| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
lmo0558 |
Listeria monocytogenes EGD-e |
984498
|
|
16802601
|
lmo0558 |
|
NP_464086.1 |
hypothetical protein |
Virulence factor |
MUTATION: pgl mutant exhibited a 15 to 30 fold defect in growth in vivo [Ref6341:Crimmins et al., 2009]. |
19398547
|
|
|
lmo2821 |
Listeria monocytogenes EGD-e |
984504
|
|
16804858
|
lmo2821 |
|
NP_466343.1 |
similar to internalin, Unknown, putative peptidoglycan bound protein (LPXTG motif) |
Virulence factor |
MUTATION: mutant attenuated in virulence after intravenous infection of mice [Ref6342:Sabet et al., 2005]. |
16177371
|
|
|
lmo2067 |
Listeria monocytogenes EGD-e |
984795
|
|
16804106
|
lmo2067 |
|
NP_465591.1 |
similar to conjugated bile acid hydrolase |
Virulence factor |
MUTATION: deletion of bsh decreased resistance to bile, bacterial faecal carriage in guinea pigs and liver colonization in mice [Ref6343:Dussurget et al., 2002]. |
12180927
|
|
|
gtcA from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
984958
|
|
16804587
|
lmo2549 |
|
NP_466072.1 |
wall teichoic acid glycosylation protein GtcA |
Virulence factor |
MUTATION: a gtcA mutant was attenuated in mice [Ref6344:Autret et al., 2001] |
11254558
|
|
|
cheA |
Listeria monocytogenes EGD-e |
985032
|
|
16802734
|
lmo0692 |
AL591976 |
NP_464219 |
two-component sensor histidine kinase CheA |
Virulence factor |
MUTATION: mutant reduced invasion of Caco-2 cells compared to wild type [Ref6345:Dons et al., 2004]. |
15155625
|
|
|
cheY |
Listeria monocytogenes EGD-e |
985049
|
|
16802733
|
lmo0691 |
AL591976 |
NP_464218 |
chemotaxis response regulator CheY |
Virulence factor |
MUTATION: mutant reduced invasion of Caco-2 cells compared to wild type [Ref6345:Dons et al., 2004]. |
15155625
|
|
|
rnhB from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
985073
|
|
16803313
|
lmo1273 |
|
NP_464798.1 |
similar to ribonuclease H rnh |
Virulence factor |
MUTATION: mutant attenuated in mice, multiplication was significantly impaired [Ref6346:Bigot et al., 2009]. |
19246760
|
|
|
lmo1269 |
Listeria monocytogenes EGD-e |
985087
|
|
16803309
|
lmo1269 |
|
NP_464794.1 |
similar to type-I signal peptidase |
Virulence factor |
MUTATION: lmo1269 (sipX) is attenuated in mice [Ref6347:Bonnemain et al., 2004]. |
14982622
|
|
|
lmo1271 |
Listeria monocytogenes EGD-e |
985089
|
|
16803311
|
lmo1271 |
|
NP_464796.1 |
similar to signal peptidase I |
Virulence factor |
MUTATION: lmo1271 (sipZ) mutant is attenuated in mice [Ref6347:Bonnemain et al., 2004]. |
14982622
|
|
|
tig |
Listeria monocytogenes EGD-e |
985096
|
|
16803307
|
lmo1267 |
|
NP_464792.1 |
trigger factor |
Virulence factor |
MUTATION: mutant showed reduced capacity to persist in spleens and livers of infected mice [Ref6348:Bigot et al., 2006]. |
17021213
|
|
|
iap |
Listeria monocytogenes EGD-e |
985140
|
|
16802625
|
lmo0582 |
AL591975 |
NP_464110 |
invasion associated secreted endopeptidase |
Virulence factor |
MUTATION: mutant is strongly attenuated in mice, deletion led to abnormal cell division and loss of motility [Ref6349:Pilgrim et al., 2003]. |
12761132
|
|
|
inlA from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
985151
|
|
16802477
|
lmo0433 |
|
NP_463962.1 |
Internalin A |
Virulence factor |
MUTATION: attenuated in mice [Ref6350:Lingnau et al., 1995]. |
7558297
|
|
|
aroA |
Listeria monocytogenes EGD-e |
985307
|
|
16803640
|
lmo1600 |
AL591979 |
NP_465125 |
bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase |
Virulence factor |
MUTATION: attenuated in mice [Ref6351:Loeffler et al., 2006]. |
16790768
|
|
|
clpB |
Listeria monocytogenes EGD-e |
985416
|
|
16804245
|
lmo2206 |
AL591982 |
NP_465730 |
hypothetical protein |
Virulence factor |
