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pilQ from Neisseria meningitidis Z2491

Victor ID 2956
Gene Name pilQ from Neisseria meningitidis Z2491
Sequence Strain (Species/Organism) Neisseria meningitidis Z2491
NCBI Gene ID 906644
NCBI Protein GI 15793635
Locus Tag NMA0650
Protein Accession NP_283457.1
Other Database IDs UniProtKB-ID: PILQ_NEIMA
UniRef100: UniRef100_Q9JVW4
UniRef90: UniRef90_Q70M91
UniRef50: UniRef50_Q5FAD2
UniParc: UPI00000C4A06
EMBL: AL157959
EMBL-CDS: CAM07913.1
RefSeq_NT: NC_003116.1
EnsemblGenome: EBNEIG00000001408
EnsemblGenome_TRS: EBNEIT00000001408
EnsemblGenome_PRO: EBNEIP00000001408
GenomeReviews: AL157959_GR
KEGG: nma:NMA0650
HOGENOM: HBG482665
OMA: QNVPWDQ
ProtClustDB: CLSK878435
BioCyc: NMEN122587:NMA0650-MONOMER
Taxonomy ID 122587
Gene Starting Position 635587
Gene Ending Position 637872
Gene Strand (Orientation) -
Protein Name pilus secretin
DNA Sequence 
>gi|15793034:635587-637872 Neisseria meningitidis Z2491, complete genome
ATCAATAGCGCAGGCTGTTGCCGGCCGTACCCATAATCCTCGGGGTAATGAAAATCAGCAGTTCGCGGCG
GTCGGTTTTTTTCCCGCGTGTTTTAAAGAGGTTGCCGATAACGGGGATGTCGCCCAACAGGGGGACTTTG
GTCAGCGTATTGCCGTTGTCTTCTTCATAAATACCGCCGACAATCAATGTGCCGCCGTTTTCAACCATAG
CCTGCGTATTCAGGTTTTTGGTCGAAATACACAGGATCGTCTGATTACCGGAGGCACATTGCGCAGGCGA
GTCCTTGTTGATTTTGACGGTCATAATGATTTGGCCGTCGGGCGTGATGTTCGGCGTAACGGTCAGCCCC
AAGACGGCTTTTTTGAGTTCCGTGTTCGTGCTGCTGCCGCCGTTCGCGATTGAGGTTACGGTGAAAGGAA
TTTCGTAACCGGATTCGATTTTGGCCTCTTTGCGGTTTTGGGTCAGCACGCGCGGATTGGCAAGCGTTTT
GGTTTTTGAAAGCGATTCGGATGCGGACAATTCCAAATTCAAGGCACCGGAGGAAATCGCGCGCACCAGC
GAAATGCTGTTTGCGGCAGCGGTAATCGGCAGGTTGATTTTGGTTTCGGCCCCCCATTTATCGTCGCCGC
CGAAGCCGGAGTTTACCCCCCAGCCGAATGCGCTTGTATCATTTTTCAGCTTTTTCTTGCCTGTCGCGCC
GAATTTAACGCCCAAATCGCGCGAGAAGCCGTCTGCCGCTTCGACGATACGCGCCTCAATCATCACTTGT
TGCGCGGGTACGTCCAATTCGTCAATCAGTTTGCGGAATTTTTCGATGACGCTGCGGGTATCGGTAACAA
TCAGGGTATTGGTGGCGGGATCGATCAGCACGCTGCCCCTGCCGCTGACAAGCGTATTGCGGTTTCCGGT
CGTGTCGGCATTGTCCAAACGCAGGATGCTGCGGAATTCTTCCACATTTTTGTATTTCAATTGGAAGTTT
TGTGAATACAGCGCGCCCAGATCGGCAATGTCTTTTTCCGCCTGTAAGAAGGCTTTGTCTTTGGCAAGCA
GCTCGTCGCGGGGCGCGATGTTGACGATGTTCCCTTGTTGGCGCATATCGAGGTTGCGTGCCTGCATAAC
CAAATCCAAAGCCTGATCCCAAGGTACGTCTTTGAGGGAGAGGGTCATTTTGCCGTTGACGGAGTCGCTG
GCAACAATGTTCATCCCGGATTCTTTTGCCAAAATCTGCAGGATGGTGCGGATTTCGACATCTTGGAAGT
