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ilvI from Neisseria meningitidis FAM18

Victor ID 2940
Gene Name ilvI from Neisseria meningitidis FAM18
Sequence Strain (Species/Organism) Neisseria meningitidis FAM18
NCBI Gene ID 4676427
NCBI Protein GI 121635234
Locus Tag NMC1497
Protein Accession YP_975479.1
Other Database IDs UniProtKB-ID: A1KV01_NEIMF
UniRef100: UniRef100_A1KV01
UniRef90: UniRef90_B4RJ12
UniRef50: UniRef50_Q89AP7
UniParc: UPI0000ECF5A5
EMBL: AM421808
EMBL-CDS: CAM10700.1
RefSeq_NT: NC_008767.1
EnsemblGenome: EBNEIG00000007542.
EnsemblGenome_TRS: EBNEIT00000007542
EnsemblGenome_PRO: EBNEIP00000007311
GenomeReviews: AM421808_GR
KEGG: nmc:NMC1497
eggNOG: COG0028
HOGENOM: HBG323037
OMA: ANLAMQN
ProtClustDB: CLSK878135
BioCyc: NMEN272831:NMC1497-MONOMER
Taxonomy ID 272831
Gene Starting Position 1515408
Gene Ending Position 1517135
Gene Strand (Orientation) -
Protein Name acetolactate synthase isozyme III large subunit
DNA Sequence 
>gi|121633901:1515408-1517135 Neisseria meningitidis FAM18, complete genome
CTTACGCCTTTTCGTCCGCACGCATATGCGGCGGAAGTACCATTTCGTCCAAACCTTTGCCGTTGCCGAC
CATGGGCATCACATTCTGTTTCTGGTCGGTCAGGAAGTCGATAAACACCAGCCTGTCTTTTTGGTTCAAT
GCTTCCAACAACGCACCTTCCACATCAGACTTCTTGTCCACGCGGATACCGATATGGCCGTATGCCTCGG
CAAGTTTGACGAAATCGGGCAAAGAATCGAAATAAGTTTCCGACTCTCGGCCGCCGTAATATATTTCCTG
CCACTGGCGTACCATACCGAGATAACCGTTGTTCAGCGTAATGACGTTAACCGGAATCCGATATTGGAAA
CAGGTGGACAACTCTTGGATGTTCATCTGAATCGAGCCGTCGCCGGTAATACAGAATACGTCTTGATCCG
GGGCGGCAAGTTTTGCACCAATCGCATAAGGCAGACCCACGCCCATCGTACCCAAACCGCCGGAATTGAG
CCATTGGCGCGGACGTTCGAAGGGATAATATTGAGCCGCAAACATTTGATGCTGCCCTACATCCGATGTG
ATGATTGCCGAATTGCCGGTAATCTCGGCAAGCTTCTGAATCACATATTGTGGCTTGATAATTTCGCTGC
CGTTGTCAAACCACAAGCAATCTTGGGAACGCCATTCCTCTATGGTTTTCCACCATTTGCCCAAAGCATC
TTCAGACGGCATGAACTCTTGTTTTTGCCACAGCGCAACCATCTCAGACAAAACATTTTTCACGTCGCCG
ACAATCGGAATGTCCACCTTCACGCGTTTGGCGATGCTGGAAGGATCGACATCGATATGGATAACCTTCT
TCGCCTTCTCGAAAAATTTGGACGGTACGGAAACCACACGGTCGTCAAAACGCGCACCTACGGCAAGAAC
GACATCCGCATTCTGCATGGCAAGGTTTGCCTCGTAAGTACCGTGCATACCGAGCATACCGAGGAATTGG
CGGTCGCCGGAAGGATAAGCGCCCAAGCCCATCAGCGTACCCGTGCACGGAGCACCCGTCATTCGGACAA
ATCGGGTCAGCTCTTCAGAAGCATTACCCAACACCACGCCGCCGCCAAAATAGACGACCGGACGTTTGGC
AGATGCCAACATCTGCACGGCCTTTTTAATCTGACCGATATGCCCTTGAACAACCGGTTGATACGAACGG
ATAAAAATGTCTTCCTGAGGATAGCTGAATTTCGCCATCGCCTGCGTAACATCTTTCGGGACATCAACCA
CCACGGGCCCCGGTCGGCCGCTTGCGGCAATTTGGAACGCCTTTTTAATGGTTTCCGCCAACTCATTGAT
GTCCGTAACCAGGAAATTGTGTTTGACGCACGGACGGGTAATACCCACCGTATCAACTTCTTGGAACGCA
TCCGTACCAATCAGGGAATTGCCTACCTGCCCGCTGATGACCACCATCGGAATCGAATCCGTATAGGCAG
TAGCAATACCGGTCAGTGCATTGGTAACGCCCGGGCCGGATGTAACCAATGCCACGCCCACCTTACCGCT
GACGCGCGCATACGCATCTGCCGCGTGTACTGCCGCCTGCTCGTGACGGGTCAGAATGTGCTTGAATTTA
TTGAGTTGGAAAAGGGCATCGTAGATTTCGATAACCGCACCGCCGGGATAACCGAAAACGTACTCGACAC
CTTCGGCTTTGAGACTCTGCACTATGATTTGCGCGCCTGATAACTGCA
Protein Sequence 
>gi|121635234|ref|YP_975479.1| acetolactate synthase isozyme III large subunit [Neisseria meningitidis FAM18] MQLSGAQIIVQSLKAEGVEYVFGYPGGAVIEIYDALFQLNKFKHILTRHEQAAVHAADAYARVSGKVGVALVTSGPGVTNALTGIATAYTDSIPMVVISGQVGNSLIGTDAFQEVDTVGITRPCVKHNFLVTDINELAETIKKAFQIAASGRPGPVVVDVPKDVTQAMAKFSYPQEDIFIRSYQPVVQGHIGQIKKAVQMLASAKRPVVYFGGGVVLGNASEELTRFVRMTGAPCTGTLMGLGAYPSGDRQFLGMLGMHGTYEANLAMQNADVVLAVGARFDDRVVSVPSKFFEKAKKVIHIDVDPSSIAKRVKVDIPIVGDVKNVLSEMVALWQKQEFMPSEDALGKWWKTIEEWRSQDCLWFDNGSEIIKPQYVIQKLAEITGNSAIITSDVGQHQMFAAQYYPFERPRQWLNSGGLGTMGVGLPYAIGAKLAAPDQDVFCITGDGSIQMNIQELSTCFQYRIPVNVITLNNGYLGMVRQWQEIYYGGRESETYFDSLPDFVKLAEAYGHIGIRVDKKSDVEGALLEALNQKDRLVFIDFLTDQKQNVMPMVGNGKGLDEMVLPPHMRADEKA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ilvI mutant is attenuated in rats (Sun et al., 2000).
COG COG0028EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Sun et al., 2000: Sun YH, Bakshi S, Chalmers R, Tang CM. Functional genomics of Neisseria meningitidis pathogenesis. Nature medicine. 2000; 6(11); 1269-1273. [PubMed: 11062540].