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purL from Neisseria meningitidis Z2491

Victor ID 2951
Gene Name purL from Neisseria meningitidis Z2491
Sequence Strain (Species/Organism) Neisseria meningitidis Z2491
NCBI Gene ID 906445
NCBI Protein GI 15793449
Locus Tag NMA0445
Protein Accession NP_283271.1
Other Database IDs UniProtKB-ID: PUR4_NEIMA
UniRef100: UniRef100_Q9JWC5
UniRef90: UniRef90_Q5F7J4
UniRef50: UniRef50_Q47XX7
UniParc: UPI0000132A58
EMBL: AL157959
EMBL-CDS: CAM07730.1
RefSeq_NT: NC_003116.1
EnsemblGenome: EBNEIG00000000397
EnsemblGenome_TRS: EBNEIT00000000397
EnsemblGenome_PRO: EBNEIP00000000397
GenomeReviews: AL157959_GR
KEGG: nma:NMA0445
HOGENOM: HBG335309
OMA: ERGIAYY
ProtClustDB: PRK05297
BioCyc: NMEN122587:NMA0445-MONOMER
Taxonomy ID 122587
Gene Starting Position 418263
Gene Ending Position 422225
Gene Strand (Orientation) -
Protein Name phosphoribosylformylglycinamidine synthase
DNA Sequence 
>gi|15793034:418263-422225 Neisseria meningitidis Z2491, complete genome
GTTAGCCCAAGGCTTTACGTGCGCCGGCGAAGAGGCGGTACCAGCCGGACAATTCCGTCCAGTCTTCCGG
TTTCCAGCTCATTTGTGCGGCGCGGTATACACGTTCAGGATGCGGCATCATGATGGTAACGCGGCCGTCG
GCGTTGGTCACGCCGGCGATGCCTTGCGGCGAGCCGTTGGGGTTGAGCGGGTAGGTTTGGGTAATTTGGT
TTTGTCCGTCCACATATTGCAACGCAATGCCCAAATCGGCAGAAATGTTGCCGCCGTGAAGCGCGAAGTC
GGCGCGGCCTTCGCCGTGGCTGACGACGACGGGCAGGCTGGAGCCTTGCATTTCGTTCAGAATCAGGGAG
GCTGATTTGGGGACGTGAACCATGCTCAGGCGCGCTTCGAACTGTTCGCTCAGGTTGCGCTTGAACTTCG
GCCAGCCTGCCGTGCCGGGGATGATTTCGGCGAGGTTGCTGACCATCTGGCAGCCGTTGCACACGCCCAA
TGTCAGCGTGTTCGGGTCGGTGAAGAAGGCGGCGAACTGGTCGCGTAAGGCGGGGTGGAACAGGATGGAT
TTCGCCCAGCCTTTGCCCGCGCCGAGTACGTCGCCGTAGCTGAAGCCGCCGCACGCCGCCAGCATTTTGA
AGTCGGCAAGGTGGACGCGGCCTGCCATCAGGTCGGACATATGCACGTCGTAGGCATCGAAACCGGCACG
GGTGAAGGCGGCGGCCATTTCGATTTGCCCGTTTACGCCCTGTTCGCGCAGGATGGCGATTTTGGGTTTC
GCGCCGCTGTTGATAAACGGCGCGGCGATGTCTTCGTTCACGTCGAATTTCAGGTTGGCAAACAATGCGC
TGCGTCCGTTGTCGCCAATCAGGGCAAACTCGCTGTCGGCGCAGGCAGGGTTGTCGCGCAGGCGTTGGAT
TTGATGGCTGGTTTCTTGCCAGGTTTGTTGCAGTTTGATTAGGTTGTCAGAAATAAGGTGCGTTTGCCCG
TCGCGGATGATTAACGTGTTCTCATCAGTTAACGTACCGATTTCAAAGACATTATGATGCAGCTGTTGTT
GATAGAATAAATTGATAATATCGGCAACATCTTGTTTTCTAACTTGGATAACAGCACCCAACTCTTCATT
AAATAATGTGCGGGCAATGGTTTCTTGCCATTCAGCCAACGCTTTTACCTCTTCAGTCCGCAATGATTGA
GACAGAGCGGTATGGTTGGTAATAAATGTTTGTGCAAGCAATAAATTTAAATCTATATCCAAGCCGCACC
