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purL from Neisseria meningitidis alpha14

Victor ID 3890
Gene Name purL from Neisseria meningitidis alpha14
Sequence Strain (Species/Organism) Neisseria meningitidis alpha14
NCBI Gene ID 8221129
NCBI Protein GI 254804191
Locus Tag NMO_0171
Protein Accession YP_003082412.1
Other Database IDs UniProtKB-ID: C6S4S8_NEIML
UniRef100: UniRef100_C6S4S8
UniRef90: UniRef90_Q5F7J4
UniRef50: UniRef50_Q47XX7
UniParc: UPI0001B02B43
EMBL: AM889136
EMBL-CDS: CBA03632.1
RefSeq_NT: NC_013016.1
EnsemblGenome: EBNEIG00000014623.
EnsemblGenome_TRS: EBNEIT00000014623
EnsemblGenome_PRO: EBNEIP00000014277
GenomeReviews: AM889136_GR
ProtClustDB: PRK05297
Taxonomy ID 662598
Gene Starting Position 174156
Gene Ending Position 178118
Gene Strand (Orientation) -
Protein Name phosphoribosylformylglycinamidine synthase
DNA Sequence 
>gi|254804028:174156-178118 Neisseria meningitidis alpha14, complete genome
GTTAGCCCAAGGCTTTACGTGCGCCGGCAAAGAGGCGGTACCAGCCGGACAGTTCCGTCCAGCCTTCCGG
TTTCCAGCTCATTTGTGCGGCGCGGTACACGCGTTCGGGGTGGGGCATCATGATGGTCACGCGGCCGTCG
GCGTTGGTAATGCCGGCGATGCCTTGCGGCGAGCCGTTGGGGTTGAGCGGATAGGTTTGGGTAACCTGGT
TTTGACCGTCCACATATTGCAGCGCGATGCCCAAATCGGCGGAAATATTGCCGCCGTGAAGCGCGAAGTC
GGCGCGGCCTTCGCCGTGGCTGACGACGACGGGCAGGCTGGAGCCTTGCATTTCGTTCAGAATCAGCGAC
GCGGATTTGGGGACATGAACCATGCTCAGGCGCGCTTCAAACTGTTCGCTCAGGTTGCGTTTGAACTTCG
GCCAGCCTGCCGTGCCGGGGATGATTTCGGCAAGGTTGCTGACCATTTGGCAGCCGTTGCACACGCCCAA
TGTCAGCGTGTCCGGGTCGGCGAAGAATGCGGCAAACTGGTCGCGCAGAGCAGGGTGGAACAGAATCGAT
TTCGCCCAGCCTTCGCCCGCGCCGAGTACGTCGCCGTAGCTGAAGCCGCCGCACGCCGCCAGCATTTTGA
AGTCGGCAAGGCGGAAGCGGCCTGCCATCAGGTCGGACATATGCACGTCGTAAGCATCGAAACCGGCGCG
GGTAAAGGCGGCGGCCATTTCGATTTGCCCGTTTACGCCCTGTTCGCGCAGGATGGCGATTTTGGGTTTC
GCGCCGCTGTTGATAAACGGCGCGGCGATGTCTTCGTTCACGTCGAATTTCACGTCGGCAAACAATGCGC
TGCGGTCGTTGTCGCCAATCAGTGCGAACTCGCTGTCGGCGCAGGCAGGGTTGTCGCGCAGGCGTTGGAT
TTGATGGCTGGTTTCTTGCCAGGTTTGTTGCAGTTTGATTAGGTTGTCAGAAATAAGGTGCGTTTGCCCG
TCGCGGATGATTAACGTGTTCTCATCAGTTAACGTACCGATTTCAAAGACATTATGATGCAGCTGTTGTT
GATAGAATAAATTGATAATATCGGCAACATCTTGTTTTCTAACTTGGATAACAGCACCCAACTCTTCATT
AAATAATGTGCGGGCAATGGTTTCTTGCCATTCAGCCAACGCTTTTACCTCTTCAGTCCGCAATGATTGA
GACAGAGCGGTATGGTTGGTAATAAATGTTTGTGCAAGCAATAAATTTAAATCTATATCCAAGCCGCACC