MUTATION: mutant displayed 100 fold decrease in virulence in bacteria, also attenuated in mice [Ref6352:Chastanet et al., 2004]. |
14762012
|
|
|
lmo1745 |
Listeria monocytogenes EGD-e |
985561
|
|
16803785
|
lmo1745 |
|
NP_465270.1 |
similar to two-component response regulator |
Virulence factor |
MUTATION: VirR deletion severely decreased virulence in mice and invasion in cell culture [Ref6353:Mandin et al., 2005]. |
16102006
|
|
|
lmo1695 |
Listeria monocytogenes EGD-e |
985618
|
|
16803735
|
lmo1695 |
|
NP_465220.1 |
similar to putative membrane proteins |
Virulence factor |
MUTATION: attenuated in mice [Ref6354:Thedieck et al., 2006]. |
17042784
|
|
|
aroB |
Listeria monocytogenes EGD-e |
985753
|
|
16803966
|
lmo1927 |
AL591981 |
NP_465451 |
3-dehydroquinate synthase |
Virulence factor |
MUTATION: attenuated in mice [Ref6351:Loeffler et al., 2006]. |
16790768
|
|
|
lmo1829 |
Listeria monocytogenes EGD-e |
985887
|
|
16803869
|
lmo1829 |
|
NP_465354.1 |
similar to fibronectin binding proteins |
Virulence factor |
MUTATION: FbpA mutant attenuated in mice [Ref6355:Dramsi et al., 2004]. |
15228540
|
|
|
lmo1821 |
Listeria monocytogenes EGD-e |
985901
|
|
16803861
|
lmo1821 |
|
NP_465346.1 |
similar to putative phosphoprotein phosphatase |
Virulence factor |
MUTATION: mutant attenuated in mice [Ref6356:Archambaud et al., 2005]. |
15813732
|
|
|
inlC |
Listeria monocytogenes EGD-e |
985945
|
|
16803826
|
lmo1786 |
AL591981 |
NP_465311 |
internalin C |
Virulence factor |
MUTATION: attenuated virulence in mice [Ref6357:Engelbrecht et al., 1996]. |
8878044
|
|
|
lmo1076 |
Listeria monocytogenes EGD-e |
986264
|
|
16803116
|
lmo1076 |
|
NP_464601.1 |
similar to autolysin (EC 3.5.1.28) (N-acetylmuramoyl-L-alanine amidase) |
Virulence factor |
MUTATION: aut deletion mutants show reduced invasiveness and virulence in mice and guinea pigs [Ref6358:Cabanes et al., 2004]. |
15009888
|
|
|
pycA from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
986269
|
|
16803112
|
lmo1072 |
|
NP_464597.1 |
highly similar to pyruvate carboxylase |
Virulence factor |
MUTATION: pycA mutant unable to replicate in mammalian cells, attenuated in mice [Ref6359:Schär et al., 2010]. |
20097852
|
|
|
dltA |
Listeria monocytogenes EGD-e |
986449
|
|
16803014
|
lmo0974 |
AL591977 |
NP_464499 |
D-alanine--poly(phosphoribitol) ligase subunit 1 |
Virulence factor |
MUTATION: mutant displayed impaired adherence to various cell lines in vitro, and impaired virulence in mice [Ref6360:Abachin et al., 2002]. |
11849532
|
|
|
lmo0931 |
Listeria monocytogenes EGD-e |
986568
|
|
16802971
|
lmo0931 |
|
NP_464456.1 |
similar to lipoate protein ligase A |
Virulence factor |
MUTATION: mutant strain defective for growth, less virulent in animals by a factor of 300 [Ref6361:O'Riordan et al., 2003]. |
14564012
|
|
|
lmo0135 |
Listeria monocytogenes EGD-e |
986748
|
|
16802183
|
lmo0135 |
|
NP_463668.1 |
similar to oligopeptide ABC transport system substrate-binding proteins |
Virulence factor |
MUTATION: deletion mutant showed reduced bacterial adherence to host cells, severely attenuated in mice [Ref6362:Xayarath et al., 2009]. |
19818015
|
|
|
clpE from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
986780
|
|
16803037
|
lmo0997 |
|
NP_464522.1 |
ATP-dependent protease |
Virulence factor |
MUTATION: mutant strain was avirulent in mice, eliminated in the liver, affected cell division [Ref6363:Nair et al., 1999]. |
9987121
|
|
|
sod |
Listeria monocytogenes EGD-e |
986791
|
|
16803479
|
lmo1439 |
|
NP_464964.1 |
superoxide dismutase |
Virulence factor |
MUTATION: deletion mutant attenuated in mice [Ref6364:Archambaud et al., 2006]. |
16905535
|
|
|
fri |
Listeria monocytogenes EGD-e |
986847
|
|
16802983
|
lmo0943 |
