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purL from Neisseria meningitidis MC58

Victor ID 3024
Gene Name purL from Neisseria meningitidis MC58
Sequence Strain (Species/Organism) Neisseria meningitidis MC58
NCBI Gene ID 904131
NCBI Protein GI 15677824
Locus Tag NMB1996
Protein Accession NP_274988.1
Other Database IDs UniProtKB-ID: PUR4_NEIMB
UniRef100: UniRef100_Q9JXK5
UniRef90: UniRef90_Q5F7J4
UniRef50: UniRef50_Q47XX7
UniParc: UPI0000132A59
EMBL: AE002098
EMBL-CDS: AAF42323.1
RefSeq_NT: NC_003112.2
EnsemblGenome: EBNEIG00000010690
EnsemblGenome_TRS: EBNEIT00000010690
EnsemblGenome_PRO: EBNEIP00000010310
GenomeReviews: AE002098_GR
KEGG: nme:NMB1996
NMPDR: fig|122586.1.peg.1922
TIGR: NMB1996
HOGENOM: HBG335309
OMA: ERGIAYY
ProtClustDB: PRK05297
BioCyc: NMEN122586:NMB_1996-MONOMER
Taxonomy ID 122586
Gene Starting Position 2102031
Gene Ending Position 2105993
Gene Strand (Orientation) +
Protein Name phosphoribosylformylglycinamidine synthase
DNA Sequence 
>gi|77358697:2102031-2105993 Neisseria meningitidis MC58, complete genome
CATGTCTGTCGTTTTGCCCTTGCGCGGCGTTACCGCCCTTTCCGATTTCCGTGTTGAAAAACTCTTGCAA
AAAGCCGCCGCACTCGGTCTGCCCGAAGTCAAATTAAGCAGCGAATTTTGGTATTTCGTCGGCAGCGAGA
AAGCACTTGATGCCGCGACTGTCGAAAAACTGCAAGCCTTGTTGGCGGCGCAAAGCGTTGAACAAACGCC
AAAAGCGCGCGAGGGCTTGCATTTGTTTTTGGTCACGCCCCGTTTGGGTACGATTTCGCCGTGGGCTTCC
AAGGCGACCAATATCGCGGAAAACTGCGGTTTGGCAGGCATCGAACGCATCGAGCGCGGTATGGCGGTGT
GGCTGGAAGGTCGTCTGAACGATGAACAGAAACAGCAATGGGCGGCTTTGCTGCACGACCGCATGACCGA
AAGCGTGCTGCCCGATTTTCAGACGGCCTCCAAATTATTCCACCATCTCGAATCCGAAACTTTCTCCGGC
GTCGATGTTTTGGGCGGCGGTAAAGAAGCTTTGGTCAAAGCCAATACCGAAATGGGCTTGGCACTTTCCG
CCGACGAAATCGATTATCTGGTCGAAAACTATCAGGCTTTGCAGCGCAATCCGTCCGATGTTGAATTGAT
GATGTTCGCGCAGGCAAACAGCGAACACTGCCGCCACAAAATCTTCAACGCCGATTTCATCCTCAACGGC
GAAAAGCAGCCCAAATCCCTCTTCGGTATGATACGCGACACACACAACGCGCATCCCGAAGGCACGGTCG
TTGCCTATAAAGACAATTCGTCCGTAATCGAAGGCGCGAAAATCGAGCGTTTCTATCCGAATGCGGCGGA
AAACCAAGGCTACCGTTTCCACGAGGAAGACACGCATATCATCATGAAAGTGGAAACGCACAACCACCCG
ACCGCCATCGCGCCGTTTGCGGGTGCGGCGACGGGCGCGGGCGGCGAAATCCGCGACGAAGGCGCGACGG
GCAAAGGTTCGCGTCCGAAAGCGGGCCTGACCGGCTTTACCGTGTCCAACCTCAATATTCCCGACCTCAA
ACAGCCGTGGGAACAAGACTACGGCAAGCCGGAACATATTTCCTCGCCGCTGGACATCATGATTGAAGGC
CCGATCGGCGGCGCGGCGTTCAACAACGAATTCGGCCGCCCCAACCTCTTGGGCTACTTCCGCACTTTTG
