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pycA from Listeria monocytogenes EGD-e

Victor ID 519
Gene Name pycA from Listeria monocytogenes EGD-e
Sequence Strain (Species/Organism) Listeria monocytogenes EGD-e
NCBI Gene ID 986269
NCBI Protein GI 16803112
Locus Tag lmo1072
Protein Accession NP_464597.1
Other Database IDs UniProtKB-ID: Q8Y846_LISMO
UniRef100: UniRef100_D2P0Z3
UniRef90: UniRef90_D2P0Z3
UniRef50: UniRef50_Q9KWU4
UniParc: UPI0000054DCE
EMBL: AL591977
EMBL-CDS: CAC99150.1
RefSeq_NT: NC_003210.1
HSSP: P24182
GenomeReviews: AL591824_GR
KEGG: lmo:lmo1072
GenoList: LMO1072
HOGENOM: HBG717218
OMA: DIVQSQI
ProtClustDB: PRK12999
BioCyc: LMON169963:LMO1072-MONOMER
Taxonomy ID 169963
Gene Starting Position 1099265
Gene Ending Position 1102705
Gene Strand (Orientation) +
Protein Name highly similar to pyruvate carboxylase
DNA Sequence 
>gi|16802048:1099265-1102705 Listeria monocytogenes EGD-e, complete genome
AATGAATCGAATTAAAAAAGTATTAGTAGCAAACCGCGGAGAAATTGCTATCCGTGTTATGCGTGCGTGT
ACTGAACTCAAAATCAAAACAGTGGCTATTTATTCACAAGAAGATACTGGAAGTTTTCACCGGTATAAAT
CAGATGAAGCTTATCTGGTTGGAGCAGGGAAAAAGCCTATTGATGCGTATCTAGATATCGAAAACATAAT
AGAGATTGCTAAAGAATCTGGTGCAGACGCGATTCATCCGGGATATGGTTTCTTGTCCGAAAACATTGAA
TTTGCTCGTCGTTGTGAGCAAGAAGGCATTATTTTCGTTGGTCCTAAATCAAAACACCTAGATATGTTTG
GTGACAAAATTAAAGCAAAAGAACAAGCCCTATTAGCTGATATTCCAGTAATTCCGGGAAGTAATGGACC
CGTGGCTGGTATTAAAGAAGTAGAAGAATTTGGTGAGAAAAACGGTTATCCATTAATGATTAAAGCTTCC
CTTGGAGGCGGCGGTCGTGGTATGCGTGTCGTAGAATCAAAAGAACATGTCAAAGAAAGCTTTGAACGCG
CATCTTCAGAAGCAAAAGCTGCATTCGGAAATGATGAAGTATATGTAGAAAAATGTGTGATGAATCCAAA
ACATATTGAAGTACAAATTCTTGGTGACACCCATGGCAACATCGTTCATTTATTCGAACGTGATTGTTCA
ATACAACGACGTCATCAAAAAGTAGTAGAAGTAGCTCCGTGTAATGCGATTACTTCTGAACTACGTAACC
GAATCTGTGATGCTGCAGTAAAACTAATGAAAAATGTTGATTATATTAATGCTGGAACGGTTGAATTTTT
AGTTGAAGGTGACGATTTCTACTTTATCGAAGTAAATCCTCGTGTCCAAGTGGAGCATACAATTACAGAA
ATGATTACTGGTATTGATATCGTTCAATCACAATTATTCATTGCAGATGGTTATGCACTTCACGACCAAC
TAGTAGCTATTCCTAAGCAAGAGGATATCCATATTCACGGTTCTGCTATTCAAAGCCGTATTACAACGGA
AGATCCACTTAATAACTTTATGCCAGATACTGGTCGAGTAGATACGTATCGTTCCACAGGTGGTTTTGGT