AL591977 |
NP_464468 |
non-heme iron-binding ferritin |
Virulence factor |
MUTATION: mutant was impaired in ability to survive in macrophage cells and was attenuated in mice [Ref6365:Olsen et al., 2005]. |
15758237
|
|
|
inlB from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
986892
|
|
16802478
|
lmo0434 |
|
NP_463963.1 |
Internalin B |
Virulence factor |
MUTATION: attenuated in mice [Ref6350:Lingnau et al., 1995]. |
7558297
|
|
|
prfA from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
987031
|
|
16802246
|
lmo0200 |
|
NP_463731.1 |
listeriolysin positive regulatory protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6366:Chakraborty et al., 1992]. |
1729245
|
|
|
plcA |
Listeria monocytogenes EGD-e |
987032
|
|
16802247
|
lmo0201 |
|
NP_463732.1 |
phosphatidylinositol-specific phospholipase c |
Virulence factor |
MUTATION: mutant had attenuated virulence in mice, failed to grow in host tissues [Ref6367:Camilli et al., 1991]. |
1847723
|
|
|
hly from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
987033
|
|
16802248
|
lmo0202 |
|
NP_463733.1 |
listeriolysin O precursor |
Virulence factor |
MUTATION: mutant strain resulted in a 100-fold virulence defect in mice, prematurely killed host cell [Ref6368:Glomski et al., 2002]. |
11901168
|
|
|
mpl from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
987034
|
|
16802249
|
lmo0203 |
|
NP_463734.1 |
Zinc metalloproteinase precursor |
Virulence factor |
MUTATION: attenuated in mice [Ref6369:Raveneau et al., 1992]. |
1311708
|
|
|
actA |
Listeria monocytogenes EGD-e |
987035
|
|
16802250
|
lmo0204 |
AL591974 |
NP_463735 |
actin-assembly inducing protein precursor |
Virulence factor |
MUTATION: mutant impaired in cell to cell spread, attenuated in maternal organs [Ref6370:Bakardjiev et al., 2005]. |
15871123
|
|
|
plcB from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
987036
|
|
16802251
|
lmo0205 |
|
NP_463736.1 |
phospholipase C |
Virulence factor |
MUTATION: deletion mutants showed reduced virulence in mice, escape from vacuole and cell-to-cell spread [Ref6371:Smith et al., 1995]. |
7591052
|
|
|
flaA from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
987167
|
|
16802732
|
lmo0690 |
|
NP_464217.1 |
flagellin |
Virulence factor |
MUTATION: mutant strain impaired colonization in plant tissue [Ref6372:Gorski et al., 2009]. |
19357783
|
|
|
clpC from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
987203
|
|
16802278
|
lmo0232 |
|
NP_463763.1 |
endopeptidase Clp ATP-binding chain C |
Virulence factor |
MUTATION: mutant strain showed a restricted capacity to grow in bone-marrow-derived macrophages, and an attenuated virulence in mice [Ref6373:Rouquette et al., 1996]. |
8885268
|
|
|
ami |
Listeria monocytogenes EGD-e |
987254
|
|
16804596
|
lmo2558 |
AL591983 |
NP_466081 |
autolysin, amidase |
Virulence factor |
MUTATION: mutant strains showed a significant reduction in adherence to several cell types, attenuated in mice [Ref6374:Milohanic et al., 2001]. |
11251838
|
|
|
inlG |
Listeria monocytogenes EGD-e |
987350
|
|
16802308
|
lmo0262 |
|
NP_463793.1 |
internalin G |
Virulence factor |
MUTATION: mutant showed loss in virulence, reduced numbers of viable bacteria in both liver and spleen of mice [Ref6375:Raffelsbauer et al., 1998]. |
9862466
|
|
|
inlH |
Listeria monocytogenes EGD-e |
987355
|
|
16802309
|
lmo0263 |
|
NP_463794.1 |
internalin H |
Virulence factor |
MUTATION: mutant showed loss in virulence, reduced numbers of viable bacteria in both liver and spleen of mice [Ref6375:Raffelsbauer et al., 1998]. |
9862466
|
|
|
inlE |
Listeria monocytogenes EGD-e |
987358
|
|
16802310
|
lmo0264 |
|
NP_463795.1 |
internalin E |
Virulence factor |
