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iap

Victor ID 508
Gene Name iap
Sequence Strain (Species/Organism) Listeria monocytogenes EGD-e
NCBI Gene ID 985140
NCBI Protein GI 16802625
Locus Tag lmo0582
Genbank Accession AL591975
Protein Accession NP_464110
Other Database IDs UniProtKB-ID: P60_LISMO
UniRef100: UniRef100_P21171
UniRef90: UniRef90_P21171
UniRef50: UniRef50_Q01839
UniParc: UPI000013105E
EMBL: X52268
EMBL: M80351
EMBL: AL591975
EMBL-CDS: CAA36509.1
EMBL-CDS: AAA25280.1
EMBL-CDS: CAC98661.1
RefSeq_NT: NC_003210.1
MEROPS: C40.007
GenomeReviews: AL591824_GR
KEGG: lmo:lmo0582
GenoList: LMO0582
HOGENOM: HBG362075
ProtClustDB: PRK13914
BioCyc: LMON169963:LMO0582-MONOMER
Taxonomy ID 169963
Gene Starting Position 618931
Gene Ending Position 620379
Gene Strand (Orientation) -
Protein Name invasion associated secreted endopeptidase
Protein pI 9.88
Protein Weight 46769.16
Protein Length 482
Protein Note iap; p60; autolytic enzyme; can cleave bacterial peptidoglycan; secreted by SecA2 system
DNA Sequence 
>gi|16802048:618931-620379 Listeria monocytogenes EGD-e, complete genome
ATTATACGCGACCGAAGCCAACTAGATATTTACCCCAGCCAGAGCCGTGGATGTTATCGTATTTAACGCC
ATTGTCTTGCGCGTTAATCATTTGACCATTACCAACGTAGATACCAACGTGAGAAATTCCGCTACCATAG
TCAAAGAATACTAAATCACCAGGTTTTGCTTGAGATTCAGAGATTCTTGTAGTGCTAGCGTATTGTGCGC
CAGAAGTACGTGGAAGGGAGATTCCCGCTTTAGCAAATACATATTTAGTGTAACCAGAGCAATCAAATGT
AGTTGGTCCGTTACCACCCCATGAATAAGCTTTTCCAAGGTGTTTTTGAGCTTCAGCAATAATAGCACTT
GCACTTGAATTGCTGTTATTGTTGGAAGAACCTTGATTAGCATTCGTATTTGAGTTTGTATTCGTATTAG
TATTTGAGTTTGTATTAGTATTTTTAGATGGTGTATTTGTATTAGTATTGTTTGTATTTGTATTTGTATT
TGTATTTGTATTTGTTTTATTAGCATTTGTGTTTGTAGATGGTGCAGGAGCTGGTTTTGCAGCTTCTGTT
GGTGCTTTAGGTGCTGTTTGTTGTTGCGTTGCTGTTTCTTTTTTCTCTGTAGTAGCAGTATTTGTGTTAG
TATTTTCTTTAACTACTGGAGCTGCTTGTTTTTCAGCTGCTGGAGCTTCCGTTTTCACTTCTGCTTTTGG
AGTAGCTGTGTTAGCAGTTTGTTTAATAGCAAGCTTTTGACCTACATAAATAGAAGAAGAAGATAAATTA
TTCCATGACATAATGTCTTGAACAGAAACACCGTATTTTACGGATAAAGCCCAAATAGTGTCACCGCTTT
TAACAGCGTGTGTAGTAGCATTTTGATCTACTACTGGAGTTTCTTTCGTTTCTGCTACTTTAGGCGCAGG
TGTAGTTGCTTGTGTAGTTTGTTTTACTTCAGTTTTTGTTTCTGCAGCAGGTGCAGCTTGTTGAGTAGTA
GTTTCTTTTTTCACTTCTTGTGTTGGTGCAACTGGAGTGCTTACTGCTTTGTCAGTTAAGTATTTACCGT
TAACGAAACCAGTTTTTCCATCGTTGTAAGTAATTTTGTGCCAGCCGTTAGATTCGGTTGTTTCAACAGT
TACTTTTGTTCCACCTTTGATGGACGTAATAATACTGTTATCAACACCAGCGCCACTACGGACGTTTAAC
CAAGTTGCGCTAACAGATTTCTCTGTTTTTTCAGCAGCAGCAACCTCATTATTTACTTGTAATTTTTGAC
CTGGTACGATTTTATCTGTTGTTAAATTGTTTGCTTTTTTAATTGCGTCAACAGTAGTCCCTTTACTTTG
TGCGATACCCCAAAGAGTATCACCAGCTTCGACTACTACAGTGCTTGCGGATGCGATTGTTGGCGCAGCA
AATGCTGTTACCGCAATCCCAGCTGTAGCCGCGATAGTTGCTTTTTTCA
Protein Sequence 
>gi|16802625|ref|NP_464110.1| invasion associated secreted endopeptidase [Listeria monocytogenes EGD-e]
MKKATIAATAGIAVTAFAAPTIASASTVVVEAGDTLWGIAQSKGTTVDAIKKANNLTTDKIVPGQKLQVN
NEVAAAEKTEKSVSATWLNVRSGAGVDNSIITSIKGGTKVTVETTESNGWHKITYNDGKTGFVNGKYLTD
KAVSTPVAPTQEVKKETTTQQAAPAAETKTEVKQTTQATTPAPKVAETKETPVVDQNATTHAVKSGDTIW
ALSVKYGVSVQDIMSWNNLSSSSIYVGQKLAIKQTANTATPKAEVKTEAPAAEKQAAPVVKENTNTNTAT
TEKKETATQQQTAPKAPTEAAKPAPAPSTNTNANKTNTNTNTNTNTNNTNTNTPSKNTNTNSNTNTNTNS
NTNANQGSSNNNSNSSASAIIAEAQKHLGKAYSWGGNGPTTFDCSGYTKYVFAKAGISLPRTSGAQYAST
TRISESQAKPGDLVFFDYGSGISHVGIYVGNGQMINAQDNGVKYDNIHGSGWGKYLVGFGRV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mutant is strongly attenuated in mice, deletion led to abnormal cell division and loss of motility (Pilgrim et al., 2003).
COG COG0791M, under M: Cell wall/membrane/envelope biogenesis
References
Pilgrim et al., 2003: Pilgrim S, Kolb-Mäurer A, Gentschev I, Goebel W, Kuhn M. Deletion of the gene encoding p60 in Listeria monocytogenes leads to abnormal cell division and loss of actin-based motility. Infection and immunity. 2003; 71(6); 3473-3484. [PubMed: 12761132].