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hrpA from Neisseria meningitidis 053442

Victor ID 2918
Gene Name hrpA from Neisseria meningitidis 053442
Sequence Strain (Species/Organism) Neisseria meningitidis 053442
NCBI Gene ID 5796971
NCBI Protein GI 161869191
Locus Tag NMCC_0194
Protein Accession YP_001598357.1
Other Database IDs UniProtKB-ID: A9M0L0_NEIM0
UniRef100: UniRef100_A9M0L0
UniRef90: UniRef90_A9M0L0
UniRef50: UniRef50_A9M0L0
UniParc: UPI0001610521
EMBL: CP000381
EMBL-CDS: ABX72404.1
RefSeq_NT: NC_010120.1
EnsemblGenome: EBNEIG00000012572.
EnsemblGenome_TRS: EBNEIT00000012572
EnsemblGenome_PRO: EBNEIP00000012114
GenomeReviews: CP000381_GR
KEGG: nmn:NMCC_0194
HOGENOM: HBG576132
OMA: QTNFSAT
ProtClustDB: CLSK878439
BioCyc: NMEN374833:NMCC_0194-MONOMER
Taxonomy ID 374833
Gene Starting Position 191848
Gene Ending Position 195312
Gene Strand (Orientation) -
Protein Name ATP-dependent RNA helicase HrpA
DNA Sequence 
>gi|161869018:191848-195312 Neisseria meningitidis 053442, complete genome
TTTATTTTTCAATTTTTTCCCACTCTTTCAACAGCCGCTTCACCGACACCGGATACGGTGTCTTCAATTC
CTGCGCGAACAGCGACACCCTCAATTCTTCAATCATCCATTTAAACGCGGCGAGGCCGTCTGAAATGGGG
AGACCTTGTTTAATCAGGCTGTCTGTTTTTTCCTGCCACATTTGTTCCAGCTCTTGGATATCGGCTTCGC
GGGCTGCGTCGCGGGCGGGGTTGCTGCTGTATTTTTCGAGGCGCAGGGTCATGGCTTTGAGGTAGATGGG
GAGGCGCGGCCATTGTGCCCACGGGGTTCGGGTGGCGAAGCCGGCGGCGAGCAGGGTTTGCAGGCGTAGT
CTTAGAAGGTGGGTCAATGGGTGTTTGCCGAGTTTGCTGTTGAGTTCGGCGTAGACGGCGGCGGTTTCCT
GCAGGTAGCGGCTGAGGGCTTCTTTGACGGCGGGCAGGCGGCTGCGGGCGCGTTTGATTTGTTCTTTGAA
GGCTTTTTCGTTGCGCGGCAGCTCGTCTTCGCCGATAAAGGCGCGGTCGCAGACGGCTTGGGTGAGGTCG
TCGCGCAGAGTGTCGGCGTTGATGTGTTTGAGCAGCATGGCAGCTTGGGTGAAGCCTTGGATGCCTTTGT
TCAAATCCTTTACCTGCTCTTTTAATTGCAGCTTCATCAATTCGATGACACCTTGACGGTGTGCCTGCTC
TGCGGCTTCTGTGGTATCAAACAGGCGCAGGGCGATGCGGCCGTCTTTTTCTTTTTGTAGGCCGAGATAG
CCGGTGAGCTGTTGTTTGCCGCGTGCGAATTTGATGGATTCGGGCAGGGTGCCGATGTCCCATGCGGTGA
CGTTGTCGCGCTCAAATTCTTGGGTGTTGTCGCGGAAGGTAACGGCGGCGGCTTGACCGAGTTGTTGTTG
CAATTCGTGCAGTTTGCGGCCGCCGGCAAGCTCTTGTCCGCCGTCGTCGATAATGCGGAGGTTGAAATAG
CAGTGTTCGGGCAGCCTGAACGCGGCCCATTCGTCTTGGTTGATTTGCTCGAATATGCGGATGTCGCCTG