GTTCGGTTGGATGCTGGTAACGGCTTCCAAGGAACAGTAGTAACACCATTTTATGATTCATTACTAGTAA
AATTATGTACTTGGGGAATGACATTTGAGCAAGCAACGCGCAAAATGCGTCGTAACCTGATCGAATTCCG
TATCCGCGGTGTCAAAACGAACATTCCTTTCTTATTGAATGTAGTTCGTCATCCAGATTTTGCGAGTGGT
AATTACAATACAAGCTTTATCGATACAACTCCGGAACTATTTAAATTTCCACATATTCGCGACCGTGGTA
CGAAAACGTTGCGTTATATTGGTAATGTAACTGTTAATGGTTTCCCAGGAATTAAGCACCGTGATAAACC
TGTTTATGCAGAACCACGTTTGCCAAAAATTCCTTATGGTTCGCAAATCTCTCCAGGAACAAAACAAATT
TTGGATGCAAAAGGTCCAGAAGGCGTTGTCGACTGGGTGAAAAAACAAGAAGAAGTACTTTTGACAGATA
CTACGCTTCGAGATGCACATCAATCTCTACTTGCGACACGTGTTCGTTCAAAAGATATTTTTCAAGTGGC
AGACGCAATGGCACATTTATTACCAAATATGTTCTCATTTGAAATGTGGGGAGGGGCGACTTTTGACGTG
GCATATCGTTTCCTAAATGAAGATCCATGGGTGCGCCTAGAAACACTTAGAAAACAAATTCCAAATGTGA
TGTTCCAAATGTTACTTCGCGGAGCTAATGCAGTTGGGTATAAAAACTACCCTGACAATGTTATCCGTGA
ATTCGTTAAGCAATCAGCACAATCCGGTGTCGATGTATTCCGCGTGTTTGACAGCTTAAACTGGATCAAA
GGCATGGAAGTGTCCATTGATGCTGTTCGTGAAGCAGGGAAGGTCGTAGAGGCTGCTATCTGCTATACAG
GAGATATCGATGATGACACAAGAACGAAATATACGATTGATTACTATAAAGATATGGCGAAAGAGCTCGT
TGCTCAAGGTACGCATATTTTAGGCATTAAAGATATGGCTGGACTTTTAAAACCACAAGCAGCTTACCGT
TTAATTGGTGAATTAAAAGATACAGTAGATGTTCCAATCCACCTTCATACACATGACACAAGCGGCAACG
GTATTTATACTTACGCAGCAGCAGTCAGTGCAGGAGTTGACATTGTGGATGTTGCATCAAGCGCGATGAG
TGGGGCTACAAGCCAACCAAGTATGACTGGTCTTTACTACGGATTAGTGAATGGTAACCGTCAAACGAAC
TTAGACGCTCAAAATTCCCAAATCATTAATCATTACTGGGAAGATGTCCGTCACTATTATAAAGACTTTG
ACAATGCGCTTAATTCACCTCAAACAGAAGTATACATTCATGAAATGCCAGGTGGTCAATATACTAACCT
TCAACAACAAGCCATTGCAGTTGGACTAGGCGATCGTTGGGACGAAGTGAAAGAAATGTATACAGTGGTT
AATCAAATGTTTGGTGATATCGTTAAAGTAACACCTTCTTCCAAAGTTGTTGGAGACTTGGCGCTATTCA
TGGTTCAAAATGAATTATCCGAAGAAGATGTATATGAAAAAGGCGATACCATTGATTTCCCAGATTCCGT
TATCGAATTCTTTATGGGGGAAATTGGTCAACCATACGGCGGCTTCCCAGAAAAACTTCAAAAACTAGTA
CTCAAAGGACGTACACCACTTACAGATCGTCCAGGCGCTTTAATGGAGCCAGTTAACTTTGTTGATGTCA
AAGCAGAATTAAAAGAAAAAATGGGTTATGAACCAACTGAAAAAGATGTCATTTCCTATATTTTATATCC
AAAAGTGTTCCTAGATTATCAAGATATGATTAACAAATATGGTGATGTAACAGTCCTTGATACACCGACA
TTCTATAAAGGAATGCGTTTAGGGGAAACAATCGAAGTAGAACTTGAAAAAGGAAAAATCCTTTTAATCA
AGCTAAATTCCATTGGTGAACCAATTGCGGATGGCACACGTGTTATCTATTTTGAATTGAATGGACAACC
