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rfaD

Victor ID 2998
Gene Name rfaD
Sequence Strain (Species/Organism) Neisseria meningitidis MC58
NCBI Gene ID 902942
NCBI Protein GI 15676725
Locus Tag NMB0828
Protein Accession NP_273870.1
Other Database IDs UniProtKB-ID: HLDD_NEIMB
UniRef100: UniRef100_Q9K002
UniRef90: UniRef90_Q5F9J0
UniRef50: UniRef50_Q5F9J0
UniParc: UPI00000C4598
EMBL: AE002098
EMBL-CDS: AAF41240.1
RefSeq_NT: NC_003112.2
EnsemblGenome: EBNEIG00000010197
EnsemblGenome_TRS: EBNEIT00000010197
EnsemblGenome_PRO: EBNEIP00000009817
GenomeReviews: AE002098_GR
KEGG: nme:NMB0828
NMPDR: fig|122586.1.peg.804
TIGR: NMB0828
HOGENOM: HBG755066
OMA: DWCQDER
ProtClustDB: CLSK877767
BioCyc: NMEN122586:NMB_0828-MONOMER
Taxonomy ID 122586
Gene Starting Position 851288
Gene Ending Position 852292
Gene Strand (Orientation) +
Protein Name ADP-L-glycero-D-mannoheptose-6-epimerase
DNA Sequence 
>gi|77358697:851288-852292 Neisseria meningitidis MC58, complete genome
TATGACCATCATCGTAACAGGCGCGGCCGGCTTTATCGGCAGCAACATCGTCAAAGCACTTAATCAACGC
GGTATTACTGACATTGTTGCCGTCGATAATTTGAGCAAAGGCGAAAAATTCAAAAACCTTGCCGAGTGCG
AAATCGCCCATTATCTCGACAAACACGAATTCATCCGCCAAGTGAGGGAACACATTTTACCTTATCAAAA
CATCGAAGCCGTTTTCCATCAAGGCGCGTGTTCCGATACGATGAACCACGACGGTTTGTATATGATGGAC
AACAACTACCAGTACACGCTGGATTTGCTGGACTGGTGTCAGGACGAACGCATCCCCTTCCTTTATGCCT
CCAGTGCGGCGGTTTACGGCAAAGGAGAAATCTTCCGCGAAGAGCGCGAACTCGAAAAACCGCTCAACGT
GTACGGCTACTCCAAATTCCTGTTCGACCAAGTATTGCGTCGCCGCATGAAAGAAGGTCTCACCGCCCAA
GTCGTCGGCTTCCGCTACTTCAATGTTTACGGACAACACGAACAACACAAAGGCCGCATGGCATCCGTCG
CCTTCCACCACTTCCACCAATACCGCGAACACGGTTACGTCAACCTGTTCGGCAGTAACGACGGCTACGG
CAACGGCGAACAAACCCGCGACTTCGTCAGCGTCGAAGACGTTGCCAAAGTCAACCTCTACTTCTTCGAC
CATCCCGAACTTTCCGGCATCTACAACCTCGGTACCGGCCGCAGCCAACAGTTCAACGAACTCGCCGCCG
CCACCGTCAACGCATGCCGCGCCGCCGAAGGCAAACCTGAAATGAGCTTGAAAGAGTTGGTAGAAGAAGA
ACTTATCCGCTACATTCCCTTCCCCGACGCGCTCAAAGGCAAATACCAAAGCTTCACCCAAGCCGACATC
ACCAAATTGCGCGAAGCCGGATATAAGGAAGAATTTTTCGATGTCAAATCAGGCGTCGACCGCTACGTCA
AATGGATGCTGGAAAATTTGGCTTA
Protein Sequence 
>gi|15676725|ref|NP_273870.1| ADP-L-glycero-D-manno-heptose-6-epimerase [Neisseria meningitidis MC58] MTIIVTGAAGFIGSNIVKALNQRGITDIVAVDNLSKGEKFKNLAECEIAHYLDKHEFIRQVREHILPYQNIEAVFHQGACSDTMNHDGLYMMDNNYQYTLDLLDWCQDERIPFLYASSAAVYGKGEIFREERELEKPLNVYGYSKFLFDQVLRRRMKEGLTAQVVGFRYFNVYGQHEQHKGRMASVAFHHFHQYREHGYVNLFGSNDGYGNGEQTRDFVSVEDVAKVNLYFFDHPELSGIYNLGTGRSQQFNELAAATVNACRAAEGKPEMSLKELVEEELIRYIPFPDALKGKYQSFTQADITKLREAGYKEEFFDVKSGVDRYVKWMLENLA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: rfaD mutant is attenuated in mice (Zarantonelli et al., 2006).
COG COG0451MG, under M: Cell wall/membrane/envelope biogenesis; G: Carbohydrate transport and metabolism
References
Zarantonelli et al., 2006: Zarantonelli ML, Huerre M, Taha MK, Alonso JM. Differential role of lipooligosaccharide of Neisseria meningitidis in virulence and inflammatory response during respiratory infection in mice. Infection and immunity. 2006; 74(10); 5506-5512. [PubMed: 16988225].