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pilF from Neisseria meningitidis FAM18

Victor ID 2935
Gene Name pilF from Neisseria meningitidis FAM18
Sequence Strain (Species/Organism) Neisseria meningitidis FAM18
NCBI Gene ID 4676178
NCBI Protein GI 121635535
Locus Tag NMC1844
Protein Accession YP_975780.1
Other Database IDs UniProtKB-ID: A1KVV5_NEIMF
UniRef100: UniRef100_A1KVV5
UniRef90: UniRef90_P37094
UniRef50: UniRef50_P37094
UniParc: UPI00000C4E0C
EMBL: AM421808
EMBL-CDS: CAM11010.1
RefSeq_NT: NC_008767.1
EnsemblGenome: EBNEIG00000008084.
EnsemblGenome_TRS: EBNEIT00000008084
EnsemblGenome_PRO: EBNEIP00000007853
GenomeReviews: AM421808_GR
KEGG: nmc:NMC1844
eggNOG: COG2804
HOGENOM: HBG485518
OMA: PLGRREN
ProtClustDB: CLSK877498
BioCyc: NMEN272831:NMC1844-MONOMER
Taxonomy ID 272831
Gene Starting Position 1874893
Gene Ending Position 1876569
Gene Strand (Orientation) -
Protein Name type IV pilus assembly protein
DNA Sequence 
>gi|121633901:1874893-1876569 Neisseria meningitidis FAM18, complete genome
CCTAATCGTTGGTATTTGCCGTTACCTCTTCCAATGAAGTAATGCCCTGCATAACTTTCAAAATACCGGC
CCGGCGCAAATCCACCATACCCTCCTTATAGGCAACGTCCAAAATATCCACTTCCGTACCGTTGTTCATA
ATCACACGCTGCATTTCTTCGCTGATGGGCATAACCTCATACACGCCCGCACGCCCCTTATAACCCTGCC
CCCGGCAACGGTCGCAACCGACGGCGCGGTAAAGTTTCCAATCTTTTGCAAGGTCCTCATCGGTGAAGCC
GACTTCCTTCAAAGCAGAGGCAGACGGGCGTTCCACTTCCTGTTTGCAGCTCGAACACAGCCTGCGTAAA
AGACGCTGCGCCATAATCAGGCTGACCGAACTGGCAATATTAAACGGCGCGACACCCATATTCAGCATAC
GCGACAACGTCGCCGGCGCATTATTGGTGTGCAGGGTGGAAAACACCATATGCCCTGTTTGTGCCGCCTT
AATCGCAATATCGGCAGTTTCCAAATCACGAATCTCACCGACCATAATGATGTCCGGGTCCTGACGCAGG
AAAGACTTCAAAGCAGCGGCAAAAGTCAGGCCCTGCTTATCATTGACGTTAACCTGATTGATGCCCGGCA
GGTTAATCTCGGCAGGGTCTTCCGCCGTTGCAATATTTACCGACTCCGTATTCAAAATATTCAAACAGGT
ATAGAGCGACACCGTCTTACCCGAACCCGTCGGACCGGTTACCAGCACCATCCCGTAGGGACGGTGAATC
GCTTCCAACAACAATTTTTTCTGAAACGGCTCAAAACCGAGCTGGTCGATGTTCAAAGACGCGGCATCGG
AATTCAAAATCCGCATCACGACCTTTTCGCCAAACAGCGTCGGCAATGTGCTGACACGGAAATCGACAGG
CTTGCCGCCCTTTTGAAAGGTCAGCTGCATCCTGCCGTCCTGCGGTATCCGTTTTTCGGAAATGTCCAAA
CGCGACATTACCTTAATCCGGGAAGCAAGCTGCCCCCTTACCGCAATGGGCGGCTGAACCACCTCGCGGA
GCTGCCCGTCCACACGGAAACGGATACGGGCATTGTGTTCGTAAAACTCGAAATGGATGTCCGATGCCCC
GCTGCGCAAGGCATCCGACAAAGTCTTATGGATAAACCTCGGAACAGGGCCGTCTTCTGCCTCCTCGTTG
TCGATATACAGGGTGTGGCTTTCCTCTTCCTCCTGCCCCTCCCCAAGCTCCTGAAGCAGCGATGTCGAAC
GCGAACCCACCCAATCGAGCAAACCCGCCAACTGGTCATCCTCGACAATGACCAACTCAACCTCAATCCC
TGCGGCAGAAACGGTTTTCTGAATTTGCGGCATCTGTGTCGGATCGGAAACCGCAAAAAATACTTTGTCG
CCCCGACGGAAAACCGGCACACAGTGGAACTCCACCATCTGCTCCTCCGTCAACACCCCCATCAGCACCC
TGTGGCGCGGATAATGACGCAAATCAAGAATCGAATAACTGAACACCCTCGCAATCAATGCCGCAAGCGA
CTTGGGCGAAATGACACCGTCTGAAAACAGCATCGGCAACACTTCCTTACCCGCCTGCGACTCATTGTAG
TAATGCTCGGCCTGCTCAACAGTAACCACCTGGTTTTGAACCAGAATCCTCAGCAAACCTACGCTCA
Protein Sequence 
>gi|121635535|ref|YP_975780.1| type IV pilus assembly protein [Neisseria meningitidis FAM18] MSVGLLRILVQNQVVTVEQAEHYYNESQAGKEVLPMLFSDGVISPKSLAALIARVFSYSILDLRHYPRHRVLMGVLTEEQMVEFHCVPVFRRGDKVFFAVSDPTQMPQIQKTVSAAGIEVELVIVEDDQLAGLLDWVGSRSTSLLQELGEGQEEEESHTLYIDNEEAEDGPVPRFIHKTLSDALRSGASDIHFEFYEHNARIRFRVDGQLREVVQPPIAVRGQLASRIKVMSRLDISEKRIPQDGRMQLTFQKGGKPVDFRVSTLPTLFGEKVVMRILNSDAASLNIDQLGFEPFQKKLLLEAIHRPYGMVLVTGPTGSGKTVSLYTCLNILNTESVNIATAEDPAEINLPGINQVNVNDKQGLTFAAALKSFLRQDPDIIMVGEIRDLETADIAIKAAQTGHMVFSTLHTNNAPATLSRMLNMGVAPFNIASSVSLIMAQRLLRRLCSSCKQEVERPSASALKEVGFTDEDLAKDWKLYRAVGCDRCRGQGYKGRAGVYEVMPISEEMQRVIMNNGTEVDILDVAYKEGMVDLRRAGILKVMQGITSLEEVTANTND
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pilF mutant were unable to colonize human nasopharyngeal tissue in an organ culture model (Exley et al., 2009).
COG COG2804NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport
References
Exley et al., 2009: Exley RM, Sim R, Goodwin L, Winterbotham M, Schneider MC, Read RC, Tang CM. Identification of meningococcal genes necessary for colonization of human upper airway tissue. Infection and immunity. 2009; 77(1); 45-51. [PubMed: 18936183].