MUTATION: mutant showed loss in virulence, reduced numbers of viable bacteria in both liver and spleen of mice [Ref6375:Raffelsbauer et al., 1998]. |
9862466
|
|
|
clpP from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
987364
|
|
16804506
|
lmo2468 |
|
NP_465991.1 |
ATP-dependent Clp protease proteolytic subunit |
Virulence factor |
MUTATION: mutant strain showed reduced bacterial escape from phagosomes of macrophages and attenuated virulence in mice [Ref6376:Gaillot et al., 2000]. |
10760131
|
|
|
lmo0292 |
Listeria monocytogenes EGD-e |
987455
|
|
16802338
|
lmo0292 |
|
NP_463823.1 |
similar to heat-shock protein htrA serine protease |
Virulence factor |
MUTATION: attenuated in mice [Ref6377:Wilson et al., 2006]. |
16369036
|
|
|
lmo2537 |
Listeria monocytogenes EGD-e |
987487
|
|
16804575
|
lmo2537 |
|
NP_466060.1 |
similar to UDP-N-acetylglucosamine 2-epimerase |
Virulence factor |
MUTATION: mutant avirulent in mice [Ref6378:Dubail et al., 2006]. |
16952950
|
|
|
lmo0317 |
Listeria monocytogenes EGD-e |
987534
|
|
16802362
|
lmo0317 |
|
NP_463847.1 |
similar to phosphomethylpyrimidine kinase (ThiD) |
Virulence factor |
MUTATION: knockout inhibited growth in mMWB and reduced spread in epithelial cells [Ref6379:Schauer et al., 2009]. |
19181806
|
|
|
relA from Listeria monocytogenes EGD-e |
Listeria monocytogenes EGD-e |
987788
|
|
16803563
|
lmo1523 |
|
NP_465048.1 |
similar to (p)ppGpp synthetase |
Virulence factor |
MUTATION: impaired growth, avirulent in a murine model [Ref6380:Taylor et al., 2002]. |
11790730
|
|
|
lmo0415 |
Listeria monocytogenes EGD-e |
987823
|
|
16802459
|
lmo0415 |
|
NP_463944.1 |
similar to endo-1,4-beta-xylanase |
Virulence factor |
MUTATION: lmo0415 (pgdA) is attenuated in mice [Ref6381:Boneca et al., 2007]. |
17215377
|
|
|
plcB from Listeria monocytogenes str. 4b F2365 |
Listeria monocytogenes str. 4b F2365 |
2797078
|
|
46906437
|
LMOf2365_0216 |
|
YP_012826.1 |
phospholipase C |
Virulence factor |
MUTATION: deletion mutants showed reduced virulence in mice, escape from vacuole and cell-to-cell spread [Ref6371:Smith et al., 1995]. |
7591052
|
|
|
hly from Listeria monocytogenes str. 4b F2365 |
Listeria monocytogenes str. 4b F2365 |
2797098
|
|
46906434
|
LMOf2365_0213 |
|
YP_012823.1 |
listeriolysin O |
Virulence factor |
MUTATION: mutant strain resulted in a 100-fold virulence defect in mice, prematurely killed host cell [Ref6368:Glomski et al., 2002]. |
11901168
|
|
|
degU |
Listeria monocytogenes str. 4b F2365 |
2797137
|
|
46908687
|
LMOf2365_2488 |
AE017262 |
YP_015076 |
DNA-binding response regulator DegU |
Virulence factor |
MUTATION: mutant strain showed reduction in motility, attenuated in mice [Ref6557:Williams et al., 2005]. |
16213668
|
|
|
inlF from Listeria monocytogenes str. 4b F2365 |
Listeria monocytogenes str. 4b F2365 |
2797185
|
|
46906647
|
LMOf2365_0429 |
|
YP_013036.1 |
internalin |
Virulence factor |
MUTATION: deletion mutant avirulent in mice [Ref6558:Engelbrecht et al., 1998]. |
9791184
|
|
|
recQ |
Listeria monocytogenes str. 4b F2365 |
2797731
|
|
46908944
|
LMOf2365_2745 |
|
YP_015333.1 |
ATP-dependent DNA helicase RecQ |
Virulence factor |
MUTATION: a recQ mutant was attenuated in mice [Ref6344:Autret et al., 2001] |
11254558
|
|
|
LMOf2365_0094 |
Listeria monocytogenes str. 4b F2365 |
2798471
|
|
46906316
|
LMOf2365_0094 |
|
YP_012705.1 |
pentapeptide repeats domain protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6559:Reid et al., 2003]. |
14638794
|
|
|
inlA from Listeria monocytogenes str. 4b F2365 |
Listeria monocytogenes str. 4b F2365 |
2798475
|
|
46906689
|
LMOf2365_0471 |
|
YP_013078.1 |
internalin A |
Virulence factor |
MUTATION: attenuated in mice [Ref6350:Lingnau et al., 1995]. |
7558297
|
|
|
LMOf2365_1971 |
