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pilF from Neisseria meningitidis Z2491

Victor ID 2965
Gene Name pilF from Neisseria meningitidis Z2491
Sequence Strain (Species/Organism) Neisseria meningitidis Z2491
NCBI Gene ID 907288
NCBI Protein GI 15795030
Locus Tag NMA2159
Protein Accession NP_284852.1
Other Database IDs UniProtKB-ID: A1ITY6_NEIMA
UniRef100: UniRef100_A1KVV5
UniRef90: UniRef90_P37094
UniRef50: UniRef50_P37094
UniParc: UPI00000C4E0C
EMBL: AL157959
EMBL-CDS: CAM09255.1
RefSeq_NT: NC_003116.1
EnsemblGenome: EBNEIG00000001805.
EnsemblGenome_TRS: EBNEIT00000001805
EnsemblGenome_PRO: EBNEIP00000001805
GenomeReviews: AL157959_GR
KEGG: nma:NMA2159
HOGENOM: HBG485518
OMA: PLGRREN
ProtClustDB: CLSK877498
Taxonomy ID 122587
Gene Starting Position 2105363
Gene Ending Position 2107039
Gene Strand (Orientation) -
Protein Name type IV pilus assembly protein
DNA Sequence 
>gi|15793034:2105363-2107039 Neisseria meningitidis Z2491, complete genome
CCTAATCGTTGGTATTTGCCGTTACCTCTTCCAATGAAGTAATGCCCTGCATAACTTTCAAAATACCGGC
CCGGCGCAAATCCACCATACCCTCCTTATAGGCAACGTCCAAAATATCCACTTCCGTACCGTTGTTCATA
ATCACACGCTGCATTTCTTCGCTGATGGGCATAACCTCATACACGCCCGCACGCCCCTTATAACCCTGCC
CCCGGCAACGGTCGCAACCGACGGCGCGGTAAAGTTTCCAATCTTTTGCAAGGTCCTCATCGGTGAAGCC
GACTTCCTTCAAAGCAGAGGCAGACGGGCGTTCCACTTCCTGTTTGCAGCTCGAACACAGCCTGCGTAAA
AGACGCTGCGCCATAATCAGGCTGACCGAACTGGCAATATTAAACGGCGCGACACCCATATTCAGCATAC
GCGACAACGTCGCCGGCGCATTATTGGTGTGCAGGGTGGAAAACACCATATGCCCTGTTTGTGCCGCCTT
AATCGCAATATCGGCAGTTTCCAAATCACGAATCTCACCGACCATAATGATGTCCGGGTCCTGACGCAGG
AAAGACTTCAAAGCAGCGGCAAAAGTCAGACCCTGCTTATCATTGACGTTAACCTGATTGATGCCCGGCA
GGTTAATCTCGGCAGGGTCTTCCGCCGTTGCAATATTTACCGACTCCGTATTCAAAATATTCAAACAGGT
ATAGAGCGACACCGTCTTACCCGAACCCGTCGGACCGGTTACCAGCACCATCCCGTAGGGACGGTGAATC
GCTTCCAACAACAATTTTTTCTGAAACGGCTCAAAACCGAGCTGGTCGATGTTCAAAGACGCGGCATCGG
AATTCAAAATCCGCATCACGACCTTTTCGCCAAACAGCGTCGGCAATGTGCTGACACGGAAATCGACAGG
CTTGCCGCCCTTTTGAAAGGTCAGCTGCATCCTGCCGTCCTGCGGTATCCGTTTTTCGGAAATGTCCAAA
CGCGACATTACCTTAATCCGGGAAGCAAGCTGCCCCCTTACCGCAATGGGCGGCTGAACCACCTCGCGGA
GCTGCCCGTCCACACGGAAACGGATACGGGCATTGTGTTCGTAAAACTCGAAATGGATGTCCGATGCCCC
GCTGCGCAAGGCATCCGACAAAGTCTTATGGATAAACCTCGGAACAGGGCCGTCTTCTGCCTCCTCGTTG
TCGATATACAGGGTGTGGCTTTCCTCTTCCTCCTGCCCCTCCCCAAGCTCCTGAAGCAGCGATGTCGAAC
GCGAACCCACCCAATCGAGCAAACCCGCCAACTGGTCATCCTCGACAATGACCAACTCAACCTCAATCCC
TGCGGCAGAAACGGTTTTCTGAATTTGCGGCATCTGTGTCGGATCGGAAACCGCAAAAAATACTTTGTCG
CCCCGACGGAAAACCGGCACACAGTGGAACTCCACCATCTGCTCCTCCGTCAACACCCCCATCAGCACCC
TGTGGCGCGGATAATGACGCAAATCAAGAATCGAATAACTGAACACCCTCGCAATCAATGCCGCAAGCGA
CTTGGGCGAAATGACACCGTCTGAAAACAGCATCGGCAACACTTCCTTACCCGCCTGCGACTCATTGTAG
TAATGCTCGGCCTGCTCAACAGTAACCACCTGGTTTTGAACCAGAATCCTCAGCAAACCTACGCTCA
Protein Sequence 
>gi|218768895|ref|YP_002343407.1| type IV pilus assembly protein [Neisseria meningitidis Z2491] MSVGLLRILVQNQVVTVEQAEHYYNESQAGKEVLPMLFSDGVISPKSLAALIARVFSYSILDLRHYPRHRVLMGVLTEEQMVEFHCVPVFRRGDKVFFAVSDPTQMPQIQKTVSAAGIEVELVIVEDDQLAGLLDWVGSRSTSLLQELGEGQEEEESHTLYIDNEEAEDGPVPRFIHKTLSDALRSGASDIHFEFYEHNARIRFRVDGQLREVVQPPIAVRGQLASRIKVMSRLDISEKRIPQDGRMQLTFQKGGKPVDFRVSTLPTLFGEKVVMRILNSDAASLNIDQLGFEPFQKKLLLEAIHRPYGMVLVTGPTGSGKTVSLYTCLNILNTESVNIATAEDPAEINLPGINQVNVNDKQGLTFAAALKSFLRQDPDIIMVGEIRDLETADIAIKAAQTGHMVFSTLHTNNAPATLSRMLNMGVAPFNIASSVSLIMAQRLLRRLCSSCKQEVERPSASALKEVGFTDEDLAKDWKLYRAVGCDRCRGQGYKGRAGVYEVMPISEEMQRVIMNNGTEVDILDVAYKEGMVDLRRAGILKVMQGITSLEEVTANTND
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pilF mutant were unable to colonize human nasopharyngeal tissue in an organ culture model (Exley et al., 2009).
References
Exley et al., 2009: Exley RM, Sim R, Goodwin L, Winterbotham M, Schneider MC, Read RC, Tang CM. Identification of meningococcal genes necessary for colonization of human upper airway tissue. Infection and immunity. 2009; 77(1); 45-51. [PubMed: 18936183].