GCCCTGCAAACGCCATTTCTACCAAAACGGCAAACAAGCCGCCGTCGCTGCGGTCGTGATACGCCAAGAG
TTTGTCTTCGGCGACAAGCTGCTGAATCACGTTGTAAAACGCTTTCAGACGACTTGTATCGTCCAAATCG
GGCGCGTCGCCGCTCATATTGTTGTACACCTGACCAAACGCCGAGCCGCCCATACGCGCTTTGCCGAAGC
CCAAATCGACAAACAGCAATACGCTGTCCTCGACGTTTTTCAATTCGGGCGTAACGGTTTTGCGTACGTC
TTGAACCGGCGCGAACGCGGAGATAATCAGGCTCAACGGCGAAACGACGGATTTTTTCTCTTCGCCGTCC
TGCCACACGGTTTTCATCGACAGGCTGTCTTTGCCCACGGGAATGCTCAAATCCAATGCCTGACAGGCTT
TGGAAACCGCTTCGACGGTGCGGTAGAGTTTTTCGTCTTCGCCTTCGTTGCCGCACGCCGCCATCCAGTT
GGCGGAGAGTTTGATGTTGCCGATGTCGCCGATATTGGCTGCCGCGATGTTGGTGATGGCTTCGCCGACG
CACATTCTGCCCGAAGCAGGCGCGTCAAACAGGGCGACGGTCGGTTTTTCGCCCATGCTCATCGCTTCGC
CGCGATAAGTGTTGAAGCCCATCATGGTAACGGCGCAGTCGGCTACGGGGGTTTGGTATTTGCCGACCAT
TTGGTCGCGGTGGGTCATGCCGCCGACGCTGCGGTCGCCGATGGTAATCAGGAAGTTTTTGGCGGCTACG
GCAGGCAGGCGCAGAACGCGGTAGGCGGCTTCAGTAATGTCGATATCGCCCGCGTGAAACGGTTTTTTGG
ACGGCGCAACCGTTTTGTCGGTACGCGTGGTTTTGGGCGGTTTGCCGAGCAAGACGTTCAACGGCAAATC
GACAGGGTTGTTGGAGAACAAATCGTCGCGTACTTTCAAATGGCCGTCGTCGGTCGCCGTACCGACTACC
GCAAACGGGCAGCGTTCACGTTCGCAGATGGAGCGGAAGATGTCCAAATCTTTTTCCAAAATCGACAATA
CATAACGCTCTTGCGATTCGTTGCACCAGATTTGCAGCGGGTTGAGACCGTGTTCTTCCAGCGGCACTTC
GCGCAGCTTGAATACCGCGCCGCGTCCGGCATCGTTGACGAGTTCGGGGAAGGCGTTGGACAAGCCGCCC
GCGCCAACGTCGTGGATGGAGATAATCGGGTTTTTGTCGCCGAGCTGCCAGCAGCGGTCGATCACTTCCT
GCGCGCGGCGTTCGATTTCGGGGTTGCCGCGTTGTACGGAGTTGAAGTCTAAAGACGCGTCGTTTGTGCC
GGTATCCATCGAAGAAGCCGCGCCGCCGCCCAAGCCGATAAGCATACCCGGGCCGCCCAGTTGGATCAGC
AACGCGCCTTCGGGGATTTCGTCTTTATGCGTCTGCTGCGCCTGAATGCTGCCCAAGCCGCCGGCAATCA
TAATCGGTTTGTGGTAGCCGCGAACCTGACCGTCAAATTTTTCTTCAAAAGTGCGGAAGTAGCCCAAGAG
GTTGGGGCGGCCGAATTCGTTGTTGAACGCCGCGCCGCCGATGGGGCCTTCAATCATAATGTCCAGCGGC
GAGGAAATATGTTCCGGCTTGCCGTAATCTTGTTCCCACGGCTGTTTGAGGCCGGGGATGTTGAGGTTGG
ACACGGTAAAGCCGGTCAAGCCTGCTTTCGGACGCGAACCTTTGCCCGTCGCACCTTCGTCGCGGATTTC
GCCGCCCGCGCCCGTTGCCGCGCCCGCAAACGGCGCGATGGCGGTCGGGTGGTTGTGCGTTTCCACTTTC
ATGATGATATGCGTGTCTTCCTCGTGGAAACGGTAGCCTTGGTTTTCTGCCGCATTTGGATAGAAACGTT
CGACTTTTGCGCCTTCGATCACGGATGAGTTGTCTTTGTAGGCAACGACTGTGCCTTCGGGATGCGCGTT
GTGCGTGTCGCGTATCATACCGAAGAGCGATTTCGGCTGTTTTTCGCCGTTGAGGATGAAGTCGGCGTTG
AAGATTTTGTGGCGGCAGTGTTCGCTGTTTGCCTGCGCGAACATCATCAGCTCCACATCAGACGGATTGC
GCTGCAAAGCCTGATAGTTTTCAACCAGATAATCGATTTCGTCGGCGGAGAGTGCCAAACCCATTTCGGT