Listeria monocytogenes str. 4b F2365 |
2798554
|
|
46908175
|
LMOf2365_1971 |
|
YP_014564.1 |
ATP-dependent DNA helicase RecQ, putative |
Virulence factor |
MUTATION: a recQ mutant was attenuated in mice [Ref6344:Autret et al., 2001] |
11254558
|
|
|
gtcA from Listeria monocytogenes str. 4b F2365 |
Listeria monocytogenes str. 4b F2365 |
2798680
|
|
46908721
|
LMOf2365_2522 |
|
YP_015110.1 |
cell wall teichoic acid glycosylation protein GtcA |
Virulence factor |
MUTATION: a gtca mutant showed diminished ability to invade intestinal epithelial cells, was attenuated in mice [Ref6344:Autret et al., 2001]. |
11254558
|
|
|
agrA |
Listeria monocytogenes str. 4b F2365 |
2798696
|
|
46906282
|
LMOf2365_0060 |
AE017262 |
YP_012671 |
accessory gene regulator protein A |
Virulence factor |
MUTATION: virulence of a agrA mutant was attenuated in a mouse [Ref6560:Autret et al., 2003]. |
12874326
|
|
|
mpl from Listeria monocytogenes str. 4b F2365 |
Listeria monocytogenes str. 4b F2365 |
2799022
|
|
46906435
|
LMOf2365_0214 |
|
YP_012824.1 |
zinc metallopeptidase |
Virulence factor |
MUTATION: attenuated in mice [Ref6369:Raveneau et al., 1992]. |
1311708
|
|
|
ctsR |
Listeria monocytogenes str. 4b F2365 |
2799165
|
|
46906462
|
LMOf2365_0241 |
AE017262 |
YP_012851 |
transcriptional regulator CtsR |
Virulence factor |
MUTATION: attenuated virulence in spleens of mice [Ref6561:Karatzas et al., 2003]. |
12940983
|
|
|
inlB from Listeria monocytogenes str. 4b F2365 |
Listeria monocytogenes str. 4b F2365 |
2799227
|
|
0
|
LMOf2365_0472 |
|
- |
pseudo |
Virulence factor |
MUTATION: attenuated in mice [Ref6350:Lingnau et al., 1995]. |
7558297
|
|
|
prfA from Listeria monocytogenes str. 4b F2365 |
Listeria monocytogenes str. 4b F2365 |
2799457
|
|
46906432
|
LMOf2365_0211 |
|
YP_012821.1 |
listeriolysin regulatory protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6366:Chakraborty et al., 1992]. |
1729245
|
|
|
clpP from Listeria monocytogenes str. 4b F2365 |
Listeria monocytogenes str. 4b F2365 |
2799536
|
|
46908640
|
LMOf2365_2441 |
|
YP_015029.1 |
ATP-dependent Clp protease proteolytic subunit |
Virulence factor |
MUTATION: mutant strain showed reduced bacterial escape from phagosomes of macrophages and virulence in mice [Ref6376:Gaillot et al., 2000]. |
10760131
|
|
|
prsA-2 |
Listeria monocytogenes str. 4b F2365 |
2799631
|
|
46908453
|
LMOf2365_2252 |
|
YP_014842.1 |
protein export protein |
Virulence factor |
MUTATION: mutant attenuated in mice, impaired cell to cell spread in host cells [Ref6562:Alonzo et al., 2009]. |
19451247
|
|
|
clpP from Listeria monocytogenes HCC23 |
Listeria monocytogenes HCC23 |
7078568
|
|
217964793
|
LMHCC_1513 |
|
YP_002350471.1 |
ATP-dependent Clp protease proteolytic subunit |
Virulence factor |
MUTATION: mutant strain showed reduced bacterial escape from phagosomes of macrophages and virulence in mice [Ref6376:Gaillot et al., 2000]. |
10760131
|
|
|
LMHCC_0048 |
Listeria monocytogenes HCC23 |
7078927
|
|
217963347
|
LMHCC_0048 |
|
YP_002349025.1 |
cell wall teichoic acid glycosylation protein GtcA |
Virulence factor |
MUTATION: a gtcA mutant was attenuated in mice [Ref6344:Autret et al., 2001] |
11254558
|
|
|
LMHCC_0614 |
Listeria monocytogenes HCC23 |
7078992
|
|
217963906
|
LMHCC_0614 |
|
YP_002349584.1 |
ATP-dependent DNA helicase, recQ |
Virulence factor |
MUTATION: a recQ mutant was attenuated in mice [Ref6344:Autret et al., 2001] |
11254558
|
|
|
clpP from Listeria monocytogenes HCC23 |
Listeria monocytogenes HCC23 |
7079328
|
|
217963429
|
LMHCC_0131 |
|
YP_002349107.1 |
ATP-dependent Clp protease proteolytic subunit |
Virulence factor |
MUTATION: mutant strain showed reduced bacterial escape from phagosomes of macrophages and virulence in mice [Ref6376:Gaillot et al., 2000]. |