ACGTGAGATTAACATCCAAGATATGAACGTTCAATCTACTGTTATTGCACGCCGTAAGATTGATACAACT
AACCCTGAACATGTTGGAGCGACAATGACAGGTTCAGTCATTCAAGTTGTTGTGAAAAAAGGCGACTCTG
TGAAAAAAGGAGATCCACTACTAATCACAGAAGCAATGAAAATGGAAACAACGATTCAAGCGCCTTTCGA
TGGAGAAGTTAGCAGCATTTATGTTTCTGACGGCGATACTATCGAATCTGGTGATCTATTAATTGAAGTA
AACAGAATTTA
Protein Sequence 
>gi|16803112|ref|NP_464597.1| pyruvate carboxylase [Listeria monocytogenes EGD-e] MNRIKKVLVANRGEIAIRVMRACTELKIKTVAIYSQEDTGSFHRYKSDEAYLVGAGKKPIDAYLDIENIIEIAKESGADAIHPGYGFLSENIEFARRCEQEGIIFVGPKSKHLDMFGDKIKAKEQALLADIPVIPGSNGPVAGIKEVEEFGEKNGYPLMIKASLGGGGRGMRVVESKEHVKESFERASSEAKAAFGNDEVYVEKCVMNPKHIEVQILGDTHGNIVHLFERDCSIQRRHQKVVEVAPCNAITSELRNRICDAAVKLMKNVDYINAGTVEFLVEGDDFYFIEVNPRVQVEHTITEMITGIDIVQSQLFIADGYALHDQLVAIPKQEDIHIHGSAIQSRITTEDPLNNFMPDTGRVDTYRSTGGFGVRLDAGNGFQGTVVTPFYDSLLVKLCTWGMTFEQATRKMRRNLIEFRIRGVKTNIPFLLNVVRHPDFASGNYNTSFIDTTPELFKFPHIRDRGTKTLRYIGNVTVNGFPGIKHRDKPVYAEPRLPKIPYGSQISPGTKQILDAKGPEGVVDWVKKQEEVLLTDTTLRDAHQSLLATRVRSKDIFQVADAMAHLLPNMFSFEMWGGATFDVAYRFLNEDPWVRLETLRKQIPNVMFQMLLRGANAVGYKNYPDNVIREFVKQSAQSGVDVFRVFDSLNWIKGMEVSIDAVREAGKVVEAAICYTGDIDDDTRTKYTIDYYKDMAKELVAQGTHILGIKDMAGLLKPQAAYRLIGELKDTVDVPIHLHTHDTSGNGIYTYAAAVSAGVDIVDVASSAMSGATSQPSMTGLYYGLVNGNRQTNLDAQNSQIINHYWEDVRHYYKDFDNALNSPQTEVYIHEMPGGQYTNLQQQAIAVGLGDRWDEVKEMYTVVNQMFGDIVKVTPSSKVVGDLALFMVQNELSEEDVYEKGDTIDFPDSVIEFFMGEIGQPYGGFPEKLQKLVLKGRTPLTDRPGALMEPVNFVDVKAELKEKMGYEPTEKDVISYILYPKVFLDYQDMINKYGDVTVLDTPTFYKGMRLGETIEVELEKGKILLIKLNSIGEPIADGTRVIYFELNGQPREINIQDMNVQSTVIARRKIDTTNPEHVGATMTGSVIQVVVKKGDSVKKGDPLLITEAMKMETTIQAPFDGEVSSIYVSDGDTIESGDLLIEVNRI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pycA mutant unable to replicate in mammalian cells, attenuated in mice (Schär et al., 2010).
COG COG1038C, under C: Energy production and conversion
References
Schär et al., 2010: Schär J, Stoll R, Schauer K, Loeffler DI, Eylert E, Joseph B, Eisenreich W, Fuchs TM, Goebel W. Pyruvate carboxylase plays a crucial role in carbon metabolism of extra- and intracellularly replicating Listeria monocytogenes. Journal of bacteriology. 2010; 192(7); 1774-1784. [PubMed: 20097852].