTTCCGCCCGCCTGCCGCAAACGCCGCGCCAAGACCCGAACAGCCAATCG
CCGTTTTTCGTCATCGAAGCCGACGAATACGACACCGCCTTTTTCGACAAACGTTCTAAATTCGTGCATT
ACCGTCCGCGTACCGCCGTGTTGAACAATCTGGAATTCGACCACGCCGACATCTTTGCCGACTTGGGCGC
GATACAGACCCAGTTCCACTACCTCGTGCGTACCGTGCCGTCTGAAGGCTTAATCGTCTGCAACGGACGG
CAGCAAAGCCTGCAAGATACTTTGGACAAAGGCTGCTGGACGCCGGTGGAAAAATTCGGCACGGAACACG
GCTGGCAGGCCGGCGAAGCCAATGCCGACGGCTCGTTCGACGTGTTGCTCGACGGCAAAACCGCCGGACG
CGTCAAATGGGATTTGATGGGCAGGCACAACCGCATGAACGCGCTCGCCGTCATTGCCGCCGCGCGTCAT
GTCGGTGTCGATATTCAGACCGCCTGCGAAGCCTTGGGCGCGTTTAAAAACGTCAAACGCCGGATGGAAA
TCAAAGGCACGGCAAACGGCATCACCGTTTACGACGACTTCGCCCACCACCCGACCGCCATCGAAACCAC
GATTCAAGGTTTGCGCCAACGCGTCGGCGGCGCGCGCATCCTCGCCGTCCTCGAACCGCGTTCCAACACG
ATGAAGCTGGGCACGATGAAGTCCGCCCTGCCTGTAAGCCTCAAAGAAGCCGACCAAGTGTTCTGCTACG
CCGGCGGCGTGGACTGGGACGTCGCCGAAGCCCTCGCGCCTTTGGGCGGCAGGCTGAACGTCGGCAAAGA
CTTCGATGCCTTCGTTGCCGAAATCGTGAAAAACGCCGAAGTAGGCGACCATATTTTGGTGATGAGCAAC
GGCGGTTTCGGCGGAATACACGGAAAGCTGCTGGAAGCTTTGAGATA
Protein Sequence 
>gi|15677021|ref|NP_274173.1| UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase [Neisseria meningitidis MC58] MKHIHIIGIGGTFMGGLAAIAKEAGFEVSGCDAKMYPPMSTQLEALGIDVYEGFDAAQLDEFKADVYVIGNVAKRGMDVVEAILNLGLPYISGPQWLSENVLHHHWVLGVAGTHGKTTTASMLAWVLEYAGLAPGFLIGGVPENFGVSARLPQTPRQDPNSQSPFFVIEADEYDTAFFDKRSKFVHYRPRTAVLNNLEFDHADIFADLGAIQTQFHYLVRTVPSEGLIVCNGRQQSLQDTLDKGCWTPVEKFGTEHGWQAGEANADGSFDVLLDGKTAGRVKWDLMGRHNRMNALAVIAAARHVGVDIQTACEALGAFKNVKRRMEIKGTANGITVYDDFAHHPTAIETTIQGLRQRVGGARILAVLEPRSNTMKLGTMKSALPVSLKEADQVFCYAGGVDWDVAEALAPLGGRLNVGKDFDAFVAEIVKNAEVGDHILVMSNGGFGGIHGKLLEALR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mpl-1 mutant is attenuated in rats (Sun et al., 2000).
COG COG0773M, under M: Cell wall/membrane/envelope biogenesis
References
Sun et al., 2000: Sun YH, Bakshi S, Chalmers R, Tang CM. Functional genomics of Neisseria meningitidis pathogenesis. Nature medicine. 2000; 6(11); 1269-1273. [PubMed: 11062540].