CGGTTTTGGCGATGGCTTGGGCGAGTTGGGGCAGGATGGGGGCGTTGCGGTCGGGGTTTTGGCTTAAAAA
TTGGGTGATGAATTCGGGCACGGGCACGCAGATGCGGCGGATTTGCTTGGGCAGTGCTTTGATTTGCAAC
TGGATTTTTTCGCGTATCATGCCGGGCACCAGCCATTCGAGCGACGGCGCGTGCAGGCGGTTGAGGACGG
TCAGCGGCACGGTCATGGTCACGCCGTCTAGCGGATGGTGCGGCTCGAAGCGGTAGGAAAGTTTGAATTT
GCCGTCTGCGGTTTGCCAGAATTTGGGGAACTGTTCTTCGGTAATGTGTGCGGCGGCGTGTTGCATCAGA
TCGTCGCGGCTGAGGAACAGCAGGCGCGGATTGTCGCGCTCGGCGGTTTTGAGCCAGGCTTGGAAGGTGC
GGATGTCGGCGAGGGGTAGGGGTTTCAGACGGTTTTTTTGGGGTGCAGGCTGCTTTTTGGGTTGAGGGTC
GTTTGAAACCGCTGAAGCTGCGGCACTCTGTTCCCCCTCCTGTGGGAGAGGGTTAGGGAGAGGGTTTGCT
GTGGTTGCGGAGAAGTTGGTTTGGGTGGCAACTGTTTTGCCCTCTCCCCAGCCCTCCCCCACGGGGGAGG
GAGAGGGTTGCTGCAGATTTGCAGGACGCAGGTCGTCTGAAAACGTTGAAGCTGAGGCACTCTGTTCCCT
CTCCTGCGGGAGAGGGTTTGTTGAGGTTGCGGAAAAGTTGGTTTGTGTGGCAACTGTTTTGCCCTCTCCC
CAGCCCTCCCCCACGGGGGAGGGGGCGGTTTGCTGCAGATTTGCAGGACGCAGGTCGTCTGAAAACGTTG
AAGCTGAGGCACTCTGTTCCCTCTCCTGCGGGAGAGGGTTTGCTGCGGTTGCGGAAAAGTTGGTTTGTGC
GGCAACTGTTTTGCCCTCTCCCCGACCCTCCCTCTCGGGGGAGGGGGTGGGTTGCTGAGTAGCGTAGGTT
GGGTTGTCAAACCCAACAGTTTTTGCAGTTGCGGCTGATGTTGGGTTTTCAACCCAACCTACGGTGTTGC
CGTGATTTTCATTTTGGCGAGACCCATTACGCTTGTTTTTACGAAACTCGTTGCGCTCATTTTCAGACGA
CCTCTCGGCTTTGTCAGATTCAATAATCCGTACGGAATCTTCACTTCCCCAAACGCTGCCTTGCGCGTCT
TTCCAAGCCATTTCGGGCAGTCGTTCGTTATAAAACGCAAACAGGGCTTCGTCATCGACCAGCACGTCTT
GCTTGCGCGATTTGTGTTCGAGTTCGGTAATTTCTTTAATCAGCTTTTTGTTGTGGACAAAAAAATCCGC
TTTCAAATCGCATTCCTGCGCCACCAACGCGCTGCGGATAAAGATTTCGCGCGCTTCTTCGGGGGCAACT
TTGCCGTAAGACACGGGGCGGCGCGGCAATACGGTCAGGCCGTAAAGCGTCACGCGTTCGCTGGCGACGA
CTTCGCCGCGTTTTTGTTCCCAGTGCGGCTCGAAATAGTGGTAGCGGACGAGGTGCGGGGCTTCCTGCTC
AATCCATTCGGGCTGGATAACGGCGACGTCGCGCGCATAAAGTTTTGTCGTTTCAACGAGTTCTGCCGCC
ATCACCCATTTGGGTTTGGCTTTGAACAGGGCGGAGGCGGGGAAAAGGTGGAAACGGCTGCCGCGCGCGC
CGGTATAGTCGTTGCCGTCGGGCGATTTCATGCCGACGTTGGCGATAAGGCCGGTGAGCAGGGCGCGGTG
GATTTGTTCGTAGCCCGCTTCTTTGGCGGCGCGGATTTGGGCGCGGTGTTGTTTCTTATCCAGTTGTTTT
TGTTTGCGTTTGGCGGATAAGTCTTGATCGCCTTGGTTTTCAGACGACGTAAGCTGCTTGATTTCGGAAA
GTCGTCTGAAAGCCGCTTCCTTGGTGGTCAAACCCATTTCAATCGCGGTTTGGGCAAGCTGGTGGTGCAG
CTCGCGCCACTCGCGCATCCGCAGGTGCGACAGGAAATATTGGCGGCACCATTGCACCAGCTGCTTGTTG
GACAAACCTTTGTCGCGCTCGCGCTGGAAACTGTCCCAAATATTCAGGTAGGCAAGGAAATCGGATTGCT
