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purL from Neisseria meningitidis FAM18

Victor ID 2943
Gene Name purL from Neisseria meningitidis FAM18
Sequence Strain (Species/Organism) Neisseria meningitidis FAM18
NCBI Gene ID 4676582
NCBI Protein GI 121635654
Locus Tag NMC1972
Protein Accession YP_975899.1
Other Database IDs UniProtKB-ID: A1KW75_NEIMF
UniRef100: UniRef100_A1KW75
UniRef90: UniRef90_Q5F7J4
UniRef50: UniRef50_Q47XX7
UniParc: UPI0000ECF96C
EMBL: AM421808
EMBL-CDS: CAM11131.1
RefSeq_NT: NC_008767.1
EnsemblGenome: EBNEIG00000008124.
EnsemblGenome_TRS: EBNEIT00000008124
EnsemblGenome_PRO: EBNEIP00000007893
GenomeReviews: AM421808_GR
KEGG: nmc:NMC1972
NMPDR: fig|487.2.peg.1459
eggNOG: COG0046
HOGENOM: HBG335309
OMA: ERGIAYY
ProtClustDB: PRK05297
BioCyc: NMEN272831:NMC1972-MONOMER
Taxonomy ID 272831
Gene Starting Position 2010139
Gene Ending Position 2014116
Gene Strand (Orientation) +
Protein Name phosphoribosylformylglycinamidine synthase
DNA Sequence 
>gi|121633901:2010139-2014116 Neisseria meningitidis FAM18, complete genome
TTTGAGAGCCGAATCCATGTCTGTCGTTTTGCCCTTGCGCGGCGTTACCGCCCTTTCCGATTTCCGTGTC
GAAAAACTCTTGCAAAAAGCCGCCGCACTCGGACTGCCCGAAGTCAAATTAAGCAGCGAATTTTGGTATT
TCGCCGGCAGCGAGAAAGCATTGGATGCCGCGACTGTCGAAAAACTGCAAGCCTTGTTGGCGGCGCAAAG
CGTTGAACAAACGCCAAAAGCGCGCGAGGGCTTGCATTTGTTTTTGGTAACGCCCCGTTTGGGTACGATT
TCGCCGTGGGCTTCCAAGGCGACCAATATCGCGGAAAACTGCGGTTTGGCAGGCATCGAGCGCATCGAGC
GCGGCATGGCGGTGTGGCTGGAAGGTGCGCTTACCGATGAACAGAAACAGCAATGGGCGGCGTTGCTGCA
CGACCGCATGACCGAATCCGTGCTGCCCGATTTTCAGACGGCATCCAAATTATTCCACCATCTCGAATCC
GAAACCTTTTCCACCGTTGATGTTTTAGGCGGCGGTAAAGAGGCTTTGGTCAAAGCCAATACCGAAATGG
GTTTGGCACTCTCCGCCGACGAAATCGATTATCTGGTTGAAAACTATCAGGCTTTGCAACGCAATCCGTC
CGATGTGGAGCTGATGATGTTCGCGCAGGCAAACAGCGAACACTGCCGCCACAAAATCTTCAACGCCGAC
TTCATCCTCAACGGCGAAAAACAACCGAAATCCCTTTTCGGCATGATACGCGACACGCACAACGCGCATC
CCGAAGGCACGGTCGTCGCTTATAAAGACAATTCGTCCGTGATCGAAGGCGCGAAAATCGAGCGTTTCTA
TCCGAATGCGGCGGAAAACCAAGGCTACCGTTTCCACGAGGAAGACACGCATATCATCATGAAAGTGGAA
ACGCACAACCACCCGACCGCCATCGCGCCGTTTGCAGGCGCGGCAACGGGCGCGGGCGGCGAAATCCGCG
ACGAAGGCGCAACGGGCAAAGGTTCGCGTCCGAAAGCAGGCTTGACCGGCTTTACCGTGTCCAACCTCAA
CATCCCCGGCCTCAAACAGCCGTGGGAACAAGATTACGGCAAGCCGGAACATATTTCCTCGCCGCTGGAC
ATCATGATTGAAGGCCCGATCGGCGGCGCGGCGTTCAACAACGAATTCGGCCGCCCCAACCTCTTGGGCT