ATTGGCTTTGACCAAAGCCTCTTTACCGCCGCCCAAAACATCGACGGTGGAAAAGGTTTCGGATTCGAGA
TGGTGGAATAATTTGGATGCCGTCTGAAAATCGGGCAGCACGGATTCAGTCATGCGGTCGTGCAGCAAAG
CCGCCCATTGCTGTTGCTGTTCATCGGTAAGCGCACCTTCCAGCCACACCGCCATGCCGCGCTCGATGCG
TTCGATGCCTGCCAAACCGCAGTTTTCCGCGATATTGGTCGCCTTGGAAGCCCACGGCGAAATCGTACCC
AAACGGGGCGTGACCAAAAACAAATGCAAGCCCTCGCGCGCTTTTGGCGTTTGTTCAACGCTTTGCGCCG
CCAACAAGGCTTGCAGTTTTTCGACAGTCGCGGCATCAAGTGCTTTCTCGCTGCCGACGAAATACCAAAA
TTCGCTGCTTAATTTGACTTCGGGCAGACCGAGTGCGGCGGCTTTTTGCAAGAGTTTTTCAACACGGAAA
TCGGAAAGGGCGGTAACGCCGCGCAAGGGCAAAACGACAGACA
Protein Sequence 
>gi|218767429|ref|YP_002341941.1| phosphoribosylformylglycinamidine synthase [Neisseria meningitidis Z2491] MSVVLPLRGVTALSDFRVEKLLQKAAALGLPEVKLSSEFWYFVGSEKALDAATVEKLQALLAAQSVEQTPKAREGLHLFLVTPRLGTISPWASKATNIAENCGLAGIERIERGMAVWLEGALTDEQQQQWAALLHDRMTESVLPDFQTASKLFHHLESETFSTVDVLGGGKEALVKANTEMGLALSADEIDYLVENYQALQRNPSDVELMMFAQANSEHCRHKIFNADFILNGEKQPKSLFGMIRDTHNAHPEGTVVAYKDNSSVIEGAKVERFYPNAAENQGYRFHEEDTHIIMKVETHNHPTAIAPFAGAATGAGGEIRDEGATGKGSRPKAGLTGFTVSNLNIPGLKQPWEQDYGKPEHISSPLDIMIEGPIGGAAFNNEFGRPNLLGYFRTFEEKFDGQVRGYHKPIMIAGGLGSIQAQQTHKDEIPEGALLIQLGGPGMLIGLGGGAASSMDTGTNDASLDFNSVQRGNPEIERRAQEVIDRCWQLGDKNPIISIHDVGAGGLSNAFPELVNDAGRGAVFKLREVPLEEHGLNPLQIWCNESQERYVLSILEKDLDIFRSICERERCPFAVVGTATDDGHLKVRDDLFSNNPVDLPLNVLLGKPPKTTRTDKTVAPSKKPFHAGDIDITEAAYRVLRLPAVAAKNFLITIGDRSVGGMTHRDQMVGKYQTPVADCAVTMMGFNTYRGEAMSMGEKPTVALFDAPASGRMCVGEAITNIAAANIGDIGNIKLSANWMAACGNEGEDEKLYRTVEAVSKACQALDLSIPVGKDSLSMKTVWQDGEEKKSVVSPLSLIISAFAPVQDVRKTVTPELKNVEDSVLLFVDLGFGKARMGGSAFGQVYNNMSGDAPDLDDTSRLKAFYNVIQQLVAEDKLLAYHDRSDGGLFAVLVEMAFAGRCGLDIDLNLLLAQTFITNHTALSQSLRTEEVKALAEWQETIARTLFNEELGAVIQVRKQDVADIINLFYQQQLHHNVFEIGTLTDENTLIIRDGQTHLISDNLIKLQQTWQETSHQIQRLRDNPACADSEFALIGDNGRSALFANLKFDVNEDIAAPFINSGAKPKIAILREQGVNGQIEMAAAFTRAGFDAYDVHMSDLMAGRVHLADFKMLAACGGFSYGDVLGAGKGWAKSILFHPALRDQFAAFFTDPNTLTLGVCNGCQMVSNLAEIIPGTAGWPKFKRNLSEQFEARLSMVHVPKSASLILNEMQGSSLPVVVSHGEGRADFALHGGNISADLGIALQYVDGQNQITQTYPLNPNGSPQGIAGVTNADGRVTIMMPHPERVYRAAQMSWKPEDWTELSGWYRLFAGARKALG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purL mutant is attenuated in rats (Sun et al., 2000).
References
Sun et al., 2000: Sun YH, Bakshi S, Chalmers R, Tang CM. Functional genomics of Neisseria meningitidis pathogenesis. Nature medicine. 2000; 6(11); 1269-1273. [PubMed: 11062540].