10760131
|
|
|
srtB from Listeria monocytogenes HCC23 |
Listeria monocytogenes HCC23 |
7079719
|
|
217963658
|
LMHCC_0362 |
|
YP_002349336.1 |
sortase, SrtB family |
Virulence factor |
MUTATION: mutant showed attenuated virulence in mice [Ref6821:Bierne et al., 2004]. |
15028680
|
|
|
LMHCC_2768 |
Listeria monocytogenes HCC23 |
7080110
|
|
217966039
|
LMHCC_2768 |
|
YP_002351717.1 |
ATP-dependent DNA helicase RecQ |
Virulence factor |
MUTATION: a recQ mutant was attenuated in mice [Ref6344:Autret et al., 2001] |
11254558
|
|
|
LMHCC_2601 |
Listeria monocytogenes HCC23 |
7080876
|
|
217965872
|
LMHCC_2601 |
|
YP_002351550.1 |
pentapeptide repeats domain protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6559:Reid et al., 2003]. |
14638794
|
|
|
LMHCC_1438 |
Listeria monocytogenes HCC23 |
7081139
|
|
217964719
|
LMHCC_1438 |
|
YP_002350397.1 |
Exo-glucosaminidase LytG (Exo-beta-N-acetylglucosaminidase lytG) (Peptidoglycan hydrolase lytG) (AutolysinlytG) |
Virulence factor |
MUTATION: mutant strain severely attenuated in cell culture, impaired for adhesion to certain eukaryotic cells [Ref6822:Wang and Lin, 2008]. |
18599819
|
|
|
inlF from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7702134
|
|
226223039
|
Lm4b_00433 |
|
YP_002757146.1 |
internalin, peptidoglycan bound protein (LPXTG motif) |
Virulence factor |
MUTATION: deletion mutant avirulent in mice [Ref6558:Engelbrecht et al., 1998]. |
9791184
|
|
|
inlA from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7702161
|
|
226223065
|
Lm4b_00461 |
|
YP_002757172.1 |
Internalin A |
Virulence factor |
MUTATION: attenuated in mice [Ref6350:Lingnau et al., 1995]. |
7558297
|
|
|
pycA from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7702259
|
|
226223686
|
Lm4b_01088 |
|
YP_002757793.1 |
pyruvate carboxylase |
Virulence factor |
MUTATION: pycA mutant unable to replicate in mammalian cells, attenuated in mice [Ref6359:Schär et al., 2010]. |
20097852
|
|
|
relA from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7702376
|
|
226224124
|
Lm4b_01533 |
|
YP_002758231.1 |
(p)ppGpp synthetase |
Virulence factor |
MUTATION: impaired growth, avirulent in murine model [Ref6380:Taylor et al., 2002]. |
11790730
|
|
|
gtcA from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7702426
|
|
226225097
|
Lm4b_02518 |
|
YP_002759204.1 |
cell wall teichoic acid glycosylation protein GtcA |
Virulence factor |
MUTATION: a gtcA mutant was attenuated in mice [Ref6344:Autret et al., 2001] |
11254558
|
|
|
mpl from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7702498
|
|
226222832
|
Lm4b_00201 |
|
YP_002756939.1 |
Zinc metalloproteinase precursor |
Virulence factor |
MUTATION: attenuated in mice [Ref6369:Raveneau et al., 1992]. |
1311708
|
|
|
inlB from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7702512
|
|
226223066
|
Lm4b_00462 |
|
YP_002757173.1 |
Internalin B |
Virulence factor |
MUTATION: attenuated in mice [Ref6350:Lingnau et al., 1995]. |
7558297
|
|
|
lsp |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7702964
|
|
226224447
|
Lm4b_01860 |
|
YP_002758554.1 |
signal peptidase II |
Virulence factor |
MUTATION: mutant strain showed a reduced efficiency of phagosomal escape in eucaryotic cells and an attenuated virulence [Ref6840:Réglier-Poupet et al., 2003]. |
12975369
|
|
|
Lm4b_01887 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7702988
|
|
226224474
|
Lm4b_01887 |
|
YP_002758581.1 |
Hypothetical protein containing ChW-repeats |
Virulence factor |
MUTATION: attenuated in mice [Ref6559:Reid et al., 2003]. |
14638794
|
|
|
clpE from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7703080
|
|
226223615
|
Lm4b_01017 |
|
YP_002757722.1 |