ACTTCCGCACTTTTGAAGAAAAATTTGACGGTCAGGTTCGCGGCTACCACAAACCGATTATGATTGCCGG
CGGCTTGGGCAGCATTCAGGCGCAGCAGACGCATAAAGACGAAATCCCCGAAGGCGCGTTGCTGATCCAA
CTGGGCGGCCCGGGCATGCTTATCGGCTTGGGCGGCGGCGCGGCTTCTTCGATGGATACCGGCACGAACG
ACGCTTCTTTAGACTTCAACTCCGTACAACGCGGCAACCCCGAAATCGAACGCCGCGCGCAGGAAGTCAT
CGACCGCTGCTGGCAGCTCGGCGACAAAAACCCGATTATCTCCATCCACGACGTGGGCGCAGGAGGTTTG
TCCAACGCCTTCCCCGAACTGGTCAACGATGCCGGACGCGGCGCGGTATTCGAGCTGCGCGAAGTGCCGT
TGGAAGAACACGGTTTAACGCCTTTGCAAATCTGGTGCAACGAATCGCAAGAGCGTTATGTGTTGTCGAT
TTTGGAAAAAGATTTGGATACCTTCCGCGCCATCTGCGAACGCGAACGCTGCCCGTTTGCCGTGGTCGGT
ACAGCGACCGACGACGGTCATTTGAAAGTGCGCGACGATTTGTTCGCCAACAACCCCATCGATTTGCCGT
TGAACGTCTTGCTCGGCAAACCGCCCAAAACCACGCGTACCGACAAAACAGTTACGCCATCTAAAAAACC
GTTTCACGCCGACGATATCGACATCACCGAAGCCGCCTACCGCGTTTTGCACCTGCCTGCCGTAGCCGCC
AAAAACTTCCTGATTACCATCGGCGACCGCAGCGTCGGCGGCATGACCCACCGCGACCAAATGGTCGGCA
AATACCAAACCCCCGTAGCCGACTGCGCCGTTACCATGATGGGCTTCAATACCTATCGCGGCGAAGCAAT
GTCTATGGGCGAAAAACCGACCGTCGCCCTGTTTGACGCGCCTGCTTCGGGCAGAATGTGCGTCGGCGAA
GCCATCACCAACATCGCGGCGGTCAACATCGGCGACATCGGCAACATCAAGCTCTCCGCCAACTGGATGG
CGGCGTGCGGCAACGAAGGCGAAGACGAAAAACTCTACCGCACCGTCGAAGCGGTTTCCAAAGCCTGTCA
GGCATTGGATTTGAGCATTCCCGTGGGCAAAGACAGCCTGTCGATGAAAACCGTATGGCAGGATGGCGAA
GAGAAAAAATCCGTCGTTTCGCCGTTGAGCCTGATTATCTCCGCGTTCGCGCCGGTTCAAGACGTACGCA
AAACCGTTACGCCCGAATTGAAAAACGTCGAGGACAGCGTATTGCTGTTTGTCGATTTGGGCTTCGGCAA
AGCGCGTATGGGCGGCTCTGCATTCGGTCAGGTATACAACAACATGAGCGGCGACGCGCCCGATTTGGAC
GACACAGGCCGTCTGAAAGCGTTTTACAACGTGATTCAACAGCTTGTCGCCGAAGACAAACTCTTGGCAT
ACCACGACCGCAGCGACGGCGGCTTGTTTGCCGTTTTGGTAGAAATGGCGTTTGCAGGGCGGTGCGGCTT
GGATATAGATTTAAATTTATTGCTTGCACAAACATTTATTACCAACCATACCGCTCTGTCTCAATCATTG
CGGACTGAAGAGGTAAAAGCGTTGGCTGAATGGCAAGAAACCATTGCCCGCACATTATTTAATGAAGAGT
TGGGTGCTGTTATCCAAGTTAGAAAACAAGATGTTGCCGATATTATCAATTTATTCTATCAACAACAGCT
GCATCATAATGTCTTTGAAATCGGTACGTTAACTGATGAGAACACGTTAATCATCCGCGACGGGCAAACG
CACCTTATTTCTGACAACCTAATCAAACTGCAACAAACCTGGCAAGAAACCAGCCATCAAATCCAACGCC
TGCGCGACAACCCTGCCTGCGCCGACAGCGAGTTTGCCCTGATTGGCGACAACGACCGCAGCGCATTGTT
TGCCAACCTGAAATTCGACGTGAACGAAGACATCGCCGCGCCGTTTATCAACAGCGGCGCGAAACCCAAA
ATCGCCATCCTGCGCGAACAGGGCGTGAACGGGCAAATCGAAATGGCCGCCGCCTTCACCCGCGCCGGAT
TCGATGCTTACGACGTGCATATGTCCGACCTGATGGCAGGCCGCTTCCGCCTTGCCGACTTCAAAATGCT
GGCGGCGTGCGGCGGCTTCAGCTACGGCGACGTACTCGGCGCGGGCGAAGGCTGGGCGAAATCCATCCTG
TTCCACCCTGCCTTGCGCGACCAATTTGCCGCCTTCTTTGCCGATCCGGACACGCTGACATTGGGCGTGT