TGTCGGTAAAGCGTTCATGCGCCTTGGCGGCGGCATCGCGTGCCTCCAGCGGCCGCTCGCGCGGGTCTTG
AATCGATAGCGCGGACGCAATCACCAATATTTCCGCCATGCAGTCGTGCTTCTTCGCCGCCAACAAAATG
CGCGCGATTTTCGGGTCGATGGGCAGGCGCGCCATTTGTTCGCCGAGTTTGGTCAGACGGTAGCGCGTGT
TGGTACCGATATGGCCCGAACTGTTTTGCAGGCCGTCTGAAACATTGGCCGGGTTGGATCGTGCATCCAT
GCCTGATCCGCGTATTTGGTTTTTCATATTTTGCA
Protein Sequence 
>gi|161869191|ref|YP_001598357.1| ATP-dependent RNA helicase HrpA [Neisseria meningitidis 053442] MQNMKNQIRGSGMDARSNPANVSDGLQNSSGHIGTNTRYRLTKLGEQMARLPIDPKIARILLAAKKHDCMAEILVIASALSIQDPRERPLEARDAAAKAHERFTDKQSDFLAYLNIWDSFQRERDKGLSNKQLVQWCRQYFLSHLRMREWRELHHQLAQTAIEMGLTTKEAAFRRLSEIKQLTSSENQGDQDLSAKRKQKQLDKKQHRAQIRAAKEAGYEQIHRALLTGLIANVGMKSPDGNDYTGARGSRFHLFPASALFKAKPKWVMAAELVETTKLYARDVAVIQPEWIEQEAPHLVRYHYFEPHWEQKRGEVVASERVTLYGLTVLPRRPVSYGKVAPEEAREIFIRSALVAQECDLKADFFVHNKKLIKEITELEHKSRKQDVLVDDEALFAFYNERLPEMAWKDAQGSVWGSEDSVRIIESDKAERSSENERNEFRKNKRNGSRQNENHGNTVGWVENPTSAATAKTVGFDNPTYATQQPTPSPEREGRGEGKTVAAQTNFSATAANPLPQEREQSASASTFSDDLRPANLQQTAPSPVGEGWGEGKTVATQTNFSATSTNPLPQEREQSASASTFSDDLRPANLQQPSPSPVGEGWGEGKTVATQTNFSATTANPLPNPLPQEGEQSAAASAVSNDPQPKKQPAPQKNRLKPLPLADIRTFQAWLKTAERDNPRLLFLSRDDLMQHAAAHITEEQFPKFWQTADGKFKLSYRFEPHHPLDGVTMTVPLTVLNRLHAPSLEWLVPGMIREKIQLQIKALPKQIRRICVPVPEFITQFLSQNPDRNAPILPQLAQAIAKTAGDIRIFEQINQDEWAAFRLPEHCYFNLRIIDDGGQELAGGRKLHELQQQLGQAAAVTFRDNTQEFERDNVTAWDIGTLPESIKFARGKQQLTGYLGLQKEKDGRIALRLFDTTEAAEQAHRQGVIELMKLQLKEQVKDLNKGIQGFTQAAMLLKHINADTLRDDLTQAVCDRAFIGEDELPRNEKAFKEQIKRARSRLPAVKEALSRYLQETAAVYAELNSKLGKHPLTHLLRLRLQTLLAAGFATRTPWAQWPRLPIYLKAMTLRLEKYSSNPARDAAREADIQELEQMWQEKTDSLIKQGLPISDGLAAFKWMIEELRVSLFAQELKTPYPVSVKRLLKEWEKIEK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: hrpA mutants are deficient in the ability to live/grow in HeLa cells (Talà et al., 2008).
COG COG1643L, under L: Replication, recombination and repair
References
Talà et al., 2008: Talà A, Progida C, De Stefano M, Cogli L, Spinosa MR, Bucci C, Alifano P. The HrpB-HrpA two-partner secretion system is essential for intracellular survival of Neisseria meningitidis. Cellular microbiology. 2008; 10(12); 2461-2482. [PubMed: 18680551].