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pilQ from Neisseria meningitidis FAM18

Victor ID 2928
Gene Name pilQ from Neisseria meningitidis FAM18
Sequence Strain (Species/Organism) Neisseria meningitidis FAM18
NCBI Gene ID 4675619
NCBI Protein GI 121634273
Locus Tag NMC0408
Protein Accession YP_974518.1
Other Database IDs UniProtKB-ID: A1KS86_NEIMF
UniRef100: UniRef100_A1KS86
UniRef90: UniRef90_A1KS86
UniRef50: UniRef50_Q5FAD2
UniParc: UPI0000ECF5DA
EMBL: AM421808
EMBL-CDS: CAM09716.1
RefSeq_NT: NC_008767.1
EnsemblGenome: EBNEIG00000008168.
EnsemblGenome_TRS: EBNEIT00000008168
EnsemblGenome_PRO: EBNEIP00000007937
GenomeReviews: AM421808_GR
KEGG: nmc:NMC0408
eggNOG: COG4796
HOGENOM: HBG482665
OMA: SISLQYA
ProtClustDB: CLSK878435
BioCyc: NMEN272831:NMC0408-MONOMER
Taxonomy ID 272831
Gene Starting Position 427191
Gene Ending Position 428961
Gene Strand (Orientation) -
Protein Name pilus secretin
DNA Sequence 
>gi|121633901:427191-428961 Neisseria meningitidis FAM18, complete genome
ATCAATAGCGCAGGCTGTTGCCGGCCGTACCCATAATCCTCGGGGTAATGAAAATCAGCAGTTCGCGGCG
GTCGGTTTTTTTCCCGCGTGTTTTAAAGAGGTTGCCGATAACGGGGATGTCGCCCAACAGGGGGACTTTG
GTCAGCGTATTGCCGTTGTCTTCTTCATAAATACCGCCGACAATCAATGTGCCGCCGTTTTCAACCATAG
CCTGCGTATTCAGGTTTTTGGTCGAAATACACAGGATCGTCTGATTACCGGAGGCACATTGCGCAGGCGA
GTCCTTGTTGATTTTGACGGTCATAATGATTTGGCCGTCGGGCGTGATGTTCGGCGTAACGGTCAGCCCC
AAGACGGCTTTTTTGAGTTCCGTGTTCGTGCTGCTGCCGCCGTTCGCGATTGAGGTTACGGTGAAAGGAA
TTTCGTAACCGGATTCGATTTTGGCCTCTTTGCGGTTTTGGGTCAGCACGCGCGGATTGGCAAGCGTTTT
GGTTTTTGAAAGCGATTCGGATGCGGACAATTCCAAATTCAAGGCACCGGAGGAAATCGCGCGCACCAGC
GAAATGCTGTTTGCGGCAGCGGTAATCGGCAGGTTGATTTTGGTTTCGGCCCCCCATTTATCGTCGCCGC
CGAAGCCGGAGTTTACCCCCCAGCCGAATGCGCTTGTATCATTTTTCAGCTTTTTCTTGCCTGTCGCGCC
GAATTTAACGCCCAAATCGCGCGAGAAGCCGTCTGCCGCTTCGACGATACGCGCCTCAATCATCACTTGT
TGCGCGGGTACGTCCAATTCGTCAATCAGTTTGCGGAATTTTTCGATGACGCTGCGGGTATCGGTAACAA
TCAGGGTATTGGTGGCGGGATCGATCAGCACGCTGCCCCTGCCGCTGACAAGCGTATTGCGGTTTCCGGT
TGTGTCGGCATTGTCCAAACGCAGGATGCTGCGGAATTCTTCCACATTTTTGTATTTCAATTGGAAGTTT
TGTGAATACAGCGCGCCCAGATCGGCAATGTCTTTTTCCGCCTGTAAGAAGGCTTTGTCTTTGGCAAGCA
GCTCGTCGCGGGGCGCGATGTTGACGATGTTCCCTTGTTGGCGCATATCGAGGTTGCGTGCCTGCATAAC
CAAATCCAAAGCCTGATCCCAAGGTACGTCTTTGAGGGAGAGGGTCATTTTGCCGTTGACGGAGTCGCTG
GCAACAATGTTCATCCCGGATTCTTTTGCCAAAATCTGCAGGATGGTGCGGATTTCGACATCTTGGAAGT
CAAGGGAGATTTTCCGGCCTGTTGGATACGGATACTGCGGACTTGGTAGACGGTGCGGCAGCCTGTTGTT
TTGCCGGTGCGGCAGGCGCGGCTTTTACGGCGGGGCGTGCGGGGGCGGACACGGTATCGTCCGATTCGTT
AATGAATATCCAAACTTTGTTCCCGCGTACTTCGGTATTGTATTGGCCCGGTTTGTTCAGATTCAGAACC
AGACGCGCACGGCTGCTGTTTTGTGCGGCACTGATTTTGCTCAACAGAGGATCGGCATATTCGAGTACCT
GTTGATCCATGGAAATGCCGGTTTGTTCAAAGTCCAAGGCGATGCGGGCCGGTGAGGAGGTTACGAAGCC
GGTCGGGTTGACAATCTCTTTGTCAAAGCTGACTTTGACGATTTTCTGTTTGTTGGGCAGGGAGGAAACT
TTGATGTCTGTAATGTTTCCTGCCGATGCTGTCTGAAAGGCGGCGGTTGCGACAAAGAGACCGGAAATGA
TTTTTGTCAGTTTGGTATTCA
Protein Sequence 
>gi|121634273|ref|YP_974518.1| pilus secretin [Neisseria meningitidis FAM18] MNTKLTKIISGLFVATAAFQTASAGNITDIKVSSLPNKQKIVKVSFDKEIVNPTGFVTSSPARIALDFEQTGISMDQQVLEYADPLLSKISAAQNSSRARLVLNLNKPGQYNTEVRGNKVWIFINESDDTVSAPARPAVKAAPAAPAKQQAAAPSTKSAVSVSTGRKISLDFQDVEIRTILQILAKESGMNIVASDSVNGKMTLSLKDVPWDQALDLVMQARNLDMRQQGNIVNIAPRDELLAKDKAFLQAEKDIADLGALYSQNFQLKYKNVEEFRSILRLDNADTTGNRNTLVSGRGSVLIDPATNTLIVTDTRSVIEKFRKLIDELDVPAQQVMIEARIVEAADGFSRDLGVKFGATGKKKLKNDTSAFGWGVNSGFGGDDKWGAETKINLPITAAANSISLVRAISSGALNLELSASESLSKTKTLANPRVLTQNRKEAKIESGYEIPFTVTSIANGGSSTNTELKKAVLGLTVTPNITPDGQIIMTVKINKDSPAQCASGNQTILCISTKNLNTQAMVENGGTLIVGGIYEEDNGNTLTKVPLLGDIPVIGNLFKTRGKKTDRRELLIFITPRIMGTAGNSLRY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pilQ mutant were unable to colonize human nasopharyngeal tissue in an organ culture model (Exley et al., 2009).
COG COG4796U, under U: Intracellular trafficking, secretion, and vesicular transport
References
Exley et al., 2009: Exley RM, Sim R, Goodwin L, Winterbotham M, Schneider MC, Read RC, Tang CM. Identification of meningococcal genes necessary for colonization of human upper airway tissue. Infection and immunity. 2009; 77(1); 45-51. [PubMed: 18936183].