AAGAAAAATTTGACGGTCAGGTTCGCGGCTATCACAAACCGATTATGATTGCCGGCGGCTTGGGCAGCAT
TCAGGCGCAGCAGACGCATAAAGACGAAATCCCCGAAGGCGCATTGCTGATCCAACTGGGCGGCCCGGGT
ATGCTTATCGGCTTGGGCGGCGGCGCGGCTTCTTCGATGGATACCGGCACAAACGACGCGTCTTTGGACT
TCAACTCCGTGCAACGCGGCAACCCCGAAATCGAACGCCGCGCGCAGGAAGTCATCGACCGCTGCTGGCA
GCTCGGCGGCAAAAACCCGATTATCTCCATCCACGACGTAGGCGCGGGCGGCCTGTCCAACGCCTTCCCC
GAACTGGTCAACGATGCCAGACGCGGCGCAGTATTCAAGCTGCGCGAAGTGCCGCTTGAAGAACACGGCC
TCAACCCGCTGCAAATCTGGTGCAACGAATCGCAAGAGCGTTATGTGTTGTCGATTTTGGAAAAAGATTT
GGATGCTTTCCGCGCCATCTGCGAACGCGAACGCTGCCCGTTTGCCGTAGTCGGCACGGCGACTGACGAC
GGTCATTTGAAAGTACGCGACGATTTGTTCGCCAACAATCCCGTCGATTTGCCGTTGAACGTCTTGCTCG
GCAAACTGCCCAAAACCACGCGCACCGACAAAACGGTTGCACCGTCCAAAAAACCGTTTCACGCGGGCGA
TATCGACATTACCGAAGCCGCCTACCGCGTTTTGCGCCTGCCTGCCGTAGCCGCCAAAAACTTCCTGATT
ACCATCGGCGACCGCAGCGTCGGCGGTTTGACGCACCGCGACCAAATGGTCGGCAAATATCAAACTCCAG
TAGCCGACTGCGCCGTTACCATGATGGGCTTCAACACCTATCGCGGTGAAGCGATGTCTATGGGCGAAAA
ACCGACCGTCGCCCTGTTTGATGCGCCTGCTTCGGGCAGAATGTGCGTCGGCGAAGCCATCACCAACATC
GCGGCGGTCAACATCGGAGACATCGGCAACATCAAACTCTCCGCCAACTGGATGGCGGCGTGCGGCAACG
AAGGCGAAGACGAAAAACTCTACCGCACTGTCGAAGCCGTTTCCAAAGCCTGTCAGGCATTGGATTTGAG
CATCCCCGTGGGCAAAGACAGCCTGTCGATGAAAACCGTTTGGCAGGACGGCGAGGAGAAAAAATCCGTG
GTTTCACCGTTGAGCCTGATTATCTCAGCGTTCGCGCCTGTGAAAGACGTACGCAAGACTGTTACGCCTG
AGTTGAAAAACGTCGAAGACAGCGTATTGTTGTTTGTCGATTTGGGCTTCGGCAAAGCGCGTATGGGCGG
TTCGGCGTTTGGTCAGGTGTACAACAATATGAGCGGCGACGCGCCCGATTTGGACGATACAGGTCGTCTG
AAAGCCTTTTACAGTGTGATTCAGCAGCTTGTTGCCGAAAACAAACTCTTGGCGTATCACGACCGCAGCG
ACGGCGGCTTGTTTGCCGTTTTGGTAGAAATGGCGTTTGCGGGGCGGTGCGGCTTGGATATAGATTTAAA
TTTATTGCTTGCACAAACATTTATTACCAACCATACCGCTCTGTCTCAATCATTGCGGACTGAAGAGGTA
AAAGCGTTGGCTGAATGGCAAGAAACCATTGCCCGCACATTATTTAATGAAGAGTTGGGTGCTGTTATCC
AAGTTAGAAAACAAGATGTTGCCGATATTATCAATTTATTCTATCAACAACAGCTGCATCATAATGTCTT
TGAAATCGGTACGTTAACTGATGAGAACACGTTAATCATCCGCGACGGGCAAACGCACCTTATTTCTGAC
AACCTAATCAAACTGCAACAAACCTGGCAAGAAACCAGCCATCAAATCCAACGCCTGCGCGACAACCCTG
CCTGCGCCGACAGCGAGTTCGCACTGATTGGCGACAACGAACGCAGCGCATTGTTTGCCGACGTGAAGTT
CGACGTGAACGAAGACATCGCCGCGCCGTTTATCAACAGCGGCGCGAAACCCAAAATCGCCATCCTGCGC
GAACAGGGCGTAAACGGGCAAATCGAAATGGCCGCCGCCTTTACCCGCGCCGGATTCGATGCTTACGACG
TGCATATGTCCGACCTGATGGCAGGCCGCATCCACCTCGCCGACTTCAAAATGCTGGCGGCGTGCGGCGG
CTTCAGCTACGGCGACGTACTCGGCGCGGGCGAAGGCTGGGCGAAATCGATTCTGTTCCACCCTGCTCTG
CGCGACCAGTTTGCCGCCTTCTTCGCCGACCCGGACACGCTGACATTGGGCGTGTGCAACGGCTGCCAAA