GCCCCGCAAACGCCATTTCTACCAAAACGGCAAACAAGCCGCCGTCGCTGCGGTCGTGATACGCCAAAAG
TTTGTCTTCGGCGACAAGCTGTTGAACCACGTTGTAAAACGCTTTCAGACGGCCTGTATCGTCCAAATCA
GGCGCATCGCCGGTCATGTTGTTGTAAGCCTGACCGAACGCCGAGCCGCCCATACGCGCTTTGCCGAAGC
CCAAATCGACAAACAGCAATACGCTGTCTTCAACGTTTTTCAATTCGGGCGTAACAGTCTTGCGTACGTC
TTCCACCGGCGCAAACGCGGAGATAATCAGGCTCAACGGCGAAACAACGGATTTTTTCTCTTCACCGTCC
TGCCACACGGTTTTCATCGACAGGCTGTCTTTGCCTACGGGAATGCTCAAATCCAATGCCTGACAGGCTT
TGGAGACCGCTTCGACGGTGCAGTAGAGTTTTTCGTCTTCGCCCTCATTGCCGCACGCCGCCATCCAGTT
GGCGGAAAGTTTGATGTTGCCGATGTCGCCGATGTTGACCGCCGCGATGTTGGTGATGGCTTCGCCGACG
CACATTCTGCCCGAGGCGGGCGCGTCAAACAGGGCAACGGTCGGTTTTTCGCCCATAGACATTGCTTCGC
CGCGATAGGTATTGAAGCCCATCATGGTAACGGCGCAGTCGGCTACGGGGGTTTGGTATTTGCCGACCAT
TTGGTCGCGGTGGGTCATGCCGCCGACGCTGCGGTCGCCGATGGTAATCAGGAAGTTTTTGGCGGCTACG
GCAGGCAGGCGCAAAACGCGGTAGGCGGCTTCGGTGATGTCGATATCGTCGGCGTGAAACGGTTTTTTGG
ACGGCGTAACCGTTTTGTCGGTACGCGTGGTTTTGGGCGGTTTGCCGAGCAAGACGTTCAGCGGCAAATC
GACGGGGTTGTTGGCGAACAAATCGTCGCGCACTTTCAAATGGCCGTCGTCGGTCGCCGTGCCGACCACG
GCAAACGGGCAGCGTTCGCGTTCGCAGATGGCGCGGAAGGTGTCCAAATCTTTTTCCAAAATCGACAACA
CATAACGCTCTTGCGATTCGTTACACCAGATTTGCAAAGGCGTTAAACCGTGTTCTTCCAACGGCACTTC
GCGCAGCTTGAATACCGCGCCGCGTCCGGCATCGTTGACGAGTTCGGGGAAGGCGTTGGACAAACCGCCC
GCGCCCACGTCGTGGATGGAGATAATCGGGTTTTTGCCGCCGAGCTGCCAGCAGCGGTCGATGACTTCCT
GCGCGCGGCGTTCGATTTCGGGGTTGCCGCGTTGTACGGAATTGAAGTCTAAAGACGCGTCGTTCGTGCC
GGTATCCATCGAAGAAGCCGCGCCGCCGCCCAAGCCGATAAGCATGCCCGGGCCGCCCAGTTGGATCAGC
AACGCGCCTTCGGGGATTTCGTCTTTATGCGTCTGCTGCGCCTGAATGCTGCCCAAGCCGCCGGCAATCA
TAATCGGTTTGTGGTAGCCGCGAACCTGACCGTCAAACTTCTCTTCAAAAGTGCGGAAGTAGCCCAAGAG
GTTGGGGCGGCCGAATTCGTTGTTGAACGCCGCGCCGCCGATCGGACCTTCGATCATGATGTCCAGCGGC
GAGGAAATATGTTCCGGCTTGCCGTAATCTTGTTCCCACGGCTGTTTGAGGCCGGGGATGTTGAGGTTGG
ACACGGTAAAGCCGGTCAAGCCTGCTTTCGGACGCGAACCTTTGCCCGTTGCGCCTTCGTCGCGGATTTC
GCCGCCCGCGCCCGTTGCCGCGCCTGCAAACGGCGCGATGGCGGTCGGGTGGTTGTGCGTTTCCACTTTC
ATGATGATATGCGTGTCTTCCTCGTGGAAACGGTAGCCTTGGTTTTCCGCCGCATTCGGATAGAAACGCT
CGATTTTCGCGCCTTCGATCACGGACGAATTGTCTTTATAGGCGACGACCGTACCTTCGGGATGCGCGTT
GTGCGTGTCGCGTATCATGCCGAACAGGGATTTCGGTTGTTTTTCGCCGTTGAGGATGAAATCGGCGTTG
AAGATTTTGTGGCGGCAGTGTTCGCTGTTTGCCTGCGCGAACATCATCAGTTCCACATCGGACGGATTGC
GCTGCAAAGCCTGATAGTTTTCAACCAGATAATCGATTTCGTCGGCGGAGAGTGCCAAACCCATTTCGGT
ATTGGCTTTGACCAAAGCCTCTTTACCGCCGCCTAAAACATCAACGGTGGAAAAGGTTTCGGATTCGAGA