CAAGGGAGATTTTCCGGCCTGTGAAGGTTTTGGGCGCATTGTTCACGCCGCCTGACTCGAGGTTTTGTTT
TTTCGGCAGGACTTGGAAGGTAAAGTATCCGGGCGCGGCGGATTTGTTGACGAGTTCCCAGTTGCCGGCT
GTTGTGATAATCAGCTGGGTGTCGTTATTGAGGCGTTTCAGCGTAACCTTTTGAACCGGTGTTTTAAAGT
CTGCCACATCCAAACTGCGTTGGAGCGTGGTCGGCAGGGTATGGTTTTTCAGCGTAACGATGATGTGGTC
GTGCTGTTGGCTGATGTCGGGCTGCCCGGCAAAGCCCAATGCAGCCAATTCGATAATGCCGGCATTTTTG
CCGTCTTTGCGGAAATCGATATTGGTTTGTTTTGCTGGTGTTGCCGCCTGTTGTTTTGCTGGTGCTGCCG
TCTGTTGTTTTGCTGATGCCGCCGCCTGTTGTTTTGCCGGGCTGAACGGTGCGGATACGGATACTACGGA
CTCGGTAAACGGTGCGGCAGCCTGTTGTTTTGCCGGGGTAAAGGGTTTGGATACGGATACTGCGGACTTG
GTAGACGGTGCGGCAGCCTGTTGTTTTGCCGGTGCGGCAGGCGCGGCTTTTACGGCGGGGCGTGCGGGGG
CGGACACGGTATCGTCCGATTCGTTAATGAATATCCAAACTTTGTTCCCGCGTACTTCGGTATTGTATTG
GCCCGGTTTGTTCAGATTCAGAACCAGACGCGCACGGCTGCTGTTTTGTGCGGCACTGATTTTGCTCAAC
AGGGGATCGGCATATTCGAGTACCTGTTGATCCATGGAAATGCCGGTTTGTTCAAAGTCCAAGGCGATGC
GGGCCGGTGAGGAGGTTACGAAGCCGGTCGGGTTGACAATCTCTTTGTCAAAGCTGACTTTGACGATTTT
CTGTTTGTTGGGCAGGGAGGAAACTTTGATGTCTGTAATGTTTCCTGCCGATGCTGTCTGAAAGGCGGCG
GTTGCGACAAAGAGACCGGAAATGATTTTTGTCAGTTTGGTATTCA
Protein Sequence 
>gi|218767605|ref|YP_002342117.1| pilus secretin [Neisseria meningitidis Z2491] MNTKLTKIISGLFVATAAFQTASAGNITDIKVSSLPNKQKIVKVSFDKEIVNPTGFVTSSPARIALDFEQTGISMDQQVLEYADPLLSKISAAQNSSRARLVLNLNKPGQYNTEVRGNKVWIFINESDDTVSAPARPAVKAAPAAPAKQQAAAPSTKSAVSVSKPFTPAKQQAAAPFTESVVSVSAPFSPAKQQAAASAKQQTAAPAKQQAATPAKQTNIDFRKDGKNAGIIELAALGFAGQPDISQQHDHIIVTLKNHTLPTTLQRSLDVADFKTPVQKVTLKRLNNDTQLIITTAGNWELVNKSAAPGYFTFQVLPKKQNLESGGVNNAPKTFTGRKISLDFQDVEIRTILQILAKESGMNIVASDSVNGKMTLSLKDVPWDQALDLVMQARNLDMRQQGNIVNIAPRDELLAKDKAFLQAEKDIADLGALYSQNFQLKYKNVEEFRSILRLDNADTTGNRNTLVSGRGSVLIDPATNTLIVTDTRSVIEKFRKLIDELDVPAQQVMIEARIVEAADGFSRDLGVKFGATGKKKLKNDTSAFGWGVNSGFGGDDKWGAETKINLPITAAANSISLVRAISSGALNLELSASESLSKTKTLANPRVLTQNRKEAKIESGYEIPFTVTSIANGGSSTNTELKKAVLGLTVTPNITPDGQIIMTVKINKDSPAQCASGNQTILCISTKNLNTQAMVENGGTLIVGGIYEEDNGNTLTKVPLLGDIPVIGNLFKTRGKKTDRRELLIFITPRIMGTAGNSLRY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pilQ mutant were unable to colonize human nasopharyngeal tissue in an organ culture model (Exley et al., 2009).
References
Exley et al., 2009: Exley RM, Sim R, Goodwin L, Winterbotham M, Schneider MC, Read RC, Tang CM. Identification of meningococcal genes necessary for colonization of human upper airway tissue. Infection and immunity. 2009; 77(1); 45-51. [PubMed: 18936183].