ATP-dependent protease |
Virulence factor |
MUTATION: mutant strain was avirulent in mice, eliminated in the liver, affected cell division [Ref6363:Nair et al., 1999]. |
9987121
|
|
|
clpC from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7703657
|
|
226222861
|
Lm4b_00252 |
|
YP_002756968.1 |
endopeptidase Clp ATP-binding chain C |
Virulence factor |
MUTATION: mutant strain showed a restricted capacity to grow in bone-marrow-derived macrophages, and an attenuated virulence in mice [Ref6373:Rouquette et al., 1996]. |
8885268
|
|
|
Lm4b_00320 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7703714
|
|
226222928
|
Lm4b_00320 |
|
YP_002757035.1 |
heat-shock protein htrA serine protease |
Virulence factor |
MUTATION: attenuated in mice [Ref6377:Wilson et al., 2006]. |
16369036
|
|
|
flaA from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7703775
|
|
226223321
|
Lm4b_00718 |
|
YP_002757428.1 |
flagellin protein |
Virulence factor |
MUTATION: mutant strain impaired colonization in plant tissue [Ref6372:Gorski et al., 2009], reduced adhesion [Ref6841:Tresse et al., 2009]. |
19357783
19295651
|
|
|
hly from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7704059
|
|
226222831
|
Lm4b_00200 |
|
YP_002756938.1 |
listeriolysin O precursor |
Virulence factor |
MUTATION: mutant strain resulted in a 100-fold virulence defect in mice, prematurely killed host cell [Ref6368:Glomski et al., 2002]. |
11901168
|
|
|
prfA from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7704073
|
|
226222829
|
Lm4b_00197 |
|
YP_002756936.1 |
listeriolysin positive regulatory protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6366:Chakraborty et al., 1992]. |
1729245
|
|
|
clpP from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7704098
|
|
226225016
|
Lm4b_02437 |
|
YP_002759123.1 |
ATP-dependent Clp protease proteolytic subunit |
Virulence factor |
MUTATION: mutant strain showed reduced bacterial escape from phagosomes of macrophages and virulence in mice [Ref6376:Gaillot et al., 2000]. |
10760131
|
|
|
plcB from Listeria monocytogenes serotype 4b str. CLIP 80459 |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7704359
|
|
226222834
|
Lm4b_00203 |
|
YP_002756941.1 |
phospholipase C |
Virulence factor |
MUTATION: deletion mutants showed reduced virulence in mice, escape from vacuole and cell-to-cell spread [Ref6371:Smith et al., 1995]. |
7591052
|
|
|
srtA |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7704527
|
|
226223548
|
Lm4b_00948 |
|
YP_002757655.1 |
Sortase |
Virulence factor |
MUTATION: attenuated in mice [Ref6342:Sabet et al., 2005]. |
16177371
|
|
|
pycA from Listeria monocytogenes 08-5578 |
Listeria monocytogenes 08-5578 |
8748143
|
|
284801404
|
LM5578_1155 |
|
YP_003413269.1 |
pyruvate carboxylase |
Virulence factor |
MUTATION: pycA mutant unable to replicate in mammalian cells, attenuated in mice [Ref6359:Schär et al., 2010]. |
20097852
|
|
|
pycA from Listeria monocytogenes 08-5923 |
Listeria monocytogenes 08-5923 |
8757905
|
|
284994546
|
LM5923_1109 |
|
YP_003416314.1 |
pyruvate carboxylase |
Virulence factor |
MUTATION: pycA mutant unable to replicate in mammalian cells, attenuated in mice [Ref6359:Schär et al., 2010]. |
20097852
|
|
|
pLM33_p09 |
Listeria monocytogenes Lm1 |
9350422
|
|
298740856
|
pLM33_p09 |
|
YP_003727993.1 |
pLM33 0009 |
Virulence factor |
MUTATION: pLM33_p09 (ctpA) mutant is attenuated in in vivo persistence in mice [Ref6903:Francis and Thomas, 1997]. |
9049996
|
|
|
agrD' |
Listeria monocytogenes DG119D |
|
|
157939819
|
|
|
|
accessory gene regulator protein D |
Virulence factor |
MUTATION: agrD mutant reduced invasion of Caco-2 intestinal epithelial cells, attenuated in mice [Ref7264:Riedel et al., 2009].