TGGTGGAATAATTTGGATGCCGTCTGAAAATCGGGCAGCACCGATTCGGTCATGCGGTCGTGCAGCAACG
CCGCCCATTGCCGTTTCTGTTCATCGGTAAGCGCACCTTCCAGCCACACCGCCATGCCGCGCTCGATGCG
CTCGATGCCTGCCAAACCGCAGTTTTCCGCGATATTGGTCGCCTTGGAAGCCCACGGCGAAATCGTACCC
AAACGGGGCGTTACCAAAAACAAATGCAAGCCCTCGCGCGCTTTTGGCGTTTGTTCAACGCTTTGCGCCG
CCAACAAGGCTTGCAGTTTTTCGACAGTCGCGGCATCCAATGCTTTCTCGCTGCCGGCGAAATACCAAAA
TTCGCTGCTTAATTTGACTTCGGGCAGTCCGAGTGCGGCGGCTTTTTGCAAGAGTTTTTCGACACGGAAA
TCGGAAAGGGCGGTAACGCCGCGCAAGGGCAAAACGACAGACA
Protein Sequence 
>gi|254804191|ref|YP_003082412.1| phosphoribosylformylglycinamidine synthase [Neisseria meningitidis alpha14] MSVVLPLRGVTALSDFRVEKLLQKAAALGLPEVKLSSEFWYFAGSEKALDAATVEKLQALLAAQSVEQTPKAREGLHLFLVTPRLGTISPWASKATNIAENCGLAGIERIERGMAVWLEGALTDEQKRQWAALLHDRMTESVLPDFQTASKLFHHLESETFSTVDVLGGGKEALVKANTEMGLALSADEIDYLVENYQALQRNPSDVELMMFAQANSEHCRHKIFNADFILNGEKQPKSLFGMIRDTHNAHPEGTVVAYKDNSSVIEGAKIERFYPNAAENQGYRFHEEDTHIIMKVETHNHPTAIAPFAGAATGAGGEIRDEGATGKGSRPKAGLTGFTVSNLNIPGLKQPWEQDYGKPEHISSPLDIMIEGPIGGAAFNNEFGRPNLLGYFRTFEEKFDGQVRGYHKPIMIAGGLGSIQAQQTHKDEIPEGALLIQLGGPGMLIGLGGGAASSMDTGTNDASLDFNSVQRGNPEIERRAQEVIDRCWQLGGKNPIISIHDVGAGGLSNAFPELVNDAGRGAVFKLREVPLEEHGLTPLQIWCNESQERYVLSILEKDLDTFRAICERERCPFAVVGTATDDGHLKVRDDLFANNPVDLPLNVLLGKPPKTTRTDKTVTPSKKPFHADDIDITEAAYRVLRLPAVAAKNFLITIGDRSVGGMTHRDQMVGKYQTPVADCAVTMMGFNTYRGEAMSMGEKPTVALFDAPASGRMCVGEAITNIAAVNIGDIGNIKLSANWMAACGNEGEDEKLYCTVEAVSKACQALDLSIPVGKDSLSMKTVWQDGEEKKSVVSPLSLIISAFAPVEDVRKTVTPELKNVEDSVLLFVDLGFGKARMGGSAFGQAYNNMTGDAPDLDDTGRLKAFYNVVQQLVAEDKLLAYHDRSDGGLFAVLVEMAFAGRCGLDIDLNLLLAQTFITNHTALSQSLRTEEVKALAEWQETIARTLFNEELGAVIQVRKQDVADIINLFYQQQLHHNVFEIGTLTDENTLIIRDGQTHLISDNLIKLQQTWQETSHQIQRLRDNPACADSEFALIGDNDRSALFADVKFDVNEDIAAPFINSGAKPKIAILREQGVNGQIEMAAAFTRAGFDAYDVHMSDLMAGRFRLADFKMLAACGGFSYGDVLGAGEGWAKSILFHPALRDQFAAFFADPDTLTLGVCNGCQMVSNLAEIIPGTAGWPKFKRNLSEQFEARLSMVHVPKSASLILNEMQGSSLPVVVSHGEGRADFALHGGNISADLGIALQYVDGQNQVTQTYPLNPNGSPQGIAGITNADGRVTIMMPHPERVYRAAQMSWKPEGWTELSGWYRLFAGARKALG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purL mutant is attenuated in rats (Sun et al., 2000).
COG COG0046F, under F: Nucleotide transport and metabolism
References
Sun et al., 2000: Sun YH, Bakshi S, Chalmers R, Tang CM. Functional genomics of Neisseria meningitidis pathogenesis. Nature medicine. 2000; 6(11); 1269-1273. [PubMed: 11062540].