GCAACGGCTGCCAGATGGTCAGCAACCTCGCCGAGATTATCCCGGGTGCAGAGGCATGGCCTAAATTCAA
ACGCAACCTGAGCGAACAGTTTGAAGCACGCCTGAGCATGGTTCACGTTCCGAAATCAGCGTCGCTGATT
CTGAACGAAATGCAAGGCTCCAGCCTGCCTGTCGTGGTCAGCCACGGCGAAGGCCGCGCCGACTTCGCGC
TTCACGGCGGCAATATTTCCGCCGATTTGGGCATCGCGCTGCAATATGTGGACGGTCAAAACCAAGTGAC
CCAAACCTACCCGCTCAACCCCAACGGCTCGCCGCAAGGCATCGCCGGCGTTACCAACGCCGACGGCCGC
GTGACCATCATGATGCCGCATCCGGAACGCGTGTACCGTGCCGCACAAATGAGCTGGAAACCAGAAGACT
GGACGGAATTGTCCGGCTGGTACCGCCTCTTTGCCGGCGCACGTAAAGCCTTGGGCTA
Protein Sequence 
>gi|121635654|ref|YP_975899.1| phosphoribosylformylglycinamidine synthase [Neisseria meningitidis FAM18] MRAESMSVVLPLRGVTALSDFRVEKLLQKAAALGLPEVKLSSEFWYFAGSEKALDAATVEKLQALLAAQSVEQTPKAREGLHLFLVTPRLGTISPWASKATNIAENCGLAGIERIERGMAVWLEGALTDEQKQQWAALLHDRMTESVLPDFQTASKLFHHLESETFSTVDVLGGGKEALVKANTEMGLALSADEIDYLVENYQALQRNPSDVELMMFAQANSEHCRHKIFNADFILNGEKQPKSLFGMIRDTHNAHPEGTVVAYKDNSSVIEGAKIERFYPNAAENQGYRFHEEDTHIIMKVETHNHPTAIAPFAGAATGAGGEIRDEGATGKGSRPKAGLTGFTVSNLNIPGLKQPWEQDYGKPEHISSPLDIMIEGPIGGAAFNNEFGRPNLLGYFRTFEEKFDGQVRGYHKPIMIAGGLGSIQAQQTHKDEIPEGALLIQLGGPGMLIGLGGGAASSMDTGTNDASLDFNSVQRGNPEIERRAQEVIDRCWQLGDKNPIISIHDVGAGGLSNAFPELVNDAGRGAVFELREVPLEEHGLTPLQIWCNESQERYVLSILEKDLDTFRAICERERCPFAVVGTATDDGHLKVRDDLFANNPIDLPLNVLLGKPPKTTRTDKTVTPSKKPFHADDIDITEAAYRVLHLPAVAAKNFLITIGDRSVGGMTHRDQMVGKYQTPVADCAVTMMGFNTYRGEAMSMGEKPTVALFDAPASGRMCVGEAITNIAAVNIGDIGNIKLSANWMAACGNEGEDEKLYRTVEAVSKACQALDLSIPVGKDSLSMKTVWQDGEEKKSVVSPLSLIISAFAPVQDVRKTVTPELKNVEDSVLLFVDLGFGKARMGGSAFGQVYNNMSGDAPDLDDTGRLKAFYNVIQQLVAEDKLLAYHDRSDGGLFAVLVEMAFAGRCGLDIDLNLLLAQTFITNHTALSQSLRTEEVKALAEWQETIARTLFNEELGAVIQVRKQDVADIINLFYQQQLHHNVFEIGTLTDENTLIIRDGQTHLISDNLIKLQQTWQETSHQIQRLRDNPACADSEFALIGDNDRSALFANLKFDVNEDIAAPFINSGAKPKIAILREQGVNGQIEMAAAFTRAGFDAYDVHMSDLMAGRFRLADFKMLAACGGFSYGDVLGAGEGWAKSILFHPALRDQFAAFFADPDTLTLGVCNGCQMVSNLAEIIPGAEAWPKFKRNLSEQFEARLSMVHVPKSASLILNEMQGSSLPVVVSHGEGRADFALHGGNISADLGIALQYVDGQNQVTQTYPLNPNGSPQGIAGVTNADGRVTIMMPHPERVYRAAQMSWKPEDWTELSGWYRLFAGARKALG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purL mutant is attenuated in rats (Sun et al., 2000).
COG COG0046F, under F: Nucleotide transport and metabolism
References
Sun et al., 2000: Sun YH, Bakshi S, Chalmers R, Tang CM. Functional genomics of Neisseria meningitidis pathogenesis. Nature medicine. 2000; 6(11); 1269-1273. [PubMed: 11062540].