|
19154329
|
|
|
attM |
Listeria monocytogenes ATCC43251 |
|
|
2745842
|
|
|
|
putative transcriptional attenuator leader peptide |
Virulence factor |
MUTATION: attM mutant is attenuated in mice [Ref6344:Autret et al., 2001].
|
11254558
|
|
|
CelR |
|
|
|
|
|
|
|
|
Virulence factor |
MUTATION: celR mutant is attenuated in mice [Ref6344:Autret et al., 2001].
|
11254558
|
|
|
Dfp |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7704069
|
|
226224428
|
Lm4b_01841 |
FM242711 |
YP_002758535 |
pantothenate metabolism flavoprotein |
Virulence factor |
MUTATION: dfp mutant is attenuated in mice [Ref6344:Autret et al., 2001]. |
11254558
|
|
|
hpt |
Listeria monocytogenes P14 |
|
|
18129341
|
|
|
|
putative hexose-6-phosphate transporter |
Virulence factor |
MUTATION: hfp deletion mutant showed attenuated virulence in mice [Ref7265:Chico-Calero et al., 2002].
|
11756655
|
|
|
irpA |
Listeria monocytogenes EGD |
|
|
1403357
|
|
|
|
internalin-related protein A precursor |
Virulence factor |
MUTATION: irpA mutant is attenuated in mice [Ref7266:Domann et al., 1997].
|
8975898
|
|
|
LpeA (orf 3387.1) |
Listeria monocytogenes |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: lpeA mutant strain failed to invade epithelial Caco-2 and hepatocyte TiB73 cell lines [Ref7267:Réglier-Poupet et al., 2003b].
|
12496198
|
|
|
ORF483 |
Listeria monocytogenes |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: ORF483 mutant is attenuated in mice [Ref6344:Autret et al., 2001]. |
11254558
|
|
|
ORF626 |
Listeria monocytogenes |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: ORF626 mutant is attenuated in mice [Ref6344:Autret et al., 2001]. |
11254558
|
|
|
pbpX |
Listeria monocytogenes L99 |
|
|
307570078
|
|
|
|
penicillin-binding protein, putative |
Virulence factor |
MUTATION: pbpX mutant is attenuated in mice [Ref6344:Autret et al., 2001]. |
11254558
|
|
|
Ptb |
Listeria monocytogenes serotype 4b str. CLIP 80459 |
7702587
|
|
226223970
|
Lm4b_01378 |
FM242711 |
YP_002758077 |
phosphotransbutyrylase |
Virulence factor |
MUTATION: ptb mutant is attenuated in mice [Ref6344:Autret et al., 2001]. |
11254558
|
|
|
svpA |
Listeria monocytogenes L99 |
|
|
307571771
|
|
|
|
surface virulence-associated protein A |
Virulence factor |
MUTATION: svpA mutant strain strongly attenuated in mice, had restricted bacterial growth in organs [Ref7268:Borezée et al., 2001].
|
11700342
|
|
|
YtgP |
Listeria monocytogenes |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: ytgP mutant is attenuated in mice [Ref6344:Autret et al., 2001]. |
11254558
|
|
|
mogR |
Listeria monocytogenes EGD-e |
985015
|
|
16802716
|
lmo0674 |
AL591976 |
NP_464201 |
hypothetical protein |
Virulence factor |
MUTATION: mogR deletion mutant has a 250-fold decrease in virulence in mice and has reduced capacity for cell-to-cell spread [Ref7334:Gründling et al., 2004]. |
15302931
|