TGGTCAGCAACCTTGCCGAAATCATCCCCGGCACGGCAGGCTGGCCGAAGTTCAAACGCAACCTGAGCGA
ACAGTTTGAAGCACGCCTGAGCATGGTTCACGTTCCGAAATCAGCGTCGCTGATTCTGAACGAAATGCAA
GGCTCCAGCCTGCCTGTCGTGGTCAGCCACGGCGAAGGCCGCGCCGACTTCGCGCTTCACGGCGGCAATA
TTTCCGCCGATTTGGGCATTGCGCTGCAATACATCGACGGACAAAACCAAGTGACCCAAACTTATCCGCT
CAACCCCAACGGCTCGCCTCAAGGCATCGCCGGCGTTACTAACGCCGACGGCCGCATCACCATCATGATG
CCCCACCCCGAACGCGTGTACCGTGCCGCGCAAATGAGCTGGAAACCGGAAGGCTGGACGGAACTGTCCG
GCTGGTACCGCCTCTTTGCCGGCGCACGTAAAGCCTTGGGCTA
Protein Sequence 
>gi|15677824|ref|NP_274988.1| phosphoribosylformylglycinamidine synthase [Neisseria meningitidis MC58] MSVVLPLRGVTALSDFRVEKLLQKAAALGLPEVKLSSEFWYFVGSEKALDAATVEKLQALLAAQSVEQTPKAREGLHLFLVTPRLGTISPWASKATNIAENCGLAGIERIERGMAVWLEGRLNDEQKQQWAALLHDRMTESVLPDFQTASKLFHHLESETFSGVDVLGGGKEALVKANTEMGLALSADEIDYLVENYQALQRNPSDVELMMFAQANSEHCRHKIFNADFILNGEKQPKSLFGMIRDTHNAHPEGTVVAYKDNSSVIEGAKIERFYPNAAENQGYRFHEEDTHIIMKVETHNHPTAIAPFAGAATGAGGEIRDEGATGKGSRPKAGLTGFTVSNLNIPDLKQPWEQDYGKPEHISSPLDIMIEGPIGGAAFNNEFGRPNLLGYFRTFEEKFDGQVRGYHKPIMIAGGLGSIQAQQTHKDEIPEGALLIQLGGPGMLIGLGGGAASSMDTGTNDASLDFNSVQRGNPEIERRAQEVIDRCWQLGGKNPIISIHDVGAGGLSNAFPELVNDARRGAVFKLREVPLEEHGLNPLQIWCNESQERYVLSILEKDLDAFRAICERERCPFAVVGTATDDGHLKVRDDLFANNPVDLPLNVLLGKLPKTTRTDKTVAPSKKPFHAGDIDITEAAYRVLRLPAVAAKNFLITIGDRSVGGLTHRDQMVGKYQTPVADCAVTMMGFNTYRGEAMSMGEKPTVALFDAPASGRMCVGEAITNIAAVNIGDIGNIKLSANWMAACGNEGEDEKLYRTVEAVSKACQALDLSIPVGKDSLSMKTVWQDGEEKKSVVSPLSLIISAFAPVKDVRKTVTPELKNVEDSVLLFVDLGFGKARMGGSAFGQVYNNMSGDAPDLDDTGRLKAFYSVIQQLVAENKLLAYHDRSDGGLFAVLVEMAFAGRCGLDIDLNLLLAQTFITNHTALSQSLRTEEVKALAEWQETIARTLFNEELGAVIQVRKQDVADIINLFYQQQLHHNVFEIGTLTDENTLIIRDGQTHLISDNLIKLQQTWQETSHQIQRLRDNPACADSEFALIGDNERSALFADVKFDVNEDIAAPFINSGAKPKIAILREQGVNGQIEMAAAFTRAGFDAYDVHMSDLMAGRIHLADFKMLAACGGFSYGDVLGAGEGWAKSILFHPALRDQFAAFFADPDTLTLGVCNGCQMVSNLAEIIPGTAGWPKFKRNLSEQFEARLSMVHVPKSASLILNEMQGSSLPVVVSHGEGRADFALHGGNISADLGIALQYIDGQNQVTQTYPLNPNGSPQGIAGVTNADGRITIMMPHPERVYRAAQMSWKPEGWTELSGWYRLFAGARKALG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purL mutant is attenuated in rats (Sun et al., 2000).
COG COG0046F, under F: Nucleotide transport and metabolism
References
Sun et al., 2000: Sun YH, Bakshi S, Chalmers R, Tang CM. Functional genomics of Neisseria meningitidis pathogenesis. Nature medicine. 2000; 6(11); 1269-1273. [PubMed: 11062540].